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Research Output

2020

CNTNAP2 is targeted to endosomes by the polarity protein PAR3

Gao, R., Pratt, C. P., Yoon, S., Martin-de-Saavedra, M. D., Forrest, M. P. & Penzes, P., Feb 1 2020, In : European Journal of Neuroscience. 51, 4, p. 1074-1086 13 p.

Research output: Contribution to journalArticle

Common Regulatory Targets of NFIA, NFIX and NFIB during Postnatal Cerebellar Development

Fraser, J., Essebier, A., Brown, A. S., Davila, R. A., Harkins, D., Zalucki, O., Shapiro, L. P., Penzes, P., Wainwright, B. J., Scott, M. P., Gronostajski, R. M., Bodén, M., Piper, M. & Harvey, T. J., Feb 1 2020, In : Cerebellum. 19, 1, p. 89-101 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Estradiol reverses excitatory synapse loss in a cellular model of neuropsychiatric disorders

Erli, F., Palmos, A. B., Raval, P., Mukherjee, J., Sellers, K. J., Gatford, N. J. F., Moss, S. J., Brandon, N. J., Penzes, P. & Srivastava, D. P., Dec 1 2020, In : Translational psychiatry. 10, 1, 16.

Research output: Contribution to journalArticle

Open Access
Open Access

Usp9X Controls Ankyrin-Repeat Domain Protein Homeostasis during Dendritic Spine Development

Yoon, S., Parnell, E., Kasherman, M., Forrest, M. P., Myczek, K., Premarathne, S., Sanchez Vega, M. C., Piper, M., Burne, T. H. J., Jolly, L. A., Wood, S. A. & Penzes, P., Feb 5 2020, In : Neuron. 105, 3, p. 506-521.e7

Research output: Contribution to journalArticle

3 Scopus citations
2019

A novel role for the late-onset Alzheimer’s disease (LOAD)-associated protein Bin1 in regulating postsynaptic trafficking and glutamatergic signaling

Schürmann, B., Bermingham, D. P., Kopeikina, K. J., Myczek, K., Yoon, S., Horan, K. E., Kelly, C. J., Martin-de-Saavedra, M. D., Forrest, M. P., Fawcett-Patel, J. M., Smith, K. R., Gao, R., Bach, A., Burette, A. C., Rappoport, J. Z., Weinberg, R. J., Martina, M. & Penzes, P., Jan 1 2019, In : Molecular Psychiatry.

Research output: Contribution to journalArticle

3 Scopus citations

Exchange protein directly activated by cAMP 2 is required for corticotropin-releasing hormone-mediated spine loss

Xie, Z., Penzes, P. & Srivastava, D. P., Oct 1 2019, In : European Journal of Neuroscience. 50, 7, p. 3108-3114 7 p.

Research output: Contribution to journalArticle

Open Access

Kalirin-7 prevents dendritic spine dysgenesis induced by amyloid beta-derived oligomers

Xie, Z., Shapiro, L. P., Cahill, M. E., Russell, T. A., Lacor, P. N., Klein, W. L. & Penzes, P., May 2019, In : European Journal of Neuroscience. 49, 9, p. 1091-1101 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Loss of EPAC2 alters dendritic spine morphology and inhibitory synapse density

Jones, K. A., Sumiya, M., Woolfrey, K. M., Srivastava, D. P. & Penzes, P., Jul 2019, In : Molecular and Cellular Neuroscience. 98, p. 19-31 13 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Partial Loss of USP9X Function Leads to a Male Neurodevelopmental and Behavioral Disorder Converging on Transforming Growth Factor β Signaling

Undiagnosed Diseases Network, Jan 1 2019, (Accepted/In press) In : Biological psychiatry.

