• 22150 Citations
1979 …2021
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Personal profile

Research Interests

Our lab is interested in the effects of oxygen on cell metabolism, and in the molecular mechanisms underlying cellular oxygen sensing. The signaling pathways activated by hypoxia, and their regulation of transcriptional and post-translational responses in diverse cell types are also of major interest. Current studies focus on the role of mitochondrial redox signaling in the development of pulmonary hypertension. Other current studies focus on cardiomyocyte regeneration in the heart and molecular factors that regulate hypertrophic and hyperplastic remodeling responses.

Education/Academic qualification

PhD, Albany Medical College

… → 1980

Keywords

  • Cancer Biology
  • Cardiovascular Diseases
  • Cell Biology
  • Lungs / Breathing Problems
  • Metabolism
  • Parkinson’s Disease
  • Pulmonary Hypertension
  • Signal Transduction

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Grants 2005 2021

Parkinson Disease
Neurons
Mitochondrial DNA
Clustered Regularly Interspaced Short Palindromic Repeats
Cell Aging
Levodopa
Parkinson Disease
Dyskinesias
Dopaminergic Neurons
Muscarinic M4 Receptors

Research Output 1979 2019

4 Citations (Scopus)

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair

Zhang, S., Weinberg, S., DeBerge, M., Gainullina, A., Schipma, M. J., Kinchen, J. M., Ben-Sahra, I., Gius, D. R., Yvan-Charvet, L., Chandel, N., Schumacker, P. T. & Thorp, E. B., Feb 5 2019, In : Cell Metabolism. 29, 2, p. 443-456.e5

Research output: Contribution to journalArticle

Electron Transport
Fatty Acids
Macrophages
Interleukin-10
NAD
6 Citations (Scopus)

Mitochondrial complex III is essential for suppressive function of regulatory T cells

Weinberg, S. E., Singer, B., Steinert, E. M., Martinez, C. A., Mehta, M. M., Martínez-Reyes, I., Gao, P., Helmin, K. A., Abdala-Valencia, H., Sena, L. A., Schumacker, P. T., Turka, L. A. & Chandel, N., Jan 24 2019, In : Nature. 565, 7740, p. 495-499 5 p.

Research output: Contribution to journalLetter

Electron Transport Complex III
Regulatory T-Lymphocytes
Electron Transport
T-Lymphocytes
Self Tolerance
3 Citations (Scopus)

Sensors and signals: the role of reactive oxygen species in hypoxic pulmonary vasoconstriction

Smith, K. A. & Schumacker, P. T., Feb 15 2019, In : Journal of Physiology. 597, 4, p. 1033-1043 11 p.

Research output: Contribution to journalArticle

Vasoconstriction
Reactive Oxygen Species
Lung
Cell Hypoxia
Critical Pathways
4 Citations (Scopus)
Hypoxia-Inducible Factor 1
Erythropoiesis
Pulmonary Hypertension
Up-Regulation
Protein Kinases
4 Citations (Scopus)

mRNA-binding protein tristetraprolin is essential for cardiac response to iron deficiency by regulating mitochondrial function

Sato, T., Chang, H. C., Bayeva, M., Shapiro, J. S., Ramos-Alonso, L., Kouzu, H., Jiang, X., Liu, T., Yar, S., Sawicki, K. T., Chen, C., Martínez-Pastor, M. T., Stumpo, D. J., Schumacker, P. T., Blackshear, P. J., Ben-Sahra, I., Puig, S. & Ardehali, H., Jul 3 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 27, p. E6291-E6300

Research output: Contribution to journalArticle

Tristetraprolin
Carrier Proteins
Iron
Messenger RNA
Electron Transport Complex III