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Research Output 1979 2020

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2020

Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain

Graves, S. M., Xie, Z., Stout, K. A., Zampese, E., Burbulla, L. F., Shih, J. C., Kondapalli, J., Patriarchi, T., Tian, L., Brichta, L., Greengard, P., Krainc, D., Schumacker, P. T. & Surmeier, D. J., Jan 1 2020, In : Nature Neuroscience. 23, 1, p. 15-20 6 p.

Research output: Contribution to journalArticle

Monoamine Oxidase
Electron Transport
Dopamine
Mitochondrial Membranes
Hydrogen Peroxide
2019
1 Citation (Scopus)

Drp1S600 phosphorylation regulates mitochondrial fission and progression of nephropathy in diabetic mice

Galvan, D. L., Long, J., Green, N., Chang, B. H., Lin, J. S., Schumacker, P. T., Truong, L. D., Overbeek, P. & Danesh, F. R., Jan 1 2019, In : Journal of Clinical Investigation. 129, 7, p. 2807-2823 17 p.

Research output: Contribution to journalArticle

Open Access
Mitochondrial Dynamics
Diabetic Nephropathies
Serine
Phosphorylation
Dynamins
15 Citations (Scopus)

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair

Zhang, S., Weinberg, S., DeBerge, M., Gainullina, A., Schipma, M. J., Kinchen, J. M., Ben-Sahra, I., Gius, D. R., Yvan-Charvet, L., Chandel, N., Schumacker, P. T. & Thorp, E. B., Feb 5 2019, In : Cell Metabolism. 29, 2, p. 443-456.e5

Research output: Contribution to journalArticle

Electron Transport
Fatty Acids
Macrophages
Interleukin-10
NAD
5 Citations (Scopus)

Sensors and signals: the role of reactive oxygen species in hypoxic pulmonary vasoconstriction

Smith, K. A. & Schumacker, P. T., Feb 15 2019, In : Journal of Physiology. 597, 4, p. 1033-1043 11 p.

Research output: Contribution to journalArticle

Vasoconstriction
Reactive Oxygen Species
Lung
Cell Hypoxia
Critical Pathways
2018
4 Citations (Scopus)

JNK2 up-regulates hypoxia-inducible factors and contributes to hypoxia-induced erythropoiesis and pulmonary hypertension

Sala, M. A., Chen, C., Zhang, Q., Do-Umehara, H. C., Wu, W., Misharin, A. V., Waypa, G. B., Fang, D., Budinger, G. R. S., Liu, S., Chandel, N. S., Schumacker, P. T., Sznajder, J. I. & Liu, J., Jan 1 2018, In : Journal of Biological Chemistry. 293, 1, p. 271-284 14 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Erythropoiesis
Pulmonary Hypertension
Up-Regulation
Protein Kinases
6 Citations (Scopus)

mRNA-binding protein tristetraprolin is essential for cardiac response to iron deficiency by regulating mitochondrial function

Sato, T., Chang, H. C., Bayeva, M., Shapiro, J. S., Ramos-Alonso, L., Kouzu, H., Jiang, X., Liu, T., Yar, S., Sawicki, K. T., Chen, C., Martínez-Pastor, M. T., Stumpo, D. J., Schumacker, P. T., Blackshear, P. J., Ben-Sahra, I., Puig, S. & Ardehali, H., Jul 3 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 27, p. E6291-E6300

Research output: Contribution to journalArticle

Tristetraprolin
Carrier Proteins
Iron
Messenger RNA
Electron Transport Complex III

MRNA-binding protein tristetraprolin is essential for cardiac response to iron deficiency by regulating mitochondrial function

Sato, T., Chang, H. C., Bayeva, M., Shapiro, J. S., Alonso, R. L., Kouzu, H., Jiang, X., Liu, T., Yar, S., Sawicki, K. T., Chen, C., Martinez-Pastor, M. T., Stumpo, D. J., Schumacker, P. T., Blackshear, P. J., Sahra, B. I., Puig, S. & Ardehali, H., Dec 1 2018, In : Sapporo Medical journal. 87, 1-6, p. 98-99 2 p.