Research output: Contribution to journalArticle

6 Scopus citations

The CNTNAP2-CASK complex modulates GluA1 subcellular distribution in interneurons

Gao, R., Zaccard, C. R., Shapiro, L. P., Dionisio, L. E., Martin-de-Saavedra, M. D., Piguel, N. H., Pratt, C. P., Horan, K. E. & Penzes, P., May 14 2019, In : Neuroscience Letters. 701, p. 92-99 8 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

Ankyrins: Roles in synaptic biology and pathology

Smith, K. R. & Penzes, P., Sep 2018, In : Molecular and Cellular Neuroscience. 91, p. 131-139 9 p.

Research output: Contribution to journalReview article

5 Scopus citations

A Schizophrenia-Linked KALRN Coding Variant Alters Neuron Morphology, Protein Function, and Transcript Stability

Russell, T. A., Grubisha, M. J., Remmers, C. L., Kang, S. K., Forrest, M. P., Smith, K. R., Kopeikina, K. J., Gao, R., Sweet, R. A. & Penzes, P., Mar 15 2018, In : Biological psychiatry. 83, 6, p. 499-508 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Characterization of CNTNAP2 nanostructures on interneuronal dendrites

Gao, R., Piguel, N. H., Melendez-Zaidi, A. E., Martin-de-Saavedra, M. D., Yoon, S., Forrest, M. P., Myczek, K., Zhang, G., Russell, T. A., Csernansky, J. G., Surmeier, D. J. & Penzes, P., Sep 1 2018, In : Molecular Psychiatry. 23, 9, 1 p.

Research output: Contribution to journalArticle

CNTNAP2 stabilizes interneuron dendritic arbors through CASK

Gao, R., Piguel, N. H., Melendez-Zaidi, A. E., Martin-de-Saavedra, M. D., Yoon, S., Forrest, M. P., Myczek, K., Zhang, G., Russell, T. A., Csernansky, J. G., Surmeier, D. J. & Penzes, P., Sep 1 2018, In : Molecular Psychiatry. 23, 9, p. 1832-1850 19 p.

Research output: Contribution to journalArticle

9 Scopus citations

Dendritic structural plasticity and neuropsychiatric disease

Forrest, M. P., Parnell, E. & Penzes, P., Apr 1 2018, In : Nature Reviews Neuroscience. 19, 4, p. 215-234 20 p.

Research output: Contribution to journalReview article

68 Scopus citations

Disruption of the psychiatric risk gene Ankyrin 3 enhances microtubule dynamics through GSK3/CRMP2 signaling

Garza, J. C., Qi, X., Gjeluci, K., Leussis, M. P., Basu, H., Reis, S. A., Zhao, W. N., Piguel, N. H., Penzes, P., Haggarty, S. J., Martens, G. J., Poelmans, G. & Petryshen, T. L., Dec 1 2018, In : Translational psychiatry. 8, 1, 135.

Research output: Contribution to journalArticle

7 Scopus citations

Neurodevelopmental disorder-associated ZBTB20 gene variants affect dendritic and synaptic structure

Jones, K. A., Luo, Y., Dukes-Rimsky, L., Srivastava, D. P., Koul-Tewari, R., Russell, T. A., Shapiro, L. P., Srivastava, A. K. & Penzes, P., Oct 2018, In : PloS one. 13, 10, e0203760.

Research output: Contribution to journalArticle

2 Scopus citations

Synaptic proteome compensation and resilience to psychosis in Alzheimer's disease

Krivinko, J. M., Erickson, S. L., Ding, Y., Sun, Z., Penzes, P., MacDonald, M. L., Yates, N. A., Ikonomovic, M. D., Lopez, O. L., Sweet, R. A. & Kofler, J., Oct 2018, In : American Journal of Psychiatry. 175, 10, p. 999-1009 11 p.

