Philip D Compton

  • 1406 Citations
20082020
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Research Output 2008 2019

  • 1406 Citations
  • 37 Article
  • 2 Review article
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Article
2019
1 Citation (Scopus)

A novel crosslinking protocol stabilizes amyloid β oligomers capable of inducing Alzheimer's-associated pathologies

Cline, E. N., Das, A., Bicca, M. A., Mohammad, S. N., Schachner, L. F., Kamel, J. M., DiNunno, N., Weng, A., Paschall, J. D., Bu, R. L., Khan, F. M., Rollins, M. G., Ives, A. N., Shekhawat, G. S., Nunes-Tavares, N., de Mello, F. G., Compton, P. D., Kelleher, N. L. & Klein, W. L., Mar 1 2019, In : Journal of neurochemistry. 148, 6, p. 822-836 15 p.

Research output: Contribution to journalArticle

Pathology
Oligomers
Amyloid
Crosslinking
Alzheimer Disease
1 Citation (Scopus)

Measurement of Individual Ions Sharply Increases the Resolution of Orbitrap Mass Spectra of Proteins

Kafader, J. O., Melani, R. D., Senko, M. W., Makarov, A. A., Kelleher, N. L. & Compton, P. D., Feb 19 2019, In : Analytical Chemistry. 91, 4, p. 2776-2783 8 p.

Research output: Contribution to journalArticle

Ions
Proteins
Carbonic Anhydrases
Optical resolving power
Mass spectrometry
1 Citation (Scopus)

Mo-, V-, and Fe-Nitrogenases Use a Universal Eight-Electron Reductive-Elimination Mechanism to Achieve N2 Reduction

Harris, D. F., Lukoyanov, D. A., Kallas, H., Trncik, C., Yang, Z. Y., Compton, P. D., Kelleher, N., Einsle, O., Dean, D. R., Hoffman, B. M. & Seefeldt, L. C., Jul 30 2019, In : Biochemistry. 58, 30, p. 3293-3301 9 p.

Research output: Contribution to journalArticle

Nitrogenase
Electrons
Rate constants
Hydrides
Hydrogenase
1 Citation (Scopus)

Standard Proteoforms and Their Complexes for Native Mass Spectrometry

Schachner, L. F., Ives, A. N., McGee, J. P., Melani, R. D., Kafader, J. O., Compton, P. D., Patrie, S. M. & Kelleher, N. L., Jul 15 2019, In : Journal of the American Society for Mass Spectrometry. 30, 7, p. 1190-1198 9 p.

Research output: Contribution to journalArticle

Mass spectrometry
Mass Spectrometry
Benchmarking
Mass spectrometers
Standardization
2018
12 Citations (Scopus)

Accurate Sequence Analysis of a Monoclonal Antibody by Top-Down and Middle-Down Orbitrap Mass Spectrometry Applying Multiple Ion Activation Techniques

Fornelli, L., Srzentić, K., Huguet, R., Mullen, C., Sharma, S., Zabrouskov, V., Fellers, R. T., Durbin, K. R., Compton, P. D. & Kelleher, N. L., Jul 17 2018, In : Analytical Chemistry. 90, 14, p. 8421-8429 9 p.

Research output: Contribution to journalArticle

Mass spectrometry
Chemical activation
Monoclonal Antibodies
Ions
Photodissociation
6 Citations (Scopus)

A Targeted, Differential Top-Down Proteomic Methodology for Comparison of ApoA-I Proteoforms in Individuals with High and Low HDL Efflux Capacity

Seckler, H. D. S., Fornelli, L., Mutharasan, R. K., Thaxton, C. S., Fellers, R., Daviglus, M., Sniderman, A., Rader, D., Kelleher, N. L., Lloyd-Jones, D. M., Compton, P. D. & Wilkins, J. T., Jun 1 2018, In : Journal of Proteome Research. 17, 6, p. 2156-2164 9 p.