Research output: Contribution to journalArticle

Tristetraprolin
Carrier Proteins
Iron
23 Citations (Scopus)

Systemic isradipine treatment diminishes calcium-dependent mitochondrial oxidant stress

Guzman, J. N., Ilijic, E., Yang, B., Sanchez-Padilla, J., Wokosin, D., Galtieri, D., Kondapalli, J., Schumacker, P. T. & Surmeier, D. J., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2266-2280 15 p.

Research output: Contribution to journalArticle

Isradipine
Dopaminergic Neurons
Oxidants
Calcium
Mitochondrial Degradation
1 Citation (Scopus)

The Phillip Morris Foundation for a smoke-free world: A cause for concern

Goldberg, D. S., Lederer, D. J., MacKenzie, E. J., Moss, M., Samet, J. M., Schumacker, P. T., Wedzicha, J. A. & Wynia, M. K., Nov 2018, In : Annals of the American Thoracic Society. 15, 11, p. 1269-1272 4 p.

Research output: Contribution to journalArticle

Smoke
2017
15 Citations (Scopus)

Real-time in vivo mitochondrial redox assessment confirms enhanced mitochondrial reactive oxygen species in diabetic nephropathy

Galvan, D. L., Badal, S. S., Long, J., Chang, B. H., Schumacker, P. T., Overbeek, P. A. & Danesh, F. R., Nov 1 2017, In : Kidney international. 92, 5, p. 1282-1287 6 p.

Research output: Contribution to journalArticle

Diabetic Nephropathies
Oxidation-Reduction
Reactive Oxygen Species
Biosensing Techniques
Green Fluorescent Proteins
21 Citations (Scopus)

Sirt3 protects dopaminergic neurons from mitochondrial oxidative stress

Shi, H., Deng, H. X., Gius, D., Schumacker, P. T., Surmeier, D. J. & Ma, Y. C., May 15 2017, In : Human molecular genetics. 26, 10, p. 1915-1926 12 p.

Research output: Contribution to journalArticle

Sirtuin 3
Dopaminergic Neurons
Oxidative Stress
Superoxide Dismutase
Acetylation
7 Citations (Scopus)

Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling

Rines, A. K., Chang, H. C., Wu, R., Sato, T., Khechaduri, A., Kouzu, H., Shapiro, J., Shang, M., Burke, M. A., Jiang, X., Chen, C., Rawlings, T. A., Lopaschuk, G. D., Schumacker, P. T., Abel, E. D. & Ardehali, H., Jan 24 2017, In : Nature communications. 8, 14095.

Research output: Contribution to journalArticle

Phosphotransferases
proteins
ischemia
Proteins
Palmitates
61 Citations (Scopus)

The mitochondrial respiratory chain is essential for haematopoietic stem cell function

Ansó, E., Weinberg, S. E., Diebold, L. P., Thompson, B. J., Malinge, S., Schumacker, P. T., Liu, X., Zhang, Y., Shao, Z., Steadman, M., Marsh, K. M., Xu, J., Crispino, J. D. & Chandel, N. S., May 31 2017, In : Nature Cell Biology. 19, 6, p. 614-625 12 p.

Research output: Contribution to journalArticle

Electron Transport
Hematopoietic Stem Cells
Fetal Stem Cells
Respiration
Adult Stem Cells
2016
34 Citations (Scopus)

Dynamin-related protein 1 deficiency improves mitochondrial fitness and protects against progression of diabetic nephropathy

Ayanga, B. A., Badal, S. S., Wang, Y., Galvan, D. L., Chang, B. H., Schumacker, P. T. & Danesh, F. R., Jan 1 2016, In : Journal of the American Society of Nephrology. 27, 9, p. 2733-2747 15 p.