Research output: Contribution to journalArticle

4 Scopus citations
2017

Cadherin-10 maintains excitatory/inhibitory ratio through interactions with synaptic proteins

Smith, K. R., Jones, K. A., Kopeikina, K. J., Burette, A. C., Copits, B. A., Yoon, S., Forrest, M. P., Fawcett-Patel, J. M., Hanley, J. G., Weinberg, R. J., Swanson, G. T. & Penzes, P., Nov 15 2017, In : Journal of Neuroscience. 37, 46, p. 11127-11139 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

Kalirin reduction rescues psychosis-associated behavioral deficits in APPswe/PSEN1dE9 transgenic mice

Krivinko, J. M., Erickson, S. L., Abrahamson, E. E., Wills, Z. P., Ikonomovic, M. D., Penzes, P. & Sweet, R. A., Jun 1 2017, In : Neurobiology of Aging. 54, p. 59-70 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci

Forrest, M. P., Zhang, H., Moy, W., McGowan, H., Leites, C., Dionisio, L. E., Xu, Z., Shi, J., Sanders, A. R., Greenleaf, W. J., Cowan, C. A., Pang, Z. P., Gejman, P. V., Penzes, P. & Duan, J., Sep 7 2017, In : Cell stem cell. 21, 3, p. 305-318.e8

Research output: Contribution to journalArticle

34 Scopus citations

Selective loss of smaller spines in Schizophrenia

MacDonald, M. L., Alhassan, J., Newman, J. T., Richard, M., Gu, H., Kelly, R. M., Sampson, A. R., Fish, K. N., Penzes, P., Wills, Z. P., Lewis, D. A. & Sweet, R. A., Jun 1 2017, In : American Journal of Psychiatry. 174, 6, p. 586-594 9 p.

Research output: Contribution to journalArticle

32 Scopus citations
2016

Age-dependent increase in Kalirin-9 and Kalirin-12 transcripts in human orbitofrontal cortex

Grubisha, M. J., Lin, C. W., Tseng, G. C., Penzes, P., Sibille, E. & Sweet, R. A., Oct 1 2016, In : European Journal of Neuroscience. 44, 7, p. 2483-2492 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Developmental Trajectories of Auditory Cortex Synaptic Structures and Gap-Prepulse Inhibition of Acoustic Startle Between Early Adolescence and Young Adulthood in Mice

Moyer, C. E., Erickson, S. L., Fish, K. N., Thiels, E., Penzes, P. & Sweet, R. A., May 1 2016, In : Cerebral Cortex. 26, 5, p. 2115-2126 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Epac signaling is required for cocaine-induced change in ampa receptor subunit composition in the ventral tegmental area

Liu, X., Chen, Y., Tong, J., Reynolds, A. M., Proudfoot, S. C., Qi, J., Penzes, P., Lu, Y. & Liu, Q. S., Apr 27 2016, In : Journal of Neuroscience. 36, 17, p. 4802-4815 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

Reversal of dendritic phenotypes in 16p11.2 microduplication mouse model neurons by pharmacological targeting of a network hub

Blizinsky, K. D., Diaz-Castro, B., Forrest, M. P., Schürmann, B., Bach, A. P., Martin-De-saavedra, M. D., Wang, L., Csernansky, J. G., Duan, J. & Penzes, P., Jul 26 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 30, p. 8520-8525 6 p.

Research output: Contribution to journalArticle

23 Scopus citations

Synaptic Abnormalities and Neuroplasticity: Molecular Mechanisms of Cognitive Dysfunction in Genetic Mouse Models of Schizophrenia

Gao, R., Russell, T. A. & Penzes, P., Jan 1 2016, Handbook of Behavioral Neuroscience. Elsevier B.V., p. 375-390 16 p. (Handbook of Behavioral Neuroscience; vol. 23).

Research output: Chapter in Book/Report/Conference proceedingChapter

2015

Altered glutamate protein co-expression network topology linked to spine loss in the auditory cortex of schizophrenia

MacDonald, M. L., Ding, Y., Newman, J., Hemby, S., Penzes, P., Lewis, D. A., Yates, N. A. & Sweet, R. A., Jun 1 2015, In : Biological psychiatry. 77, 11, p. 959-968 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders

Gao, R. & Penzes, P., Jan 1 2015, In : Current Molecular Medicine. 15, 2, p. 146-167 22 p.

