If you made any changes in Pure, your changes will be visible here soon.

Personal profile

Research Interests

I am interested in understanding the cellular and molecular mechanisms for cell-type specific degeneration in neurodegenerative diseases. I am mainly focused on corticospinal motor neurons that degenerate in ALS, and HSP.

Education/Academic qualification

PhD, Louisiana State University

… → 2002

Research interests

  • Neurology
  • Neuroscience
  • Neurosurgery

Fingerprint Dive into the research topics where Pembe Hande Ozdinler is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 11 Similar Profiles
Motor Neurons Medicine & Life Sciences
Amyotrophic Lateral Sclerosis Medicine & Life Sciences
Axons Medicine & Life Sciences
Neurons Medicine & Life Sciences
Ubiquitin Thiolesterase Medicine & Life Sciences
Motor Neuron Disease Medicine & Life Sciences
Dendrites Medicine & Life Sciences
Motor Cortex Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2006 2024

Motor Neurons
Proteomics
Proteins
Health
Therapeutics
Amyotrophic Lateral Sclerosis
Motor Neurons
Neurodegenerative Diseases
Motor Neuron Disease
Drug Discovery
Motor Neurons
Transgenes
Primary Cell Culture
Neuroprotective Agents
Endoplasmic Reticulum
TDP-43 Proteinopathies
Mitochondria
Frontotemporal Dementia
Neurodegenerative Diseases
Frontotemporal Lobar Degeneration

Research Output 1999 2018

  • 3039 Citations
  • 28 Article
  • 4 Review article
  • 2 Comment/debate
  • 1 Chapter
3 Citations (Scopus)

Incorporating upper motor neuron health in ALS drug discovery

Dervishi, I. & Ozdinler, P. H., Mar 1 2018, In : Drug Discovery Today. 23, 3, p. 696-703 8 p.

Research output: Contribution to journalReview article

Amyotrophic Lateral Sclerosis
Motor Neurons
Drug Discovery
Health
Clinical Trials
2 Citations (Scopus)

Protein-protein interactions reveal key canonical pathways, upstream regulators, interactome domains, and novel targets in ALS

Dervishi, I., Gozutok, O., Murnan, K., Gautam, M., Heller, D., Bigio, E. H. & Ozdinler, P. H., Dec 1 2018, In : Scientific reports. 8, 1, 14732.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Proteins
14-3-3 Proteins
Mutation
Neurodegenerative Diseases

Apical dendrite degeneration, a novel cellular pathology for Betz cells in ALS

Genc, B., Jara, JH., Lagrimas, AK., Pytel, P., Roo, RP., Mesulam, MM., Geula, C., Bigio, EH. & Ozdinler, PH., Feb 2017, In : Scientific Reports.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Apical dendrite degeneration, a novel cellular pathology for Betz cells in ALS

Genç, B., Jara, J. H., Lagrimas, A. K. B., Pytel, P., Roos, R. P., Mesulam, M-M., Geula, C., Bigio, E. H. & Ozdinler, P. H., Feb 6 2017, In : Scientific reports. 7, 41765.

Research output: Contribution to journalArticle

Dendrites
Pathology
Motor Cortex
Alzheimer Disease
Frontotemporal Dementia
3 Citations (Scopus)

Evidence for an early innate immune response in the motor cortex of ALS

Jara, J. H., Genç, B., Stanford, M. J., Pytel, P., Roos, R. P., Weintraub, S., Mesulam, M-M., Bigio, E. H., Miller, R. J. & Ozdinler, P. H., Jun 26 2017, In : Journal of Neuroinflammation. 14, 1, 129.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Motor Cortex
Chemokine CCL2
CCR2 Receptors
Innate Immunity