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Peng Ji

  • 891 Citations
20042022
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Personal profile

Research Interests

The research in my laboratory focuses on the studies of normal hematopoiesis and myeloid malignancies. Major research areas include: 1) Mechanistic studies of chromatin condensation during erythropoiesis under steady state and stress/disease conditions. 2) Studies of mDia formin proteins in homing and migration of hematopoietic stem cells, as well as the role of mDia1 in the pathogenesis of myelodysplastic syndromes. 3) The role of Pleckstrin-2 (Plek2) in normal erythropoiesis and red cell related diseases. We use molecular and cell biology techniques and mouse genetics in many of these studies.

Training Experience

2010Fellowship, Whitehead Institute for Biomedical Research
2013Residency, Northwestern University, McGaw Medical Center (Northwestern Memorial Hospital)

Education/Academic qualification

PhD, Albert Einstein College

… → 2006

MD, Peking University

… → 2000

Research interests

  • Blood Cancer (leukemia and lymphomas)
  • Cell Biology
  • Cytoskeleton
  • Developmental Biology
  • Genetics
  • Stem Cells
  • Transplantation

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  • 7 Similar Profiles
Erythropoiesis Medicine & Life Sciences
Erythroblasts Medicine & Life Sciences
Myelodysplastic Syndromes Medicine & Life Sciences
Chromatin Medicine & Life Sciences
Erythropoietin Medicine & Life Sciences
Actins Medicine & Life Sciences
Histones Medicine & Life Sciences
Cyclin A Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2009 2022

The role of bone marrow inflammation in the progression of clonal hematopoiesis to blood cancers

Ji, P.

U.S. Army Medical Research and Materiel Command

9/1/19 → 8/31/21

Project: Research project

Osteitis
Hematopoiesis
Bone Marrow
Inflammation
Neoplasms

Targeting Plek2 for the treatment of myeloproliferative neoplasms

Ji, P. & Stein, B. L.

Leukemia & Lymphoma Society

7/1/19 → 6/30/22

Project: Research project

Targeting Pleckstrin-2 for the treatment of myeloproliferative neoplasms (19POST34381031)

Ji, P.

American Heart Association

1/1/19 → 12/31/20

Project: Research project

Neoplasms
Thrombosis
Bone Marrow Diseases
Therapeutics
B-Cell Lymphoma

Identification of small molecule inhibitors of Plek2 for the treatment of myeloproliferative neoplasms

Ji, P. & Mishra, R. K.

University Hospitals Health System

1/1/19 → 12/31/20

Project: Research project

Neoplasms
Therapeutics
Bone Marrow Diseases
Mutation
Hematopoiesis

The role of Plek2 in the pathogenesis of myeloproliferative neoplasms

Ji, P.

Leukemia & Lymphoma Society

7/1/17 → 6/30/22

Project: Research project

Neoplasms
Bone Marrow Diseases
platelet protein P47
Philadelphia Chromosome
Mutation

Research Output 2004 2019

8 Citations (Scopus)

Aurora kinase A inhibition provides clinical benefit, normalizes megakaryocytes, and reduces bone marrow fibrosis in patients with myelofibrosis: A phase I trial

Gangat, N., Marinaccio, C., Swords, R., Watts, J. M., Gurbuxani, S., Rademaker, A., Fought, A. J., Frankfurt, O., Altman, J. K., Wen, Q. J., Farnoud, N., Famulare, C. A., Patel, A., Tapia, R., Vallapureddy, R. R., Barath, S., Graf, A., Handlogten, A., Zblewski, D., Patnaik, M. M. & 14 others, Al-Kali, A., Dinh, Y. T., Prahl, K. E., Patel, S., Nobrega, J. C., Tejera, D., Thomassen, A., Gao, J., Ji, P., Rampal, R. K., Giles, F. J., Tefferi, A., Stein, B. & Crispino, J. D., Aug 15 2019, In : Clinical Cancer Research. 25, 16, p. 4898-4906 9 p.

Research output: Contribution to journal › Article

Aurora Kinase A
Primary Myelofibrosis
Megakaryocytes
Fibrosis
Splenomegaly
2 Citations (Scopus)

Cytokine-regulated phosphorylation and activation of TET2 by JAK2 in hematopoiesis

Jeong, J. J., Gu, X., Nie, J., Sundaravel, S., Liu, H., Kuo, W. L., Bhagat, T. D., Pradhan, K., Cao, J., Nischal, S., McGraw, K. L., Bhattacharyya, S., Bishop, M. R., Artz, A., Thirman, M. J., Moliterno, A., Ji, P., Levine, R. L., Godley, L. A., Steidl, U. & 6 others, Bieker, J. J., List, A. F., Saunthararajah, Y., He, C., Verma, A. & Wickrema, A., Jun 2019, In : Cancer discovery. 9, 6, p. 778-795 18 p.

Research output: Contribution to journal › Article

Open Access
Cytosine
Hematopoiesis
Epigenomics
Phosphorylation
Cytokines
2 Citations (Scopus)

Disruption of erythroid nuclear opening and histone release in myelodysplastic syndromes

Zhao, B., Liu, H., Mei, Y., Liu, Y., Han, X., Yang, J., Wickrema, A. & Ji, P., Mar 1 2019, In : Cancer medicine. 8, 3, p. 1169-1174 6 p.

Research output: Contribution to journal › Article

Open Access
Myelodysplastic Syndromes
Histones
Erythropoiesis
Erythroblasts
Chromatin

Mammalian diaphanous-related formin 1 (mDia1) coordinates mast cell migration and secretion through its actin-nucleating activity

Klein, O., Krier-Burris, R. A., Lazki-Hagenbach, P., Gorzalczany, Y., Mei, Y., Ji, P., Bochner, B. S. & Sagi-Eisenberg, R., Oct 2019, In : Journal of Allergy and Clinical Immunology. 144, 4, p. 1074-1090 17 p.

Research output: Contribution to journal › Article

Mast Cells
Cell Movement
Actins
Secretory Vesicles
Phenotype

Rats provide a superior model of human stress erythropoiesis

Zhang, J., Liu, Y., Han, X., Mei, Y., Yang, J., Zhang, Z. J., Lu, X. & Ji, P., Oct 2019, In : Experimental Hematology. 78, p. 21-34.e3

Research output: Contribution to journal › Article

Erythropoiesis
Spleen
Bone Marrow
Phenotype
Splenomegaly