Research output: Contribution to journalArticle

123 Scopus citations

Loss of Microtubule-Associated Protein 2 Immunoreactivity Linked to Dendritic Spine Loss in Schizophrenia

Shelton, M. A., Newman, J. T., Gu, H., Sampson, A. R., Fish, K. N., MacDonald, M. L., Moyer, C. E., Dibitetto, J. V., Dorph-Petersen, K. A., Penzes, P., Lewis, D. A. & Sweet, R. A., Sep 15 2015, In : Biological psychiatry. 78, 6, p. 374-385 12 p., 12440.

Research output: Contribution to journalArticle

46 Scopus citations

Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2/Caspr2 knockout neurons

Varea, O., Martin-de-Saavedra, M. D., Kopeikina, K. J., Schürmann, B., Fleming, H. J., Fawcett-Patel, J. M., Bach, A., Jang, S., Peles, E., Kim, E. & Penzes, P., May 12 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 19, p. 6176-6181 6 p.

Research output: Contribution to journalArticle

52 Scopus citations
2014

Abnormal kalirin signaling in neuropsychiatric disorders

Remmers, C., Sweet, R. A. & Penzes, P., Apr 2014, In : Brain Research Bulletin. 103, p. 29-38 10 p.

Research output: Contribution to journalReview article

19 Scopus citations

A sequence variant in human KALRN impairs protein function and coincides with reduced cortical thickness

Russell, T. A., Blizinsky, K. D., Cobia, D. J., Cahill, M. E., Xie, Z., Sweet, R. A., Duan, J., Gejman, P. V., Wang, L., Csernansky, J. G. & Penzes, P., 2014, In : Nature communications. 5, 4858.

Research output: Contribution to journalArticle

18 Scopus citations

Coordinated nuclear and synaptic shuttling of afadin promotes spine plasticity and histone modifications

Van Leeuwen, J. E., Rafalovich, I., Sellers, K., Jones, K. A., Griffith, T. N., Huda, R., Miller, R. J., Srivastava, D. P. & Penzes, P., Apr 11 2014, In : Journal of Biological Chemistry. 289, 15, p. 10831-10842 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Psychiatric Risk Factor ANK3/Ankyrin-G Nanodomains Regulate the Structure and Function of Glutamatergic Synapses

Smith, K. R., Kopeikina, K. J., Fawcett-Patel, J. M., Leaderbrand, K., Gao, R., Schürmann, B., Myczek, K., Radulovic, J., Swanson, G. T. & Penzes, P., Oct 22 2014, In : Neuron. 84, 2, p. 399-415 17 p.

Research output: Contribution to journalArticle

72 Scopus citations

Scaffold protein X11α interacts with kalirin-7 in dendrites and recruits it to Golgi outposts

Jones, K. A., Eng, A. G., Raval, P., Srivastava, D. P. & Penzes, P., Dec 19 2014, In : Journal of Biological Chemistry. 289, 51, p. 35517-35529 13 p., A38.

Research output: Contribution to journalArticle

6 Scopus citations
2013

Developmental vulnerability of synapses and circuits associated with neuropsychiatric disorders

Penzes, P., Buonanno, A., Passafaro, M., Sala, C. & Sweet, R. A., Jul 1 2013, In : Journal of Neurochemistry. 126, 2, p. 165-182 18 p.

Research output: Contribution to journalReview article

69 Scopus citations

Insights into rapid modulation of neuroplasticity by brain estrogens

Srivastava, D. P., Woolfrey, K. M. & Penzes, P., Oct 1 2013, In : Pharmacological Reviews. 65, 4, p. 1318-1350 33 p.

Research output: Contribution to journalReview article

70 Scopus citations

Kalirin-7 mediates cocaine-induced AMPA receptor and spine plasticity, enabling incentive sensitization

Wang, X., Cahill, M. E., Werner, C. T., Christoffel, D. J., Golden, S. A., Xie, Z., Loweth, J. A., Marinelli, M., Russo, S. J., Penzes, P. & Wolf, M. E., Jul 25 2013, In : Journal of Neuroscience. 33, 27, p. 11012-11022 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

Matrix rigidity activates wnt signaling through down-regulation of dickkopf-1 protein

Barbolina, M. V., Liu, Y., Gurler, H., Kim, M., Kajdacsy-Balla, A. A., Rooper, L., Shepard, J., Weiss, M., Shea, L. D., Penzes, P., Ravosa, M. J. & Stack, M. S., Jan 4 2013, In : Journal of Biological Chemistry. 288, 1, p. 141-151 11 p.