Research output: Contribution to journalArticle

Dynamins
Protein Deficiency
Podocytes
Diabetic Nephropathies
Mitochondrial Dynamics
11 Citations (Scopus)

Intermediate filament aggregates cause mitochondrial dysmotility and increase energy demands in giant axonal neuropathy

Israeli, E., Dryanovski, D. I., Schumacker, P. T., Chandel, N. S., Singer, J. D., Julien, J. P., Goldman, R. D. & Opal, P., Jun 1 2016, In : Human molecular genetics. 25, 11, p. 2143-2157 15 p.

Research output: Contribution to journalArticle

Giant Axonal Neuropathy
Intermediate Filaments
Mutation
Physiological Stress
Cell Shape
2015
19 Citations (Scopus)

Asbestos-induced pulmonary fibrosis is augmented in 8-oxoguanine DNA glycosylase knockout mice

Cheresh, P., Morales-Nebreda, L., Kim, S. J., Yeldandi, A., Williams, D. B., Cheng, Y., Mutlu, G. M., Scott Budinger, G. R., Ridge, K., Schumacker, P. T., Bohr, V. A. & Kamp, D. W., Jan 1 2015, In : American journal of respiratory cell and molecular biology. 52, 1, p. 25-36 12 p.

Research output: Contribution to journalArticle

DNA Glycosylases
Alveolar Epithelial Cells
Pulmonary Fibrosis
Asbestos
Knockout Mice
15 Citations (Scopus)

Cyclic stretch stimulates mitochondrial reactive oxygen species and Nox4 signaling in pulmonary artery smooth muscle cells

Wedgwood, S., Lakshminrusimha, S., Schumacker, P. T. & Steinhorn, R. H., Jul 15 2015, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 309, 2, p. L196-L203

Research output: Contribution to journalArticle

Persistent Fetal Circulation Syndrome
Electron Transport Complex III
Pulmonary Artery
Smooth Muscle Myocytes
Reactive Oxygen Species
12 Citations (Scopus)

Hypoxia inducible factor signaling and experimental persistent pulmonary hypertension of the newborn

Wedgwood, S., Lakshminrusimha, S., Schumacker, P. T. & Steinhorn, R. H., Jan 1 2015, In : Frontiers in Pharmacology. 6, MAR, 47.

Research output: Contribution to journalArticle

Persistent Fetal Circulation Syndrome
Pulmonary Artery
Smooth Muscle Myocytes
Lung
Pulmonary Hypertension
7 Citations (Scopus)

Identification of fumarate hydratase inhibitors with nutrient-dependent cytotoxicity

Takeuchi, T., Schumacker, P. T. & Kozmin, S. A., Jan 21 2015, In : Journal of the American Chemical Society. 137, 2, p. 564-567 4 p.

Research output: Contribution to journalArticle

Fumarate Hydratase
Cytotoxicity
Nutrients
Enzymes
Pharmacology
28 Citations (Scopus)

Mouse lung development and NOX1 induction during hyperoxia are developmentally regulated and mitochondrial ROS dependent

Datta, A., Kim, G. A., Taylor, J. M., Gugino, S. F., Farrow, K. N., Schumacker, P. T. & Berkelhamer, S. K., Aug 18 2015, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 309, 4, p. L369-L377

Research output: Contribution to journalArticle

Hyperoxia
Reactive Oxygen Species
Lung
Right Ventricular Hypertrophy
Bronchopulmonary Dysplasia
2014
70 Citations (Scopus)

Mitochondria in lung biology and pathology: More than just a powerhouse

Schumacker, P. T., Gillespie, M. N., Nakahira, K., Choi, A. M. K., Crouser, E. D., Piantadosi, C. A. & Bhattacharya, J., Jun 1 2014, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 306, 11, p. L962-L974

