Grants per year
Personal profile
Research Interests
The research in my laboratory focuses on the studies of normal hematopoiesis and myeloid malignancies. Major research areas include: 1) Mechanistic studies of chromatin condensation during erythropoiesis under steady state and stress/disease conditions. 2) Studies of mDia formin proteins in homing and migration of hematopoietic stem cells, as well as the role of mDia1 in the pathogenesis of myelodysplastic syndromes. 3) The role of Pleckstrin-2 (Plek2) in normal erythropoiesis and red cell related diseases. We use molecular and cell biology techniques and mouse genetics in many of these studies.
Training Experience
2010 | Fellowship, Whitehead Institute for Biomedical Research |
2013 | Residency, Northwestern University, McGaw Medical Center (Northwestern Memorial Hospital) |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Developmental Biology, Albert Einstein College
… → 2006
MD, Medicine, Peking University
… → 2000
Research interests keywords
- Blood Cancer (leukemia and lymphomas)
- Cell Biology
- Cytoskeleton
- Developmental Biology
- Genetics
- Stem Cells
- Transplantation
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Collaborations and top research areas from the last five years
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Targeting gasdermin D to treat myelodysplastic syndromes
National Heart, Lung, and Blood Institute
8/1/23 → 5/31/27
Project: Research project
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The role of Gasdermin D in the inflammation-driven pathogenesis of myelodysplastic syndromes
7/1/23 → 6/30/25
Project: Research project
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Collaborative Research NSF-ANR: Mechanisms of terminal erythroid enucleation
4/1/23 → 3/31/26
Project: Research project
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Role of FGF23 peptides in chronic kidney disease (CKD)
David, N. V., David, N. V., Ji, P., Ji, P., Martin, A. & Martin, A.
National Institute of Diabetes and Digestive and Kidney Diseases
1/1/23 → 11/30/27
Project: Research project
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An ultra-low-input RNase footprinting assay to quantify cytosolic and mitochondrial translation simultaneously
Ji, Z., Ji, Z., Ji, Z., Ji, P. & Ji, P.
National Heart, Lung, and Blood Institute
1/17/22 → 12/31/25
Project: Research project
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Bone-derived C-terminal FGF23 cleaved peptides increase iron availability in acute inflammation
Courbon, G., Thomas, J. J., Martinez-Calle, M., Wang, X., Spindler, J., Von Drasek, J., Hunt-Tobey, B., Mehta, R., Isakova, T., Chang, W., Creemers, J. W. M., Ji, P., Martin, A. & David, V., Jul 6 2023, In: Blood. 142, 1, p. 106-118 13 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Clonal hematopoiesis and bone marrow inflammation
Xie, X., Su, M., Ren, K., Ma, X., Lv, Z., Li, Z., Mei, Y. & Ji, P., May 2023, In: Translational Research. 255, p. 159-170 12 p.Research output: Contribution to journal › Review article › peer-review
1 Scopus citations -
PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371
Chen, H., Bai, Y., Kobayashi, M., Xiao, S., Cai, W., Barajas, S., Chen, S., Miao, J., Meke, F. N., Vemula, S., Ropa, J. P., Croop, J. M., Boswell, H. S., Wan, J., Jia, Y., Liu, H., Li, L. S., Altman, J. K., Eklund, E. A., Ji, P., & 6 others , Jan 19 2023, In: Blood. 141, 3, p. 244-259 16 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Prognostic significance of copy number gains of MYC detected by fluorescence in situ hybridization in large B-cell lymphoma
Zak, T., Santana-Santos, L., Gao, J., Behdad, A., Aqil, B., Wolniak, K. L., Lu, X., Ji, P., Chen, Q., Chen, Y. H., Karmali, R. & Sukhanova, M., 2023, (Accepted/In press) In: Leukemia and Lymphoma.Research output: Contribution to journal › Article › peer-review
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Targeting pleckstrin-2/Akt signaling reduces proliferation in myeloproliferative neoplasm models
Han, X., Mei, Y., Mishra, R. K., Bi, H., Jain, A. D., Schiltz, G. E., Zhao, B., Sukhanova, M., Wang, P., Grigorescu, A. A., Weber, P. C., Piwinski, J. J., Prado, M. A., Paulo, J. A., Stephens, L., Anderson, K. E., Abrams, C. S., Yang, J. & Ji, P., Mar 15 2023, In: Journal of Clinical Investigation. 133, 6, e159638.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations