Praveen Thumbikat

  • 750 Citations
20012017

Personal profile

Research Interests

The focus of research in my laboratory is to understand the immune basis of prostate disease in humans. We have a particular emphasis on chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), a debilitating medical condition characterized by dysuria and pelvic pain. My laboratory is very interested in understanding the mechanism underlying inflammation of the human prostate and it's impact on prostate diseases. The laboratory utilizes comparative animal models that closely track human prostate disease to examine prostate disease mechanisms and also as tools for translational research. Some specific areas of research interest are as follows - 1. Th1/Th17 mechanisms in chronic pelvic pain: We are interested in understanding the mechanism of T cell mediated pain, the effectors of the pain pathway and measures to modulate Th1/Th17 immune response in animal models and ultimately in humans. 2. Chemokine mechanisms in chronic pelvic pain:We are in the process of identifying the mechanisms that appear to mediate chemokine mediated pelvic pain by focusing both on the prostate as well as on neuronal mechanisms of central sensitization. A further focus of this project is the role of mast cells and mast cell-released intermediates in the pathogenesis of chronic pelvic pain. Identification of biomarkers for CP/CPPS in humans is also an emphasis of this project. 3. Pattern recognition receptors in prostate inflammation: Deficiencies in TLR4 signaling pathways result in increased susceptibility to bacterial infection, and profound defects in innate and adaptive immunity. We are in the process of studying the microbial pathogenesis of prostatic bacterial isolates and dissecting TLR signaling pathways in prostate cells.

Keywords

  • Autoimmunity
  • Immunology
  • Pain
  • Immune Regulation
  • Inflammation
  • Urology
  • Infectious Diseases-bacteria
  • Microbial Pathogenesis

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Research Output 2001 2017

Commensal bacterial modulation of the host immune response to ameliorate pain in a murine model of chronic prostatitis

Murphy, S. F., Schaeffer, A. J., Done, J. D., Quick, M. L., Acar, U. & Thumbikat, P. Aug 1 2017 In : Pain. 158, 8, p. 1517-1527 11 p.

Research output: Contribution to journalArticle

Prostatitis
Staphylococcus epidermidis
Pain
Pelvic Pain
Hyperalgesia
1 Citations

Bacterial prostatitis: Bacterial virulence, clinical outcomes, and new directions

Krieger, J. N. & Thumbikat, P. 2016 In : Microbiology Spectrum. 4, 1, UTI-0004-2012

Research output: Contribution to journalArticle

Prostatitis
Virulence
virulence
Escherichia coli
etiology
1 Citations

Role of PAR2 in the Development of Lower Urinary Tract Dysfunction

Roman, K., Murphy, S. F., Done, J. D., McKenna, K. E., Schaeffer, A. J. & Thumbikat, P. Aug 1 2016 In : Journal of Urology. 196, 2, p. 588-598 11 p.

Research output: Contribution to journalArticle

Prostatitis
Urinary Tract
Urinary Bladder
Prostate
Chronic Pain
10 Citations

A human prostatic bacterial isolate alters the prostatic microenvironment and accelerates prostate cancer progression

Simons, B. W., Durham, N. M., Bruno, T. C., Grosso, J. F., Schaeffer, A. J., Ross, A. E., Hurley, P. J., Berman, D. M., Drake, C. G., Thumbikat, P. & Schaeffer, E. M. Feb 1 2015 In : Journal of Pathology. 235, 3, p. 478-489 12 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Inflammation
Prostate
Infection
Neoplasms
2 Citations

A population-based study on the association between benign prostatic enlargement and rheumatoid arthritis

Tzeng, Y. M., Kao, L. T., Lin, H. C., Huang, C. Y. & Thumbikat, P. Jul 14 2015 In : PLoS ONE. 10, 7, e0133013

Research output: Contribution to journalArticle

Hexosaminidase A
Blood Flow Velocity
Rheumatoid Arthritis
rheumatoid arthritis
Graduate Dental Education