Grants per year
Personal profile
Research Interests
The research in my laboratory focuses on the studies of normal hematopoiesis and myeloid malignancies. Major research areas include: 1) Mechanistic studies of chromatin condensation during erythropoiesis under steady state and stress/disease conditions. 2) Studies of mDia formin proteins in homing and migration of hematopoietic stem cells, as well as the role of mDia1 in the pathogenesis of myelodysplastic syndromes. 3) The role of Pleckstrin-2 (Plek2) in normal erythropoiesis and red cell related diseases. We use molecular and cell biology techniques and mouse genetics in many of these studies.
Training Experience
| 2010 | Fellowship, Whitehead Institute for Biomedical Research |
| 2013 | Residency, Northwestern University, McGaw Medical Center (Northwestern Memorial Hospital) |
Education/Academic qualification
PhD, Albert Einstein College
… → 2006
MD, Peking University
… → 2000
Keywords
- Blood Cancer (leukemia and lymphomas)
- Cell Biology
- Cytoskeleton
- Developmental Biology
- Genetics
- Stem Cells
- Transplantation
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- 6 Similar Profiles
Erythropoiesis
Medicine & Life Sciences
Erythroblasts
Medicine & Life Sciences
Myelodysplastic Syndromes
Medicine & Life Sciences
Chromatin
Medicine & Life Sciences
Histones
Medicine & Life Sciences
Cyclin A
Medicine & Life Sciences
Erythropoietin
Medicine & Life Sciences
Erythrocytes
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2009 2022
Targeting Pleckstrin-2 for the treatment of myeloproliferative neoplasms (19POST34381031)
1/1/19 → 12/31/20
Project: Research project
Neoplasms
Thrombosis
Bone Marrow Diseases
Therapeutics
B-Cell Lymphoma
The role of Plek2 in the pathogenesis of myeloproliferative neoplasms
7/1/17 → 6/30/22
Project: Research project
Neoplasms
Bone Marrow Diseases
platelet protein P47
Philadelphia Chromosome
Mutation
The roles of pleckstrin-2 as a functional node in erythropoiesis
National Institute of Diabetes, Digestive and Kidney Diseases
4/10/15 → 1/31/20
Project: Research project
Erythropoiesis
GTP Phosphohydrolases
Erythropoietin
Actins
Cell Differentiation
Targeting Plek2 as a Novel Approach for the Treatment of Myeloproliferative Neoplasms
Northwestern Memorial Hospital
1/1/17 → 12/31/17
Project: Research project
Neoplasms
Therapeutics
Bone Marrow Diseases
Mutation
Myeloid Cells
The Role of mDia1 in the Aberrant Innate Immune Signaling in del(5q) Myelodysplastic Syndromes
U.S. Army Medical Research and Materiel Command
9/15/15 → 9/14/18
Project: Research project
Research Output 2004 2019
Disruption of erythroid nuclear opening and histone release in myelodysplastic syndromes
Zhao, B., Liu, H., Mei, Y., Liu, Y., Han, X., Yang, J., Wickrema, A. & Ji, P., Mar 1 2019, In : Cancer medicine. 8, 3, p. 1169-1174 6 p.Research output: Contribution to journal › Article
Open Access
Myelodysplastic Syndromes
Histones
Erythropoiesis
Erythroblasts
Chromatin
10
Citations
(Scopus)
Age-related inflammatory bone marrow microenvironment induces ineffective erythropoiesis mimicking del(5q) MDS
Mei, Y., Zhao, B., Basiorka, A. A., Yang, J., Cao, L., Zhang, J., List, A. & Ji, P., Apr 1 2018, In : Leukemia. 32, 4, p. 1023-1033 11 p.Research output: Contribution to journal › Article
Erythropoiesis
Myelodysplastic Syndromes
Bone Marrow
Anemia
Knockout Mice
Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2 V617F -positive myeloproliferative neoplasms
Zhao, B., Mei, Y., Cao, L., Zhang, J., Sumagin, R., Yang, J., Gao, J., Schipma, M. J., Wang, Y., Thorsheim, C., Zhao, L., Stalker, T., Stein, B., Wen, Q. J., Crispino, J. D., Abrams, C. S. & Ji, P., Jan 2 2018, In : Journal of Clinical Investigation. 128, 1, p. 125-140 16 p.Research output: Contribution to journal › Article
Blood Vessels
Neoplasms
Erythrocyte Volume
Thrombocytosis
Philadelphia Chromosome
Targeting age-related inflammation in myelodysplastic syndromes
Mei, Y. & Ji, P., Oct 1 2018, In : Oncotarget. 9, 83, p. 35376-35377 2 p.Research output: Contribution to journal › Editorial
Myelodysplastic Syndromes
Innate Immunity
Inflammation
1
Citation
(Scopus)
USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism
Melo-Cardenas, J., Xu, Y., Wei, J., Tan, C., Kong, S., Gao, B., Montauti, E., Kirsammer, G., Licht, J. D., Yu, J., Ji, P., Crispino, J. D. & Fang, D., Jul 26 2018, In : Blood. 132, 4, p. 423-434 12 p.Research output: Contribution to journal › Article
Myeloid Leukemia
Ubiquitin
Peptide Hydrolases
Chemical activation
Acute Myeloid Leukemia