Grants per year
Personal profile
Research Interests
The research in my laboratory focuses on the studies of normal hematopoiesis and myeloid malignancies. Major research areas include: 1) Mechanistic studies of chromatin condensation during erythropoiesis under steady state and stress/disease conditions. 2) Studies of mDia formin proteins in homing and migration of hematopoietic stem cells, as well as the role of mDia1 in the pathogenesis of myelodysplastic syndromes. 3) The role of Pleckstrin-2 (Plek2) in normal erythropoiesis and red cell related diseases. We use molecular and cell biology techniques and mouse genetics in many of these studies.
Training Experience
| 2010 | Fellowship, Whitehead Institute for Biomedical Research |
| 2013 | Residency, Northwestern University, McGaw Medical Center (Northwestern Memorial Hospital) |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Developmental Biology, Albert Einstein College
… → 2006
MD, Medicine, Peking University
… → 2000
Research interests keywords
- Blood Cancer (leukemia and lymphomas)
- Cell Biology
- Cytoskeleton
- Developmental Biology
- Genetics
- Stem Cells
- Transplantation
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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The role of Gasdermin D in the bone marrow microenvironment during clonal hematopoiesis progression
Ji, P. (PD/PI)
2/1/25 → 1/31/27
Project: Research project
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Functional roles of DDX41 in the homeostasis of G quadruplexes in erythropoiesis
Ji, P. (PD/PI) & Godley, L. A. (Co-Investigator)
National Institute of Diabetes and Digestive and Kidney Diseases
9/5/24 → 8/31/29
Project: Research project
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Elucidating the Role of Aged Bone Marrow Microenvironment in MDS Progression Using Human Organoid Models
Ji, P. (Other)
7/1/24 → 6/30/27
Project: Research project
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Developing small molecule inhibitors of Pleckstrin-2 to treat thrombosis
Ji, P. (PD/PI) & Ji, P. (PD/PI)
Aplexis, Inc., National Heart, Lung, and Blood Institute
3/15/24 → 2/28/26
Project: Research project
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Targeting gasdermin D to treat myelodysplastic syndromes
Ji, P. (PD/PI)
National Heart, Lung, and Blood Institute
8/1/23 → 5/31/27
Project: Research project
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Development of iPSC-derived human bone marrow organoid for autonomous hematopoiesis and patient-derived HSPC engraftment
Ren, K., Li, E., Aydemir, I., Liu, Y., Han, X., Bi, H., Wang, P., Tao, K., Ji, A., Chen, Y. H., Yang, J., Sukhanova, M. & Ji, P., Jan 14 2025, In: Blood Advances. 9, 1, p. 54-65 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Polycomb group protein Mel18 inhibits hematopoietic stem cell self-renewal through repressing the transcription of self-renewal and proliferation genes
Cai, W., Liu, X., Barajas, S., Xiao, S., Vemula, S., Chen, H., Yang, Y., Bochers, C., Henley, D., Liu, S., Jia, Y., Hong, M., Mays, T. M., Capitano, M. L., Liu, H., Ji, P., Gao, Z., Pasini, D., Wan, J. & Yue, F. & 4 others, , Feb 2025, In: Leukemia. 39, 2, p. 296-307 12 p., 550.Research output: Contribution to journal › Article › peer-review
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Usefulness of Flow Cytometry Monocyte Partitioning in the Diagnosis of Chronic Myelomonocytic Leukemia in a Real-World Setting
Liu, Y., Tariq, H., Fu, L., Gao, J., Jagtiani, T., Wolniak, K., Aqil, B., Ji, P., Chen, Y.-H. & Chen, Q. C., Apr 2025, In: Cancers. 17, 7, 1229.Research output: Contribution to journal › Article › peer-review
Open Access -
Clinical implications of additional chromosomal abnormalities in adult acute myeloid leukemia with inv (16)/t(16;16)/CBFB::MYH11
Gao, J., Santana-Santos, L., Fu, L., Alvey, E., Chen, Q., Wolniak, K., Xia, Z., Aqil, B., Behdad, A., Ji, P., Sukhanova, M., Abaza, Y., Altman, J. K., Chen, Y. H. & Lu, X., Jun 2024, In: European Journal of Haematology. 112, 6, p. 964-974 11 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Pleckstrin-2 Mediates the Activation of AKT in Prostate Cancer and Is Repressed by Androgen Receptor
Han, X., Zhang, A., Wang, P., Bi, H., Ren, K., Li, E., Yang, X., Aydemir, I., Tao, K., Lin, J., Abdulkadir, S. A., Yang, J. & Ji, P., Oct 2024, In: American Journal of Pathology. 194, 10, p. 1986-1996 11 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations