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Personal profile

Research Interests

Our lab is interested in the effects of oxygen on cell metabolism, and in the molecular mechanisms underlying cellular oxygen sensing. The signaling pathways activated by hypoxia, and their regulation of transcriptional and post-translational responses in diverse cell types are also of major interest. Current studies focus on the role of mitochondrial redox signaling in the development of pulmonary hypertension. Other current studies focus on cardiomyocyte regeneration in the heart and molecular factors that regulate hypertrophic and hyperplastic remodeling responses.

Education/Academic qualification

PhD, Albany Medical College

… → 1980

Research interests

  • Cancer Biology
  • Cardiovascular Diseases
  • Cell Biology
  • Lungs / Breathing Problems
  • Metabolism
  • Parkinson’s Disease
  • Pulmonary Hypertension
  • Signal Transduction

Fingerprint Dive into the research topics where Paul T Schumacker is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 21 Similar Profiles
Reactive Oxygen Species Medicine & Life Sciences
Oxidants Medicine & Life Sciences
Oxygen Medicine & Life Sciences
Mitochondria Medicine & Life Sciences
Lung Medicine & Life Sciences
Cardiac Myocytes Medicine & Life Sciences
Dogs Medicine & Life Sciences
Oxidation-Reduction Medicine & Life Sciences

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Grants 2005 2021

Parkinson Disease
Neurons
Mitochondrial DNA
Clustered Regularly Interspaced Short Palindromic Repeats
Cell Aging
Levodopa
Parkinson Disease
Dyskinesias
Dopaminergic Neurons
Muscarinic M4 Receptors

Research Output 1979 2019

Drp1S600 phosphorylation regulates mitochondrial fission and progression of nephropathy in diabetic mice

Galvan, D. L., Long, J., Green, N., Chang, B. H., Lin, J. S., Schumacker, P. T., Truong, L. D., Overbeek, P. & Danesh, F. R., Jan 1 2019, In : Journal of Clinical Investigation. 129, 7, p. 2807-2823 17 p.

Research output: Contribution to journalArticle

Open Access
Mitochondrial Dynamics
Diabetic Nephropathies
Serine
Phosphorylation
Dynamins
8 Citations (Scopus)

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair

Zhang, S., Weinberg, S., DeBerge, M., Gainullina, A., Schipma, M. J., Kinchen, J. M., Ben-Sahra, I., Gius, D. R., Yvan-Charvet, L., Chandel, N., Schumacker, P. T. & Thorp, E. B., Feb 5 2019, In : Cell Metabolism. 29, 2, p. 443-456.e5

Research output: Contribution to journalArticle

Electron Transport
Fatty Acids
Macrophages
Interleukin-10
NAD

Happy 30th anniversary to the Red Journal!

Schumacker, P. T., Jan 1 2019, In : American journal of respiratory cell and molecular biology. 61, 1, p. 1-2 2 p.

Research output: Contribution to journalEditorial

Open Access
Anniversaries and Special Events
21 Citations (Scopus)

Mitochondrial complex III is essential for suppressive function of regulatory T cells

Weinberg, S. E., Singer, B., Steinert, E. M., Martinez, C. A., Mehta, M. M., Martínez-Reyes, I., Gao, P., Helmin, K. A., Abdala-Valencia, H., Sena, L. A., Schumacker, P. T., Turka, L. A. & Chandel, N., Jan 24 2019, In : Nature. 565, 7740, p. 495-499 5 p.

Research output: Contribution to journalLetter

Electron Transport Complex III
Regulatory T-Lymphocytes
Electron Transport
T-Lymphocytes
Self Tolerance
5 Citations (Scopus)

Sensors and signals: the role of reactive oxygen species in hypoxic pulmonary vasoconstriction

Smith, K. A. & Schumacker, P. T., Feb 15 2019, In : Journal of Physiology. 597, 4, p. 1033-1043 11 p.

Research output: Contribution to journalArticle

Vasoconstriction
Reactive Oxygen Species
Lung
Cell Hypoxia
Critical Pathways