Philip D Compton

Personal profile

Education/Academic qualification

Bioanalytical Chemistry, PhD, University of Virginia

… → 2009

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Mass spectrometry Chemical Compounds

Proteomics Medicine & Life Sciences

Mass Spectrometry Medicine & Life Sciences

Proteins Chemical Compounds

Ions Chemical Compounds

Electrons Chemical Compounds

Mass spectrometers Chemical Compounds

Nitrogenase Chemical Compounds

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Grants 2012 2020

2 Finished
2 Active

Acquisition of a Thermo Fisher Scientific Q Exactive UHMR mass spectrometer

Compton, P. D.

Office of the Director, National Institutes of Health

4/1/18 → 3/31/20

Project: Research project

Mass spectrometers

methane monooxygenase

Clustered Regularly Interspaced Short Palindromic Repeats

Metalloproteins

Nitrogenase

National Resource for Translational and Developmental Proteomics

Compton, P. D., Goo, Y. A., Kelleher, N. L., Ntai, I. & Thomas, P. M.

National Institute of General Medical Sciences

8/1/15 → 5/31/20

Project: Research project

Proteomics

Technology

Biomedical Technology

Translational Medical Research

Research

Protein-Based Barcodes for Mapping B-Cell Differentiation at High Resolution

Compton, P. D., Kelleher, N. L., Ntai, I. & Thomas, P. M.

Paul G. Allen Family Foundation

3/1/14 → 10/1/18

Project: Research project

Cell Differentiation

B-Lymphocytes

Proteomics

Histone Code

Proteins

Developing a Hybrid Mass Spectrometer to Accelerate the Human Proteome Project

Chandel, N., Compton, P. D. & Kelleher, N. L.

W. M. Keck Foundation

7/15/12 → 7/14/17

Project: Research project

Research Output 2008 2019

1440 Citations
38 Article
2 Review article

1 Citation (Scopus)

A novel crosslinking protocol stabilizes amyloid β oligomers capable of inducing Alzheimer's-associated pathologies

Cline, E. N., Das, A., Bicca, M. A., Mohammad, S. N., Schachner, L. F., Kamel, J. M., DiNunno, N., Weng, A., Paschall, J. D., Bu, R. L., Khan, F. M., Rollins, M. G., Ives, A. N., Shekhawat, G. S., Nunes-Tavares, N., de Mello, F. G., Compton, P. D., Kelleher, N. L. & Klein, W. L., Mar 1 2019, In : Journal of neurochemistry. 148, 6, p. 822-836 15 p.

Research output: Contribution to journal › Article

Pathology

Oligomers

Amyloid

Crosslinking

Alzheimer Disease

3 Citations (Scopus)

Measurement of Individual Ions Sharply Increases the Resolution of Orbitrap Mass Spectra of Proteins

Kafader, J. O., Melani, R. D., Senko, M. W., Makarov, A. A., Kelleher, N. L. & Compton, P. D., Feb 19 2019, In : Analytical Chemistry. 91, 4, p. 2776-2783 8 p.

Research output: Contribution to journal › Article

Ions

Proteins

Carbonic Anhydrases

Optical resolving power

Mass spectrometry

2 Citations (Scopus)

Mo-, V-, and Fe-Nitrogenases Use a Universal Eight-Electron Reductive-Elimination Mechanism to Achieve N₂ Reduction

Harris, D. F., Lukoyanov, D. A., Kallas, H., Trncik, C., Yang, Z. Y., Compton, P. D., Kelleher, N. L., Einsle, O., Dean, D. R., Hoffman, B. M. & Seefeldt, L. C., Jul 30 2019, In : Biochemistry. 58, 30, p. 3293-3301 9 p.

Research output: Contribution to journal › Article

Nitrogenase

Electrons

Rate constants

Hydrides

Hydrogenase

3 Citations (Scopus)

Standard Proteoforms and Their Complexes for Native Mass Spectrometry

Schachner, L. F., Ives, A. N., McGee, J. P., Melani, R. D., Kafader, J. O., Compton, P. D., Patrie, S. M. & Kelleher, N. L., Jul 15 2019, In : Journal of the American Society for Mass Spectrometry. 30, 7, p. 1190-1198 9 p.

Research output: Contribution to journal › Article

Mass spectrometry

Mass Spectrometry

Benchmarking

Mass spectrometers

Standardization

STORI Plots Enable Accurate Tracking of Individual Ion Signals

Kafader, J. O., Beu, S. C., Early, B. P., Melani, R. D., Durbin, K. R., Zabrouskov, V., Makarov, A. A., Maze, J. T., Shinholt, D. L., Yip, P. F., Kelleher, N. L., Compton, P. D. & Senko, M. W., Nov 1 2019, In : Journal of the American Society for Mass Spectrometry. 30, 11, p. 2200-2203 4 p.

Research output: Contribution to journal › Article

Ions

Observation

Disintegration

Spectral resolution

Signal analysis