• 23667 Citations
1979 …2021

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Article
2020

Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain

Graves, S. M., Xie, Z., Stout, K. A., Zampese, E., Burbulla, L. F., Shih, J. C., Kondapalli, J., Patriarchi, T., Tian, L., Brichta, L., Greengard, P., Krainc, D., Schumacker, P. T. & Surmeier, D. J., Jan 1 2020, In : Nature neuroscience. 23, 1, p. 15-20 6 p.

Research output: Contribution to journalArticle

2 Scopus citations
2019

Drp1S600 phosphorylation regulates mitochondrial fission and progression of nephropathy in diabetic mice

Galvan, D. L., Long, J., Green, N., Chang, B. H., Lin, J. S., Schumacker, P., Truong, L. D., Overbeek, P. & Danesh, F. R., Jan 1 2019, In : Journal of Clinical Investigation. 129, 7, p. 2807-2823 17 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair

Zhang, S., Weinberg, S., DeBerge, M., Gainullina, A., Schipma, M., Kinchen, J. M., Ben-Sahra, I., Gius, D. R., Yvan-Charvet, L., Chandel, N. S., Schumacker, P. T. & Thorp, E. B., Feb 5 2019, In : Cell Metabolism. 29, 2, p. 443-456.e5

Research output: Contribution to journalArticle

28 Scopus citations

Sensors and signals: the role of reactive oxygen species in hypoxic pulmonary vasoconstriction

Smith, K. A. & Schumacker, P. T., Feb 15 2019, In : Journal of Physiology. 597, 4, p. 1033-1043 11 p.

Research output: Contribution to journalArticle

5 Scopus citations
2018

JNK2 up-regulates hypoxia-inducible factors and contributes to hypoxia-induced erythropoiesis and pulmonary hypertension

Sala, M. A., Chen, C., Zhang, Q., Do-Umehara, H. C., Wu, W., Misharin, A. V., Waypa, G. B., Fang, D., Budinger, G. R. S., Liu, S., Chandel, N. S., Schumacker, P. T., Sznajder, J. I. & Liu, J., Jan 1 2018, In : Journal of Biological Chemistry. 293, 1, p. 271-284 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

mRNA-binding protein tristetraprolin is essential for cardiac response to iron deficiency by regulating mitochondrial function

Sato, T., Chang, H. C., Bayeva, M., Shapiro, J. S., Ramos-Alonso, L., Kouzu, H., Jiang, X., Liu, T., Yar, S., Sawicki, K. T., Chen, C., Martínez-Pastor, M. T., Stumpo, D. J., Schumacker, P. T., Blackshear, P. J., Ben-Sahra, I., Puig, S. & Ardehali, H., Jul 3 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 27, p. E6291-E6300

Research output: Contribution to journalArticle

6 Scopus citations

MRNA-binding protein tristetraprolin is essential for cardiac response to iron deficiency by regulating mitochondrial function

Sato, T., Chang, H. C., Bayeva, M., Shapiro, J. S., Alonso, R. L., Kouzu, H., Jiang, X., Liu, T., Yar, S., Sawicki, K. T., Chen, C., Martinez-Pastor, M. T., Stumpo, D. J., Schumacker, P. T., Blackshear, P. J., Sahra, B. I., Puig, S. & Ardehali, H., Dec 1 2018, In : Sapporo Medical journal. 87, 1-6, p. 98-99 2 p.

Research output: Contribution to journalArticle

Systemic isradipine treatment diminishes calcium-dependent mitochondrial oxidant stress

Guzman, J. N., Ilijic, E., Yang, B., Sanchez-Padilla, J., Wokosin, D., Galtieri, D., Kondapalli, J., Schumacker, P. T. & Surmeier, D. J., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2266-2280 15 p.

