• 1494 Citations
1977 …2022
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Research Output 1977 2019

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Article
2018
1 Citation (Scopus)

A role for heat shock factor 1 in hypercapnia-induced inhibition of inflammatory cytokine expression

Lu, Z., Casalino Matsuda, M. S., Nair, A., Buchbinder, A., Budinger, GR. S., Sporn, P. H. & Gates, K. L., Jul 1 2018, In : FASEB Journal. 32, 7, p. 3614-3622 9 p.

Research output: Contribution to journalArticle

Hypercapnia
Shock
Hot Temperature
Cytokines
Interleukin-6
T-cells
MicroRNAs
RNA
Data storage equipment
Epithelial Cells
1 Citation (Scopus)
Hypercapnia
Nucleosomes
Lipid Metabolism
Epithelial Cells
Carbon Monoxide
2016
3 Citations (Scopus)

Dimensions and Role-Specific Mediators of Surrogate Trust in the ICU

Hutchison, P. J., McLaughlin, K., Corbridge, T., Michelson, K. N., Emanuel, L., Sporn, P. H. S. & Crowley-Matoka, M., Dec 1 2016, In : Critical care medicine. 44, 12, p. 2208-2214 7 p.

Research output: Contribution to journalArticle

Interviews
Mental Competency
Communication
Beneficence
Physicians
2 Citations (Scopus)

Focused Screening Identifies Evoxine as a Small Molecule That Counteracts CO2-Induced Immune Suppression

Helenius, I. T., Nair, A., Bittar, H. E. T., Sznajder, J. I., Sporn, P. H. S. & Beitel, G. J., Apr 1 2016, In : Journal of Biomolecular Screening. 21, 4, p. 363-371 9 p.

Research output: Contribution to journalArticle

Pulmonary diseases
AMP-Activated Protein Kinases
Hypercapnia
Chemokine CCL2
Macrophages
14 Citations (Scopus)

Hypercapnia suppresses the HIF-dependent adaptive response to hypoxia

Selfridge, A. C., Cavadas, M. A. S., Scholz, C. C., Campbell, E. L., Welch, L. C., Lecuona, E., Colgan, S. P., Barrett, K. E., Sporn, P. H. S., Sznajder, J. I., Cummins, E. P. & Taylor, C. T., May 27 2016, In : Journal of Biological Chemistry. 291, 22, p. 11800-11808 9 p.

Research output: Contribution to journalArticle

Hypercapnia
Carbon Dioxide
Degradation
Vacuolar Proton-Translocating ATPases
Pulmonary diseases
5 Citations (Scopus)

Identification of drosophila Zfh2 as a mediator of hypercapnic immune regulation by a genome-wide RNA interference screen

Helenius, I. T., Haake, R. J., Kwon, Y. J., Hu, J. A., Krupinski, T., Marina Casalino-Matsuda, S., Sporn, P. H. S., Sznajder, J. I. & Beitel, G. J., Jan 15 2016, In : Journal of Immunology. 196, 2, p. 655-667 13 p.

Research output: Contribution to journalArticle

Hypercapnia
RNA Interference
Drosophila
Genome
Carbon Monoxide
6 Citations (Scopus)

Pleural hypercarbia after lung surgery is associated with persistent alveolopleural fistulae

Bharat, A., Graf, N., Mullen, A., Kanter, J., Andrei, A. C., Sporn, P. H. S., DeCamp, M. M. & Sznajder, J. I., Jan 2016, In : CHEST. 149, 1, p. 220-227 8 p.

Research output: Contribution to journalArticle

Hypercapnia
Fistula
Air
Lung
Oxygen
2015
4 Citations (Scopus)

Decreased CXCL12 is associated with impaired alveolar epithelial cell migration and poor lung healing after lung resection

Kanter, J. A., Sun, H., Chiu, S., DeCamp Jr, M. M., Sporn, P. H., Sznajder, J. I. & Bharat, A., Jan 1 2015, In : Surgery (United States). 158, 4, p. 1073-1082 10 p.

Research output: Contribution to journalArticle

Alveolar Epithelial Cells
Cell Movement
Actin Depolymerizing Factors
Lung
Air
25 Citations (Scopus)
Hypercapnia
Autophagy
Macrophages
Lung Diseases
Bacteria
2 Citations (Scopus)

Pleural gas analysis for detection of alveolopleural fistulae

Bharat, A., Graf, N., Cassidy, E., Smith, S., Gillespie, C. T., Meyerson, S. L., Sporn, P. H., Sznajder, J. I. & DeCamp Jr, M. M., Jun 1 2015, In : Annals of Thoracic Surgery. 99, 6, p. 2179-2182 4 p.

