Philip D Compton

  • 1635 Citations
20082020

Research output per year

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Research Output

  • 1635 Citations
  • 44 Article
  • 2 Review article
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Article
2020

Individual Ion Mass Spectrometry Enhances the Sensitivity and Sequence Coverage of Top-Down Mass Spectrometry

Kafader, J. O., Durbin, K. R., Melani, R. D., Des Soye, B. J., Schachner, L. F., Senko, M. W., Compton, P. D. & Kelleher, N. L., Mar 6 2020, In : Journal of Proteome Research. 19, 3, p. 1346-1350 5 p.

Research output: Contribution to journalArticle

Multiplexed mass spectrometry of individual ions improves measurement of proteoforms and their complexes

Kafader, J. O., Melani, R. D., Durbin, K. R., Ikwuagwu, B., Early, B. P., Fellers, R. T., Beu, S. C., Zabrouskov, V., Makarov, A. A., Maze, J. T., Shinholt, D. L., Yip, P. F., Tullman-Ercek, D., Senko, M. W., Compton, P. D. & Kelleher, N. L., Apr 1 2020, In : Nature Methods. 17, 4, p. 391-394 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Native vs Denatured: An in Depth Investigation of Charge State and Isotope Distributions

Kafader, J. O., Melani, R. D., Schachner, L. F., Ives, A. N., Patrie, S. M., Kelleher, N. L. & Compton, P. D., Mar 4 2020, In : Journal of the American Society for Mass Spectrometry. 31, 3, p. 574-581 8 p.

Research output: Contribution to journalArticle

Novel Interface for High-Throughput Analysis of Biotherapeutics by Electrospray Mass Spectrometry

Park, H. M., Winton, V. J., Drader, J. J., Manalili Wheeler, S., Lazar, G. A., Kelleher, N. L., Liu, Y., Tran, J. C. & Compton, P. D., Jan 21 2020, In : Analytical Chemistry. 92, 2, p. 2186-2193 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Thorough performance evaluation of 213 nm ultraviolet photodissociation for top-down proteomics

Fornelli, L., Srzentić, K., Toby, T. K., Doubleday, P. F., Huguet, R., Mullen, C., Melani, R. D., Seckler, H. D. S., DeHart, C. J., Weisbrod, C. R., Durbin, K. R., Greer, J. B., Early, B. P., Fellers, R. T., Zabrouskov, V., Thomas, P. M., Compton, P. D. & Kelleher, N. L., Jan 1 2020, In : Molecular and Cellular Proteomics. 19, 2, p. 405-420 16 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Voltage Rollercoaster Filtering of Low-Mass Contaminants During Native Protein Analysis

McGee, J. P., Melani, R. D., Goodwin, M., McAlister, G., Huguet, R., Senko, M. W., Compton, P. D. & Kelleher, N. L., Mar 4 2020, In : Journal of the American Society for Mass Spectrometry. 31, 3, p. 763-767 5 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

A novel crosslinking protocol stabilizes amyloid β oligomers capable of inducing Alzheimer's-associated pathologies

Cline, E. N., Das, A., Bicca, M. A., Mohammad, S. N., Schachner, L. F., Kamel, J. M., DiNunno, N., Weng, A., Paschall, J. D., Bu, R. L., Khan, F. M., Rollins, M. G., Ives, A. N., Shekhawat, G., Nunes-Tavares, N., de Mello, F. G., Compton, P. D., Kelleher, N. L. & Klein, W. L., Mar 2019, In : Journal of neurochemistry. 148, 6, p. 822-836 15 p.

Research output: Contribution to journalArticle

3 Scopus citations

Measurement of Individual Ions Sharply Increases the Resolution of Orbitrap Mass Spectra of Proteins

Kafader, J. O., Melani, R. D., Senko, M. W., Makarov, A. A., Kelleher, N. L. & Compton, P. D., Feb 19 2019, In : Analytical Chemistry. 91, 4, p. 2776-2783 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Mo-, V-, and Fe-Nitrogenases Use a Universal Eight-Electron Reductive-Elimination Mechanism to Achieve N2 Reduction

Harris, D. F., Lukoyanov, D. A., Kallas, H., Trncik, C., Yang, Z. Y., Compton, P., Kelleher, N., Einsle, O., Dean, D. R., Hoffman, B. M. & Seefeldt, L. C., Jul 30 2019, In : Biochemistry. 58, 30, p. 3293-3301 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Standard Proteoforms and Their Complexes for Native Mass Spectrometry

Schachner, L. F., Ives, A. N., McGee, J. P., Melani, R. D., Kafader, J. O., Compton, P. D., Patrie, S. M. & Kelleher, N. L., Jul 15 2019, In : Journal of the American Society for Mass Spectrometry. 30, 7, p. 1190-1198 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

STORI Plots Enable Accurate Tracking of Individual Ion Signals

Kafader, J. O., Beu, S. C., Early, B. P., Melani, R. D., Durbin, K. R., Zabrouskov, V., Makarov, A. A., Maze, J. T., Shinholt, D. L., Yip, P. F., Kelleher, N. L., Compton, P. D. & Senko, M. W., Nov 1 2019, In : Journal of the American Society for Mass Spectrometry. 30, 11, p. 2200-2203 4 p.

