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Personal profile

Research Interests

The research in my laboratory focuses on the studies of normal hematopoiesis and myeloid malignancies. Major research areas include: 1) Mechanistic studies of chromatin condensation during erythropoiesis under steady state and stress/disease conditions. 2) Studies of mDia formin proteins in homing and migration of hematopoietic stem cells, as well as the role of mDia1 in the pathogenesis of myelodysplastic syndromes. 3) The role of Pleckstrin-2 (Plek2) in normal erythropoiesis and red cell related diseases. We use molecular and cell biology techniques and mouse genetics in many of these studies.

Training Experience

2010Fellowship, Whitehead Institute for Biomedical Research
2013Residency, Northwestern University, McGaw Medical Center (Northwestern Memorial Hospital)

Education/Academic qualification

PhD, Albert Einstein College

… → 2006

MD, Peking University

… → 2000

Keywords

  • Blood Cancer (leukemia and lymphomas)
  • Cell Biology
  • Cytoskeleton
  • Developmental Biology
  • Genetics
  • Stem Cells
  • Transplantation

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  • 4 Similar Profiles
Erythropoiesis Medicine & Life Sciences
Erythroblasts Medicine & Life Sciences
Myelodysplastic Syndromes Medicine & Life Sciences
Chromatin Medicine & Life Sciences
Histones Medicine & Life Sciences
Cyclin A Medicine & Life Sciences
Erythropoietin Medicine & Life Sciences
Erythrocytes Medicine & Life Sciences

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Grants 2009 2022

Neoplasms
Therapeutics
Bone Marrow Diseases
Mutation
Hematopoiesis
Neoplasms
Thrombosis
Bone Marrow Diseases
Therapeutics
B-Cell Lymphoma
Neoplasms
Bone Marrow Diseases
platelet protein P47
Philadelphia Chromosome
Mutation
Erythropoiesis
GTP Phosphohydrolases
Erythropoietin
Actins
Cell Differentiation

Research Output 2004 2019

Disruption of erythroid nuclear opening and histone release in myelodysplastic syndromes

Zhao, B., Liu, H., Mei, Y., Liu, Y., Han, X., Yang, J., Wickrema, A. & Ji, P., Mar 1 2019, In : Cancer medicine. 8, 3, p. 1169-1174 6 p.

Research output: Contribution to journalArticle

Open Access
Myelodysplastic Syndromes
Histones
Erythropoiesis
Erythroblasts
Chromatin
13 Citations (Scopus)

Age-related inflammatory bone marrow microenvironment induces ineffective erythropoiesis mimicking del(5q) MDS

Mei, Y., Zhao, B., Basiorka, A. A., Yang, J., Cao, L., Zhang, J., List, A. & Ji, P., Apr 1 2018, In : Leukemia. 32, 4, p. 1023-1033 11 p.

Research output: Contribution to journalArticle

Erythropoiesis
Myelodysplastic Syndromes
Bone Marrow
Anemia
Knockout Mice

Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2 V617F -positive myeloproliferative neoplasms

Zhao, B., Mei, Y., Cao, L., Zhang, J., Sumagin, R., Yang, J., Gao, J., Schipma, M. J., Wang, Y., Thorsheim, C., Zhao, L., Stalker, T., Stein, B., Wen, Q. J., Crispino, J. D., Abrams, C. S. & Ji, P., Jan 2 2018, In : Journal of Clinical Investigation. 128, 1, p. 125-140 16 p.

Research output: Contribution to journalArticle

Blood Vessels
Neoplasms
Erythrocyte Volume
Thrombocytosis
Philadelphia Chromosome

Targeting age-related inflammation in myelodysplastic syndromes

Mei, Y. & Ji, P., Oct 1 2018, In : Oncotarget. 9, 83, p. 35376-35377 2 p.

Research output: Contribution to journalEditorial

Myelodysplastic Syndromes
Innate Immunity
Inflammation
2 Citations (Scopus)

USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism

Melo-Cardenas, J., Xu, Y., Wei, J., Tan, C., Kong, S., Gao, B., Montauti, E., Kirsammer, G., Licht, J. D., Yu, J., Ji, P., Crispino, J. D. & Fang, D., Jul 26 2018, In : Blood. 132, 4, p. 423-434 12 p.

Research output: Contribution to journalArticle

Myeloid Leukemia
Ubiquitin
Peptide Hydrolases
Chemical activation
Acute Myeloid Leukemia