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Research Output

  • 3790 Citations
  • 29 Article
  • 5 Review article
  • 1 Chapter
  • 1 Comment/debate
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Article
2020

The Electrophysiological Determinants of Corticospinal Motor Neuron Vulnerability in ALS

Jara, J. H., Sheets, P. L., Nigro, M. J., Perić, M., Brooks, C., Heller, D. B., Martina, M., Andjus, P. R. & Ozdinler, P. H., May 19 2020, In : Frontiers in Molecular Neuroscience. 13, 73.

Research output: Contribution to journalArticle

Open Access
2019

MCP1-CCR2 and neuroinflammation in the ALS motor cortex with TDP-43 pathology

Jara, J. H., Gautam, M., Kocak, N., Xie, E. F., Mao, Q., Bigio, E. H. & Özdinler, P. H., Oct 30 2019, In : Journal of neuroinflammation. 16, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
Open Access
2 Scopus citations
2018

Protein-protein interactions reveal key canonical pathways, upstream regulators, interactome domains, and novel targets in ALS

Dervishi, I., Gozutok, O., Murnan, K., Gautam, M., Heller, D., Bigio, E. & Ozdinler, P. H., Dec 1 2018, In : Scientific reports. 8, 1, 14732.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Apical dendrite degeneration, a novel cellular pathology for Betz cells in ALS

Genç, B., Jara, J. H., Lagrimas, A. K. B., Pytel, P., Roos, R. P., Mesulam, M-M., Geula, C., Bigio, E. H. & Ozdinler, P. H., Feb 6 2017, In : Scientific reports. 7, 41765.

Research output: Contribution to journalArticle

24 Scopus citations

Evidence for an early innate immune response in the motor cortex of ALS

Jara, J. H., Genç, B., Stanford, M. J., Pytel, P., Roos, R. P., Weintraub, S., Mesulam, M. M., Bigio, E. H., Miller, R. J. & Özdinler, P. H., Jun 26 2017, In : Journal of neuroinflammation. 14, 1, 129.

Research output: Contribution to journalArticle

8 Scopus citations

Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron disease

Fil, D., DeLoach, A., Yadav, S., Alkam, D., MacNicol, M., Singh, A., Compadre, C. M., Goellner, J. J., O'Brien, C. A., Fahmi, T., Basnakian, A. G., Calingasan, N. Y., Klessner, J. L., Beal, F. M., Peters, O. M., Metterville, J., Brown, R. H., Ling, K. K. Y., Rigo, F., Ozdinler, P. H. & 1 others, Kiaei, M., Feb 15 2017, In : Human molecular genetics. 26, 4, p. 686-701 16 p.

Research output: Contribution to journalArticle

26 Scopus citations
2016

Absence of UCHL 1 function leads to selective motor neuropathy.

b, G., jara, JH., mc, S., m, M., stanford, MJ., gautam, M., klessner, JL., sekerkova, G., heller, DB., Cox, GA., Heckman, CJ., DiDonato, CJ. & Ozdinler, PH., Mar 2016, In : Ann Clin Transl Neurol. 3, 5, p. 331-345 15 p.

Research output: Contribution to journalArticle

16 Scopus citations

Complementary feature selection from alternative splicing events and gene expression for phenotype prediction

Labuzzetta, C. J., Antonio, M. L., Watson, P. M., Wilson, R. C., Laboissonniere, L. A., Trimarchi, J. M., Genc, B., Ozdinler, P. H., Watson, D. K. & Anderson, P. E., Sep 1 2016, In : Bioinformatics. 32, 17, p. i421-i429

Research output: Contribution to journalArticle

3 Scopus citations

Healthy and diseased corticospinal motor neurons are selectively transduced upon direct AAV2-2 injection into the motor cortex

Jara, J. H., Stanford, M. J., Zhu, Y., Tu, M., Hauswirth, W. W., Bohn, M. C., Devries, S. H. & Özdinler, P. H., Mar 1 2016, In : Gene therapy. 23, 3, p. 272-282 11 p.

