Grants per year
Personal profile
Research Interests
I am interested in understanding the cellular and molecular mechanisms for cell-type specific degeneration in neurodegenerative diseases. I am mainly focused on corticospinal motor neurons that degenerate in ALS, and HSP.
Education/Academic qualification
PhD, Louisiana State University
… → 2002
Research interests
- Neurology
- Neuroscience
- Neurosurgery
Fingerprint Dive into the research topics where Pembe Hande Ozdinler is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 23 Similar Profiles
Motor Neurons
Medicine & Life Sciences
Amyotrophic Lateral Sclerosis
Medicine & Life Sciences
Motor Neuron Disease
Medicine & Life Sciences
Neurons
Medicine & Life Sciences
Axons
Medicine & Life Sciences
Ubiquitin Thiolesterase
Medicine & Life Sciences
Motor Cortex
Medicine & Life Sciences
Dendrites
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2006 2024
Investigation and assessment of UCHL1 as a novel target
Mitsubishi Tanabe Pharma Holdings America, Inc.
12/19/19 → 12/19/20
Project: Research project
Motor Neurons
Pharmaceutical Preparations
Investigation and Confirmation of Novel Targets by Utilization of Proteomics
Mitsubishi Tanabe Pharma Corporation
10/1/19 → 9/30/20
Project: Research project
Motor Neurons
Proteomics
Proteins
Health
Therapeutics
SRA: Preclinical Investigation of SBT Discovery Compounds in Upper Motor Neuron Cell Based Model of ALS
8/1/19 → 8/1/22
Project: Research project
Motor Neurons
Transgenes
Primary Cell Culture
Neuroprotective Agents
Endoplasmic Reticulum
Novel Protein Aggregation Inhibitors and Upper Motor Neuron Stabilizers for ALS and other Neurodegenerative Diseases
Ozdinler, P. H. & Silverman, R. B.
8/1/19 → 4/30/24
Project: Research project
Amyotrophic Lateral Sclerosis
Motor Neurons
Neurodegenerative Diseases
Motor Neuron Disease
Drug Discovery
The Role of Mitochondria in TDP-43 Proteinopathy
Fushimi, K., Kiskinis, E., Ozdinler, P. H. & Wu, J.
National Institute of Neurological Disorders and Stroke
9/30/18 → 6/30/23
Project: Research project
TDP-43 Proteinopathies
Mitochondria
Frontotemporal Dementia
Neurodegenerative Diseases
Frontotemporal Lobar Degeneration
Research Output 1999 2019
Complexity of generating mouse models to study the upper motor neurons: Let us shift focus from mice to neurons
Genc, B., Gozutok, O. & Ozdinler, P. H., Aug 2 2019, In : International journal of molecular sciences. 20, 16, 3848.Research output: Contribution to journal › Review article
Open Access
Motor Neurons
neurons
Neurons
mice
Motor Neuron Disease
MCP1-CCR2 and neuroinflammation in the ALS motor cortex with TDP-43 pathology
Jara, J. H., Gautam, M., Kocak, N., Xie, E. F., Mao, Q., Bigio, E. H. & Özdinler, P. H., Oct 30 2019, In : Journal of neuroinflammation. 16, 1, 1 p.Research output: Contribution to journal › Article
Open Access
Motor Cortex
Pathology
Microglia
Motor Neurons
Monocytes
3
Citations
(Scopus)
Incorporating upper motor neuron health in ALS drug discovery
Dervishi, I. & Ozdinler, P. H., Mar 2018, In : Drug Discovery Today. 23, 3, p. 696-703 8 p.Research output: Contribution to journal › Review article
Amyotrophic Lateral Sclerosis
Motor Neurons
Drug Discovery
Health
Clinical Trials
2
Citations
(Scopus)
Protein-protein interactions reveal key canonical pathways, upstream regulators, interactome domains, and novel targets in ALS
Dervishi, I., Gozutok, O., Murnan, K., Gautam, M., Heller, D., Bigio, E. & Ozdinler, P. H., Dec 1 2018, In : Scientific reports. 8, 1, 14732.Research output: Contribution to journal › Article
Amyotrophic Lateral Sclerosis
Proteins
14-3-3 Proteins
Mutation
Neurodegenerative Diseases
17
Citations
(Scopus)
Apical dendrite degeneration, a novel cellular pathology for Betz cells in ALS
Genç, B., Jara, J. H., Lagrimas, A. K. B., Pytel, P., Roos, R. P., Mesulam, M-M., Geula, C., Bigio, E. H. & Ozdinler, P. H., Feb 6 2017, In : Scientific reports. 7, 41765.Research output: Contribution to journal › Article
Dendrites
Pathology
Motor Cortex
Alzheimer Disease
Frontotemporal Dementia