Research output: Contribution to journalArticle

Apolipoprotein A-I
Proteomics
HDL Cholesterol
Bearings (structural)
Lipoylation
1 Citation (Scopus)

Estimating the Distribution of Protein Post-Translational Modification States by Mass Spectrometry

Compton, P. D., Kelleher, N. L. & Gunawardena, J., Aug 3 2018, In : Journal of Proteome Research. 17, 8, p. 2727-2734 8 p.

Research output: Contribution to journalArticle

Post Translational Protein Processing
Mass spectrometry
Mass Spectrometry
Proteins
Peptide Hydrolases
10 Citations (Scopus)

Mechanism of N2 Reduction Catalyzed by Fe-Nitrogenase Involves Reductive Elimination of H2

Harris, D. F., Lukoyanov, D. A., Shaw, S., Compton, P., Tokmina-Lukaszewska, M., Bothner, B., Kelleher, N., Dean, D. R., Hoffman, B. M. & Seefeldt, L. C., Feb 6 2018, In : Biochemistry. 57, 5, p. 701-710 10 p.

Research output: Contribution to journalArticle

Nitrogenase
Proteins
Protons
Catalytic Domain
Molybdoferredoxin
5 Citations (Scopus)

The Ups and Downs of Repeated Cleavage and Internal Fragment Production in Top-Down Proteomics

Lyon, Y. A., Riggs, D., Fornelli, L., Compton, P. D. & Julian, R. R., Jan 1 2018, In : Journal of the American Society for Mass Spectrometry. 29, 1, p. 150-157 8 p.

Research output: Contribution to journalArticle

Proteomics
Ions
Photodissociation
Proteins
Statistics
25 Citations (Scopus)

Top-down characterization of endogenous protein complexes with native proteomics

Skinner, O. S., Haverland, N. A., Fornelli, L., Melani, R. D., Do Vale, L. H. F., Seckler, H. S., Doubleday, P. F., Schachner, L. F., Srzentić, K., Kelleher, N. L. & Compton, P. D., Jan 1 2018, In : Nature Chemical Biology. 14, 1, p. 36-41 6 p.

Research output: Contribution to journalArticle

Proteomics
Proteins
Biological Phenomena
Heart Neoplasms
Post Translational Protein Processing
2017
23 Citations (Scopus)

Advancing Top-down Analysis of the Human Proteome Using a Benchtop Quadrupole-Orbitrap Mass Spectrometer

Fornelli, L., Durbin, K. R., Fellers, R. T., Early, B. P., Greer, J. B., LeDuc, R. D., Compton, P. D. & Kelleher, N. L., Feb 3 2017, In : Journal of Proteome Research. 16, 2, p. 609-618 10 p.

Research output: Contribution to journalArticle

Mass spectrometers
Proteome
Proteomics
Data acquisition
Fourier Analysis
4 Citations (Scopus)

Chromatographic efficiency and selectivity in top-down proteomics of histones

Zhou, Y., Zhang, X., Fornelli, L., Compton, P. D., Kelleher, N. L. & Wirth, M. J., Feb 15 2017, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 1044-1045, p. 47-53 7 p.

Research output: Contribution to journalArticle

Liquid chromatography
Reverse-Phase Chromatography
Proteomics
Histones
Mass spectrometry
11 Citations (Scopus)

Defining Gas-Phase Fragmentation Propensities of Intact Proteins During Native Top-Down Mass Spectrometry

Haverland, N. A., Skinner, O. S., Fellers, R. T., Tariq, A. A., Early, B. P., LeDuc, R. D., Fornelli, L., Compton, P. D. & Kelleher, N. L., Jun 1 2017, In : Journal of the American Society for Mass Spectrometry. 28, 6, p. 1203-1215 13 p.

Research output: Contribution to journalArticle

Mass spectrometry
Mass Spectrometry
Gases
Proteins
Aspartic Acid
4 Citations (Scopus)

Native Electron Capture Dissociation Maps to Iron-Binding Channels in Horse Spleen Ferritin

Skinner, O. S., McAnally, M. O., Van Duyne, R. P., Schatz, G. C., Breuker, K., Compton, P. D. & Kelleher, N. L., Oct 17 2017, In : Analytical Chemistry. 89, 20, p. 10711-10716 6 p.

