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Research Output 1979 2020

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Review article
2019

Roles of HIF1 and HIF2 in pulmonary hypertension: It all depends on the context

Waypa, G. B. & Schumacker, P. T., Dec 1 2019, In : European Respiratory Journal. 54, 6, 1901929.

Research output: Contribution to journalReview article

Open Access
2017
55 Citations (Scopus)

Calcium and Parkinson's disease

Surmeier Jr, D. J., Schumacker, P. T., Guzman, J. D., Ilijic, E., Yang, B. & Zampese, E., Feb 19 2017, In : Biochemical and Biophysical Research Communications. 483, 4, p. 1013-1019 7 p.

Research output: Contribution to journalReview article

Parkinson Disease
Calcium
Oxidants
Disease Progression
Mitochondrial Degradation
43 Citations (Scopus)

Redox signaling during hypoxia in mammalian cells

Smith, K. A., Waypa, G. B. & Schumacker, P. T., Oct 1 2017, In : Redox Biology. 13, p. 228-234 7 p.

Research output: Contribution to journalReview article

Oxidation-Reduction
Reactive Oxygen Species
Cells
Mitochondria
NADPH Oxidase
2016
42 Citations (Scopus)

Mitochondrial function in sepsis

Arulkumaran, N., Deutschman, C. S., Pinsky, M. R., Zuckerbraun, B., Schumacker, P. T., Gomez, H., Gomez, A., Murray, P. & Kellum, J. A., Mar 1 2016, In : Shock. 45, 3, p. 271-281 11 p.

Research output: Contribution to journalReview article

Sepsis
Mitochondria
Oxidative Phosphorylation
Research
Adenosine Triphosphate
59 Citations (Scopus)

O2 sensing, mitochondria and ROS signaling: The fog is lifting

Waypa, G. B., Smith, K. A. & Schumacker, P. T., Feb 1 2016, In : Molecular Aspects of Medicine. 47-48, p. 76-89 14 p.

Research output: Contribution to journalReview article

Mitochondria
Weather
Fog
Reactive Oxygen Species
Oxygen
2014
504 Citations (Scopus)

Mitochondrial ROS in cancer: Initiators, amplifiers or an Achilles' heel?

Sabharwal, S. S. & Schumacker, P. T., Oct 27 2014, In : Nature Reviews Cancer. 14, 11, p. 709-721 13 p.

Research output: Contribution to journalReview article

Reactive Oxygen Species
Mitochondria
Neoplasms
Mitochondrial DNA
Cell Communication
2013
104 Citations (Scopus)

Calcium, bioenergetics, and neuronal vulnerability in Parkinson's disease

Surmeier, D. J. & Schumacker, P. T., Apr 12 2013, In : Journal of Biological Chemistry. 288, 15, p. 10736-10741 6 p.

Research output: Contribution to journalReview article

Energy Metabolism
Neurons
Parkinson Disease
Calcium
Pathology
38 Citations (Scopus)

Increased p22phox/Nox4 expression is involved in remodeling through hydrogen peroxide signaling in experimental persistent pulmonary hypertension of the newborn

Wedgwood, S., Lakshminrusimha, S., Czech, L., Schumacker, P. T. & Steinhorn, R. H., May 10 2013, In : Antioxidants and Redox Signaling. 18, 14, p. 1765-1776 12 p.

Research output: Contribution to journalReview article

Persistent Fetal Circulation Syndrome
Hydrogen Peroxide
Muscle
Cyclin D1
Pulmonary Artery
2012
68 Citations (Scopus)

Physiological phenotype and vulnerability in Parkinson's disease

Surmeier, D. J., Guzman, J. N., Sanchez, J. & Schumacker, P. T., Jul 2012, In : Cold Spring Harbor Perspectives in Medicine. 2, 7, a009290.

Research output: Contribution to journalReview article

Parkinson Disease
Neurons
Phenotype
Action Potentials
Cell Respiration
2011
127 Citations (Scopus)
Dopaminergic Neurons
Oxidants
Parkinson Disease
Calcium
Physiological Stress
409 Citations (Scopus)

Unraveling the biological roles of reactive oxygen species

Murphy, M. P., Holmgren, A., Larsson, N. G., Halliwell, B., Chang, C. J., Kalyanaraman, B., Rhee, S. G., Thornalley, P. J., Partridge, L., Gems, D., Nyström, T., Belousov, V., Schumacker, P. T. & Winterbourn, C. C., Apr 6 2011, In : Cell Metabolism. 13, 4, p. 361-366 6 p.