Research output: Contribution to journalArticle

28 Scopus citations

The Phillip Morris Foundation for a smoke-free world: A cause for concern

Goldberg, D. S., Lederer, D. J., MacKenzie, E. J., Moss, M., Samet, J. M., Schumacker, P. T., Wedzicha, J. A. & Wynia, M. K., Nov 2018, In : Annals of the American Thoracic Society. 15, 11, p. 1269-1272 4 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Real-time in vivo mitochondrial redox assessment confirms enhanced mitochondrial reactive oxygen species in diabetic nephropathy

Galvan, D. L., Badal, S. S., Long, J., Chang, B. H., Schumacker, P. T., Overbeek, P. A. & Danesh, F. R., Nov 2017, In : Kidney international. 92, 5, p. 1282-1287 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

Sirt3 protects dopaminergic neurons from mitochondrial oxidative stress

Shi, H., Deng, H. X., Gius, D., Schumacker, P. T., Surmeier, D. J. & Ma, Y. C., May 15 2017, In : Human molecular genetics. 26, 10, p. 1915-1926 12 p.

Research output: Contribution to journalArticle

25 Scopus citations

Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling

Rines, A. K., Chang, H. C., Wu, R., Sato, T., Khechaduri, A., Kouzu, H., Shapiro, J., Shang, M., Burke, M. A., Jiang, X., Chen, C., Rawlings, T. A., Lopaschuk, G. D., Schumacker, P. T., Abel, E. D. & Ardehali, H., Jan 24 2017, In : Nature communications. 8, 14095.

Research output: Contribution to journalArticle

8 Scopus citations

The mitochondrial respiratory chain is essential for haematopoietic stem cell function

Ansó, E., Weinberg, S. E., Diebold, L. P., Thompson, B. J., Malinge, S., Schumacker, P. T., Liu, X., Zhang, Y., Shao, Z., Steadman, M., Marsh, K. M., Xu, J., Crispino, J. D. & Chandel, N. S., May 31 2017, In : Nature Cell Biology. 19, 6, p. 614-625 12 p.

Research output: Contribution to journalArticle

73 Scopus citations
2016

Dynamin-related protein 1 deficiency improves mitochondrial fitness and protects against progression of diabetic nephropathy

Ayanga, B. A., Badal, S. S., Wang, Y., Galvan, D. L., Chang, B. H., Schumacker, P. T. & Danesh, F. R., Jan 1 2016, In : Journal of the American Society of Nephrology. 27, 9, p. 2733-2747 15 p.

Research output: Contribution to journalArticle

41 Scopus citations

Intermediate filament aggregates cause mitochondrial dysmotility and increase energy demands in giant axonal neuropathy

Israeli, E., Dryanovski, D. I., Schumacker, P. T., Chandel, N. S., Singer, J. D., Julien, J. P., Goldman, R. D. & Opal, P., Jun 1 2016, In : Human molecular genetics. 25, 11, p. 2143-2157 15 p.

Research output: Contribution to journalArticle

14 Scopus citations
2015

Asbestos-induced pulmonary fibrosis is augmented in 8-oxoguanine DNA glycosylase knockout mice

Cheresh, P., Morales-Nebreda, L., Kim, S. J., Yeldandi, A., Williams, D. B., Cheng, Y., Mutlu, G. M., Scott Budinger, G. R., Ridge, K., Schumacker, P. T., Bohr, V. A. & Kamp, D. W., Jan 1 2015, In : American journal of respiratory cell and molecular biology. 52, 1, p. 25-36 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Cyclic stretch stimulates mitochondrial reactive oxygen species and Nox4 signaling in pulmonary artery smooth muscle cells

Wedgwood, S., Lakshminrusimha, S., Schumacker, P. T. & Steinhorn, R. H., Jul 15 2015, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 309, 2, p. L196-L203

Research output: Contribution to journalArticle

17 Scopus citations

Hypoxia inducible factor signaling and experimental persistent pulmonary hypertension of the newborn

Wedgwood, S., Lakshminrusimha, S., Schumacker, P. T. & Steinhorn, R. H., Jan 1 2015, In : Frontiers in Pharmacology. 6, MAR, 47.

