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Puneet Opal

  • 1515 Citations
1991 …2024
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Personal profile

Research Interests

Ataxias, spinocerebellar ataxia, movement disorders, neurodegenerative diseases, stroke, cerebrovascular disorders.

Certifications and Licenses

Neurology

Training Experience

1996Internship, Saint Francis Hospital, Evanston
1999Residency, Univ. of Iowa Hospitals & Clinics
2003Postdoctoral Fellowship, Baylor College Of Medicine

Education/Academic qualification

PhD, Northwestern University Feinberg School of Medicine

… → 1995

MD, University of Poona

… → 1989

Keywords

  • Movement Disorders
  • Neurogenetics
  • Stroke

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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2003 2024

Understanding the Cellular Basis of Movement Disorders

Martina, M. & Opal, P.

National Institute of Neurological Disorders and Stroke

6/1/19 → 4/30/24

Project: Research project

Spinocerebellar Ataxias
Movement Disorders
Trinucleotide Repeat Expansion
Purkinje Cells
Neurodegenerative Diseases

Using VEGF-mimetic nanoparticles to treat SCA

Opal, P.

National Ataxia Foundation

3/1/19 → 2/29/20

Project: Research project

Spinocerebellar Ataxias
Nanoparticles
Vascular Endothelial Growth Factor A
Angiogenesis Inducing Agents
Neurodegenerative Diseases

Understanding pathophysiological mechanisms underlying Giant Axonal Neuropathy

Opal, P.

Muscular Dystrophy Association

2/1/19 → 1/31/22

Project: Research project

Giant Axonal Neuropathy
Intermediate Filaments
Neurites
Cranial Nerve Diseases
Mutation

BHV-4157-206: A Phase III, Long-Term, Randomized, Double-blind, Placebo-controlled Trial of BHV-4157 in Adult Subjects with Spinocerebellar Ataxia

Opal, P.

Biohaven Pharmaceuticals, Inc.

11/29/18 → 11/29/21

Project: Research project

Translational studies in Giant axonal neuropathy

Opal, P.

Hannah's Hope for Giant Axonal Neuropathy, Inc.

8/1/18 → 7/31/20

Project: Research project

Giant Axonal Neuropathy
Intermediate Filaments
Small Molecule Libraries
Recessive Genes
Mutation

Research Output 1991 2019

Loss of the dystonia gene Thap1 leads to transcriptional deficits that converge on common pathogenic pathways in dystonic syndromes

Frederick, N. M., Shah, P. V., Didonna, A., Langley, M. R., Kanthasamy, A. G. & Opal, P., Apr 15 2019, In : Human molecular genetics. 28, 8, p. 1343-1356 14 p.

Research output: Contribution to journal › Article

Dystonia
Genes
Haploinsufficiency
Nestin
Gliosis

Self-assembling vascular endothelial growth factor nanoparticles improve function in spinocerebellar ataxia type 1

Hu, Y. S., Do, J., Edamakanti, C. R., Kini, A. R., Martina, M., Stupp, S. & Opal, P., Feb 1 2019, In : Brain. 142, 2, p. 312-321 10 p.

Research output: Contribution to journal › Article

Spinocerebellar Ataxias
Nanoparticles
Vascular Endothelial Growth Factor A
Nerve Growth Factors
Neurodegenerative Diseases

ANP32A regulates histone H3 acetylation and promotes leukemogenesis

Yang, X., Lu, B., Sun, X., Han, C., Fu, C., Xu, K., Wang, M., Li, D., Chen, Z., Opal, P., Wen, Q., Crispino, J. D., Wang, Q. F. & Huang, Z., Jul 1 2018, In : Leukemia. 32, 7, p. 1587-1597 11 p.

Research output: Contribution to journal › Article

Phosphoproteins
Acetylation
Leucine
Histones
Histone Code
6 Citations (Scopus)

Mutant ataxin1 disrupts cerebellar development in spinocerebellar ataxia type 1

Edamakanti, C. R., Do, J., Didonna, A., Martina, M. & Opal, P., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2252-2265 14 p.

Research output: Contribution to journal › Article

Spinocerebellar Ataxias
Purkinje Cells
Interneurons
Stem Cells
Cerebellar Diseases
2 Citations (Scopus)

Trinucleotide Repeat Expansion Diseases, RNAi, and Cancer

Murmann, A. E., Yu, J., Opal, P. & Peter, M. E., Oct 1 2018, In : Trends in Cancer. 4, 10, p. 684-700 17 p.

Research output: Contribution to journal › Review article

Trinucleotide Repeat Expansion
RNA Interference
Trinucleotide Repeats
Neoplasms
Mutant Proteins