Research output: Contribution to journalArticle

Ferritins
Iron
Electrons
Cytochromes c
Ions
2016
30 Citations (Scopus)

An informatic framework for decoding protein complexes by top-down mass spectrometry

Skinner, O. S., Havugimana, P. C., Haverland, N. A., Fornelli, L., Early, B. P., Greer, J. B., Fellers, R. T., Durbin, K. R., Do Vale, L. H. F., Melani, R. D., Seckler, H. S., Nelp, M. T., Belov, M. E., Horning, S. R., Makarov, A. A., LeDuc, R. D., Bandarian, V., Compton, P. D. & Kelleher, N. L., Feb 25 2016, In : Nature Methods. 13, 3, p. 237-240 4 p.

Research output: Contribution to journalArticle

Informatics
Mass spectrometry
Decoding
Mass Spectrometry
Protein Subunits
6 Citations (Scopus)

CN-GELFrEE - Clear native gel-eluted liquid fraction entrapment electrophoresis

Melani, R. D., Seckler, H. S., Skinner, O. S., Do Vale, L. H. F., Catherman, A. D., Havugimana, P. C., de Sousa, M. V., Domont, G. B., Kelleher, N. L. & Compton, P. D., Feb 29 2016, In : Journal of Visualized Experiments. 2016, 108, e53597.

Research output: Contribution to journalArticle

Electrophoresis
Gels
Proteins
Liquids
Molecular Weight
32 Citations (Scopus)

Integrated bottom-up and top-down proteomics of patient-derived breast tumor xenografts

Ntai, I., LeDuc, R. D., Fellers, R. T., Erdmann-Gilmore, P., Davies, S. R., Rumsey, J., Early, B. P., Thomas, P. M., Li, S., Compton, P. D., Ellis, M. J. C., Ruggles, K. V., Fenyö, D., Boja, E. S., Rodriguez, H., Townsend, R. R. & Kelleher, N. L., Jan 1 2016, In : Molecular and Cellular Proteomics. 15, 1, p. 45-56 12 p.

Research output: Contribution to journalArticle

Heterografts
Proteomics
Tumors
Breast Neoplasms
Proteins
26 Citations (Scopus)

Mapping proteoforms and protein complexes from king cobra venom using both denaturing and native top-down proteomics

Melani, R. D., Skinner, O. S., Fornelli, L., Domont, G. B., Compton, P. D. & Kelleher, N. L., Jul 1 2016, In : Molecular and Cellular Proteomics. 15, 7, p. 2423-2434 12 p.

Research output: Contribution to journalArticle

Cobra Venoms
Proteomics
Venoms
Proteins
L-Amino Acid Oxidase
7 Citations (Scopus)

Targeted analysis of recombinant NF kappa B (RelA/p65) by denaturing and native top down mass spectrometry

Savaryn, J. P., Skinner, O. S., Fornelli, L., Fellers, R. T., Compton, P. D., Terhune, S. S., Abecassis, M. M. & Kelleher, N. L., Feb 16 2016, In : Journal of Proteomics. 134, p. 76-84 9 p.

Research output: Contribution to journalArticle

Transcription Factor RelA
NF-kappa B
Mass spectrometry
Mass Spectrometry
Transcription Factors
30 Citations (Scopus)

Unabridged analysis of human histone H3 by differential top-down mass spectrometry reveals hypermethylated proteoforms from MMSET/NSD2 overexpression

Zheng, Y., Fornelli, L., Compton, P. D., Sharma, S., Canterbury, J., Mullen, C., Zabrouskov, V., Fellers, R. T., Thomas, P. M., Licht, J. D., Senko, M. W. & Kelleher, N. L., Mar 1 2016, In : Molecular and Cellular Proteomics. 15, 3, p. 776-790 15 p.