Research output: Contribution to journalArticle

5 Scopus citations
2015

Absence of alsin function leads to corticospinal motor neuron vulnerability via novel disease mechanisms

Gautam, M., Jara, J. H., Sekerkova, G., Yasvoina, M. V., Martina, M. & Özdinler, P. H., Aug 17 2015, In : Human molecular genetics. 25, 6, p. 1074-1087 14 p.

Research output: Contribution to journalArticle

23 Scopus citations

Corticospinal motor neurons are susceptible to increased ER stress and display profound degeneration in the absence of UCHL1 function

Jara, J. H., Genç, B., Cox, G. A., Bohn, M. C., Roos, R. P., Macklis, J. D., Ulupinar, E. & Özdinler, P. H., Jan 1 2015, In : Cerebral Cortex. 25, 11, p. 4259-4272 14 p.

Research output: Contribution to journalArticle

39 Scopus citations

Visualization of sensory neurons and their projections in an upper motor neuron reporter line

Genç, B., Lagrimas, A. K. B., Kuru, P., Hess, R., Tu, M. W., Menichella, D. M., Miller, R. J., Paller, A. S. & Özdinler, P. H., Jul 29 2015, In : PloS one. 10, 7, e0132815.

Research output: Contribution to journalArticle

10 Scopus citations
2014

A novel SOD1-ALS mutation separates central and peripheral effects of mutant SOD1 toxicity

Joyce, P. I., Mcgoldrick, P., Saccon, R. A., Weber, W., Fratta, P., West, S. J., Zhu, N., Carter, S., Phatak, V., Stewart, M., Simon, M., Kumar, S., Heise, I., Bros-Facer, V., Dick, J., Corrochano, S., Stanford, M. J., Luong, T. V., Nolan, P. M., Meyer, T. & 6 others, Brandner, S., Bennett, D. L. H., Hande Ozdinler, P., Greensmith, L., Fisher, E. M. C. & Acevedo-Arozena, A., Oct 28 2014, In : Human molecular genetics. 24, 7, p. 1883-1897 15 p.

Research output: Contribution to journalArticle

26 Scopus citations

Retrograde labeling, transduction, and genetic targeting allow cellular analysis of corticospinal motor neurons: Implications in health and disease

Jara, J. H., Genç, B., Klessner, J. L. & Özdinler, P. H., Mar 26 2014, In : Frontiers in Neuroanatomy. 8, MAR, 16.

Research output: Contribution to journalArticle

16 Scopus citations

Treatment of amyotrophic lateral sclerosis: Lessons learned from many failures

Özdinler, P. H. & Silverman, R. B., Nov 13 2014, In : ACS Medicinal Chemistry Letters. 5, 11, p. 1179-1181 3 p.

Research output: Contribution to journalArticle

4 Scopus citations
2013

Could Dysregulation of UPS be a Common Underlying Mechanism for Cancer and Neurodegeneration? Lessons from UCHL1

Jara, J. H., Frank, D. D. & Özdinler, P. H., Sep 1 2013, In : Cell Biochemistry and Biophysics. 67, 1, p. 45-53 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

eGFP expression under UCHL1 promoter genetically labels corticospinal motor neurons and a subpopulation of degeneration-resistant spinal motor neurons in an ALS mouse model

Yasvoina, M. V., Genç, B., Jara, J. H., Sheets, P. L., Quinlan, K. A., Milosevic, A., Shepherd, G. M. G., Heckman, C. J. & Özdinler, P. H., May 10 2013, In : Journal of Neuroscience. 33, 18, p. 7890-7904 15 p.