Research output: Contribution to journalArticle

Mitochondria
Pathology
Lung
Reactive Oxygen Species
Mitochondrial Genome
64 Citations (Scopus)

Mitochondrial oxidant stress in locus coeruleus is regulated by activity and nitric oxide synthase

Sanchez-Padilla, J., Guzman-Lucero, J. N., Ilijic, E., Kondapalli, J., Galtieri, D. J., Yang, B., Schieber, S., Oertel, W., Wokosin, D. L., Schumacker, P. T. & Surmeier Jr, D. J., Jan 1 2014, In : Nature Neuroscience. 17, 6, p. 832-840 9 p.

Research output: Contribution to journalArticle

Locus Coeruleus
Oxidants
Nitric Oxide Synthase
Neurons
Parkinson Disease
47 Citations (Scopus)

Mitochondria-targeted Ogg1 and aconitase-2 prevent oxidant-induced mitochondrial DNA damage in alveolar epithelial cells

Kim, S. J., Cheresh, P., Williams, D., Cheng, Y., Ridge, K., Schumacker, P. T., Weitzman, S., Bohr, V. A. & Kamp, D. W., Feb 28 2014, In : Journal of Biological Chemistry. 289, 9, p. 6165-6176 12 p.

Research output: Contribution to journalArticle

Aconitate Hydratase
Alveolar Epithelial Cells
Mitochondria
Mitochondrial DNA
Oxidants
95 Citations (Scopus)

Regulation of hypoxia-induced pulmonary hypertension by vascular smooth muscle hypoxia-inducible factor-1α

Ball, M. K., Waypa, G. B., Mungai, P. T., Nielsen, J. M., Czech, L., Dudley, V. J., Beussink, L., Dettman, R., Berkelhamer, S. K., Steinhorn, R. H., Shah, S. J. & Schumacker, P. T., Feb 1 2014, In : American Journal of Respiratory and Critical Care Medicine. 189, 3, p. 314-324 11 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Vascular Smooth Muscle
Pulmonary Hypertension
Smooth Muscle
Tamoxifen
1 Citation (Scopus)

Update in pulmonary vascular diseases 2013

Hassoun, P. M. & Schumacker, P. T., Oct 1 2014, In : American journal of respiratory and critical care medicine. 190, 7, p. 738-743 6 p.

Research output: Contribution to journalArticle

Pulmonary Veno-Occlusive Disease
Pulmonary Embolism
Vascular Diseases
Pulmonary Hypertension
Lung Diseases
2013
106 Citations (Scopus)

Calcium entry and α-synuclein inclusions elevate dendritic mitochondrial oxidant stress in dopaminergic neurons

Dryanovski, D. I., Guzman, J. N., Xie, Z., Galteri, D. J., Volpicelli-Daley, L. A., Lee, V. M. Y., Miller, R. J., Schumacker, P. T. & James Surmeier, D., Jun 17 2013, In : Journal of Neuroscience. 33, 24, p. 10154-10164 11 p.

Research output: Contribution to journalArticle

Synucleins
Dopaminergic Neurons
Oxidants
Dendrites
Calcium
12 Citations (Scopus)

Cyclic stretch induces inducible nitric oxide synthase and soluble guanylate cyclase in pulmonary artery smooth muscle cells

Shah, M. R., Wedgwood, S., Czech, L., Kim, G. A., Lakshminrusimha, S., Schumacker, P. T., Steinhorn, R. H. & Farrow, K. N., Feb 1 2013, In : International journal of molecular sciences. 14, 2, p. 4334-4348 15 p.

Research output: Contribution to journalArticle

smooth muscle
muscle cells
Guanylate Cyclase
Nitric oxide
Nitric Oxide Synthase Type II
44 Citations (Scopus)

Developmental differences in hyperoxia-induced oxidative stress and cellular responses in the murine lung

Berkelhamer, S. K., Kim, G. A., Radder, J. E., Wedgwood, S., Czech, L., Steinhorn, R. H. & Schumacker, P. T., May 9 2013, In : Free Radical Biology and Medicine. 61, p. 51-60 10 p.