Research output: Contribution to journalArticle

Methylation
Histones
Mass spectrometry
Mass Spectrometry
Acetylation
2015
5 Citations (Scopus)

Mechanism of Inactivation of GABA Aminotransferase by (E)- and (Z)-(1S,3S)-3-Amino-4-fluoromethylenyl-1-cyclopentanoic Acid

Lee, H., Le, H. V., Wu, R., Doud, E., Sanishvili, R., Kellie, J. F., Compton, P. D., Pachaiyappan, B., Liu, D., Kelleher, N. L. & Silverman, R. B., Sep 18 2015, In : ACS chemical biology. 10, 9, p. 2087-2098 12 p.

Research output: Contribution to journalArticle

4-Aminobutyrate Transaminase
Acids
gamma-Aminobutyric Acid
Vigabatrin
Metabolites
18 Citations (Scopus)

Native GELFrEE: A new separation technique for biomolecular assemblies

Skinner, O. S., Do Vale, L. H. F., Catherman, A. D., Havugimana, P. C., Sousa, M. V. D., Compton, P. D. & Kelleher, N. L., Mar 3 2015, In : Analytical Chemistry. 87, 5, p. 3032-3038 7 p.

Research output: Contribution to journalArticle

Mass spectrometry
Gels
Fractionation
Buffers
Proteins
10 Citations (Scopus)

Online matrix removal platform for coupling gel-based separations to whole protein electrospray ionization mass spectrometry

Kim, K. H., Compton, P. D., Tran, J. C. & Kelleher, N. L., Jan 1 2015, In : Journal of Proteome Research. 14, 5, p. 2199-2206 8 p.

Research output: Contribution to journalArticle

Electrospray ionization
Electrospray Ionization Mass Spectrometry
Sodium Dodecyl Sulfate
Mass spectrometry
Gels
5 Citations (Scopus)

Probing asymmetric charge partitioning of protein oligomers during tandem mass spectrometry

Compton, P. D., Fornelli, L., Kelleher, N. L. & Skinner, O. S., Aug 29 2015, In : International Journal of Mass Spectrometry. 390, p. 132-136 5 p., 15491.

Research output: Contribution to journalArticle

oligomers
Oligomers
Mass spectrometry
mass spectroscopy
monomers
5 Citations (Scopus)
Proteomics
Oxidation
Proteins
Liquid chromatography
Sanitary Engineering
2014
21 Citations (Scopus)

Autopilot: An online data acquisition control system for the enhanced high-throughput characterization of intact proteins

Durbin, K. R., Fellers, R. T., Ntai, I., Kelleher, N. L. & Compton, P. D., Feb 4 2014, In : Analytical Chemistry. 86, 3, p. 1485-1492 8 p.

Research output: Contribution to journalArticle

Data acquisition
Throughput
Control systems
Proteome
Proteins
15 Citations (Scopus)

Fragmentation of integral membrane proteins in the gas phase

Skinner, O. S., Catherman, A. D., Early, B. P., Thomas, P. M., Compton, P. D. & Kelleher, N. L., May 6 2014, In : Analytical Chemistry. 86, 9, p. 4627-4634 8 p.

Research output: Contribution to journalArticle

Membrane Proteins
Gases
Protons
Electrons
Chemical activation
52 Citations (Scopus)

Optimizing capillary electrophoresis for top-down proteomics of 30-80 kDa proteins

Li, Y., Compton, P. D., Tran, J. C., Ntai, I. & Kelleher, N. L., Jan 1 2014, In : Proteomics. 14, 10, p. 1158-1164 7 p.

Research output: Contribution to journalArticle

Capillary electrophoresis
Capillary Electrophoresis
Proteomics
Proteins
Pseudomonas aeruginosa
2013
82 Citations (Scopus)

From protein complexes to subunit backbone fragments: A multi-stage approach to native mass spectrometry

Belov, M. E., Damoc, E., Denisov, E., Compton, P. D., Horning, S., Makarov, A. A. & Kelleher, N. L., Dec 3 2013, In : Analytical Chemistry. 85, 23, p. 11163-11173 11 p.

