Grants per year
Personal profile
Research Interests
The research in my laboratory focuses on the studies of normal hematopoiesis and myeloid malignancies. Major research areas include: 1) Mechanistic studies of chromatin condensation during erythropoiesis under steady state and stress/disease conditions. 2) Studies of mDia formin proteins in homing and migration of hematopoietic stem cells, as well as the role of mDia1 in the pathogenesis of myelodysplastic syndromes. 3) The role of Pleckstrin-2 (Plek2) in normal erythropoiesis and red cell related diseases. We use molecular and cell biology techniques and mouse genetics in many of these studies.
Training Experience
| 2010 | Fellowship, Whitehead Institute for Biomedical Research |
| 2013 | Residency, Northwestern University, McGaw Medical Center (Northwestern Memorial Hospital) |
Education/Academic qualification
PhD, Albert Einstein College
… → 2006
MD, Peking University
… → 2000
Research interests
- Blood Cancer (leukemia and lymphomas)
- Cell Biology
- Cytoskeleton
- Developmental Biology
- Genetics
- Stem Cells
- Transplantation
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Grants
Image-guided Interventional Combination Liver Cancer Immunotherapy
Benson III, A. B., Ji, P., Salem, R., Velichko, Y., Yaghmai, V. & Zhang, Z.
3/15/20 → 2/28/25
Project: Research project
The role of bone marrow inflammation in the progression of clonal hematopoiesis to blood cancers
U.S. Army Medical Research and Materiel Command
9/1/19 → 8/31/21
Project: Research project
Targeting Plek2 for the treatment of myeloproliferative neoplasms
7/1/19 → 6/30/22
Project: Research project
Targeting Pleckstrin-2 for the treatment of myeloproliferative neoplasms (19POST34381031)
1/1/19 → 12/31/20
Project: Research project
Identification of small molecule inhibitors of Plek2 for the treatment of myeloproliferative neoplasms
University Hospitals Health System
1/1/19 → 12/31/20
Project: Research project
Research Output
Aurora kinase A inhibition provides clinical benefit, normalizes megakaryocytes, and reduces bone marrow fibrosis in patients with myelofibrosis: A phase I trial
Gangat, N., Marinaccio, C., Swords, R., Watts, J. M., Gurbuxani, S., Rademaker, A., Fought, A. J., Frankfurt, O., Altman, J. K., Wen, Q. J., Farnoud, N., Famulare, C. A., Patel, A., Tapia, R., Vallapureddy, R. R., Barath, S., Graf, A., Handlogten, A., Zblewski, D., Patnaik, M. M. & 14 others, , Aug 15 2019, In : Clinical Cancer Research. 25, 16, p. 4898-4906 9 p.Research output: Contribution to journal › Article
10
Scopus
citations
Cytokine-regulated phosphorylation and activation of TET2 by JAK2 in hematopoiesis
Jeong, J. J., Gu, X., Nie, J., Sundaravel, S., Liu, H., Kuo, W. L., Bhagat, T. D., Pradhan, K., Cao, J., Nischal, S., McGraw, K. L., Bhattacharyya, S., Bishop, M. R., Artz, A., Thirman, M. J., Moliterno, A., Ji, P., Levine, R. L., Godley, L. A., Steidl, U. & 6 others, , Jun 2019, In : Cancer discovery. 9, 6, p. 778-795 18 p.Research output: Contribution to journal › Article
Open Access
3
Scopus
citations
Disruption of erythroid nuclear opening and histone release in myelodysplastic syndromes
Zhao, B., Liu, H., Mei, Y., Liu, Y., Han, X., Yang, J., Wickrema, A. & Ji, P., Mar 2019, In : Cancer medicine. 8, 3, p. 1169-1174 6 p.Research output: Contribution to journal › Article
Open Access
3
Scopus
citations
Mammalian diaphanous-related formin 1 (mDia1) coordinates mast cell migration and secretion through its actin-nucleating activity
Klein, O., Krier-Burris, R. A., Lazki-Hagenbach, P., Gorzalczany, Y., Mei, Y., Ji, P., Bochner, B. S. & Sagi-Eisenberg, R., Oct 2019, In : Journal of Allergy and Clinical Immunology. 144, 4, p. 1074-1090 17 p.Research output: Contribution to journal › Article