Grants per year
Personal profile
Research Interests
Clinical Interests: asthma, chronic obstructive pulmonary disease (COPD), interstitial lung disease, SARCOIDOSIS. Research Interests: airway inflammation and remodeling in asthma and COPD; effects of hypercapnia (elevated levels of CO2) on innate immunity and host defense in the lung.
Certifications and Licenses
| Critical Care Medicine | |
| Internal Medicine | |
| Pulmonary Disease |
Training Experience
| 1983 | Residency, Bronx Municipal Hospital Center |
| 1984 | Fellowship, Bronx Municipal Hospital Center |
| 1987 | Fellowship, University of Michigan Health System |
Education/Academic qualification
MD, Medicine, Wayne State University School of Medicine
… → 1980
Research interests keywords
- Asthma
- Chronic Obstructive Pulmonary Disease (COPD)
- Idiopathic Interstitial Lung Disease
- Lungs / Breathing Problems
- Respiratory Diseases
Fingerprint
Dive into the research topics where Peter H Sporn is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Prot #XTMAB-16-202: A Long-Term Multicenter Open-Label Study to Evaluate the Long-Term Safety and Durability of Effect of XTMAB-16 in Patients With Pulmonary Sarcoidosis With or Without Extra-Pulmonary Involvement
Sporn, P. H. (PD/PI)
Pharmaceutical Research Associates, Inc., Xentria, Inc.
2/7/24 → 2/7/27
Project: Research project
-
Prot #XTMAB‐16‐201: A Seamless, Phase 1b/2 Multiple Ascending Dose/Proof of Concept Study of XTMAB‐16 in Patients with Pulmonary Sarcoidosis with or without Extrapulmonary Manifestations
Sporn, P. H. (PD/PI)
Pharmaceutical Research Associates, Inc., Xentria, Inc.
9/13/23 → 9/13/26
Project: Research project
-
IPA for Fei Chen with Jesse Brown VA Medical Center
Sporn, P. H. (PD/PI) & Sporn, P. H. (PD/PI)
10/1/22 → 9/30/25
Project: Research project
-
Prot #CCMK389X2201: A Subject and Investigator Blinded, Randomized, Placebo-controlled, Repeat-dose, Multicenter Study to Investigate Efficacy, Safety, and Tolerability of CMK389 in Patients with Chronic Pulmonary Sarcoidosis
Sporn, P. H. (PD/PI)
Novartis Pharmaceuticals Corporation
10/14/21 → 12/3/24
Project: Research project
-
Distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia
The NU SCRIPT Study Investigators, 2024, (Accepted/In press) In: Nature Immunology. 25, 9, p. 1607-1622 16 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Myeloid Zfhx3 deficiency protects against hypercapnia-induced suppression of host defense against influenza A virus
Casalino-Matsuda, S. M., Chen, F., Gonzalez-Gonzalez, F. J., Matsuda, H., Nair, A., Abdala-Valencia, H., Budinger, G. R. S., Dong, J. T., Beitel, G. J. & Sporn, P. H. S., 2024, In: JCI Insight. 9, 4, e170316.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
A Novel MIP-1-Expressing Macrophage Subtype in BAL Fluid from Healthy Volunteers
Reyfman, P. A., Malsin, E. S., Khuder, B., Joshi, N., Gadhvi, G., Flozak, A. S., Carns, M. A., Aren, K., Goldberg, I. A., Kim, S., Alexander, M. J., Sporn, P. H. S., Misharin, A. V., Budinger, G. R. S., Lam, A. P., Hinchcliff, M. E., Gottardi, C. J. & Winter, D. R., Feb 1 2023, In: American journal of respiratory cell and molecular biology. 68, 2, p. 176-185 10 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Efzofitimod for the Treatment of Pulmonary Sarcoidosis
Culver, D. A., Aryal, S., Barney, J., Hsia, C. C. W., James, W. E., Maier, L. A., Marts, L. T., Obi, O. N., Sporn, P. H. S., Sweiss, N. J., Shukla, S., Kinnersley, N., Walker, G. & Baughman, R., Apr 2023, In: CHEST. 163, 4, p. 881-890 10 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
Hypercapnia increases ACE2 expression and pseudo-SARS-CoV-2 entry in bronchial epithelial cells by augmenting cellular cholesterol
Chen, F., Matsuda, A., Budinger, G. R. S., Sporn, P. H. S. & Casalino-Matsuda, S. M., 2023, In: Frontiers in immunology. 14, 1251120.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations
Datasets
-
Supplementary material from "Hypercapnia selectively modulates LPS-induced changes in innate immune and DNA replication-related gene transcription in the macrophage"
Casalino-Matsuda, S. M. (Creator), Berdnikovs, S. (Creator), Wang, N. (Contributor), Nair, A. (Creator), Gates, K. L. (Contributor), Beitel, G. J. (Creator), Sporn, P. H. S. (Creator) & Casalino-Matsuda, S. M. (Creator), The Royal Society, 2021
DOI: 10.6084/m9.figshare.c.5290088, https://rs.figshare.com/collections/Supplementary_material_from_Hypercapnia_selectively_modulates_LPS-induced_changes_in_innate_immune_and_DNA_replication-related_gene_transcription_in_the_macrophage_/5290088
Dataset
-
Mouse_transcrpts from Hypercapnia selectively modulates LPS-induced changes in innate immune and DNA replication-related gene transcription in the macrophage
Casalino-Matsuda, S. M. (Creator), Berdnikovs, S. (Creator), Wang, N. (Contributor), Nair, A. (Creator), Gates, K. L. (Contributor), Beitel, G. J. (Creator) & Sporn, P. H. S. (Creator), The Royal Society, 2021
DOI: 10.6084/m9.figshare.13698020, https://rs.figshare.com/articles/dataset/Mouse_transcrpts_from_Hypercapnia_selectively_modulates_LPS-induced_changes_in_innate_immune_and_DNA_replication-related_gene_transcription_in_the_macrophage/13698020
Dataset
-
Human_Transcripts from Hypercapnia selectively modulates LPS-induced changes in innate immune and DNA replication-related gene transcription in the macrophage
Casalino-Matsuda, S. M. (Creator), Berdnikovs, S. (Creator), Wang, N. (Contributor), Nair, A. (Creator), Gates, K. L. (Contributor), Beitel, G. J. (Creator) & Sporn, P. H. S. (Creator), The Royal Society, 2021
DOI: 10.6084/m9.figshare.13698029, https://rs.figshare.com/articles/dataset/Human_Transcripts_from_Hypercapnia_selectively_modulates_LPS-induced_changes_in_innate_immune_and_DNA_replication-related_gene_transcription_in_the_macrophage/13698029
Dataset