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Abnormal intermediate filament organization alters mitochondrial motility in giant axonal neuropathy fibroblasts

Lowery, J., Jain, N., Kuczmarski, E. R., Mahammad, S., Goldman, A., Gelfand, V. I., Opal, P. & Goldman, R. D., Feb 15 2016, In : Molecular biology of the cell. 27, 4, p. 608-616 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Alterations in neural intermediate filament organization: Functional implications and the induction of pathological changes related to motor neuron disease

Straube-West, K., Loomis, P. A., Opal, P. & Goldman, R. D., Sep 1 1996, In : Journal of cell science. 109, 9, p. 2319-2329 11 p.

Research output: Contribution to journalArticle

40 Scopus citations

An investigation of diffusion imaging techniques in the evaluation of spinocerebellar ataxia and multisystem atrophy

Rozenfeld, M. N., Nemeth, A. J., Walker, M. T., Mohan, P., Wang, X., Parrish, T. B. & Opal, P., Jan 1 2015, In : Journal of Clinical Neuroscience. 22, 1, p. 166-172 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

ANP32A regulates histone H3 acetylation and promotes leukemogenesis

Yang, X., Lu, B., Sun, X., Han, C., Fu, C., Xu, K., Wang, M., Li, D., Chen, Z., Opal, P., Wen, Q., Crispino, J. D., Wang, Q. F. & Huang, Z., Jul 1 2018, In : Leukemia. 32, 7, p. 1587-1597 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

CPD-1 null mice display a subtle neurological phenotype

Kular, R. K., Gogliotti, R. G. & Opal, P., 2010, In : PloS one. 5, 9, p. 1-7 7 p., e12649.

Research output: Contribution to journalArticle

5 Scopus citations

Dynamic aspects of cytoskeletal and karyoskeletal intermediate filament systems during the cell cycle

Goldman, R. D., Chou, Y. H., Dessev, C., Dessev, G., Eriksson, J., Goldman, A., Khuon, S., Kohnken, R., Lowy, M., Miller, R., Murphy, K., Opal, P., Skalli, O. & Straube, K., 1991, In : Cold Spring Harbor symposia on quantitative biology. 56, p. 629-642 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

Early activation of microglia and astrocytes in mouse models of spinocerebellar ataxia type 1

Cvetanovic, M., Ingram, M., Orr, H. & Opal, P., Mar 9 2015, In : Neuroscience. 289, p. 289-299 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

Generation and Characterization of LANP/pp32 Null Mice

Opal, P., Garcia, J. J., McCall, A. E., Xu, B., Weeber, E. J., Sweatt, J. D., Orr, H. T. & Zoghbi, H. Y., Apr 2004, In : Molecular and cellular biology. 24, 8, p. 3140-3149 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

Giant axonal neuropathy-associated gigaxonin mutations impair intermediate filament protein degradation

Mahammad, S., Prasanna Murthy, S. N., Didonna, A., Grin, B., Israeli, E., Perrot, R., Bomont, P., Julien, J. P., Kuczmarski, E., Opal, P. & Goldman, R. D., May 1 2013, In : Journal of Clinical Investigation. 123, 5, p. 1964-1975 12 p.

Research output: Contribution to journalArticle

60 Scopus citations

In cis autosomal dominant mutation of Senataxin associated with tremor/ataxia syndrome

Bassuk, A. G., Chen, Y. Z., Batish, S. D., Nagan, N., Opal, P., Chance, P. F. & Bennett, C. L., Jan 1 2007, In : Neurogenetics. 8, 1, p. 45-49 5 p.

Research output: Contribution to journalArticle

39 Scopus citations

Intermediate filament aggregates cause mitochondrial dysmotility and increase energy demands in giant axonal neuropathy

Israeli, E., Dryanovski, D. I., Schumacker, P. T., Chandel, N. S., Singer, J. D., Julien, J. P., Goldman, R. D. & Opal, P., Jun 1 2016, In : Human molecular genetics. 25, 11, p. 2143-2157 15 p.

Research output: Contribution to journalArticle

14 Scopus citations

Intermediate filament dynamics

Eriksson, J. E., Opal, P. & Goldman, R. D., Feb 1992, In : Current Opinion in Cell Biology. 4, 1, p. 99-104 6 p.

Research output: Contribution to journalArticle

125 Scopus citations

LANP mediates neuritic pathology in Spinocerebellar ataxia type 1

Cvetanovic, M., Kular, R. K. & Opal, P., Dec 2012, In : Neurobiology of Disease. 48, 3, p. 526-532 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Loss of the dystonia gene Thap1 leads to transcriptional deficits that converge on common pathogenic pathways in dystonic syndromes

Frederick, N. M., Shah, P. V., Didonna, A., Langley, M. R., Kanthasamy, A. G. & Opal, P., Apr 15 2019, In : Human molecular genetics. 28, 8, p. 1343-1356 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

Mapmodulin/Leucine-rich Acidic Nuclear Protein Binds the Light Chain of Microtubule-associated Protein 1B and Modulates Neuritogenesis

Opal, P., Garcia, J. J., Propst, F., Matilla, A., Orr, H. T. & Zoghbi, H. Y., Sep 5 2003, In : Journal of Biological Chemistry. 278, 36, p. 34691-34699 9 p.

