Grants per year
Personal profile
Research Interests
I am interested in understanding the cellular and molecular mechanisms for cell-type specific degeneration in neurodegenerative diseases. I am mainly focused on corticospinal motor neurons that degenerate in ALS, and HSP.
Education/Academic qualification
PhD, Louisiana State University
… → 2002
Research interests
- Neurology
- Neuroscience
- Neurosurgery
Fingerprint Dive into the research topics where Pembe Hande Ozdinler is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 21 Similar Profiles
Motor Neurons
Medicine & Life Sciences
Amyotrophic Lateral Sclerosis
Medicine & Life Sciences
Motor Neuron Disease
Medicine & Life Sciences
Neurons
Medicine & Life Sciences
Axons
Medicine & Life Sciences
Ubiquitin Thiolesterase
Medicine & Life Sciences
Motor Cortex
Medicine & Life Sciences
Dendrites
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2006 2024
Investigation and Confirmation of Novel Targets by Utilization of Proteomics
Mitsubishi Tanabe Pharma Corporation
10/1/19 → 9/30/20
Project: Research project
Motor Neurons
Proteomics
Proteins
Health
Therapeutics
SRA: Preclinical Investigation of SBT Discovery Compounds in Upper Motor Neuron Cell Based Model of ALS
8/1/19 → 8/1/22
Project: Research project
Motor Neurons
Transgenes
Primary Cell Culture
Neuroprotective Agents
Endoplasmic Reticulum
Novel Protein Aggregation Inhibitors and Upper Motor Neuron Stabilizers for ALS and other Neurodegenerative Diseases
Ozdinler, P. H. & Silverman, R. B.
8/1/19 → 4/30/24
Project: Research project
Amyotrophic Lateral Sclerosis
Motor Neurons
Neurodegenerative Diseases
Motor Neuron Disease
Drug Discovery
The Role of Mitochondria in TDP-43 Proteinopathy
Fushimi, K., Kiskinis, E., Ozdinler, P. H. & Wu, J.
National Institute of Neurological Disorders and Stroke
9/30/18 → 6/30/23
Project: Research project
TDP-43 Proteinopathies
Mitochondria
Frontotemporal Dementia
Neurodegenerative Diseases
Frontotemporal Lobar Degeneration
Northwestern University Interdepartmental Neuroscience Postbaccalaureate Research Education Program
Acosta, A., Allada, R., Apkarian, A., Awatramani, R., Beeman, M., Bevan, M. D., Bozza, T. C., Cang, J., Chetkovich, D. M., Cobia, D. J., Contractor, A., Corcos, D. M., DeVries, S. H., Dewald, J. P. A., Dhar, S., Disterhoft, J. F., Dombeck, D. A., Elliott, J. M., Feng, Y., Ferreira, A. B., Gallio, M., Garcia-Anoveros, J., George Jr, A. L., Geula, C., Gordon, K. E., Gottfried, J. A., Grafman, J. H., Hartmann, M. J. Z., Heckman, C., Hespos, S. J., Jayaraman, A., Kahnt, T., Kearney, J. A., Kessler, J., Kiskinis, E., Kohtz, J., Kording, K. P., Kozorovitskiy, Y., Krainc, D., Larson, C., Lee, S. S. M., Li, L., Losh, M. C., Maccaferri, G., MacIver, M. A., Martina, M., Mazzulli, J., McLean, D., Mesulam, M., Miller, L. E., Miller, R. J., Mussa-Ivaldi, F., Nusslock, R., Opal, P., Ozdinler, P. H., Paller, K., Parrish, T. B., Prakriya, M., Radulovic, J., Raman, I. M., Reber, P. J., Redei, E., Rogalski, E., Sanchez, J. T., Sanz-Clemente, A., Savas, J. N., Schmidt, T. M., Schwartz, G. W., Segraves, M., Shepherd, G. M. G., Siddique, T., Solla, S. A., Surmeier Jr, D. J., Swanson, G. T., Topczewski, J., Tresch, M. C., Tysseling, V. M., Vassar, R. J., Voss, J. L., Wainwright, D. A., Wang, L., Weintraub, S., Woolley, C. S. & Wright, B. A.
National Institute of General Medical Sciences
5/1/17 → 4/30/22
Project: Research project
neurosciences
graduate
university
education
Research Output 1999 2019
Complexity of generating mouse models to study the upper motor neurons: Let us shift focus from mice to neurons
Genc, B., Gozutok, O. & Ozdinler, P. H., Aug 2 2019, In : International journal of molecular sciences. 20, 16, 3848.Research output: Contribution to journal › Review article
Open Access
Motor Neurons
neurons
Neurons
mice
Motor Neuron Disease
MCP1-CCR2 and neuroinflammation in the ALS motor cortex with TDP-43 pathology
Jara, J. H., Gautam, M., Kocak, N., Xie, E. F., Mao, Q., Bigio, E. H. & Özdinler, P. H., Oct 30 2019, In : Journal of neuroinflammation. 16, 1, 1 p.Research output: Contribution to journal › Article
Open Access
Motor Cortex
Pathology
Microglia
Motor Neurons
Monocytes
3
Citations
(Scopus)
Incorporating upper motor neuron health in ALS drug discovery
Dervishi, I. & Ozdinler, P. H., Mar 1 2018, In : Drug Discovery Today. 23, 3, p. 696-703 8 p.Research output: Contribution to journal › Review article
Amyotrophic Lateral Sclerosis
Motor Neurons
Drug Discovery
Health
Clinical Trials
2
Citations
(Scopus)
Protein-protein interactions reveal key canonical pathways, upstream regulators, interactome domains, and novel targets in ALS
Dervishi, I., Gozutok, O., Murnan, K., Gautam, M., Heller, D., Bigio, E. H. & Ozdinler, P. H., Dec 1 2018, In : Scientific reports. 8, 1, 14732.Research output: Contribution to journal › Article
Amyotrophic Lateral Sclerosis
Proteins
14-3-3 Proteins
Mutation
Neurodegenerative Diseases
17
Citations
(Scopus)
Apical dendrite degeneration, a novel cellular pathology for Betz cells in ALS
Genç, B., Jara, J. H., Lagrimas, A. K. B., Pytel, P., Roos, R. P., Mesulam, M-M., Geula, C., Bigio, E. H. & Ozdinler, P. H., Feb 6 2017, In : Scientific reports. 7, 41765.Research output: Contribution to journal › Article
Dendrites
Pathology
Motor Cortex
Alzheimer Disease
Frontotemporal Dementia