• 905 Citations
20042025

Research output per year

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Personal profile

Research Interests

The research in my laboratory focuses on the studies of normal hematopoiesis and myeloid malignancies. Major research areas include: 1) Mechanistic studies of chromatin condensation during erythropoiesis under steady state and stress/disease conditions. 2) Studies of mDia formin proteins in homing and migration of hematopoietic stem cells, as well as the role of mDia1 in the pathogenesis of myelodysplastic syndromes. 3) The role of Pleckstrin-2 (Plek2) in normal erythropoiesis and red cell related diseases. We use molecular and cell biology techniques and mouse genetics in many of these studies.

Training Experience

2010Fellowship, Whitehead Institute for Biomedical Research
2013Residency, Northwestern University, McGaw Medical Center (Northwestern Memorial Hospital)

Education/Academic qualification

PhD, Albert Einstein College

… → 2006

MD, Peking University

… → 2000

Research interests

  • Blood Cancer (leukemia and lymphomas)
  • Cell Biology
  • Cytoskeleton
  • Developmental Biology
  • Genetics
  • Stem Cells
  • Transplantation

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Grants

  • Research Output

    Aurora kinase A inhibition provides clinical benefit, normalizes megakaryocytes, and reduces bone marrow fibrosis in patients with myelofibrosis: A phase I trial

    Gangat, N., Marinaccio, C., Swords, R., Watts, J. M., Gurbuxani, S., Rademaker, A., Fought, A. J., Frankfurt, O., Altman, J. K., Wen, Q. J., Farnoud, N., Famulare, C. A., Patel, A., Tapia, R., Vallapureddy, R. R., Barath, S., Graf, A., Handlogten, A., Zblewski, D., Patnaik, M. M. & 14 others, Al-Kali, A., Dinh, Y. T., Prahl, K. E., Patel, S., Nobrega, J. C., Tejera, D., Thomassen, A., Gao, J., Ji, P., Rampal, R. K., Giles, F. J., Tefferi, A., Stein, B. & Crispino, J. D., Aug 15 2019, In : Clinical Cancer Research. 25, 16, p. 4898-4906 9 p.

    Research output: Contribution to journalArticle

  • 10 Scopus citations

    Cytokine-regulated phosphorylation and activation of TET2 by JAK2 in hematopoiesis

    Jeong, J. J., Gu, X., Nie, J., Sundaravel, S., Liu, H., Kuo, W. L., Bhagat, T. D., Pradhan, K., Cao, J., Nischal, S., McGraw, K. L., Bhattacharyya, S., Bishop, M. R., Artz, A., Thirman, M. J., Moliterno, A., Ji, P., Levine, R. L., Godley, L. A., Steidl, U. & 6 others, Bieker, J. J., List, A. F., Saunthararajah, Y., He, C., Verma, A. & Wickrema, A., Jun 2019, In : Cancer discovery. 9, 6, p. 778-795 18 p.

    Research output: Contribution to journalArticle

    Open Access
    3 Scopus citations

    Disruption of erythroid nuclear opening and histone release in myelodysplastic syndromes

    Zhao, B., Liu, H., Mei, Y., Liu, Y., Han, X., Yang, J., Wickrema, A. & Ji, P., Mar 2019, In : Cancer medicine. 8, 3, p. 1169-1174 6 p.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Scopus citations

    Mammalian diaphanous-related formin 1 (mDia1) coordinates mast cell migration and secretion through its actin-nucleating activity

    Klein, O., Krier-Burris, R. A., Lazki-Hagenbach, P., Gorzalczany, Y., Mei, Y., Ji, P., Bochner, B. S. & Sagi-Eisenberg, R., Oct 2019, In : Journal of Allergy and Clinical Immunology. 144, 4, p. 1074-1090 17 p.

    Research output: Contribution to journalArticle