Research output: Contribution to journalArticle

Hyperoxia
Oxidative stress
Oxidants
Oxidative Stress
Antioxidants
24 Citations (Scopus)

Hypoxia-inducible factor-2α and TGF-β signaling interact to promote normoxic glomerular fibrogenesis

Hanna, C., Hubchak, S. C., Liang, X., Rozen-Zvi, B., Schumacker, P. T., Hayashida, T. & Schnaper, H. W., Nov 1 2013, In : American Journal of Physiology - Renal Physiology. 305, 9

Research output: Contribution to journalArticle

Transforming Growth Factors
Hypoxia-Inducible Factor 1
Kidney
Protein Isoforms
Collagen
398 Citations (Scopus)

Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

Sena, L. A., Li, S., Jairaman, A., Prakriya, M., Ezponda, T., Hildeman, D. A., Wang, C-R., Schumacker, P. T., Licht, J. D., Perlman, H. R., Bryce, P. J. & Chandel, N., Feb 21 2013, In : Immunity. 38, 2, p. 225-236 12 p.

Research output: Contribution to journalArticle

CD27 Antigens
Reactive Oxygen Species
Mitochondria
T-Lymphocytes
Interleukin-2
13 Citations (Scopus)

Paradoxical regulation of hypoxia inducible factor-1α (HIF-1α) by histone deacetylase inhibitor in diffuse large B-cell lymphoma

Bhalla, S., Evens, A. M., Prachand, S., Schumacker, P. T. & Gordon, L. I., Nov 27 2013, In : PloS one. 8, 11, e81333.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
histone deacetylase
Histone Deacetylase Inhibitors
Lymphoma, Large B-Cell, Diffuse
lymphoma
28 Citations (Scopus)

Peroxiredoxin-5 targeted to the mitochondrial intermembrane space attenuates hypoxia-induced reactive oxygen species signalling

Sabharwal, S. S., Waypa, G. B., Marks, J. D. & Schumacker, P. T., Dec 15 2013, In : Biochemical Journal. 456, 3, p. 337-346 10 p.

Research output: Contribution to journalArticle

Peroxiredoxins
Reactive Oxygen Species
Oxidants
Pulmonary Artery
Muscle
44 Citations (Scopus)
Myocardial Reperfusion
Poly(ADP-ribose) Polymerases
Myocardial Ischemia
Permeability
Reperfusion
20 Citations (Scopus)

Sirtuin 3 deficiency does not augment hypoxia-induced pulmonary hypertension

Waypa, G. B., Osborne, S. W., Marks, J. D., Berkelhamer, S. K., Kondapalli, J. & Schumacker, P. T., Dec 1 2013, In : American journal of respiratory cell and molecular biology. 49, 6, p. 885-891 7 p.

Research output: Contribution to journalArticle

Sirtuin 3
Pulmonary Hypertension
Muscle
Reactive Oxygen Species
Hypoxia-Inducible Factor 1
74 Citations (Scopus)

Superoxide generated at mitochondrial complex iii triggers acute responses to hypoxia in the pulmonary circulation

Waypa, G. B., Marks, J. D., Guzy, R. D., Mungai, P. T., Schriewer, J. M., Dokic, D., Ball, M. K. & Schumacker, P. T., Feb 15 2013, In : American journal of respiratory and critical care medicine. 187, 4, p. 424-432 9 p.

Research output: Contribution to journalArticle

Pulmonary Circulation
Superoxides
Reactive Oxygen Species
Pulmonary Artery
Electron Transport Complex III
2012
40 Citations (Scopus)

Brief hyperoxia increases mitochondrial oxidation and increases phosphodiesterase 5 activity in fetal pulmonary artery smooth muscle cells

Farrow, K. N., Lee, K. J., Perez, M., Schriewer, J. M., Wedgwood, S., Lakshminrusimha, S., Smith, C. L., Steinhorn, R. H. & Schumacker, P. T., Aug 1 2012, In : Antioxidants and Redox Signaling. 17, 3, p. 460-470 11 p.

