Grants per year
Personal profile
Research Interests
Clinical Interests: asthma, chronic obstructive pulmonary disease (COPD), interstitial lung disease, SARCOIDOSIS. Research Interests: airway inflammation and remodeling in asthma and COPD; effects of hypercapnia (elevated levels of CO2) on innate immunity and host defense in the lung.
Certifications and Licenses
| Critical Care Medicine | |
| Internal Medicine | |
| Pulmonary Disease |
Training Experience
| 1983 | Residency, Bronx Municipal Hospital Center |
| 1984 | Fellowship, Bronx Municipal Hospital Center |
| 1987 | Fellowship, University of Michigan Health System |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
MD, Medicine, Wayne State University School of Medicine
… → 1980
Research interests keywords
- Asthma
- Chronic Obstructive Pulmonary Disease (COPD)
- Idiopathic Interstitial Lung Disease
- Lungs / Breathing Problems
- Respiratory Diseases
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Prot #XTMAB-16-202: A Long-Term Multicenter Open-Label Study to Evaluate the Long-Term Safety and Durability of Effect of XTMAB-16 in Patients With Pulmonary Sarcoidosis With or Without Extra-Pulmonary Involvement
Sporn, P. H. (PD/PI)
Pharmaceutical Research Associates, Inc., Xentria, Inc.
2/7/24 → 2/7/27
Project: Research project
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Prot #XTMAB‐16‐201: A Seamless, Phase 1b/2 Multiple Ascending Dose/Proof of Concept Study of XTMAB‐16 in Patients with Pulmonary Sarcoidosis with or without Extrapulmonary Manifestations
Sporn, P. H. (PD/PI)
Pharmaceutical Research Associates, Inc., Xentria, Inc.
9/13/23 → 9/13/26
Project: Research project
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IPA for Marina S. Casalino Matsuda, PhD with Jesse Brown VA Medical Center
Sporn, P. H. (PD/PI), Sporn, P. H. (PD/PI), Sporn, P. H. (PD/PI), Casalino Matsuda, M. S. (Other), Casalino Matsuda, M. S. (Other) & Casalino Matsuda, M. S. (Other)
10/1/22 → 9/30/25
Project: Research project
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IPA for Fei Chen with Jesse Brown VA Medical Center
Sporn, P. H. (PD/PI) & Sporn, P. H. (PD/PI)
10/1/22 → 9/30/25
Project: Research project
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Clinical Cases in the Diagnosis of Cardiac Sarcoidosis
Khoo, C. Y., Maning, J., Weinberg, R., Avery, R., Savas, H., Cremer, P., Sporn, P. H., Russell, S., Goodwin, R., Lehrer, S. & Okwuosa, I. S., Jul 2 2025, In: JACC: Case Reports. 30, 17, 103686.Research output: Contribution to journal › Article › peer-review
Open Access -
Hypercapnia Increases Influenza A Virus Infection of Bronchial Epithelial Cells by Augmenting Cellular Cholesterol via mTOR and Akt
Chen, F., Matsuda, A., Sporn, P. H. S. & Casalino-Matsuda, S. M., May 2025, In: International journal of molecular sciences. 26, 9, 4133.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
RETRACTED ARTICLE: Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ (Nature Immunology, (2013), 14, 5, (461-469), 10.1038/ni.2566)
Do-Umehara, H. C., Chen, C., Urich, D., Zhou, L., Qiu, J., Jang, S., Zander, A., Baker, M. A., Eilers, M., Sporn, P. H. S., Ridge, K. M., Sznajder, J. I., Budinger, G. R. S., Mutlu, G. M., Lin, A. & Liu, J., Feb 2025, In: Nature Immunology. 26, 2, p. 324 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Therapeutic doses of efzofitimod demonstrate efficacy in pulmonary sarcoidosis
Obi, O. N., Baughman, R. P., Crouser, E. D., Julian, M. W., Locke, L. W., Chandrasekaran, A., Ramesh, P., Kinnersley, N., Niranjan, V., Culver, D. A. & Sporn, P. H. S., Jan 2025, In: ERJ Open Research. 11, 1, 00536-2024.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia
The NU SCRIPT Study Investigators, 2024, (Accepted/In press) In: Nature Immunology. 25, 9, p. 1607-1622 16 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations
Datasets
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Mouse_transcrpts from Hypercapnia selectively modulates LPS-induced changes in innate immune and DNA replication-related gene transcription in the macrophage
Casalino-Matsuda, S. M. (Creator), Berdnikovs, S. (Creator), Wang, N. (Contributor), Nair, A. (Creator), Gates, K. L. (Contributor), Beitel, G. J. (Creator) & Sporn, P. H. S. (Creator), The Royal Society, 2021
DOI: 10.6084/m9.figshare.13698020, https://rs.figshare.com/articles/dataset/Mouse_transcrpts_from_Hypercapnia_selectively_modulates_LPS-induced_changes_in_innate_immune_and_DNA_replication-related_gene_transcription_in_the_macrophage/13698020
Dataset
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Human_Transcripts from Hypercapnia selectively modulates LPS-induced changes in innate immune and DNA replication-related gene transcription in the macrophage
Casalino-Matsuda, S. M. (Creator), Berdnikovs, S. (Creator), Wang, N. (Contributor), Nair, A. (Creator), Gates, K. L. (Contributor), Beitel, G. J. (Creator) & Sporn, P. H. S. (Creator), The Royal Society, 2021
DOI: 10.6084/m9.figshare.13698029, https://rs.figshare.com/articles/dataset/Human_Transcripts_from_Hypercapnia_selectively_modulates_LPS-induced_changes_in_innate_immune_and_DNA_replication-related_gene_transcription_in_the_macrophage/13698029
Dataset
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Supplementary material from "Hypercapnia selectively modulates LPS-induced changes in innate immune and DNA replication-related gene transcription in the macrophage"
Casalino-Matsuda, S. M. (Creator), Berdnikovs, S. (Creator), Wang, N. (Contributor), Nair, A. (Creator), Gates, K. L. (Contributor), Beitel, G. J. (Creator), Sporn, P. H. S. (Creator) & Casalino-Matsuda, S. M. (Creator), The Royal Society, 2021
DOI: 10.6084/m9.figshare.c.5290088, https://rs.figshare.com/collections/Supplementary_material_from_Hypercapnia_selectively_modulates_LPS-induced_changes_in_innate_immune_and_DNA_replication-related_gene_transcription_in_the_macrophage_/5290088
Dataset