Grants per year
Personal profile
Research Interests
The research in my laboratory focuses on the studies of normal hematopoiesis and myeloid malignancies. Major research areas include: 1) Mechanistic studies of chromatin condensation during erythropoiesis under steady state and stress/disease conditions. 2) Studies of mDia formin proteins in homing and migration of hematopoietic stem cells, as well as the role of mDia1 in the pathogenesis of myelodysplastic syndromes. 3) The role of Pleckstrin-2 (Plek2) in normal erythropoiesis and red cell related diseases. We use molecular and cell biology techniques and mouse genetics in many of these studies.
Training Experience
| 2010 | Fellowship, Whitehead Institute for Biomedical Research |
| 2013 | Residency, Northwestern University, McGaw Medical Center (Northwestern Memorial Hospital) |
Education/Academic qualification
PhD, Albert Einstein College
… → 2006
MD, Peking University
… → 2000
Research interests
- Blood Cancer (leukemia and lymphomas)
- Cell Biology
- Cytoskeleton
- Developmental Biology
- Genetics
- Stem Cells
- Transplantation
Fingerprint Dive into the research topics where Peng Ji is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 6 Similar Profiles
Erythropoiesis
Medicine & Life Sciences
Erythroblasts
Medicine & Life Sciences
Myelodysplastic Syndromes
Medicine & Life Sciences
Chromatin
Medicine & Life Sciences
Erythropoietin
Medicine & Life Sciences
Actins
Medicine & Life Sciences
Histones
Medicine & Life Sciences
Cyclin A
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2009 2022
The role of bone marrow inflammation in the progression of clonal hematopoiesis to blood cancers
U.S. Army Medical Research and Materiel Command
9/1/19 → 8/31/21
Project: Research project
Osteitis
Hematopoiesis
Bone Marrow
Inflammation
Neoplasms
Targeting Plek2 for the treatment of myeloproliferative neoplasms
7/1/19 → 6/30/22
Project: Research project
Targeting Pleckstrin-2 for the treatment of myeloproliferative neoplasms (19POST34381031)
1/1/19 → 12/31/20
Project: Research project
Neoplasms
Thrombosis
Bone Marrow Diseases
Therapeutics
B-Cell Lymphoma
Identification of small molecule inhibitors of Plek2 for the treatment of myeloproliferative neoplasms
University Hospitals Health System
1/1/19 → 12/31/20
Project: Research project
Neoplasms
Therapeutics
Bone Marrow Diseases
Mutation
Hematopoiesis
The role of Plek2 in the pathogenesis of myeloproliferative neoplasms
7/1/17 → 6/30/22
Project: Research project
Neoplasms
Bone Marrow Diseases
platelet protein P47
Philadelphia Chromosome
Mutation
Research Output 2004 2019
4
Citations
(Scopus)
Aurora kinase A inhibition provides clinical benefit, normalizes megakaryocytes, and reduces bone marrow fibrosis in patients with myelofibrosis: A phase I trial
Gangat, N., Marinaccio, C., Swords, R., Watts, J. M., Gurbuxani, S., Rademaker, A., Fought, A. J., Frankfurt, O., Altman, J. K., Wen, Q. J., Farnoud, N., Famulare, C. A., Patel, A., Tapia, R., Vallapureddy, R. R., Barath, S., Graf, A., Handlogten, A., Zblewski, D., Patnaik, M. M. & 14 others, , Aug 15 2019, In : Clinical Cancer Research. 25, 16, p. 4898-4906 9 p.Research output: Contribution to journal › Article
Aurora Kinase A
Primary Myelofibrosis
Megakaryocytes
Fibrosis
Splenomegaly
1
Citation
(Scopus)
Cytokine-regulated phosphorylation and activation of TET2 by JAK2 in hematopoiesis
Jeong, J. J., Gu, X., Nie, J., Sundaravel, S., Liu, H., Kuo, W. L., Bhagat, T. D., Pradhan, K., Cao, J., Nischal, S., McGraw, K. L., Bhattacharyya, S., Bishop, M. R., Artz, A., Thirman, M. J., Moliterno, A., Ji, P., Levine, R. L., Godley, L. A., Steidl, U. & 6 others, , Jun 2019, In : Cancer discovery. 9, 6, p. 778-795 18 p.Research output: Contribution to journal › Article
Open Access
Cytosine
Hematopoiesis
Epigenomics
Phosphorylation
Cytokines
Disruption of erythroid nuclear opening and histone release in myelodysplastic syndromes
Zhao, B., Liu, H., Mei, Y., Liu, Y., Han, X., Yang, J., Wickrema, A. & Ji, P., Mar 1 2019, In : Cancer medicine. 8, 3, p. 1169-1174 6 p.Research output: Contribution to journal › Article
Open Access
Myelodysplastic Syndromes
Histones
Erythropoiesis
Erythroblasts
Chromatin
Mammalian diaphanous-related formin 1 (mDia1) coordinates mast cell migration and secretion through its actin-nucleating activity
Klein, O., Krier-Burris, R. A., Lazki-Hagenbach, P., Gorzalczany, Y., Mei, Y., Ji, P., Bochner, B. S. & Sagi-Eisenberg, R., Oct 1 2019, In : Journal of Allergy and Clinical Immunology. 144, 4, p. 1074-1090 17 p.Research output: Contribution to journal › Article
Mast Cells
Cell Movement
Actins
Secretory Vesicles
Phenotype
15
Citations
(Scopus)
Age-related inflammatory bone marrow microenvironment induces ineffective erythropoiesis mimicking del(5q) MDS
Mei, Y., Zhao, B., Basiorka, A. A., Yang, J., Cao, L., Zhang, J., List, A. & Ji, P., Apr 1 2018, In : Leukemia. 32, 4, p. 1023-1033 11 p.Research output: Contribution to journal › Article
Erythropoiesis
Myelodysplastic Syndromes
Bone Marrow
Anemia
Knockout Mice