Grants per year
Personal profile
Research Interests
Our lab is interested in the effects of oxygen on cell metabolism, and in the molecular mechanisms underlying cellular oxygen sensing. The signaling pathways activated by hypoxia, and their regulation of transcriptional and post-translational responses in diverse cell types are also of major interest. Current studies focus on the role of mitochondrial redox signaling in the development of pulmonary hypertension. Other current studies focus on cardiomyocyte regeneration in the heart and molecular factors that regulate hypertrophic and hyperplastic remodeling responses.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Physiology, Albany Medical College
… → 1980
Research interests keywords
- Cancer Biology
- Cardiovascular Diseases
- Cell Biology
- Lungs / Breathing Problems
- Metabolism
- Parkinson’s Disease
- Pulmonary Hypertension
- Signal Transduction
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Collaborations and top research areas from the last five years
Grants
- 64 Finished
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Redox Regulation in the Perinatal Pulmonary Vasculature
National Heart, Lung, and Blood Institute, National Institutes of Health
9/15/19 → 6/30/21
Project: Research project
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Redox Regulation in the Perinatal Pulmonary Vasculature
National Heart, Lung, and Blood Institute, National Institutes of Health
9/15/19 → 6/30/21
Project: Research project
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Molecular and Cellular Mechanisms of Parkinson's Disease
Northwestern University, JPB Foundation
11/1/18 → 10/31/21
Project: Research project
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Disordered Proteostasis as a Driver of Disease in the Aging Lung
Northwestern University, National Institutes of Health
9/15/18 → 7/31/19
Project: Research project
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Subproject for Institution # SP0046610
Schumacker, P. T. & Surmeier Jr, D. J.
Michael J. Fox Foundation for Parkinson's Research
1/1/18 → 4/16/21
Project: Research project
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H2O2 transit through the mitochondrial intermembrane space promotes tumor cell growth in vitro and in vivo
Sabharwal, S. S., Dudley, V. J., Landwerlin, C. & Schumacker, P. T., May 2023, In: Journal of Biological Chemistry. 299, 5, 104624.Research output: Contribution to journal › Article › peer-review
Open Access -
Selected Bibliography of Recent Research in Sleep (2020-2021)
Kundel, V., Javaheri, S., Mehra, R., Schumacker, P. T., Ayas, N. & Peker, Y., May 15 2023, In: American journal of respiratory and critical care medicine. 207, 10, p. 1383-1392 10 p.Research output: Contribution to journal › Article › peer-review
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Author Correction: Disruption of mitochondrial complex I induces progressive parkinsonism (Nature, (2021), 599, 7886, (650-656), 10.1038/s41586-021-04059-0)
González-Rodríguez, P., Zampese, E., Stout, K. A., Guzman, J. N., Ilijic, E., Yang, B., Tkatch, T., Stavarache, M. A., Wokosin, D. L., Gao, L., Kaplitt, M. G., López-Barneo, J., Schumacker, P. T. & Surmeier, D. J., Mar 3 2022, In: Nature. 603, 7899, p. E1Research output: Contribution to journal › Comment/debate › peer-review
Open Access1 Scopus citations -
Ca2+ channels couple spiking to mitochondrial metabolism in substantia nigra dopaminergic neurons
Zampese, E., Wokosin, D. L., Gonzalez-Rodriguez, P., Guzman, J. N., Tkatch, T., Kondapalli, J., Surmeier, W. C., D’Alessandro, K. B., De Stefani, D., Rizzuto, R., Iino, M., Molkentin, J. D., Chandel, N. S., Schumacker, P. T. & Surmeier, D. J., Sep 2022, In: Science Advances. 8, 39, eabp8701.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo
Murphy, M. P., Bayir, H., Belousov, V., Chang, C. J., Davies, K. J. A., Davies, M. J., Dick, T. P., Finkel, T., Forman, H. J., Janssen-Heininger, Y., Gems, D., Kagan, V. E., Kalyanaraman, B., Larsson, N. G., Milne, G. L., Nyström, T., Poulsen, H. E., Radi, R., Van Remmen, H., Schumacker, P. T., & 5 others , Jun 2022, In: Nature Metabolism. 4, 6, p. 651-662 12 p.Research output: Contribution to journal › Article › peer-review
Open Access168 Scopus citations
Datasets
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Source data for "Ca2+ channels couple spiking to mitochondrial metabolism in substantia nigra dopaminergic neurons"
Zampese, E. (Contributor), Wokosin, D. L. (Contributor), Guzman-Lucero, J. N. (Contributor), Tkatch, T. (Contributor), Kondapalli, J. (Contributor), Surmeier, W. C. (Contributor), D'Alessandro, K. B. (Contributor), De Stefani, D. (Contributor), Rizzuto, R. (Contributor), Iino, M. (Contributor), Molkentin, J. D. (Contributor), Chandel, N. (Contributor), Schumacker, P. T. (Contributor) & Surmeier Jr, D. J. (Contributor), ZENODO, Aug 8 2022
DOI: 10.5281/zenodo.6949450, https://zenodo.org/record/6949450
Dataset