Grants per year
Personal profile
Research Interests
SYNAPTIC STRUCTURAL PLASTICITY: FROM MOLECULES TO COGNITIVE FUNCTIONS AND DISEASE Research in my lab centers on signal transduction networks that regulate the structural and functional plasticity of excitatory synapses. Synaptic communication between neurons within brain circuits underlies cognitive functions, and is disrupted in numerous neurodevelopmental and neuropsychiatric disorders. Most central excitatory synapses are located on dendritic spines, and spine structure is essential for normal and pathological brain function. Spine dynamics is crucial for the establishment, maintenance, and experience dependent modification of connectivity in neural circuits. Conversely, abnormal dendritic spine morphology occurs in patients with neurodegenerative, psychiatric, and neurodevelopmental disorders, including schizophrenia, autism, and Alzheimer’s disease. As spine morphology is closely associated with cognitive functions, understanding the mechanisms of regulation and dysregulation of spine plasticity is necessary to elucidate the neural bases of cognitive functions and disorders. The long-term goals of my research are: 1) to identify and characterize the molecular mechanisms that control synaptic structural plasticity. 2) to determine how they influence the development, functioning, and plasticity of brain circuits underlying cognition. 3) to uncover the molecular mechanisms underlying synaptic pathology and determine their impact on disease endophenotypes. To to achieve these objectives, we employ a multidisciplinary array of molecular, cellular, imaging, transgenic, electrophysiological, and behavioral approaches, and have assembled an outstanding team of collaborators.
Education/Academic qualification
PhD, SUNY - Buffalo
… → 1997
Research interests
- Alzheimer's Disease
- Autism Spectrum Disorders
- Brain and Nervous System
- Cytoskeleton
- Nervous System Diseases
- Neuroscience
- Schizophrenia
- Signal Transduction
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Grants 2003 2022
Developing Insulin-like growth factor binding protein 2 (IGFBP2) peptide fragment-based therapeutics to treat functional and behavioral deficits in Ph
AlisBio LLC, National Institute of Mental Health
11/18/19 → 8/31/20
Project: Research project
Optical Dissection of the Neural Circuitry Controlling Sensorimotor Gating
National Institute of Mental Health
3/15/19 → 2/28/21
Project: Research project
Synaptic and dendritic dysfunction in psychiatric disorders
Kiskinis, E., Penzes, P. & Savas, J. N.
National Institute of Mental Health
8/1/17 → 4/30/22
Project: Research project
Postsynaptic functions of neuronal adhesion molecules: focus on Cntnap2
Kiskinis, E., Penzes, P. & Savas, J. N.
National Institute of Neurological Disorders and Stroke
7/15/17 → 6/30/21
Project: Research project
Systematic Functional Interpretation of Regulatory Variants in Schizophrenia
NorthShore University HealthSystem Research Institute, National Institute of Mental Health
5/4/16 → 1/31/21
Project: Research project
Research Output 1996 2019
A novel role for the late-onset Alzheimer’s disease (LOAD)-associated protein Bin1 in regulating postsynaptic trafficking and glutamatergic signaling
Schürmann, B., Bermingham, D. P., Kopeikina, K. J., Myczek, K., Yoon, S., Horan, K. E., Kelly, C. J., Martin-de-Saavedra, M. D., Forrest, M. P., Fawcett-Patel, J. M., Smith, K. R., Gao, R., Bach, A., Burette, A. C., Rappoport, J. Z., Weinberg, R. J., Martina, M. & Penzes, P., Jan 1 2019, In : Molecular Psychiatry.Research output: Contribution to journal › Article
Exchange protein directly activated by cAMP 2 is required for corticotropin-releasing hormone-mediated spine loss
Xie, Z., Penzes, P. & Srivastava, D. P., Jan 1 2019, In : European Journal of Neuroscience.Research output: Contribution to journal › Article
Kalirin-7 prevents dendritic spine dysgenesis induced by amyloid beta-derived oligomers
Xie, Z., Shapiro, L. P., Cahill, M. E., Russell, T. A., Lacor, P. N., Klein, W. L. & Penzes, P., May 1 2019, In : European Journal of Neuroscience. 49, 9, p. 1091-1101 11 p.Research output: Contribution to journal › Article
Loss of EPAC2 alters dendritic spine morphology and inhibitory synapse density
Jones, K. A., Sumiya, M., Woolfrey, K. M., Srivastava, D. P. & Penzes, P., Jul 2019, In : Molecular and Cellular Neuroscience. 98, p. 19-31 13 p.Research output: Contribution to journal › Article
Partial Loss of USP9X Function Leads to a Male Neurodevelopmental and Behavioral Disorder Converging on Transforming Growth Factor β Signaling
Undiagnosed Diseases Network, Jan 1 2019, (Accepted/In press) In : Biological psychiatry.Research output: Contribution to journal › Article