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Personal profile

Research Interests

SYNAPTIC STRUCTURAL PLASTICITY: FROM MOLECULES TO COGNITIVE FUNCTIONS AND DISEASE Research in my lab centers on signal transduction networks that regulate the structural and functional plasticity of excitatory synapses. Synaptic communication between neurons within brain circuits underlies cognitive functions, and is disrupted in numerous neurodevelopmental and neuropsychiatric disorders. Most central excitatory synapses are located on dendritic spines, and spine structure is essential for normal and pathological brain function. Spine dynamics is crucial for the establishment, maintenance, and experience dependent modification of connectivity in neural circuits. Conversely, abnormal dendritic spine morphology occurs in patients with neurodegenerative, psychiatric, and neurodevelopmental disorders, including schizophrenia, autism, and Alzheimer’s disease. As spine morphology is closely associated with cognitive functions, understanding the mechanisms of regulation and dysregulation of spine plasticity is necessary to elucidate the neural bases of cognitive functions and disorders. The long-term goals of my research are: 1) to identify and characterize the molecular mechanisms that control synaptic structural plasticity. 2) to determine how they influence the development, functioning, and plasticity of brain circuits underlying cognition. 3) to uncover the molecular mechanisms underlying synaptic pathology and determine their impact on disease endophenotypes. To to achieve these objectives, we employ a multidisciplinary array of molecular, cellular, imaging, transgenic, electrophysiological, and behavioral approaches, and have assembled an outstanding team of collaborators.

Education/Academic qualification

PhD, SUNY - Buffalo

… → 1997

Research interests

  • Alzheimer's Disease
  • Autism Spectrum Disorders
  • Brain and Nervous System
  • Cytoskeleton
  • Nervous System Diseases
  • Neuroscience
  • Schizophrenia
  • Signal Transduction

Fingerprint Dive into the research topics where Peter Penzes is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 43 Similar Profiles
Dendritic Spines Medicine & Life Sciences
Spine Medicine & Life Sciences
Synapses Medicine & Life Sciences
Schizophrenia Medicine & Life Sciences
Neuronal Plasticity Medicine & Life Sciences
Neurons Medicine & Life Sciences
Proteins Medicine & Life Sciences
Morphogenesis Medicine & Life Sciences

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Grants 2003 2022

Sensory Gating
Startle Reflex
Acoustics
Dissection
Neurons
Psychiatry
Phenotype
Schizophrenia
Gene Dosage
Intellectual Disability
Paracrine Communication
Neuronal Plasticity
Epilepsy
Interneurons
Glutamate Receptors
Schizophrenia
Neurons
Confocal Microscopy
Synapses
Fluorescent Antibody Technique
Monomeric GTP-Binding Proteins
Protein Isoforms
Spine
Mental Disorders
Dynamin II

Research Output 1996 2019

1 Citation (Scopus)

A novel role for the late-onset Alzheimer’s disease (LOAD)-associated protein Bin1 in regulating postsynaptic trafficking and glutamatergic signaling

Schürmann, B., Bermingham, D. P., Kopeikina, K. J., Myczek, K., Yoon, S., Horan, K. E., Kelly, C. J., Martin-de-Saavedra, M. D., Forrest, M. P., Fawcett-Patel, J. M., Smith, K. R., Gao, R., Bach, A., Burette, A. C., Rappoport, J. Z., Weinberg, R. J., Martina, M. & Penzes, P., Jan 1 2019, In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Alzheimer Disease
AMPA Receptors
Synapses
Proteins
Spine
Open Access
Corticotropin-Releasing Hormone
Dendritic Spines
Corticotropin-Releasing Hormone Receptors
Spine
Proteins

Kalirin-7 prevents dendritic spine dysgenesis induced by amyloid beta-derived oligomers

Xie, Z., Shapiro, L. P., Cahill, M. E., Russell, T. A., Lacor, P. N., Klein, W. L. & Penzes, P., May 1 2019, In : European Journal of Neuroscience. 49, 9, p. 1091-1101 11 p.

Research output: Contribution to journalArticle

Dendritic Spines
Amyloid
Alzheimer Disease
Ligands
Synapses
1 Citation (Scopus)

Loss of EPAC2 alters dendritic spine morphology and inhibitory synapse density

Jones, K. A., Sumiya, M., Woolfrey, K. M., Srivastava, D. P. & Penzes, P., Jul 1 2019, In : Molecular and Cellular Neuroscience. 98, p. 19-31 13 p.

Research output: Contribution to journalArticle

Open Access
Dendritic Spines
Synapses
Neurons
Neuronal Plasticity
Spine

The CNTNAP2-CASK complex modulates GluA1 subcellular distribution in interneurons

Gao, R., Zaccard, C. R., Shapiro, L. P., Dionisio, L. E., Martin-de-Saavedra, M. D., Piguel, N. H., Pratt, C. P., Horan, K. E. & Penzes, P., May 14 2019, In : Neuroscience Letters. 701, p. 92-99 8 p.

Research output: Contribution to journalArticle

Contactins
Calcium-Calmodulin-Dependent Protein Kinases
Protein-Serine-Threonine Kinases
Interneurons
Proteins