The research in my laboratory focuses on the studies of normal hematopoiesis and myeloid malignancies. Major research areas include: 1) Mechanistic studies of chromatin condensation during erythropoiesis under steady state and stress/disease conditions. 2) Studies of mDia formin proteins in homing and migration of hematopoietic stem cells, as well as the role of mDia1 in the pathogenesis of myelodysplastic syndromes. 3) The role of Pleckstrin-2 (Plek2) in normal erythropoiesis and red cell related diseases. We use molecular and cell biology techniques and mouse genetics in many of these studies.