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Puneet Opal

  • 1553 Citations
1991 …2024
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Personal profile

Research Interests

Ataxias, spinocerebellar ataxia, movement disorders, neurodegenerative diseases, stroke, cerebrovascular disorders.

Certifications and Licenses

Neurology

Training Experience

1996Internship, Saint Francis Hospital, Evanston
1999Residency, Univ. of Iowa Hospitals & Clinics
2003Postdoctoral Fellowship, Baylor College Of Medicine

Education/Academic qualification

PhD, Northwestern University Feinberg School of Medicine

… → 1995

MD, University of Poona

… → 1989

Research interests

  • Movement Disorders
  • Neurogenetics
  • Stroke

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  • 1 Similar Profiles
Spinocerebellar Ataxias Medicine & Life Sciences
Intermediate Filaments Medicine & Life Sciences
Leucine Medicine & Life Sciences
Giant Axonal Neuropathy Medicine & Life Sciences
Nuclear Proteins Medicine & Life Sciences
Intermediate Filament Proteins Medicine & Life Sciences
Neurodegenerative Diseases Medicine & Life Sciences
Ataxia Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2003 2024

Understanding pathophysiological mechanisms underlying neurodegeneration

Goldman, R., Opal, P. & Savas, J. N.

National Institute of Neurological Disorders and Stroke

7/1/19 → 6/30/20

Project: Research project

Giant Axonal Neuropathy
Intermediate Filaments
Pathology
Proteins
Ubiquitin-Protein Ligases

Understanding the Cellular Basis of Movement Disorders

Martina, M. & Opal, P.

National Institute of Neurological Disorders and Stroke

6/1/19 → 4/30/24

Project: Research project

Spinocerebellar Ataxias
Movement Disorders
Trinucleotide Repeat Expansion
Purkinje Cells
Neurodegenerative Diseases

Using VEGF-mimetic nanoparticles to treat SCA

Opal, P.

National Ataxia Foundation

3/1/19 → 2/29/20

Project: Research project

Spinocerebellar Ataxias
Nanoparticles
Vascular Endothelial Growth Factor A
Angiogenesis Inducing Agents
Neurodegenerative Diseases

Understanding pathophysiological mechanisms underlying Giant Axonal Neuropathy

Opal, P.

Muscular Dystrophy Association

2/1/19 → 1/31/22

Project: Research project

Giant Axonal Neuropathy
Intermediate Filaments
Neurites
Cranial Nerve Diseases
Mutation

BHV-4157-206: A Phase III, Long-Term, Randomized, Double-blind, Placebo-controlled Trial of BHV-4157 in Adult Subjects with Spinocerebellar Ataxia

Opal, P.

Biohaven Pharmaceuticals, Inc.

11/29/18 → 11/29/21

Project: Research project

Research Output 1991 2019

Loss of the dystonia gene Thap1 leads to transcriptional deficits that converge on common pathogenic pathways in dystonic syndromes

Frederick, N. M., Shah, P. V., Didonna, A., Langley, M. R., Kanthasamy, A. G. & Opal, P., Apr 15 2019, In : Human molecular genetics. 28, 8, p. 1343-1356 14 p.

Research output: Contribution to journal › Article

Dystonia
Genes
Haploinsufficiency
Nestin
Gliosis
2 Citations (Scopus)

Self-assembling vascular endothelial growth factor nanoparticles improve function in spinocerebellar ataxia type 1

Hu, Y. S., Do, J., Edamakanti, C. R., Kini, A. R., Martina, M., Stupp, S. & Opal, P., Feb 1 2019, In : Brain. 142, 2, p. 312-321 10 p.

Research output: Contribution to journal › Article

Spinocerebellar Ataxias
Nanoparticles
Vascular Endothelial Growth Factor A
Nerve Growth Factors
Neurodegenerative Diseases

The role of neurofilament aggregation in neurodegeneration: Lessons from rare inherited neurological disorders

Didonna, A. & Opal, P., May 16 2019, In : Molecular neurodegeneration. 14, 1, 19.

Research output: Contribution to journal › Review article

Open Access
Intermediate Filaments
Nervous System Diseases
Intermediate Filament Proteins
Transport Vesicles
Neurotransmitter Receptor

ANP32A regulates histone H3 acetylation and promotes leukemogenesis

Yang, X., Lu, B., Sun, X., Han, C., Fu, C., Xu, K., Wang, M., Li, D., Chen, Z., Opal, P., Wen, Q., Crispino, J. D., Wang, Q. F. & Huang, Z., Jul 1 2018, In : Leukemia. 32, 7, p. 1587-1597 11 p.

Research output: Contribution to journal › Article

Phosphoproteins
Acetylation
Leucine
Histones
Histone Code
8 Citations (Scopus)

Mutant ataxin1 disrupts cerebellar development in spinocerebellar ataxia type 1

Edamakanti, C. R., Do, J., Didonna, A., Martina, M. & Opal, P., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2252-2265 14 p.

Research output: Contribution to journal › Article

Spinocerebellar Ataxias
Purkinje Cells
Interneurons
Stem Cells
Cerebellar Diseases