Research output: Contribution to journalArticle

Mass spectrometry
Proteins
Monomers
Ions
Pyruvate Kinase
34 Citations (Scopus)

Front-end electron transfer dissociation: A new ionization source

Earley, L., Anderson, L. C., Bai, D. L., Mullen, C., Syka, J. E. P., English, A. M., Dunyach, J. J., Stafford, G. C., Shabanowitz, J., Hunt, D. F. & Compton, P. D., Sep 10 2013, In : Analytical Chemistry. 85, 17, p. 8385-8390 6 p.

Research output: Contribution to journalArticle

Ion sources
Mass spectrometers
Ions
Electrons
Proton transfer
50 Citations (Scopus)

Top down proteomics of human membrane proteins from enriched mitochondrial fractions

Catherman, A. D., Li, M., Tran, J. C., Durbin, K. R., Compton, P. D., Early, B. P., Thomas, P. M. & Kelleher, N. L., Feb 5 2013, In : Analytical Chemistry. 85, 3, p. 1880-1888 9 p.

Research output: Contribution to journalArticle

Membrane Proteins
Mass spectrometry
Ions
Membranes
Proteins
2012
63 Citations (Scopus)

Evaluation of the compact high-field orbitrap for top-down proteomics of human cells

Ahlf, D. R., Compton, P. D., Tran, J. C., Early, B. P., Thomas, P. M. & Kelleher, N. L., Aug 3 2012, In : Journal of Proteome Research. 11, 8, p. 4308-4314 7 p.

Research output: Contribution to journalArticle

Proteomics
Cells
Mass spectrometry
Mass Spectrometry
Proteins
29 Citations (Scopus)

Optimization of electron transfer dissociation via informed selection of reagents and operating parameters

Compton, P. D., Strukl, J. V., Bai, D. L., Shabanowitz, J. & Hunt, D. F., Feb 7 2012, In : Analytical Chemistry. 84, 3, p. 1781-1785 5 p.

Research output: Contribution to journalArticle

Electrons
Reaction rates
Peptides
Proteins
2011
390 Citations (Scopus)

Mapping intact protein isoforms in discovery mode using top-down proteomics

Tran, J. C., Zamdborg, L., Ahlf, D. R., Lee, J. E., Catherman, A. D., Durbin, K. R., Tipton, J. D., Vellaichamy, A., Kellie, J. F., Li, M., Wu, C., Sweet, S. M. M., Early, B. P., Siuti, N., Leduc, R. D., Compton, P. D., Thomas, P. M. & Kelleher, N. L., Dec 8 2011, In : Nature. 480, 7376, p. 254-258 5 p.

Research output: Contribution to journalArticle

Proteomics
Protein Isoforms
Proteins
Proteome
Cell Aging
93 Citations (Scopus)

On the scalability and requirements of whole protein mass spectrometry

Compton, P. D., Zamdborg, L., Thomas, P. M. & Kelleher, N. L., Sep 1 2011, In : Analytical Chemistry. 83, 17, p. 6868-6874 7 p.

Research output: Contribution to journalArticle

Mass spectrometry
Scalability
Ions
Proteins
Isotopes
2010
198 Citations (Scopus)

Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates cytokinesis

Wang, Z., Udeshi, N. D., Slawson, C., Compton, P. D., Sakabe, K., Cheung, W. D., Shabanowitz, J., Hunt, D. F. & Hart, G. W., Jan 12 2010, In : Science Signaling. 3, 104

Research output: Contribution to journalArticle

Phosphorylation
Cytokinesis
Crosstalk
CDC2 Protein Kinase
Proteins
2008
68 Citations (Scopus)

Methods for analyzing peptides and proteins on a chromatographic timescale by electron-transfer dissociation mass spectrometry

Udeshi, N. D., Compton, P. D., Shabanowitz, J., Hunt, D. F. & Rose, K. L., Oct 16 2008, In : Nature Protocols. 3, 11, p. 1709-1717 9 p.

Research output: Contribution to journalArticle

Mass spectrometry
Mass Spectrometry
Electrons
Peptides
Proteins