Research output: Contribution to journalArticle

Fistula
Gases
Oxygen
Chest Tubes
Pneumothorax
2013
42 Citations (Scopus)

Hypercapnia impairs lung neutrophil function and increases mortality in murine Pseudomonas pneumonia

Gates, K. L., Howell, H. A., Nair, A., Vohwinkel, C. U., Welch, L. C., Beitel, G. J., Hauser, A. R., Sznajder, J. I. & Sporn, P. H. S., Nov 1 2013, In : American journal of respiratory cell and molecular biology. 49, 5, p. 821-828 8 p.

Research output: Contribution to journalArticle

Hypercapnia
Pseudomonas
Pneumonia
Pulmonary diseases
Neutrophils
46 Citations (Scopus)

Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ

Do-Umehara, H. C., Chen, C., Urich, D., Zhou, L., Qiu, J., Jang, S., Zander, A., Baker, M. A., Eilers, M., Sporn, P. H. S., Ridge, K. M., Sznajder, J. I., Budinger, G. R. S., Mutlu, G. M., Lin, A. & Liu, J., May 1 2013, In : Nature Immunology. 14, 5, p. 461-469 9 p.

Research output: Contribution to journalArticle

Acute Lung Injury
Inflammation
Lipopolysaccharides
Histone Deacetylase 1
Mortality
2010
65 Citations (Scopus)
Hypercapnia
Macrophages
Phagocytosis
Interleukin-6
Tumor Necrosis Factor-alpha
70 Citations (Scopus)

Myosin light chain kinase mediates transcellular intravasation of breast cancer cells through the underlying endothelial cells: A three-dimensional FRET study

Khuon, S., Liang, L., Dettman, R., Sporn, P. H., Wysolmerski, R. B. & Chew, T. L., Feb 1 2010, In : Journal of cell science. 123, 3, p. 431-440 10 p.

Research output: Contribution to journalArticle

Myosin-Light-Chain Kinase
Fluorescence Resonance Energy Transfer
Endothelial Cells
Breast Neoplasms
Myosin Type II
2009
48 Citations (Scopus)

Elevated CO2 suppresses specific Drosophila innate immune responses and resistance to bacterial infection

Helenius, I. T., Krupinski, T., Turnbull, D. W., Gruenbaum, Y., Silverman, N., Johnson, E. A., Sporn, P. H. S., Sznajder, J. I. & Beitel, G. J., Nov 3 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 44, p. 18710-18715 6 p.

Research output: Contribution to journalArticle

Hypercapnia
Bacterial Infections
Innate Immunity
Drosophila
Acidosis
68 Citations (Scopus)

Essential roles for early growth response transcription factor Egr-1 in tissue fibrosis and wound healing

Wu, M., Melichian, D. S., De La Garza, M., Gruner, K., Bhattacharyya, S., Barr, L., Nair, A., Shahrara, S., Sporn, P. H. S., Mustoe, T. A., Tourtellotte, W. G. & Varga, J., Jan 1 2009, In : American Journal of Pathology. 175, 3, p. 1041-1055 15 p.

Research output: Contribution to journalArticle

Early Growth Response Protein 1
Wound Healing
Fibrosis
Fibroblasts
Transforming Growth Factors
2008
41 Citations (Scopus)

A mechanism of benefit of soy genistein in asthma: Inhibition of eosinophil p38-dependent leukotriene synthesis

Kalhan, R., Smith, L. J., Nlend, M. C., Nair, A., Hixon, J. L. & Sporn, P. H., Jan 1 2008, In : Clinical and Experimental Allergy. 38, 1, p. 103-112 10 p.

Research output: Contribution to journalArticle

Leukotriene C4
Isoflavones
Genistein
Leukotrienes
Eosinophils
2007
2 Citations (Scopus)

Orbital emphysema in COPD with bronchopleural fistula

Upadhyay, D. & Sporn, P. H., Aug 9 2007, In : International Journal of COPD. 2, 2, p. 187-188 2 p.

Research output: Contribution to journalArticle

Orbital Fractures
Air Pressure
Emphysema
Optic Nerve
Intraocular Pressure
2006
66 Citations (Scopus)
Fibroblasts
Extracellular Matrix
Collagen Type III
Tissue
Airway Remodeling
2004
33 Citations (Scopus)

Leukotriene D4 Activates Alveolar Epithelial Na,K-ATPase and Increases Alveolar Fluid Clearance

Sloniewsky, D. E., Ridge, K. M., Adir, Y., Fries, F. P., Briva, A., Sznajder, J. I. & Sporn, P. H. S., Feb 1 2004, In : American Journal of Respiratory and Critical Care Medicine. 169, 3, p. 407-412 6 p.