Research output: Contribution to journalArticle

12 Scopus citations

Identification of fumarate hydratase inhibitors with nutrient-dependent cytotoxicity

Takeuchi, T., Schumacker, P. T. & Kozmin, S. A., Jan 21 2015, In : Journal of the American Chemical Society. 137, 2, p. 564-567 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Mouse lung development and NOX1 induction during hyperoxia are developmentally regulated and mitochondrial ROS dependent

Datta, A., Kim, G. A., Taylor, J. M., Gugino, S. F., Farrow, K. N., Schumacker, P. T. & Berkelhamer, S. K., Aug 18 2015, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 309, 4, p. L369-L377

Research output: Contribution to journalArticle

29 Scopus citations
2014

Mitochondria in lung biology and pathology: More than just a powerhouse

Schumacker, P. T., Gillespie, M. N., Nakahira, K., Choi, A. M. K., Crouser, E. D., Piantadosi, C. A. & Bhattacharya, J., Jun 1 2014, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 306, 11, p. L962-L974

Research output: Contribution to journalArticle

74 Scopus citations

Mitochondrial oxidant stress in locus coeruleus is regulated by activity and nitric oxide synthase

Sanchez-Padilla, J., Guzman, J. N., Ilijic, E., Kondapalli, J., Galtieri, D. J., Yang, B., Schieber, S., Oertel, W., Wokosin, D., Schumacker, P. T. & Surmeier, D. J., Jun 2014, In : Nature Neuroscience. 17, 6, p. 832-840 9 p.

Research output: Contribution to journalArticle

66 Scopus citations

Mitochondria-targeted Ogg1 and aconitase-2 prevent oxidant-induced mitochondrial DNA damage in alveolar epithelial cells

Kim, S. J., Cheresh, P., Williams, D., Cheng, Y., Ridge, K., Schumacker, P. T., Weitzman, S., Bohr, V. A. & Kamp, D. W., Feb 28 2014, In : Journal of Biological Chemistry. 289, 9, p. 6165-6176 12 p.

Research output: Contribution to journalArticle

50 Scopus citations

Regulation of hypoxia-induced pulmonary hypertension by vascular smooth muscle hypoxia-inducible factor-1α

Ball, M. K., Waypa, G. B., Mungai, P. T., Nielsen, J. M., Czech, L., Dudley, V. J., Beussink, L., Dettman, R., Berkelhamer, S. K., Steinhorn, R. H., Shah, S. J. & Schumacker, P. T., Feb 1 2014, In : American Journal of Respiratory and Critical Care Medicine. 189, 3, p. 314-324 11 p.

Research output: Contribution to journalArticle

106 Scopus citations

Update in pulmonary vascular diseases 2013

Hassoun, P. M. & Schumacker, P. T., Oct 1 2014, In : American journal of respiratory and critical care medicine. 190, 7, p. 738-743 6 p.

Research output: Contribution to journalArticle

1 Scopus citations
2013

Calcium entry and α-synuclein inclusions elevate dendritic mitochondrial oxidant stress in dopaminergic neurons

Dryanovski, D. I., Guzman, J. N., Xie, Z., Galteri, D. J., Volpicelli-Daley, L. A., Lee, V. M. Y., Miller, R. J., Schumacker, P. T. & James Surmeier, D., Jun 17 2013, In : Journal of Neuroscience. 33, 24, p. 10154-10164 11 p.

Research output: Contribution to journalArticle

109 Scopus citations

Cyclic stretch induces inducible nitric oxide synthase and soluble guanylate cyclase in pulmonary artery smooth muscle cells

Shah, M. R., Wedgwood, S., Czech, L., Kim, G. A., Lakshminrusimha, S., Schumacker, P. T., Steinhorn, R. H. & Farrow, K. N., Feb 1 2013, In : International journal of molecular sciences. 14, 2, p. 4334-4348 15 p.

Research output: Contribution to journalArticle

13 Scopus citations

Developmental differences in hyperoxia-induced oxidative stress and cellular responses in the murine lung

Berkelhamer, S. K., Kim, G. A., Radder, J. E., Wedgwood, S., Czech, L., Steinhorn, R. H. & Schumacker, P. T., May 9 2013, In : Free Radical Biology and Medicine. 61, p. 51-60 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

Hypoxia-inducible factor-2α and TGF-β signaling interact to promote normoxic glomerular fibrogenesis

Hanna, C., Hubchak, S. C., Liang, X., Rozen-Zvi, B., Schumacker, P. T., Hayashida, T. & Schnaper, H. W., Nov 1 2013, In : American Journal of Physiology - Renal Physiology. 305, 9

Research output: Contribution to journalArticle

29 Scopus citations

Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

Sena, L. A., Li, S., Jairaman, A., Prakriya, M., Ezponda, T., Hildeman, D. A., Wang, C. R., Schumacker, P. T., Licht, J. D., Perlman, H., Bryce, P. J. & Chandel, N. S., Feb 21 2013, In : Immunity. 38, 2, p. 225-236 12 p.

