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Personal profile

Research Interests

The research in my laboratory focuses on the studies of normal hematopoiesis and myeloid malignancies. Major research areas include: 1) Mechanistic studies of chromatin condensation during erythropoiesis under steady state and stress/disease conditions. 2) Studies of mDia formin proteins in homing and migration of hematopoietic stem cells, as well as the role of mDia1 in the pathogenesis of myelodysplastic syndromes. 3) The role of Pleckstrin-2 (Plek2) in normal erythropoiesis and red cell related diseases. We use molecular and cell biology techniques and mouse genetics in many of these studies.

Training Experience

2010Fellowship, Whitehead Institute for Biomedical Research
2013Residency, Northwestern University, McGaw Medical Center (Northwestern Memorial Hospital)

Education/Academic qualification

PhD, Albert Einstein College

… → 2006

MD, Peking University

… → 2000

Research interests

  • Blood Cancer (leukemia and lymphomas)
  • Cell Biology
  • Cytoskeleton
  • Developmental Biology
  • Genetics
  • Stem Cells
  • Transplantation

Fingerprint Dive into the research topics where Peng Ji is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 6 Similar Profiles
Erythropoiesis Medicine & Life Sciences
Erythroblasts Medicine & Life Sciences
Myelodysplastic Syndromes Medicine & Life Sciences
Chromatin Medicine & Life Sciences
Erythropoietin Medicine & Life Sciences
Actins Medicine & Life Sciences
Histones Medicine & Life Sciences
Cyclin A Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2009 2022

Bone Marrow
Bone Marrow Diseases
B-Cell Lymphoma
Bone Marrow Diseases
Bone Marrow Diseases
platelet protein P47
Philadelphia Chromosome

Research Output 2004 2019

4 Citations (Scopus)

Aurora kinase A inhibition provides clinical benefit, normalizes megakaryocytes, and reduces bone marrow fibrosis in patients with myelofibrosis: A phase I trial

Gangat, N., Marinaccio, C., Swords, R., Watts, J. M., Gurbuxani, S., Rademaker, A., Fought, A. J., Frankfurt, O., Altman, J. K., Wen, Q. J., Farnoud, N., Famulare, C. A., Patel, A., Tapia, R., Vallapureddy, R. R., Barath, S., Graf, A., Handlogten, A., Zblewski, D., Patnaik, M. M. & 14 others, Al-Kali, A., Dinh, Y. T., Prahl, K. E., Patel, S., Nobrega, J. C., Tejera, D., Thomassen, A., Gao, J., Ji, P., Rampal, R. K., Giles, F. J., Tefferi, A., Stein, B. & Crispino, J. D., Aug 15 2019, In : Clinical Cancer Research. 25, 16, p. 4898-4906 9 p.

Research output: Contribution to journalArticle

Aurora Kinase A
Primary Myelofibrosis
1 Citation (Scopus)

Cytokine-regulated phosphorylation and activation of TET2 by JAK2 in hematopoiesis

Jeong, J. J., Gu, X., Nie, J., Sundaravel, S., Liu, H., Kuo, W. L., Bhagat, T. D., Pradhan, K., Cao, J., Nischal, S., McGraw, K. L., Bhattacharyya, S., Bishop, M. R., Artz, A., Thirman, M. J., Moliterno, A., Ji, P., Levine, R. L., Godley, L. A., Steidl, U. & 6 others, Bieker, J. J., List, A. F., Saunthararajah, Y., He, C., Verma, A. & Wickrema, A., Jun 2019, In : Cancer discovery. 9, 6, p. 778-795 18 p.

Research output: Contribution to journalArticle

Open Access

Disruption of erythroid nuclear opening and histone release in myelodysplastic syndromes

Zhao, B., Liu, H., Mei, Y., Liu, Y., Han, X., Yang, J., Wickrema, A. & Ji, P., Mar 1 2019, In : Cancer medicine. 8, 3, p. 1169-1174 6 p.

Research output: Contribution to journalArticle

Open Access
Myelodysplastic Syndromes

Mammalian diaphanous-related formin 1 (mDia1) coordinates mast cell migration and secretion through its actin-nucleating activity

Klein, O., Krier-Burris, R. A., Lazki-Hagenbach, P., Gorzalczany, Y., Mei, Y., Ji, P., Bochner, B. S. & Sagi-Eisenberg, R., Oct 1 2019, In : Journal of Allergy and Clinical Immunology. 144, 4, p. 1074-1090 17 p.

Research output: Contribution to journalArticle

Mast Cells
Cell Movement
Secretory Vesicles
15 Citations (Scopus)

Age-related inflammatory bone marrow microenvironment induces ineffective erythropoiesis mimicking del(5q) MDS

Mei, Y., Zhao, B., Basiorka, A. A., Yang, J., Cao, L., Zhang, J., List, A. & Ji, P., Apr 1 2018, In : Leukemia. 32, 4, p. 1023-1033 11 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Bone Marrow
Knockout Mice