Research output: Contribution to journalArticle

3 Scopus citations
2018

Accurate Sequence Analysis of a Monoclonal Antibody by Top-Down and Middle-Down Orbitrap Mass Spectrometry Applying Multiple Ion Activation Techniques

Fornelli, L., Srzentić, K., Huguet, R., Mullen, C., Sharma, S., Zabrouskov, V., Fellers, R. T., Durbin, K. R., Compton, P. D. & Kelleher, N. L., Jul 17 2018, In : Analytical Chemistry. 90, 14, p. 8421-8429 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

A Targeted, Differential Top-Down Proteomic Methodology for Comparison of ApoA-I Proteoforms in Individuals with High and Low HDL Efflux Capacity

Seckler, H. D. S., Fornelli, L., Mutharasan, R. K., Thaxton, C. S., Fellers, R., Daviglus, M., Sniderman, A., Rader, D., Kelleher, N. L., Lloyd-Jones, D. M., Compton, P. D. & Wilkins, J. T., Jun 1 2018, In : Journal of Proteome Research. 17, 6, p. 2156-2164 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Estimating the Distribution of Protein Post-Translational Modification States by Mass Spectrometry

Compton, P. D., Kelleher, N. L. & Gunawardena, J., Aug 3 2018, In : Journal of Proteome Research. 17, 8, p. 2727-2734 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Mechanism of N2 Reduction Catalyzed by Fe-Nitrogenase Involves Reductive Elimination of H2

Harris, D. F., Lukoyanov, D. A., Shaw, S., Compton, P., Tokmina-Lukaszewska, M., Bothner, B., Kelleher, N., Dean, D. R., Hoffman, B. M. & Seefeldt, L. C., Feb 6 2018, In : Biochemistry. 57, 5, p. 701-710 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

The Ups and Downs of Repeated Cleavage and Internal Fragment Production in Top-Down Proteomics

Lyon, Y. A., Riggs, D., Fornelli, L., Compton, P. D. & Julian, R. R., Jan 1 2018, In : Journal of the American Society for Mass Spectrometry. 29, 1, p. 150-157 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Top-down characterization of endogenous protein complexes with native proteomics

Skinner, O. S., Haverland, N. A., Fornelli, L., Melani, R. D., Do Vale, L. H. F., Seckler, H. S., Doubleday, P. F., Schachner, L. F., Srzentić, K., Kelleher, N. L. & Compton, P. D., Jan 1 2018, In : Nature Chemical Biology. 14, 1, p. 36-41 6 p.

Research output: Contribution to journalArticle

38 Scopus citations
2017

Advancing Top-down Analysis of the Human Proteome Using a Benchtop Quadrupole-Orbitrap Mass Spectrometer

Fornelli, L., Durbin, K. R., Fellers, R. T., Early, B. P., Greer, J. B., LeDuc, R. D., Compton, P. D. & Kelleher, N. L., Feb 3 2017, In : Journal of Proteome Research. 16, 2, p. 609-618 10 p.

Research output: Contribution to journalArticle

34 Scopus citations

Chromatographic efficiency and selectivity in top-down proteomics of histones

Zhou, Y., Zhang, X., Fornelli, L., Compton, P. D., Kelleher, N. & Wirth, M. J., Feb 15 2017, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 1044-1045, p. 47-53 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Defining Gas-Phase Fragmentation Propensities of Intact Proteins During Native Top-Down Mass Spectrometry

Haverland, N. A., Skinner, O. S., Fellers, R. T., Tariq, A. A., Early, B. P., LeDuc, R. D., Fornelli, L., Compton, P. D. & Kelleher, N. L., Jun 1 2017, In : Journal of the American Society for Mass Spectrometry. 28, 6, p. 1203-1215 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

Native Electron Capture Dissociation Maps to Iron-Binding Channels in Horse Spleen Ferritin

Skinner, O. S., McAnally, M. O., Van Duyne, R. P., Schatz, G. C., Breuker, K., Compton, P. D. & Kelleher, N. L., Oct 17 2017, In : Analytical Chemistry. 89, 20, p. 10711-10716 6 p.