Research output: Contribution to journalArticle

433 Scopus citations

Paradoxical regulation of hypoxia inducible factor-1α (HIF-1α) by histone deacetylase inhibitor in diffuse large B-cell lymphoma

Bhalla, S., Evens, A. M., Prachand, S., Schumacker, P. T. & Gordon, L. I., Nov 27 2013, In : PloS one. 8, 11, e81333.

Research output: Contribution to journalArticle

16 Scopus citations

Peroxiredoxin-5 targeted to the mitochondrial intermembrane space attenuates hypoxia-induced reactive oxygen species signalling

Sabharwal, S. S., Waypa, G. B., Marks, J. D. & Schumacker, P. T., Dec 15 2013, In : Biochemical Journal. 456, 3, p. 337-346 10 p.

Research output: Contribution to journalArticle

30 Scopus citations
46 Scopus citations

Sirtuin 3 deficiency does not augment hypoxia-induced pulmonary hypertension

Waypa, G. B., Osborne, S. W., Marks, J. D., Berkelhamer, S. K., Kondapalli, J. & Schumacker, P. T., Dec 1 2013, In : American journal of respiratory cell and molecular biology. 49, 6, p. 885-891 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Superoxide generated at mitochondrial complex iii triggers acute responses to hypoxia in the pulmonary circulation

Waypa, G. B., Marks, J. D., Guzy, R. D., Mungai, P. T., Schriewer, J. M., Dokic, D., Ball, M. K. & Schumacker, P. T., Feb 15 2013, In : American journal of respiratory and critical care medicine. 187, 4, p. 424-432 9 p.

Research output: Contribution to journalArticle

81 Scopus citations
2012

Brief hyperoxia increases mitochondrial oxidation and increases phosphodiesterase 5 activity in fetal pulmonary artery smooth muscle cells

Farrow, K. N., Lee, K. J., Perez, M., Schriewer, J. M., Wedgwood, S., Lakshminrusimha, S., Smith, C. L., Steinhorn, R. H. & Schumacker, P. T., Aug 1 2012, In : Antioxidants and Redox Signaling. 17, 3, p. 460-470 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells

Wang, W., Wang, Y., Long, J., Wang, J., Haudek, S. B., Overbeek, P., Chang, B. H. J., Schumacker, P. T. & Danesh, F. R., Feb 8 2012, In : Cell Metabolism. 15, 2, p. 186-200 15 p.

Research output: Contribution to journalArticle

237 Scopus citations
2011

Epithelial cell death is an important contributor to oxidant-mediated acute lung injury

Budinger, GR. S., Mutlu, G. M., Urich, D., Soberanes, S., Buccellato, L. J., Hawkins, K. A., Chiarella, S. E., Radigan, K. A., Eisenbart, J., Agrawal, H., Berkelhamer, S., Hekimi, S., Zhang, J., Perlman, H. R., Schumacker, P. T., Jain, M. & Chandel, N., Apr 15 2011, In : American journal of respiratory and critical care medicine. 183, 8, p. 1043-1054 12 p.

Research output: Contribution to journalArticle

64 Scopus citations

Hydrogen peroxide regulates extracellular superoxide dismutase activity and expression in neonatal pulmonary hypertension

Wedgwood, S., Lakshminrusimha, S., Fukai, T., Russell, J. A., Schumacker, P. T. & Steinhorn, R. H., Sep 15 2011, In : Antioxidants and Redox Signaling. 15, 6, p. 1497-1506 10 p.

Research output: Contribution to journalArticle

45 Scopus citations

Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels

Mungai, P. T., Waypa, G. B., Jairaman, A., Prakriya, M., Dokic, D., Ball, M. K. & Schumacker, P. T., Sep 1 2011, In : Molecular and cellular biology. 31, 17, p. 3531-3545 15 p.