Research output: Contribution to journalArticle

Leukotriene D4
Alveolar Epithelial Cells
Lung
Acute Lung Injury
Adult Respiratory Distress Syndrome
2003
65 Citations (Scopus)

An in vitro airway wall model of remodeling

Choe, M. M., Sporn, P. H. & Swartz, M. A., Aug 1 2003, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 285, 2 29-2

Research output: Contribution to journalArticle

Airway Remodeling
Asthma
Epithelial Cells
Cilia
Tight Junctions
2002
55 Citations (Scopus)

Cellular biomechanics in the lung

Waters, C. M., Sporn, P. H. S., Liu, M. & Fredberg, J. J., Sep 1 2002, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 283, 3 27-3, p. L503-L509

Research output: Contribution to journalArticle

Biomechanical Phenomena
Lung
Smooth Muscle
Epithelial Cells
Cytoskeleton
2001
76 Citations (Scopus)

Prostaglandin E2 regulates wound closure in airway epithelium

Savla, U., Appel, H. J., Sporn, P. H. & Waters, C. M., Mar 1 2001, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 280, 3 24-3

Research output: Contribution to journalArticle

Dinoprostone
Epithelium
Wounds and Injuries
Prostaglandin-Endoperoxide Synthases
Indomethacin
1999
60 Citations (Scopus)

Decreased leukotriene C4 synthesis accompanies adherence-dependent nuclear import of 5-lipoxygenasee in human blood eosinophils

Brock, T. G., Anderson, J. A., Fries, F. P., Peters-Golden, M. & Sporn, P. H. S., Feb 1 1999, In : Journal of Immunology. 162, 3, p. 1669-1676 8 p.

Research output: Contribution to journalArticle

Arachidonate 5-Lipoxygenase
Leukotriene C4
Cell Nucleus Active Transport
Eosinophils
Leukotrienes
38 Citations (Scopus)

Keratinocyte growth factor stimulates bronchial epithelial cell proliferation in vitro and in vivo

Michelson, P. H., Tigue, M., Panos, R. J. & Sporn, P. H. S., Oct 1 1999, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 277, 4 21-4

Research output: Contribution to journalArticle

Fibroblast Growth Factor 7
Epithelial Cells
Cell Proliferation
Bromodeoxyuridine
In Vitro Techniques
1998
75 Citations (Scopus)

Keratinocyte growth factor promotes alveolar epithelial cell DNA repair after H2O2 exposure

Kristina, I. W., Pollack, N., Panos, R. J., Sporn, P. H. S. & Kamp, D. W., Nov 9 1998, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 275, 4 19-4

Research output: Contribution to journalArticle

Fibroblast Growth Factor 7
Alveolar Epithelial Cells
DNA Repair
Oxidants
DNA Breaks
13 Citations (Scopus)

Regulation of 5-lipoxygenase activity in mononuclear phagocytes: Characterization of an endogenous cytosolic inhibitor

Coffey, M. J., Wilcoxen, S. E., Sporn, P. H. & Peters-Golden, M., Jun 1 1998, In : Prostaglandins and Other Lipid Mediators. 56, 2-3, p. 103-117 15 p.

Research output: Contribution to journalArticle

Arachidonate 5-Lipoxygenase
Phagocytes
Cytosol
Leukotrienes
Macrophages
1997
4 Citations (Scopus)

Cyclic stretch of airway epithelium inhibits prostanoid synthesis

Savla, U., Sporn, P. H. & Waters, C. M., Dec 1 1997, In : American Journal of Physiology. 273, 5 PART 1

Research output: Contribution to journalArticle

Arachidonic Acid
Prostaglandins
Prostaglandin-Endoperoxide Synthases
Epithelium
Dinoprostone
38 Citations (Scopus)

Cyclic stretch of airway epithelium inhibits prostanoid synthesis

Savla, U., Sporn, P. H. S. & Waters, C. M., Dec 9 1997, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 273, 5 17-5

Research output: Contribution to journalArticle

Dinoprostone
Arachidonic Acid
Prostaglandins
Epithelium
Eicosanoids
1 Citation (Scopus)
Pulmonary Alveoli
Fibroblast Growth Factor 10
Growth Substances
Fibroblast Growth Factor 7
Alveolar Epithelial Cells
127 Citations (Scopus)

Reduced superoxide dismutase in lung cells of patients with asthma

Smith, L. J., Shamsuddin, M., Sporn, P. H., Denenberg, M. & Anderson, J., May 3 1997, In : Free Radical Biology and Medicine. 22, 7, p. 1301-1307 7 p.