Research output: Contribution to journalArticle

31 Scopus citations

Neuregulin1 signaling promotes dendritic spine growth through kalirin

Cahill, M. E., Remmers, C., Jones, K. A., Xie, Z., Sweet, R. A. & Penzes, P., Sep 1 2013, In : Journal of neurochemistry. 126, 5, p. 625-635 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

PAK1 Protein Expression in the Auditory Cortex of Schizophrenia Subjects

Deo, A. J., Goldszer, I. M., Li, S., DiBitetto, J. V., Henteleff, R., Sampson, A., Lewis, D. A., Penzes, P. & Sweet, R. A., Apr 22 2013, In : PloS one. 8, 4, e59458.

Research output: Contribution to journalArticle

9 Scopus citations

Structural Alterations of Synapses in Psychiatric and Neurodegenerative Disorders

Penzes, P., Remmers, C., Cahill, M. E., Jones, K. A., VanLeeuwen, J. E. & Woolfrey, K. M., Dec 1 2013, The Synapse: Structure and Function. Elsevier Inc, p. 281-300 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
2012

Afadin is required for maintenance of dendritic structure and excitatory tone

Srivastava, D. P., Copits, B. A., Xie, Z., Huda, R., Jones, K. A., Mukherji, S., Cahill, M. E., VanLeeuwen, J. E., Woolfrey, K. M., Rafalovich, I., Swanson, G. T. & Penzes, P., Oct 19 2012, In : Journal of Biological Chemistry. 287, 43, p. 35964-35974 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

An autism-associated variant of epac2 reveals a role for ras/epac2 signaling in controlling basal dendrite maintenance in mice

Srivastava, D. P., Woolfrey, K. M., Jones, K. A., Anderson, C. T., Smith, K. R., Russell, T. A., Lee, H., Yasvoina, M. V., Wokosin, D. L., Ozdinler, P. H., Shepherd, G. M. G. & Penzes, P., Jun 1 2012, In : PLoS biology. 10, 6, e1001350.

Research output: Contribution to journalArticle

49 Scopus citations

Colocalization between endogenous erbB4 and endogenous kalirin-7 in interneuronal dendrites

Cahill, M. & Penzes, P., Jan 2012, In : Molecular Psychiatry. 17, 1, 1 p.

Research output: Contribution to journalArticle

Control of interneuron dendritic growth through NRG1/erbB4-mediated kalirin-7 disinhibition

Cahill, M. E., Jones, K. A., Rafalovich, I., Xie, Z., Barros, C. S., Müller, U. & Penzes, P., Jan 1 2012, In : Molecular Psychiatry. 17, 1, p. 99-107 9 p.

Research output: Contribution to journalArticle

34 Scopus citations

Deconstructing signal transduction pathways that regulate the actin cytoskeleton in dendritic spines

Penzes, P. & Cahill, M. E., Jul 1 2012, In : Cytoskeleton. 69, 7, p. 426-441 16 p.

Research output: Contribution to journalReview article

32 Scopus citations

Increased expression of Kalirin-9 in the auditory cortex of schizophrenia subjects: Its role in dendritic pathology

Deo, A. J., Cahill, M. E., Li, S., Goldszer, I., Henteleff, R., VanLeeuwen, J. E., Rafalovich, I., Gao, R., Stachowski, E. K., Sampson, A. R., Lewis, D. A., Penzes, P. & Sweet, R. A., Feb 1 2012, In : Neurobiology of Disease. 45, 2, p. 796-803 8 p.

Research output: Contribution to journalArticle

30 Scopus citations