Research output: Contribution to journalArticle

7 Scopus citations
2016

An informatic framework for decoding protein complexes by top-down mass spectrometry

Skinner, O. S., Havugimana, P. C., Haverland, N. A., Fornelli, L., Early, B. P., Greer, J. B., Fellers, R. T., Durbin, K. R., Do Vale, L. H. F., Melani, R. D., Seckler, H. S., Nelp, M. T., Belov, M. E., Horning, S. R., Makarov, A. A., LeDuc, R. D., Bandarian, V., Compton, P. D. & Kelleher, N. L., Feb 25 2016, In : Nature Methods. 13, 3, p. 237-240 4 p.

Research output: Contribution to journalArticle

38 Scopus citations

CN-GELFrEE - Clear native gel-eluted liquid fraction entrapment electrophoresis

Melani, R. D., Seckler, H. S., Skinner, O. S., Do Vale, L. H. F., Catherman, A. D., Havugimana, P. C., de Sousa, M. V., Domont, G. B., Kelleher, N. L. & Compton, P. D., Feb 29 2016, In : Journal of Visualized Experiments. 2016, 108, e53597.

Research output: Contribution to journalArticle

6 Scopus citations

Integrated bottom-up and top-down proteomics of patient-derived breast tumor xenografts

Ntai, I., LeDuc, R. D., Fellers, R. T., Erdmann-Gilmore, P., Davies, S. R., Rumsey, J., Early, B. P., Thomas, P. M., Li, S., Compton, P. D., Ellis, M. J. C., Ruggles, K. V., Fenyö, D., Boja, E. S., Rodriguez, H., Townsend, R. R. & Kelleher, N. L., Jan 2016, In : Molecular and Cellular Proteomics. 15, 1, p. 45-56 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

Mapping proteoforms and protein complexes from king cobra venom using both denaturing and native top-down proteomics

Melani, R. D., Skinner, O. S., Fornelli, L., Domont, G. B., Compton, P. D. & Kelleher, N. L., Jul 2016, In : Molecular and Cellular Proteomics. 15, 7, p. 2423-2434 12 p.

Research output: Contribution to journalArticle

32 Scopus citations

Targeted analysis of recombinant NF kappa B (RelA/p65) by denaturing and native top down mass spectrometry

Savaryn, J. P., Skinner, O. S., Fornelli, L., Fellers, R. T., Compton, P. D., Terhune, S. S., Abecassis, M. M. & Kelleher, N. L., Feb 16 2016, In : Journal of Proteomics. 134, p. 76-84 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Unabridged analysis of human histone H3 by differential top-down mass spectrometry reveals hypermethylated proteoforms from MMSET/NSD2 overexpression

Zheng, Y., Fornelli, L., Compton, P. D., Sharma, S., Canterbury, J., Mullen, C., Zabrouskov, V., Fellers, R. T., Thomas, P. M., Licht, J. D., Senko, M. W. & Kelleher, N. L., Mar 2016, In : Molecular and Cellular Proteomics. 15, 3, p. 776-790 15 p.

Research output: Contribution to journalArticle

35 Scopus citations
2015

Mechanism of Inactivation of GABA Aminotransferase by (E)- and (Z)-(1S,3S)-3-Amino-4-fluoromethylenyl-1-cyclopentanoic Acid

Lee, H., Le, H. V., Wu, R., Doud, E., Sanishvili, R., Kellie, J. F., Compton, P. D., Pachaiyappan, B., Liu, D., Kelleher, N. L. & Silverman, R. B., Sep 18 2015, In : ACS chemical biology. 10, 9, p. 2087-2098 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Native GELFrEE: A new separation technique for biomolecular assemblies

Skinner, O. S., Do Vale, L. H. F., Catherman, A. D., Havugimana, P. C., Sousa, M. V. D., Compton, P. D. & Kelleher, N. L., Mar 3 2015, In : Analytical Chemistry. 87, 5, p. 3032-3038 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Online matrix removal platform for coupling gel-based separations to whole protein electrospray ionization mass spectrometry

Kim, K. H., Compton, P. D., Tran, J. C. & Kelleher, N. L., May 1 2015, In : Journal of Proteome Research. 14, 5, p. 2199-2206 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Probing asymmetric charge partitioning of protein oligomers during tandem mass spectrometry

Compton, P. D., Fornelli, L., Kelleher, N. L. & Skinner, O. S., Aug 29 2015, In : International Journal of Mass Spectrometry. 390, p. 132-136 5 p., 15491.