Research output: Contribution to journalArticle

Superoxide Dismutase
Asthma
Antioxidants
Cells
Lung
1996
27 Citations (Scopus)

Increased 5-lipoxygenase metabolism in the lungs of human subjects exposed to ozone

Coffey, M. J., Wheeler, C. S., Gross, K. B., Eschenbacher, W. L., Sporn, P. H. S. & Peters-Golden, M., Dec 18 1996, In : Toxicology. 114, 3, p. 187-197 11 p.

Research output: Contribution to journalArticle

Arachidonate 5-Lipoxygenase
Ozone
Metabolism
Alveolar Macrophages
Lung
1992
28 Citations (Scopus)
Acylation
Alveolar Macrophages
Arachidonic Acid
Metabolism
Hydrogen Peroxide
69 Citations (Scopus)

Membrane association of active 5-lipoxygenase in resting cells: Evidence for novel regulation of the enzyme in the rat alveolar macrophage

Coffey, M., Peters-Golden, M., Fantone, J. C. & Sporn, P. H. S., Jan 1 1992, In : Journal of Biological Chemistry. 267, 1, p. 570-576 7 p.

Research output: Contribution to journalArticle

Arachidonate 5-Lipoxygenase
Alveolar Macrophages
Rats
Association reactions
Membranes
1991
28 Citations (Scopus)

Basal activation of protein kinase C in rat alveolar macrophages: Implications for arachidonate metabolism

Peters-Golden, M., McNish, R. W., Sporn, P. H. S. & Balazovich, K., Dec 1 1991, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 261, 6 5-3

Research output: Contribution to journalArticle

Alveolar Macrophages
Protein Kinase C
Peritoneal Macrophages
Arachidonic Acid
Macrophages
1990
11 Citations (Scopus)

Complex effects of in vitro hyperoxia on alveolar macrophage arachidonic acid metabolism.

Sporn, P. H., Murphy, T. M. & Peters-Golden, M., Jan 1 1990, In : American Journal of Respiratory Cell and Molecular Biology. 2, 1, p. 81-90 10 p.

Research output: Contribution to journalArticle

Hyperoxia
Alveolar Macrophages
Arachidonic Acid
Metabolism
Eicosanoids
16 Citations (Scopus)
Zymosan
Alveolar Macrophages
Arachidonic Acid
Metabolism
Protein Kinase C
8 Citations (Scopus)

Glucocorticoids fail to inhibit arachidonic acid metabolism stimulated by hydrogen peroxide in the alveolar macrophage

Sporn, P. H. S., Murphy, T. M. & Peters-Golden, M., Jan 1 1990, In : Journal of Leukocyte Biology. 48, 1, p. 81-88 8 p.

Research output: Contribution to journalArticle

Alveolar Macrophages
Arachidonic Acid
Hydrogen Peroxide
Glucocorticoids
Zymosan
1988
35 Citations (Scopus)

Hydrogen-peroxide-induced arachidonic acid metabolism in the rat alveolar macrophage

Sporn, P. H. S., Peters-Golden, M. & Simon, R. H., Jan 1 1988, In : American Review of Respiratory Disease. 137, 1, p. 49-56 8 p.

Research output: Contribution to journalArticle

Alveolar Macrophages
Dinoprostone
Arachidonic Acid
Hydrogen Peroxide
Prostaglandin-Endoperoxide Synthases
1986
2 Citations (Scopus)

Fever and pneumopericardium in a patient with systemic sclerosis

Sporn, P. H. S., Albertson, R. D., Orringer, M. B. & Morganroth, M., Jan 1 1986, In : CHEST. 90, 1, p. 117-118 2 p.

Research output: Contribution to journalArticle

Pneumopericardium
Systemic Scleroderma
Fever
1983
14 Citations (Scopus)

Nonoliguric Acute Renal Failure After Captopril Therapy

Fotino, S. & Sporn, P., Jan 1 1983, In : Archives of Internal Medicine. 143, 6, p. 1252-1253 2 p.

Research output: Contribution to journalArticle

Captopril
Acute Kidney Injury
Kidney
Interstitial Nephritis
Renovascular Hypertension
1977
38 Citations (Scopus)

Tn402: a new transposable element determining trimethoprim resistance that inserts in bacteriophage lambda

Shapiro, J. A. & Sporn, P., Jan 1 1977, In : Journal of bacteriology. 129, 3, p. 1632-1635 4 p.

Research output: Contribution to journalArticle

Trimethoprim Resistance
Bacteriophage lambda
DNA Transposable Elements
Bacteriophages
Plasmids