Qi Cao

  • 8856 Citations
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Personal profile

Training Experience

2012Postdoctoral Fellowship, University of Michigan

Research Interests

I have been working on prostate cancer and epigenetics for over 15 years and published over 30 peer-reviewed publications. My major contributions to the field of prostate cancer and other cancer research include: (1) identification of PcG protein histone methyltransferase EZH2 as a biomarker for aggressive breast and prostate cancer; (2) characterization of EZH2 as an oncogene by repressing multiple tumor suppressors in breast and prostate cancer; (3) discovery of genomic loss of miR-101 in breast and prostate cancer and the upregulation of EZH2 by miR-101 in cancer; and (4) the coordinated regulation between Polycomb Repressive Complexes 1 and 2 in breast and prostate cancer progression. My work has demonstrated EZH2 and BMI1 as valuable therapeutic targets in cancer, and several pharmaceutical companies are developing EZH2- or BMI1- specific inhibitors for cancer therapy.

Education/Academic qualification

PhD, University of Michigan

… → 2008

MS, Peking University

… → 2001

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  • 6 Similar Profiles
Prostatic Neoplasms Medicine & Life Sciences
Gene Fusion Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Polycomb-Group Proteins Medicine & Life Sciences
Androgen Receptors Medicine & Life Sciences
Long Noncoding RNA Medicine & Life Sciences
MicroRNAs Medicine & Life Sciences
Sarcosine Medicine & Life Sciences

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Grants 2018 2022

RNA Editing
Prostatic Neoplasms
immune RNA
Prostatic Neoplasms
Aurora Kinases
Polycomb-Group Proteins
Triple Negative Breast Neoplasms
Breast Neoplasms
Polycomb Repressive Complex 2
Polycomb-Group Proteins
DNA Repair
Nitric Oxide Synthase Type II
Cell Lineage
Computational Biology
Histone Code
Transcription Factors

Research Output 2003 2020

  • 8856 Citations
  • 38 Article
  • 3 Comment/debate
  • 2 Letter
  • 2 Review article

BMI1 is directly regulated by androgen receptor to promote castration-resistance in prostate cancer

Zhu, S., Zhao, D., Li, C., Li, Q., Jiang, W., Liu, Q., Wang, R., Fazli, L., Li, Y., Zhang, L., Yi, Y., Meng, Q., Wang, W., Wang, G., Zhang, M., Zu, X., Zhao, W., Deng, T., Yu, J., Dong, X. & 2 others, Chen, K. & Cao, Q., Jan 2 2020, In : Oncogene. 39, 1, p. 17-29 13 p.

Research output: Contribution to journalArticle

Androgen Receptors
Prostatic Neoplasms
1 Citation (Scopus)

B lymphoma Moloney murine leukemia virus insertion region 1: An oncogenic mediator in prostate cancer

Liu, Q., Li, Q., Zhu, S., Yi, Y. & Cao, Q., May 1 2019, In : Asian Journal of Andrology. 21, 3, p. 224-232 9 p.

Research output: Contribution to journalReview article

Open Access
Moloney murine leukemia virus
Prostatic Neoplasms

Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression

Vantaku, V., Putluri, V., Bader, D. A., Maity, S., Ma, J., Arnold, J. M., Rajapakshe, K., Donepudi, S. R., von Rundstedt, F. C., Devarakonda, V., Dubrulle, J., Karanam, B., McGuire, S. E., Stossi, F., Jain, A. K., Coarfa, C., Cao, Q., Sikora, A. G., Villanueva, H., Kavuri, S. M. & 3 others, Lotan, Y., Sreekumar, A. & Putluri, N., Jan 1 2019, In : Oncogene.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Aldehyde Oxidase
2 Citations (Scopus)

N6-methyladenosine modulates nonsense-mediated mRNA decay in human glioblastoma

Li, F., Yi, Y., Miao, Y., Long, W., Long, T., Chen, S., Cheng, W., Zou, C., Zheng, Y., Wu, X., Ding, J., Zhu, K., Chen, D., Xu, Q., Wang, J., Liu, Q., Zhi, F., Ren, J., Cao, Q. & Zhao, W., Nov 15 2019, In : Cancer Research. 79, 22, p. 5785-5798 14 p.

Research output: Contribution to journalArticle

Nonsense Mediated mRNA Decay
Protein Isoforms
Stem Cells
Alternative Splicing
2 Citations (Scopus)

Polycomb group proteins EZH2 and EED directly regulate androgen receptor in advanced prostate cancer

Liu, Q., Wang, G., Li, Q., Jiang, W., Kim, J. S., Wang, R., Zhu, S., Wang, X., Yan, L., Yi, Y., Zhang, L., Meng, Q., Li, C., Zhao, D., Qiao, Y., Li, Y., Gursel, D. B., Chinnaiyan, A. M., Chen, K. & Cao, Q., Jul 15 2019, In : International Journal of Cancer. 145, 2, p. 415-426 12 p.

Research output: Contribution to journalArticle

Polycomb-Group Proteins
Androgen Receptors
Embryonic Development
Prostatic Neoplasms