Research output: Contribution to journalArticle

6 Scopus citations
5 Scopus citations
2014

Autopilot: An online data acquisition control system for the enhanced high-throughput characterization of intact proteins

Durbin, K. R., Fellers, R. T., Ntai, I., Kelleher, N. L. & Compton, P. D., Feb 4 2014, In : Analytical Chemistry. 86, 3, p. 1485-1492 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Fragmentation of integral membrane proteins in the gas phase

Skinner, O. S., Catherman, A. D., Early, B. P., Thomas, P. M., Compton, P. D. & Kelleher, N. L., May 6 2014, In : Analytical Chemistry. 86, 9, p. 4627-4634 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Optimizing capillary electrophoresis for top-down proteomics of 30-80 kDa proteins

Li, Y., Compton, P. D., Tran, J. C., Ntai, I. & Kelleher, N. L., Jan 1 2014, In : Proteomics. 14, 10, p. 1158-1164 7 p.

Research output: Contribution to journalArticle

56 Scopus citations
2013

From protein complexes to subunit backbone fragments: A multi-stage approach to native mass spectrometry

Belov, M. E., Damoc, E., Denisov, E., Compton, P. D., Horning, S., Makarov, A. A. & Kelleher, N. L., Dec 3 2013, In : Analytical Chemistry. 85, 23, p. 11163-11173 11 p.

Research output: Contribution to journalArticle

88 Scopus citations

Front-end electron transfer dissociation: A new ionization source

Earley, L., Anderson, L. C., Bai, D. L., Mullen, C., Syka, J. E. P., English, A. M., Dunyach, J. J., Stafford, G. C., Shabanowitz, J., Hunt, D. F. & Compton, P. D., Sep 10 2013, In : Analytical Chemistry. 85, 17, p. 8385-8390 6 p.

Research output: Contribution to journalArticle

40 Scopus citations

Top down proteomics of human membrane proteins from enriched mitochondrial fractions

Catherman, A. D., Li, M., Tran, J. C., Durbin, K. R., Compton, P. D., Early, B. P., Thomas, P. M. & Kelleher, N. L., Feb 5 2013, In : Analytical Chemistry. 85, 3, p. 1880-1888 9 p.

Research output: Contribution to journalArticle

51 Scopus citations
2012

Evaluation of the compact high-field orbitrap for top-down proteomics of human cells

Ahlf, D. R., Compton, P. D., Tran, J. C., Early, B. P., Thomas, P. M. & Kelleher, N. L., Aug 3 2012, In : Journal of Proteome Research. 11, 8, p. 4308-4314 7 p.

Research output: Contribution to journalArticle

66 Scopus citations

Optimization of electron transfer dissociation via informed selection of reagents and operating parameters

Compton, P. D., Strukl, J. V., Bai, D. L., Shabanowitz, J. & Hunt, D. F., Feb 7 2012, In : Analytical Chemistry. 84, 3, p. 1781-1785 5 p.

Research output: Contribution to journalArticle

33 Scopus citations
2011

Mapping intact protein isoforms in discovery mode using top-down proteomics

Tran, J. C., Zamdborg, L., Ahlf, D. R., Lee, J. E., Catherman, A. D., Durbin, K. R., Tipton, J. D., Vellaichamy, A., Kellie, J. F., Li, M., Wu, C., Sweet, S. M. M., Early, B. P., Siuti, N., Leduc, R. D., Compton, P. D., Thomas, P. M. & Kelleher, N. L., Dec 8 2011, In : Nature. 480, 7376, p. 254-258 5 p.

Research output: Contribution to journalArticle

418 Scopus citations

On the scalability and requirements of whole protein mass spectrometry

Compton, P. D., Zamdborg, L., Thomas, P. M. & Kelleher, N. L., Sep 1 2011, In : Analytical Chemistry. 83, 17, p. 6868-6874 7 p.

Research output: Contribution to journalArticle

104 Scopus citations
2010

Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates cytokinesis

Wang, Z., Udeshi, N. D., Slawson, C., Compton, P. D., Sakabe, K., Cheung, W. D., Shabanowitz, J., Hunt, D. F. & Hart, G. W., Jan 12 2010, In : Science Signaling. 3, 104, p. ra2

Research output: Contribution to journalArticle

206 Scopus citations
2008

Methods for analyzing peptides and proteins on a chromatographic timescale by electron-transfer dissociation mass spectrometry

Udeshi, N. D., Compton, P. D., Shabanowitz, J., Hunt, D. F. & Rose, K. L., Oct 16 2008, In : Nature Protocols. 3, 11, p. 1709-1717 9 p.

Research output: Contribution to journalArticle

70 Scopus citations