Research output: Contribution to journalReview article

Reactive Oxygen Species
Biological Phenomena
Biomedical Research
Pathology
Research
2010
44 Citations (Scopus)
Vascular Resistance
Oxidation-Reduction
Blood Vessels
Pulmonary Artery
Reactive Oxygen Species
46 Citations (Scopus)

Mitochondrial oxidant stress increases PDE5 activity in persistent pulmonary hypertension of the newborn

Farrow, K. N., Wedgwood, S., Lee, K. J., Czech, L., Gugino, S. F., Lakshminrusimha, S., Schumacker, P. T. & Steinhorn, R. H., Dec 31 2010, In : Respiratory Physiology and Neurobiology. 174, 3, p. 272-281 10 p.

Research output: Contribution to journalReview article

Persistent Fetal Circulation Syndrome
Type 5 Cyclic Nucleotide Phosphodiesterases
Oxidants
Pulmonary Hypertension
Smooth Muscle Myocytes
2008
161 Citations (Scopus)

Role of hypoxia-inducible factor in cell survival during myocardial ischemia-reperfusion

Loor, G. & Schumacker, P. T., Apr 1 2008, In : Cell Death and Differentiation. 15, 4, p. 686-690 5 p.

Research output: Contribution to journalReview article

Myocardial Reperfusion
Myocardial Ischemia
Cell Survival
Reperfusion Injury
Gene Expression
2005
133 Citations (Scopus)

Hypoxic pulmonary vasoconstriction: Redox events in oxygen sensing

Waypa, G. B. & Schumacker, P. T., Jan 1 2005, In : Journal of applied physiology. 98, 1, p. 404-414 11 p.

Research output: Contribution to journalReview article

Vasoconstriction
Oxidation-Reduction
Reactive Oxygen Species
Mitochondria
Oxygen
2004
113 Citations (Scopus)

Mitochondrial requirement for endothelial responses to cyclic strain: Implications for mechanotransduction

Ali, M. H., Pearlstein, D. P., Mathieu, C. E. & Schumacker, P. T., Sep 1 2004, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 287, 3 31-3, p. L486-L496

Research output: Contribution to journalReview article

Reactive Oxygen Species
Vascular Cell Adhesion Molecule-1
Mitochondria
Endothelial Cells
Umbilical Veins
2000
323 Citations (Scopus)

Cellular oxygen sensing by mitochondria: Old questions, new insight

Chandel, N. S. & Schumacker, P. T., May 1 2000, In : Journal of Applied Physiology. 88, 5, p. 1880-1889 10 p.

Research output: Contribution to journalReview article

Mitochondria
Oxygen
Hemeproteins
Hypoxia
NADPH Oxidase
1999
149 Citations (Scopus)

Cells depleted of mitochondrial DNA (ρ0) yield insight into physiological mechanisms

Chandel, N. S. & Schumacker, P. T., Jul 9 1999, In : FEBS Letters. 454, 3, p. 173-176 4 p.

Research output: Contribution to journalReview article

Mitochondria
Mitochondrial DNA
Electron Transport
Mitochondrial Genome
Oxidative Phosphorylation
1991
23 Citations (Scopus)

Oxygen delivery to tissues

Samsel, R. W. & Schumacker, P. T., Dec 1 1991, In : European Respiratory Journal. 4, 10, p. 1258-1267 10 p.

Research output: Contribution to journalReview article

Oxygen
Adult Respiratory Distress Syndrome
Sepsis
Patient Care
Health
1990
6 Citations (Scopus)

Oxygen supply and consumption in the adult respiratory distress syndrome

Schumacker, P. T. & Samsel, R. W., Jan 1 1990, In : Clinics in Chest Medicine. 11, 4, p. 715-722 8 p.

Research output: Contribution to journalReview article

Adult Respiratory Distress Syndrome
Oxygen Consumption
Oxygen
Multiple Organ Failure
Critical Illness
1989
64 Citations (Scopus)

Oxygen delivery and uptake by peripheral tissues: Physiology and pathophysiology

Schumacker, P. T. & Samsel, R. W., Jan 1 1989, In : Critical Care Clinics. 5, 2, p. 255-269 15 p.

Research output: Contribution to journalReview article

Oxygen
Vasoconstriction
Endothelium
Blood Vessels
Endotoxemia
1987
203 Citations (Scopus)

The concept of a critical oxygen delivery

Schumacker, P. T. & Cain, S. M., Jun 1 1987, In : Intensive Care Medicine. 13, 4, p. 223-229 7 p.

Research output: Contribution to journalReview article

Oxygen
Adult Respiratory Distress Syndrome
Tissue Distribution
Oxygen Consumption
Hydrogen Peroxide