No photo of Praveen Thumbikat

View Scopus Profile

Praveen Thumbikat

  • 1036 Citations
20012020

Research output per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Research Interests

The focus of research in my laboratory is to understand the immune basis of prostate disease in humans. We have a particular emphasis on chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), a debilitating medical condition characterized by dysuria and pelvic pain. My laboratory is very interested in understanding the mechanism underlying inflammation of the human prostate and it's impact on prostate diseases. The laboratory utilizes comparative animal models that closely track human prostate disease to examine prostate disease mechanisms and also as tools for translational research. Some specific areas of research interest are as follows - 1. Th1/Th17 mechanisms in chronic pelvic pain: We are interested in understanding the mechanism of T cell mediated pain, the effectors of the pain pathway and measures to modulate Th1/Th17 immune response in animal models and ultimately in humans. 2. Chemokine mechanisms in chronic pelvic pain:We are in the process of identifying the mechanisms that appear to mediate chemokine mediated pelvic pain by focusing both on the prostate as well as on neuronal mechanisms of central sensitization. A further focus of this project is the role of mast cells and mast cell-released intermediates in the pathogenesis of chronic pelvic pain. Identification of biomarkers for CP/CPPS in humans is also an emphasis of this project. 3. Pattern recognition receptors in prostate inflammation: Deficiencies in TLR4 signaling pathways result in increased susceptibility to bacterial infection, and profound defects in innate and adaptive immunity. We are in the process of studying the microbial pathogenesis of prostatic bacterial isolates and dissecting TLR signaling pathways in prostate cells.

Education/Academic qualification

PhD, University of Minnesota

… → 2004

Research interests

  • Autoimmunity
  • Immune Regulation
  • Immunology
  • Infectious Diseases: Bacteria
  • Inflammation
  • Microbial Pathogenesis
  • Pain
  • Urology

Fingerprint Dive into the research topics where Praveen Thumbikat is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 3 Similar Profiles

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants

Inflammatory Pathways in BPH/LUTS

Thumbikat, P.

NorthShore University HealthSystem Research Institute, National Institute of Diabetes, Digestive and Kidney Diseases

9/15/18 → 6/30/22

Project: Research project

    • Lipoteichoic acid mediated immune modulation of chronic pain

    Murphy, S. F., Schaeffer, A. J., Thaxton, C. S. & Thumbikat, P.

    National Institute of Diabetes, Digestive and Kidney Diseases

    8/1/16 → 7/31/21

    Project: Research project

    • Mast cells in male pelvic pain and lower urinary tract dysfunction

    Hairston, J. C., McKenna, K. E., Schaeffer, A. J. & Thumbikat, P.

    National Institute of Diabetes, Digestive and Kidney Diseases

    7/1/16 → 6/30/21

    Project: Research project

    • Diversity Supplement for T cells in Chronic Pelvic Pain

    Thumbikat, P.

    National Institute of Diabetes, Digestive and Kidney Diseases

    2/1/16 → 1/31/18

    Project: Research project

    T cells in Chronic Pelvic Pain

    Schaeffer, A. J. & Thumbikat, P.

    National Institute of Diabetes, Digestive and Kidney Diseases

    2/1/16 → 1/31/18

    Project: Research project

    Research Output

    A novel immunocompetent model of metastatic prostate cancer-induced bone pain

    Liu, Z., Murphy, S. F., Huang, J., Zhao, L., Hall, C. C., Schaeffer, A. J., Schaeffer, E. M. & Thumbikat, P., Jul 1 2020, In : Prostate. 80, 10, p. 782-794 13 p.

    Research output: Contribution to journal › Article

    • TRPV1 in experimental autoimmune prostatitis

    Roman, K., Hall, C., Schaeffer, A. J. & Thumbikat, P., Jan 1 2020, In : Prostate. 80, 1, p. 28-37 10 p.

    Research output: Contribution to journal › Article

    • Role of gram-positive bacteria in chronic pelvic pain syndrome (CPPS)

    Murphy, S. F., Anker, J. F., Mazur, D. J., Hall, C., Schaeffer, A. J. & Thumbikat, P., Feb 1 2019, In : Prostate. 79, 2, p. 160-167 8 p.

    Research output: Contribution to journal › Article

    • 3 Scopus citations

    The role of the androgen receptor in prostate development and benign prostatic hyperplasia: A review

    Vickman, R. E., Franco, O. E., Moline, D. C., Vander Griend, D. J., Thumbikat, P. & Hayward, S. W., Jan 1 2019, (Accepted/In press) In : Asian Journal of Urology.

    Research output: Contribution to journal › Review article

    Open Access
    • 1 Scopus citations

    Uropathogenic escherichia coli-induced fibrosis, leading to lower urinary tract symptoms, is associated with type 2 cytokine signaling

    Bell-Cohn, A., Mazur, D. J., Hall, C., Schaeffer, A. J. & Thumbikat, P., Apr 2019, In : American Journal of Physiology - Renal Physiology. 316, 4, p. F682-F692

    Research output: Contribution to journal › Article

    • 6 Scopus citations