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Personal profile

Research Interests

Ataxias, spinocerebellar ataxia, movement disorders, neurodegenerative diseases, stroke, cerebrovascular disorders.

Certifications and Licenses

Neurology

Training Experience

1996Internship, Saint Francis Hospital, Evanston
1999Residency, Univ. of Iowa Hospitals & Clinics
2003Postdoctoral Fellowship, Baylor College Of Medicine

Education/Academic qualification

PhD, Northwestern University Feinberg School of Medicine

… → 1995

MD, University of Poona

… → 1989

Keywords

  • Movement Disorders
  • Neurogenetics
  • Stroke

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Grants 2003 2024

Spinocerebellar Ataxias
Movement Disorders
Trinucleotide Repeat Expansion
Purkinje Cells
Neurodegenerative Diseases
Spinocerebellar Ataxias
Nanoparticles
Vascular Endothelial Growth Factor A
Angiogenesis Inducing Agents
Neurodegenerative Diseases
Giant Axonal Neuropathy
Intermediate Filaments
Neurites
Cranial Nerve Diseases
Mutation
Giant Axonal Neuropathy
Intermediate Filaments
Small Molecule Libraries
Recessive Genes
Mutation

Research Output 1991 2019

Loss of the dystonia gene Thap1 leads to transcriptional deficits that converge on common pathogenic pathways in dystonic syndromes

Frederick, N. M., Shah, P. V., Didonna, A., Langley, M. R., Kanthasamy, A. G. & Opal, P., Apr 15 2019, In : Human molecular genetics. 28, 8, p. 1343-1356 14 p.

Research output: Contribution to journalArticle

Dystonia
Genes
Haploinsufficiency
Nestin
Gliosis

Self-assembling vascular endothelial growth factor nanoparticles improve function in spinocerebellar ataxia type 1

Hu, Y. S., Do, J., Edamakanti, C. R., Kini, A. R., Martina, M., Stupp, S. & Opal, P., Feb 1 2019, In : Brain. 142, 2, p. 312-321 10 p.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
Nanoparticles
Vascular Endothelial Growth Factor A
Nerve Growth Factors
Neurodegenerative Diseases

ANP32A regulates histone H3 acetylation and promotes leukemogenesis

Yang, X., Lu, B., Sun, X., Han, C., Fu, C., Xu, K., Wang, M., Li, D., Chen, Z., Opal, P., Wen, Q., Crispino, J. D., Wang, Q. F. & Huang, Z., Jul 1 2018, In : Leukemia. 32, 7, p. 1587-1597 11 p.

Research output: Contribution to journalArticle

Phosphoproteins
Acetylation
Leucine
Histones
Histone Code
6 Citations (Scopus)

Mutant ataxin1 disrupts cerebellar development in spinocerebellar ataxia type 1

Edamakanti, C. R., Do, J., Didonna, A., Martina, M. & Opal, P., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2252-2265 14 p.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
Purkinje Cells
Interneurons
Stem Cells
Cerebellar Diseases
2 Citations (Scopus)

Trinucleotide Repeat Expansion Diseases, RNAi, and Cancer

Murmann, A. E., Yu, J., Opal, P. & Peter, M. E., Oct 1 2018, In : Trends in Cancer. 4, 10, p. 684-700 17 p.

Research output: Contribution to journalReview article

Trinucleotide Repeat Expansion
RNA Interference
Trinucleotide Repeats
Neoplasms
Mutant Proteins