Research output: Contribution to journalArticle

Type 5 Cyclic Nucleotide Phosphodiesterases
Fetal Movement
Hyperoxia
Pulmonary Artery
Smooth Muscle Myocytes
218 Citations (Scopus)

Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells

Wang, W., Wang, Y., Long, J., Wang, J., Haudek, S. B., Overbeek, P., Chang, B. H. J., Schumacker, P. T. & Danesh, F. R., Feb 8 2012, In : Cell Metabolism. 15, 2, p. 186-200 15 p.

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Podocytes
rho-Associated Kinases
Hyperglycemia
Endothelial Cells
2011
60 Citations (Scopus)

Epithelial cell death is an important contributor to oxidant-mediated acute lung injury

Budinger, GR. S., Mutlu, G. M., Urich, D., Soberanes, S., Buccellato, L. J., Hawkins, K. A., Chiarella, S. E., Radigan, K. A., Eisenbart, J., Agrawal, H., Berkelhamer, S., Hekimi, S., Zhang, J., Perlman, H. R., Schumacker, P. T., Jain, M. & Chandel, N., Apr 15 2011, In : American journal of respiratory and critical care medicine. 183, 8, p. 1043-1054 12 p.

Research output: Contribution to journalArticle

Hyperoxia
Acute Lung Injury
Oxidants
Lung Injury
Cell Death
45 Citations (Scopus)

Hydrogen peroxide regulates extracellular superoxide dismutase activity and expression in neonatal pulmonary hypertension

Wedgwood, S., Lakshminrusimha, S., Fukai, T., Russell, J. A., Schumacker, P. T. & Steinhorn, R. H., Sep 15 2011, In : Antioxidants and Redox Signaling. 15, 6, p. 1497-1506 10 p.

Research output: Contribution to journalArticle

Persistent Fetal Circulation Syndrome
Pulmonary Hypertension
Hydrogen Peroxide
Superoxide Dismutase
Lung
205 Citations (Scopus)

Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels

Mungai, P. T., Waypa, G. B., Jairaman, A., Prakriya, M., Dokic, D., Ball, M. K. & Schumacker, P. T., Sep 1 2011, In : Molecular and cellular biology. 31, 17, p. 3531-3545 15 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Reactive Oxygen Species
Calcium
Calcium-Calmodulin-Dependent Protein Kinase Kinase
Adenosine Monophosphate
75 Citations (Scopus)
Hypoxia-Inducible Factor 1
Transforming Growth Factors
Collagen
Epithelial Cells
Kidney
42 Citations (Scopus)
Cell Hypoxia
Reactive Oxygen Species
Lung
Alveolar Epithelial Cells
Critical Pathways
122 Citations (Scopus)

Mitochondrial oxidant stress triggers cell death in simulated ischemia-reperfusion

Loor, G., Kondapalli, J., Iwase, H., Chandel, N., Waypa, G. B., Guzy, R. D., Vanden Hoek, T. L. & Schumacker, P. T., Jul 1 2011, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1813, 7, p. 1382-1394 13 p.

Research output: Contribution to journalArticle

Oxidants
Reperfusion
Cell Death
Ischemia
phospholipid-hydroperoxide glutathione peroxidase
2010
48 Citations (Scopus)

Hypoxia increases ros signaling and cytosolic Ca2+ in pulmonary artery smooth muscle cells of mouse lungs slices

Desireddi, J. R., Farrow, K. N., Marks, J. D., Waypa, G. B. & Schumacker, P. T., Mar 1 2010, In : Antioxidants and Redox Signaling. 12, 5, p. 595-602 8 p.

