Praveen Thumbikat

  • 952 Citations
20012022
If you made any changes in Pure, your changes will be visible here soon.

Personal profile

Research Interests

The focus of research in my laboratory is to understand the immune basis of prostate disease in humans. We have a particular emphasis on chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), a debilitating medical condition characterized by dysuria and pelvic pain. My laboratory is very interested in understanding the mechanism underlying inflammation of the human prostate and it's impact on prostate diseases. The laboratory utilizes comparative animal models that closely track human prostate disease to examine prostate disease mechanisms and also as tools for translational research. Some specific areas of research interest are as follows - 1. Th1/Th17 mechanisms in chronic pelvic pain: We are interested in understanding the mechanism of T cell mediated pain, the effectors of the pain pathway and measures to modulate Th1/Th17 immune response in animal models and ultimately in humans. 2. Chemokine mechanisms in chronic pelvic pain:We are in the process of identifying the mechanisms that appear to mediate chemokine mediated pelvic pain by focusing both on the prostate as well as on neuronal mechanisms of central sensitization. A further focus of this project is the role of mast cells and mast cell-released intermediates in the pathogenesis of chronic pelvic pain. Identification of biomarkers for CP/CPPS in humans is also an emphasis of this project. 3. Pattern recognition receptors in prostate inflammation: Deficiencies in TLR4 signaling pathways result in increased susceptibility to bacterial infection, and profound defects in innate and adaptive immunity. We are in the process of studying the microbial pathogenesis of prostatic bacterial isolates and dissecting TLR signaling pathways in prostate cells.

Education/Academic qualification

PhD, University of Minnesota

… → 2004

Research interests

  • Autoimmunity
  • Immune Regulation
  • Immunology
  • Infectious Diseases: Bacteria
  • Inflammation
  • Microbial Pathogenesis
  • Pain
  • Urology

Fingerprint Dive into the research topics where Praveen Thumbikat is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 6 Similar Profiles
Pelvic Pain Medicine & Life Sciences
Chronic Pain Medicine & Life Sciences
Prostatitis Medicine & Life Sciences
Uropathogenic Escherichia coli Medicine & Life Sciences
Mannheimia haemolytica Medicine & Life Sciences
Prostate Medicine & Life Sciences
Lymphocyte Function-Associated Antigen-1 Medicine & Life Sciences
Urinary Tract Infections Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2008 2022

Research Output 2001 2019

2 Citations (Scopus)

Role of gram-positive bacteria in chronic pelvic pain syndrome (CPPS)

Murphy, S. F., Anker, J. F., Mazur, D. J., Hall, C., Schaeffer, A. J. & Thumbikat, P., Feb 1 2019, In : Prostate. 79, 2, p. 160-167 8 p.

Research output: Contribution to journalArticle

Pelvic Pain
Gram-Positive Bacteria
Chronic Pain
Hyperalgesia
Prostate
2 Citations (Scopus)
Uropathogenic Escherichia coli
Lower Urinary Tract Symptoms
Fibrosis
Prostate
Cytokines
1 Citation (Scopus)

A bioluminescent and fluorescent orthotopic syngeneic murine model of androgen-dependent and castration-resistant prostate cancer

Anker, J. F., Mok, H., Naseem, A. F., Thumbikat, P. & Abdulkadir, S. A., Mar 6 2018, In : Journal of Visualized Experiments. 2018, 133, e57301.

Research output: Contribution to journalArticle

Castration
Androgens
Tumors
Prostatic Neoplasms
Neoplasms
Prostatitis
Staphylococcus epidermidis
Hyperalgesia
Prostate
Pelvic Pain
2 Citations (Scopus)

Multi-faceted immunomodulatory and tissue-tropic clinical bacterial isolate potentiates prostate cancer immunotherapy

Anker, J. F., Naseem, A. F., Mok, H., Schaeffer, A. J., Abdulkadir, S. A. & Thumbikat, P., Dec 1 2018, In : Nature Communications. 9, 1, 1591.

Research output: Contribution to journalArticle

Tropics
tropical regions
Immunotherapy
Tumors
T-cells