Research output: Contribution to journalArticle

31 Scopus citations
2012

AAV2 mediated retrograde transduction of corticospinal motor neurons reveals initial and selective apical dendrite degeneration in ALS

Jara, J. H., Villa, S. R., Khan, N. A., Bohn, M. C. & Özdinler, P. H., Aug 1 2012, In : Neurobiology of Disease. 47, 2, p. 174-183 10 p.

Research output: Contribution to journalArticle

43 Scopus citations

A microfluidic device to investigate axon targeting by limited numbers of purified cortical projection neuron subtypes

Tharin, S., Kothapalli, C. R., Ozdinler, P. H., Pasquina, L., Chung, S., Varner, J., Devalence, S., Kamm, R. & MacKlis, J. D., Dec 1 2012, In : Integrative Biology (United Kingdom). 4, 11, p. 1398-1405 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

An autism-associated variant of epac2 reveals a role for ras/epac2 signaling in controlling basal dendrite maintenance in mice

Srivastava, D. P., Woolfrey, K. M., Jones, K. A., Anderson, C. T., Smith, K. R., Russell, T. A., Lee, H., Yasvoina, M. V., Wokosin, D. L., Ozdinler, P. H., Shepherd, G. M. G. & Penzes, P., Jun 2012, In : PLoS biology. 10, 6, e1001350.

Research output: Contribution to journalArticle

50 Scopus citations
2011

Corticospinal motor neurons and related subcerebral projection neurons undergo early and specific neurodegeneration in hSOD1G93A transgenic ALS mice

Özdinler, P. H., Benn, S., Yamamoto, T. H., Güzel, M., Brown, R. H. & Macklis, J. D., Mar 16 2011, In : Journal of Neuroscience. 31, 11, p. 4166-4177 12 p.

Research output: Contribution to journalArticle

93 Scopus citations
2006

IGF-I specifically enhances axon outgrowth of corticospinal motor neurons

Özdinler, P. H. & Macklis, J. D., Nov 1 2006, In : Nature Neuroscience. 9, 11, p. 1371-1381 11 p.

Research output: Contribution to journalArticle

223 Scopus citations

Prion protein (PrPc) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis

Steele, A. D., Emsley, J. G., Özdinler, P. H., Lindquist, S. & Macklis, J. D., Feb 28 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 9, p. 3416-3421 6 p.

Research output: Contribution to journalArticle

202 Scopus citations
2005

Dose and age-dependent axonal responses of embryonic trigeminal neurons to localized NGF via p75NTR receptor

Özdinler, P. H., Ulupinar, E. & Erzurumlu, R. S., Feb 5 2005, In : Journal of Neurobiology. 62, 2, p. 189-206 18 p.

Research output: Contribution to journalArticle

8 Scopus citations
2004

A chemoattractant role for NT-3 in proprioceptive axon guidance

Genç, B., Özdinler, P. H., Mendoza, A. E. & Erzurumlu, R. S., Dec 1 2004, In : PLoS biology. 2, 12

Research output: Contribution to journalArticle

44 Scopus citations

Local neurotrophin effects on central trigeminal axon growth patterns

Ozdinler, P. H., Ulupinar, E. & Erzurumlu, R. S., Jul 19 2004, In : Developmental Brain Research. 151, 1-2, p. 55-66 12 p.

Research output: Contribution to journalArticle

16 Scopus citations
2002

Slit2, a Branching-Arborization Factor for Sensory Axons in the Mammalian CNS

Özdinler, P. H. & Erzurumlu, R. S., Jun 1 2002, In : Journal of Neuroscience. 22, 11, p. 4540-4549 10 p.

Research output: Contribution to journalArticle

Open Access
66 Scopus citations
1999

High level secretion of TaqI restriction endonuclease by recombinant Escherichia coli

Toksoy, E., Özdinler, P. H., Önsan, Z. I. & Kirdar, B., Jan 1 1999, In : Biotechnology Techniques. 13, 11, p. 803-808 6 p.

Research output: Contribution to journalArticle

10 Scopus citations