Research output: Contribution to journalArticle

214 Scopus citations
79 Scopus citations
43 Scopus citations

Mitochondrial oxidant stress triggers cell death in simulated ischemia-reperfusion

Loor, G., Kondapalli, J., Iwase, H., Chandel, N. S., Waypa, G. B., Guzy, R. D., Vanden Hoek, T. L. & Schumacker, P. T., Jul 1 2011, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1813, 7, p. 1382-1394 13 p.

Research output: Contribution to journalArticle

126 Scopus citations
2010

Hypoxia increases ros signaling and cytosolic Ca2+ in pulmonary artery smooth muscle cells of mouse lungs slices

Desireddi, J. R., Farrow, K. N., Marks, J. D., Waypa, G. B. & Schumacker, P. T., Mar 1 2010, In : Antioxidants and Redox Signaling. 12, 5, p. 595-602 8 p.

Research output: Contribution to journalArticle

49 Scopus citations

Hypoxia-inducible factor-1 α expression predicts superior survival in patients with diffuse large B-cell lymphoma treated with R-CHOP

Evens, A. M., Sehn, L. H., Farinha, P., Nelson, B. P., Raji, A., Lu, Y., Brakman, A., Parimi, V., Winter, J. N., Schumacker, P. T., Gascoyne, R. D. & Gordon, L. I., Feb 20 2010, In : Journal of Clinical Oncology. 28, 6, p. 1017-1024 8 p.

Research output: Contribution to journalArticle

41 Scopus citations

Hypoxia triggers subcellular compartmental redox signaling in vascular smooth muscle cells

Waypa, G. B., Marks, J. D., Guzy, R., Mungai, P. T., Schriewer, J., Dokic, D. & Schumacker, P. T., Feb 1 2010, In : Circulation research. 106, 3, p. 526-535 10 p.

Research output: Contribution to journalArticle

203 Scopus citations

Menadione triggers cell death through ROS-dependent mechanisms involving PARP activation without requiring apoptosis

Loor, G., Kondapalli, J., Schriewer, J. M., Chandel, N. S., Vanden Hoek, T. L. & Schumacker, P. T., Dec 15 2010, In : Free Radical Biology and Medicine. 49, 12, p. 1925-1936 12 p.

Research output: Contribution to journalArticle

118 Scopus citations

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

Guzman-Lucero, J. N., Sanchez-Padilla, J., Wokosin, D. L., Kondapalli, J., Ilijic, E., Schumacker, P. T. & Surmeier Jr, D. J., Dec 2 2010, In : Nature. 468, 7324, p. 696-700 5 p.

Research output: Contribution to journalArticle

473 Scopus citations

Prolonged hypoxia increases ros signaling and RhoA activation in pulmonary artery smooth muscle and endothelial cells

Chi, A. Y., Waypa, G. B., Mungai, P. T. & Schumacker, P. T., Mar 1 2010, In : Antioxidants and Redox Signaling. 12, 5, p. 603-610 8 p.

Research output: Contribution to journalArticle

46 Scopus citations

Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report

Erzurum, S., Rounds, S. I., Stevens, T., Aldred, M., Aliotta, J., Archer, S. L., Asosingh, K., Balaban, R., Bauer, N., Bhattacharya, J., Bogaard, H., Choudhary, G., Dorn, G. W., Dweik, R., Fagan, K., Fallon, M., Finkel, T., Geraci, M., Gladwin, M. T., Hassoun, P. M. & 23 others, Humbert, M., Kaminski, N., Kawut, S. M., Loscalzo, J., McDonald, D., McMurtry, I. F., Newman, J., Nicolls, M., Rabinovitch, M., Shizuru, J., Oka, M., Polgar, P., Rodman, D., Schumacker, P., Stenmark, K., Tuder, R., Voelkel, N., Sullivan, E., Weinshilboum, R., Yoder, M. C., Zhao, Y., Gail, D. & Moore, T. M., Dec 15 2010, In : American journal of respiratory and critical care medicine. 182, 12, p. 1554-1562 9 p.

Research output: Contribution to journalArticle

49 Scopus citations