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Personal profile

Research Interests

I am interested in understanding the cellular and molecular mechanisms for cell-type specific degeneration in neurodegenerative diseases. I am mainly focused on corticospinal motor neurons that degenerate in ALS, and HSP.

Education/Academic qualification

PhD, Louisiana State University

… → 2002

Keywords

  • Neurology
  • Neuroscience
  • Neurosurgery

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Grants 2006 2023

TDP-43 Proteinopathies
Mitochondria
Frontotemporal Dementia
Neurodegenerative Diseases
Frontotemporal Lobar Degeneration
Motor Neurons
Wounds and Injuries
Spinal Cord Injuries
Paralysis
Axons
Amyotrophic Lateral Sclerosis
Research
Patient Care
Therapeutics
Amyotrophic Lateral Sclerosis
Research
Patient Care
Therapeutics

Research Output 1999 2018

  • 2772 Citations
  • 28 Article
  • 4 Review article
  • 2 Comment/debate
  • 1 Chapter
2 Citations (Scopus)

Incorporating upper motor neuron health in ALS drug discovery

Dervishi, I. & Ozdinler, P. H., Mar 1 2018, In : Drug Discovery Today. 23, 3, p. 696-703 8 p.

Research output: Contribution to journalReview article

Amyotrophic Lateral Sclerosis
Motor Neurons
Drug Discovery
Health
Clinical Trials

Protein-protein interactions reveal key canonical pathways, upstream regulators, interactome domains, and novel targets in ALS

Dervishi, I., Gozutok, O., Murnan, K., Gautam, M., Heller, D., Bigio, E. H. & Ozdinler, P. H., Dec 1 2018, In : Scientific Reports. 8, 1, 14732.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Proteins
14-3-3 Proteins
Mutation
Neurodegenerative Diseases

Apical dendrite degeneration, a novel cellular pathology for Betz cells in ALS

Genc, B., Jara, JH., Lagrimas, AK., Pytel, P., Roo, RP., Mesulam, MM., Geula, C., Bigio, EH. & Ozdinler, PH., Feb 2017, In : Scientific Reports.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Apical dendrite degeneration, a novel cellular pathology for Betz cells in ALS

Genç, B., Jara, J. H., Lagrimas, A. K. B., Pytel, P., Roos, R. P., Mesulam, M-M., Geula, C., Bigio, E. H. & Ozdinler, P. H., Feb 6 2017, In : Scientific Reports. 7, 41765.

Research output: Contribution to journalArticle

Dendrites
Pathology
Motor Cortex
Alzheimer Disease
Frontotemporal Dementia
3 Citations (Scopus)

Evidence for an early innate immune response in the motor cortex of ALS

Jara, J. H., Genç, B., Stanford, M. J., Pytel, P., Roos, R. P., Weintraub, S., Mesulam, M-M., Bigio, E. H., Miller, R. J. & Ozdinler, P. H., Jun 26 2017, In : Journal of Neuroinflammation. 14, 1, 129.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Motor Cortex
Chemokine CCL2
CCR2 Receptors
Innate Immunity