Grants per year
Personal profile
Research Interests
The research in my laboratory focuses on the studies of normal hematopoiesis and myeloid malignancies. Major research areas include: 1) Mechanistic studies of chromatin condensation during erythropoiesis under steady state and stress/disease conditions. 2) Studies of mDia formin proteins in homing and migration of hematopoietic stem cells, as well as the role of mDia1 in the pathogenesis of myelodysplastic syndromes. 3) The role of Pleckstrin-2 (Plek2) in normal erythropoiesis and red cell related diseases. We use molecular and cell biology techniques and mouse genetics in many of these studies.
Training Experience
| 2010 | Fellowship, Whitehead Institute for Biomedical Research |
| 2013 | Residency, Northwestern University, McGaw Medical Center (Northwestern Memorial Hospital) |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Albert Einstein College
… → 2006
MD, Peking University
… → 2000
Research interests
- Blood Cancer (leukemia and lymphomas)
- Cell Biology
- Cytoskeleton
- Developmental Biology
- Genetics
- Stem Cells
- Transplantation
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An ultra-low-input RNase footprinting assay to quantify cytosolic and mitochondrial translation simultaneously
National Heart, Lung, and Blood Institute
1/17/22 → 12/31/25
Project: Research project
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DRP Y1-2 Targeting Plek2 for the treatment of prostate cancer
9/1/21 → 7/31/26
Project: Research project
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Regulation of FGF23 in Chronic Kidney Disease (CKD) by iron and inflammation
David, N. V., Ji, P., Kapitsinou, P. & Martin, A.
National Institute of Diabetes and Digestive and Kidney Diseases
9/17/20 → 6/30/25
Project: Research project
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The role of Pleckstrin-2 as a functional node in myeloid proliferation
National Heart, Lung, and Blood Institute
7/9/20 → 6/30/24
Project: Research project
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Understanding thrombosis formation in myeloproliferative diseases
University of Pennsylvania, National Heart, Lung, and Blood Institute
7/1/20 → 5/31/23
Project: Research project
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Bone marrow–confined IL-6 signaling mediates the progression of myelodysplastic syndromes to acute myeloid leukemia
Mei, Y., Ren, K., Liu, Y., Ma, A., Xia, Z., Han, X., Li, E., Tariq, H., Bao, H., Xie, X., Zou, C., Zhang, D., Li, Z., Dong, L., Verma, A., Lu, X., Abaza, Y., Altman, J. K., Sukhanova, M., Yang, J., & 1 others, Sep 1 2022, In: Journal of Clinical Investigation. 132, 17, e152673.Research output: Contribution to journal › Article › peer-review
Open Access -
Comparison of myeloid neoplasms with nonclassic 3q26.2/MECOM versus classic inv(3)/t(3;3) rearrangements reveals diverse clinicopathologic features, genetic profiles, and molecular mechanisms of MECOM activation
Gao, J., Gurbuxani, S., Zak, T., Kocherginsky, M., Ji, P., Wehbe, F., Chen, Q., Chen, Y. H., Lu, X., Jennings, L., Frankfurt, O., Altman, J. & Sukhanova, M., Feb 2022, In: Genes Chromosomes and Cancer. 61, 2, p. 71-80 10 p.Research output: Contribution to journal › Article › peer-review
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Proteome remodeling and organelle clearance in mammalian terminal erythropoiesis
Ren, K., Li, E. & Ji, P., May 1 2022, In: Current opinion in hematology. 29, 3, p. 137-143 7 p.Research output: Contribution to journal › Review article › peer-review
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Comprehensive evaluation of bronchoalveolar lavage from patients with severe COVID-19 and correlation with clinical outcomes
Gelarden, I., Nguyen, J., Gao, J., Chen, Q., Morales-Nebreda, L., Wunderink, R., Li, L., Chmiel, J. S., Hrisinko, M. A., Marszalek, L., Momnani, S., Patel, P., Sumugod, R., Chao, Q., Jennings, L. J., Zembower, T. R., Ji, P. & Chen, Y. H., Jul 2021, In: Human pathology. 113, p. 92-103 12 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Membrane skeleton modulates erythroid proteome remodeling and organelle clearance
Liu, Y., Mei, Y., Han, X., Korobova, F. V., Prado, M. A., Yang, J., Peng, Z., Paulo, J. A., Gygi, S. P., Finley, D. & Ji, P., Jan 21 2021, In: Blood. 137, 3, p. 398-409 12 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations