Grants per year
Personal profile
Research Interests
The research in my laboratory focuses on the studies of normal hematopoiesis and myeloid malignancies. Major research areas include: 1) Mechanistic studies of chromatin condensation during erythropoiesis under steady state and stress/disease conditions. 2) Studies of mDia formin proteins in homing and migration of hematopoietic stem cells, as well as the role of mDia1 in the pathogenesis of myelodysplastic syndromes. 3) The role of Pleckstrin-2 (Plek2) in normal erythropoiesis and red cell related diseases. We use molecular and cell biology techniques and mouse genetics in many of these studies.
Training Experience
2010 | Fellowship, Whitehead Institute for Biomedical Research |
2013 | Residency, Northwestern University, McGaw Medical Center (Northwestern Memorial Hospital) |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Developmental Biology, Albert Einstein College
… → 2006
MD, Medicine, Peking University
… → 2000
Research interests keywords
- Blood Cancer (leukemia and lymphomas)
- Cell Biology
- Cytoskeleton
- Developmental Biology
- Genetics
- Stem Cells
- Transplantation
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Collaborations and top research areas from the last five years
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Elucidating the Role of Aged Bone Marrow Microenvironment in MDS Progression Using Human Organoid Models
Ji, P. (Other)
7/1/24 → 6/30/27
Project: Research project
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Absolute Neutrophil Count (ANC) by Duffy Status Project
Godley, L. A. (PD/PI) & Ji, P. (PD/PI)
American Society of Hematology
5/1/24 → 4/30/25
Project: Research project
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Developing small molecule inhibitors of Pleckstrin-2 to treat thrombosis
Ji, P. (PD/PI) & Ji, P. (PD/PI)
Aplexis, Inc., National Heart, Lung, and Blood Institute
3/15/24 → 2/28/26
Project: Research project
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Targeting gasdermin D to treat myelodysplastic syndromes
Ji, P. (PD/PI)
National Heart, Lung, and Blood Institute
8/1/23 → 5/31/27
Project: Research project
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The role of Gasdermin D in the inflammation-driven pathogenesis of myelodysplastic syndromes
Ji, P. (PD/PI)
7/1/23 → 6/30/25
Project: Research project
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Clinical implications of additional chromosomal abnormalities in adult acute myeloid leukemia with inv (16)/t(16;16)/CBFB::MYH11
Gao, J., Santana-Santos, L., Fu, L., Alvey, E., Chen, Q., Wolniak, K., Xia, Z., Aqil, B., Behdad, A., Ji, P., Sukhanova, M., Abaza, Y., Altman, J. K., Chen, Y. H. & Lu, X., Jun 2024, In: European Journal of Haematology. 112, 6, p. 964-974 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
PRL2 Phosphatase Promotes Oncogenic KIT Signaling in Leukemia Cells through Modulating CBL Phosphorylation
Chen, H., Bai, Y., Kobayashi, M., Xiao, S., Barajas, S., Cai, W., Chen, S., Miao, J., Meke, F. N., Yao, C., Yang, Y., Strube, K., Satchivi, O., Sun, J., Ronnstrand, L., Croop, J. M., Boswell, H. S., Jia, Y., Liu, H. & Li, L. S. & 10 others, , Jan 2024, In: Molecular Cancer Research. 22, 1, p. 94-103 10 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Prognostic significance of copy number gains of MYC detected by fluorescence in situ hybridization in large B-cell lymphoma
Zak, T., Santana-Santos, L., Gao, J., Behdad, A., Aqil, B., Wolniak, K., Lu, X., Ji, P., Chen, Q., Chen, Y. H., Karmali, R. & Sukhanova, M., 2024, In: Leukemia and Lymphoma. 65, 1, p. 26-36 11 p.Research output: Contribution to journal › Article › peer-review
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Bone-derived C-terminal FGF23 cleaved peptides increase iron availability in acute inflammation
Courbon, G., Thomas, J. J., Martinez-Calle, M., Wang, X., Spindler, J., Von Drasek, J., Hunt-Tobey, B., Mehta, R., Isakova, T., Chang, W., Creemers, J. W. M., Ji, P., Martin, A. & David, V., Jul 6 2023, In: Blood. 142, 1, p. 106-118 13 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Clonal hematopoiesis and bone marrow inflammation
Xie, X., Su, M., Ren, K., Ma, X., Lv, Z., Li, Z., Mei, Y. & Ji, P., May 2023, In: Translational Research. 255, p. 159-170 12 p.Research output: Contribution to journal › Review article › peer-review
Open Access3 Scopus citations