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Personal profile

Research Interests

SYNAPTIC STRUCTURAL PLASTICITY: FROM MOLECULES TO COGNITIVE FUNCTIONS AND DISEASE Research in my lab centers on signal transduction networks that regulate the structural and functional plasticity of excitatory synapses. Synaptic communication between neurons within brain circuits underlies cognitive functions, and is disrupted in numerous neurodevelopmental and neuropsychiatric disorders. Most central excitatory synapses are located on dendritic spines, and spine structure is essential for normal and pathological brain function. Spine dynamics is crucial for the establishment, maintenance, and experience dependent modification of connectivity in neural circuits. Conversely, abnormal dendritic spine morphology occurs in patients with neurodegenerative, psychiatric, and neurodevelopmental disorders, including schizophrenia, autism, and Alzheimer’s disease. As spine morphology is closely associated with cognitive functions, understanding the mechanisms of regulation and dysregulation of spine plasticity is necessary to elucidate the neural bases of cognitive functions and disorders. The long-term goals of my research are: 1) to identify and characterize the molecular mechanisms that control synaptic structural plasticity. 2) to determine how they influence the development, functioning, and plasticity of brain circuits underlying cognition. 3) to uncover the molecular mechanisms underlying synaptic pathology and determine their impact on disease endophenotypes. To to achieve these objectives, we employ a multidisciplinary array of molecular, cellular, imaging, transgenic, electrophysiological, and behavioral approaches, and have assembled an outstanding team of collaborators.

Education/Academic qualification

PhD, SUNY - Buffalo

… → 1997

Research interests

  • Alzheimer's Disease
  • Autism Spectrum Disorders
  • Brain and Nervous System
  • Cytoskeleton
  • Nervous System Diseases
  • Neuroscience
  • Schizophrenia
  • Signal Transduction

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  • 33 Similar Profiles
Dendritic Spines Medicine & Life Sciences
Spine Medicine & Life Sciences
Synapses Medicine & Life Sciences
Schizophrenia Medicine & Life Sciences
Neurons Medicine & Life Sciences
Neuronal Plasticity Medicine & Life Sciences
Proteins Medicine & Life Sciences
Morphogenesis Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2003 2022

Insulin-Like Growth Factor Binding Protein 2
Peptide Fragments
Feasibility Studies
Pharmacology
Therapeutics
Sensory Gating
Startle Reflex
Acoustics
Dissection
Neurons
Psychiatry
Phenotype
Schizophrenia
Gene Dosage
Intellectual Disability
Paracrine Communication
Neuronal Plasticity
Epilepsy
Interneurons
Glutamate Receptors
Schizophrenia
Neurons
Confocal Microscopy
Synapses
Fluorescent Antibody Technique

Research Output 1996 2020

Common Regulatory Targets of NFIA, NFIX and NFIB during Postnatal Cerebellar Development

Fraser, J., Essebier, A., Brown, A. S., Davila, R. A., Harkins, D., Zalucki, O., Shapiro, L. P., Penzes, P., Wainwright, B. J., Scott, M. P., Gronostajski, R. M., Bodén, M., Piper, M. & Harvey, T. J., Feb 1 2020, In : Cerebellum. 19, 1, p. 89-101 13 p.

Research output: Contribution to journalArticle

NFI Transcription Factors
Transcription Factors
Neural Stem Cells
Cerebellum
Cell Differentiation
1 Citation (Scopus)

A novel role for the late-onset Alzheimer’s disease (LOAD)-associated protein Bin1 in regulating postsynaptic trafficking and glutamatergic signaling

Schürmann, B., Bermingham, D. P., Kopeikina, K. J., Myczek, K., Yoon, S., Horan, K. E., Kelly, C. J., Martin-de-Saavedra, M. D., Forrest, M. P., Fawcett-Patel, J. M., Smith, K. R., Gao, R., Bach, A., Burette, A. C., Rappoport, J. Z., Weinberg, R. J., Martina, M. & Penzes, P., Jan 1 2019, In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Alzheimer Disease
AMPA Receptors
Synapses
Proteins
Spine

CNTNAP2 is targeted to endosomes by the polarity protein PAR3

Gao, R., Pratt, C. P., Yoon, S., Martin-de-Saavedra, M. D., Forrest, M. P. & Penzes, P., Jan 1 2019, (Accepted/In press) In : European Journal of Neuroscience.

Research output: Contribution to journalArticle

Contactins
Endosomes
Proteins
PDZ Domains
Clathrin-Coated Vesicles

Exchange protein directly activated by cAMP 2 is required for corticotropin-releasing hormone-mediated spine loss

Xie, Z., Penzes, P. & Srivastava, D. P., Oct 1 2019, In : European Journal of Neuroscience. 50, 7, p. 3108-3114 7 p.

Research output: Contribution to journalArticle

Open Access
Corticotropin-Releasing Hormone
Dendritic Spines
Corticotropin-Releasing Hormone Receptors
Spine
Proteins

Kalirin-7 prevents dendritic spine dysgenesis induced by amyloid beta-derived oligomers

Xie, Z., Shapiro, L. P., Cahill, M. E., Russell, T. A., Lacor, P. N., Klein, W. L. & Penzes, P., May 1 2019, In : European Journal of Neuroscience. 49, 9, p. 1091-1101 11 p.

Research output: Contribution to journalArticle

Dendritic Spines
Amyloid
Alzheimer Disease
Ligands
Synapses