Research output: Contribution to journalArticle

54 Scopus citations

Mutant ataxin1 disrupts cerebellar development in spinocerebellar ataxia type 1

Edamakanti, C. R., Do, J., Didonna, A., Martina, M. & Opal, P., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2252-2265 14 p.

Research output: Contribution to journalArticle

15 Scopus citations

Mutant Ataxin-1 Inhibits Neural Progenitor Cell Proliferation in SCA1

Cvetanovic, M., Hu, Y. S. & Opal, P., Apr 1 2017, In : Cerebellum. 16, 2, p. 340-347 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Neuronal atrophy early in degenerative ataxia is a compensatory mechanism to regulate membrane excitability

Dell’Orco, J. M., Wasserman, A. H., Chopra, R., Ingram, M. A. C., Hu, Y. S., Singh, V., Wulff, H., Opal, P., Orr, H. T. & Shakkottai, V. G., Aug 12 2015, In : Journal of Neuroscience. 35, 32, p. 11292-11307 16 p.

Research output: Contribution to journalArticle

50 Scopus citations

Neuronal differentiation is regulated by leucine-rich acidic nuclear protein (LANP), a member of the inhibitor of histone acetyltransferase complex

Kular, R. K., Cvetanovic, M., Siferd, S., Kini, A. R. & Opal, P., Mar 20 2009, In : Journal of Biological Chemistry. 284, 12, p. 7783-7792 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

Cummings, C. J., Sun, Y., Opal, P., Antalffy, B., Mestril, R., Orr, H. T., Dillmann, W. H. & Zoghbi, H. Y., Jul 1 2001, In : Human molecular genetics. 10, 14, p. 1511-1518 8 p.

Research output: Contribution to journalArticle

Open Access
410 Scopus citations

Purification of prominin-1+ stem cells from postnatal mouse cerebellum

Edamakanti, C. R. & Opal, P., Apr 2020, In : Journal of Visualized Experiments. 2020, 158, e60554.

Research output: Contribution to journalArticle

Self-assembling vascular endothelial growth factor nanoparticles improve function in spinocerebellar ataxia type 1

Hu, Y. S., Do, J., Edamakanti, C. R., Kini, A. R., Martina, M., Stupp, S. I. & Opal, P., Feb 1 2019, In : Brain. 142, 2, p. 312-321 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

The function of intermediate filaments in cell shape and cytoskeletal integrity

Goldman, R. D., Khuon, S., Chou, Y. H., Opal, P. & Steinert, P. M., Aug 1996, In : Journal of Cell Biology. 134, 4, p. 971-983 13 p.

Research output: Contribution to journalArticle

282 Scopus citations

The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1

Venkatraman, A., Hu, Y. S., Didonna, A., Cvetanovic, M., Krbanjevic, A., Bilesimo, P. & Opal, P., Jul 2014, In : Human molecular genetics. 23, 14, p. 3733-3745 13 p., ddu081.

Research output: Contribution to journalArticle

23 Scopus citations

The relative roles of specific N- and C-terminal phosphorylation sites in the disassembly of intermediate filament in mitotic BHK-21 cells

Chou, Y. H., Opal, P., Quinlan, R. A. & Goldman, R. D., Apr 1 1996, In : Journal of Cell Science. 109, 4, p. 817-826 10 p.

Research output: Contribution to journalArticle

56 Scopus citations

The role of gigaxonin in the degradation of the glial-specific intermediate filament protein GFAP

Lin, N. H., Huang, Y. S., Opal, P., Goldman, R. D., Messing, A. & Perng, M. D., Dec 15 2016, In : Molecular biology of the cell. 27, 25, p. 3980-3990 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

The role of LANP and ataxin 1 in E4F-mediated transcriptional repression

Cvetanovic, M., Rooney, R. J., Garcia, J. J., Toporovskaya, N., Zoghbi, H. Y. & Opal, P., Jul 2007, In : EMBO Reports. 8, 7, p. 671-677 7 p.

Research output: Contribution to journalArticle

39 Scopus citations

Vascular endothelial growth factor ameliorates the ataxic phenotype in a mouse model of spinocerebellar ataxia type 1

Cvetanovic, M., Patel, J. M., Marti, H. H., Kini, A. R. & Opal, P., Nov 2011, In : Nature Medicine. 17, 11, p. 1445-1447 3 p.

Research output: Contribution to journalArticle

59 Scopus citations