Research output: Contribution to journalArticle

Pulmonary Artery
Smooth Muscle Myocytes
Muscle
Cells
Reactive Oxygen Species
37 Citations (Scopus)

Hypoxia-inducible factor-1 α expression predicts superior survival in patients with diffuse large B-cell lymphoma treated with R-CHOP

Evens, A. M., Sehn, L. H., Farinha, P., Nelson, B. P., Raji, A., Lu, Y., Brakman, A., Parimi, V., Winter, J. N., Schumacker, P. T., Gascoyne, R. D. & Gordon, L. I., Feb 20 2010, In : Journal of Clinical Oncology. 28, 6, p. 1017-1024 8 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Lymphoma, Large B-Cell, Diffuse
Survival
Vincristine
Prednisone
194 Citations (Scopus)

Hypoxia triggers subcellular compartmental redox signaling in vascular smooth muscle cells

Waypa, G. B., Marks, J. D., Guzy, R., Mungai, P. T., Schriewer, J., Dokic, D. & Schumacker, P. T., Feb 1 2010, In : Circulation research. 106, 3, p. 526-535 10 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Oxidation-Reduction
Smooth Muscle Myocytes
Reactive Oxygen Species
Cytosol
113 Citations (Scopus)

Menadione triggers cell death through ROS-dependent mechanisms involving PARP activation without requiring apoptosis

Loor, G., Kondapalli, J., Schriewer, J. M., Chandel, N., Vanden Hoek, T. L. & Schumacker, P. T., Dec 15 2010, In : Free Radical Biology and Medicine. 49, 12, p. 1925-1936 12 p.

Research output: Contribution to journalArticle

Vitamin K 3
Cell death
Reactive Oxygen Species
Cell Death
Chemical activation
453 Citations (Scopus)

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

Guzman-Lucero, J. N., Sanchez-Padilla, J., Wokosin, D. L., Kondapalli, J., Ilijic, E., Schumacker, P. T. & Surmeier Jr, D. J., Dec 2 2010, In : Nature. 468, 7324, p. 696-700 5 p.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Oxidants
Parkinson Disease
Calcium
Purine Nucleotides
46 Citations (Scopus)

Prolonged hypoxia increases ros signaling and RhoA activation in pulmonary artery smooth muscle and endothelial cells

Chi, A. Y., Waypa, G. B., Mungai, P. T. & Schumacker, P. T., Mar 1 2010, In : Antioxidants and Redox Signaling. 12, 5, p. 603-610 8 p.

Research output: Contribution to journalArticle

Endothelial cells
Pulmonary Artery
Smooth Muscle Myocytes
Muscle
Endothelial Cells
48 Citations (Scopus)

Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report

Erzurum, S., Rounds, S. I., Stevens, T., Aldred, M., Aliotta, J., Archer, S. L., Asosingh, K., Balaban, R., Bauer, N., Bhattacharya, J., Bogaard, H., Choudhary, G., Dorn, G. W., Dweik, R., Fagan, K., Fallon, M., Finkel, T., Geraci, M., Gladwin, M. T., Hassoun, P. M. & 23 others, Humbert, M., Kaminski, N., Kawut, S. M., Loscalzo, J., McDonald, D., McMurtry, I. F., Newman, J., Nicolls, M., Rabinovitch, M., Shizuru, J., Oka, M., Polgar, P., Rodman, D., Schumacker, P., Stenmark, K., Tuder, R., Voelkel, N., Sullivan, E., Weinshilboum, R., Yoder, M. C., Zhao, Y., Gail, D. & Moore, T. M., Dec 15 2010, In : American Journal of Respiratory and Critical Care Medicine. 182, 12, p. 1554-1562 9 p.

Research output: Contribution to journalArticle

National Heart, Lung, and Blood Institute (U.S.)
Blood Vessels
Education
Lung
Lung Diseases