Grants per year
Personal profile
Training Experience
| 2012 | Postdoctoral Fellowship, University of Michigan |
Research Interests
I have been working on prostate cancer and epigenetics for over 15 years and published over 30 peer-reviewed publications. My major contributions to the field of prostate cancer and other cancer research include: (1) identification of PcG protein histone methyltransferase EZH2 as a biomarker for aggressive breast and prostate cancer; (2) characterization of EZH2 as an oncogene by repressing multiple tumor suppressors in breast and prostate cancer; (3) discovery of genomic loss of miR-101 in breast and prostate cancer and the upregulation of EZH2 by miR-101 in cancer; and (4) the coordinated regulation between Polycomb Repressive Complexes 1 and 2 in breast and prostate cancer progression. My work has demonstrated EZH2 and BMI1 as valuable therapeutic targets in cancer, and several pharmaceutical companies are developing EZH2- or BMI1- specific inhibitors for cancer therapy.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Pathology, University of Michigan
… → 2008
MS, Cell Biology, Peking University
… → 2001
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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A novel role for EZH2 in PARP regulation and PARPi-resistance in prostate cancer
Cao, Q. (PD/PI), Abdulkadir, S. A. (Co-Investigator) & Yang, R. (Co-Investigator)
7/12/24 → 6/30/29
Project: Research project
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A novel role for EZH2 in A-to-I RNA editing in prostate cancer
Cao, Q. (PD/PI), Abdulkadir, S. A. (Co-Investigator), Schaeffer, E. M. (Co-Investigator) & Meng, Q. (Other)
2/5/24 → 1/31/29
Project: Research project
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Enhancing the Comprehensive Investigation of AR mRNA Interactome in Advanced Prostate Cancer
Cao, Q. (Other), Cao, Q. (Other), Yang, R. (Other) & Yang, R. (Other)
U.S. Army Medical Research and Materiel Command
9/1/23 → 8/31/25
Project: Research project
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A non-canonical role for EZH2 in rRNA methtlation
Cao, Q. (PD/PI), Cao, Q. (PD/PI), Abdulkadir, S. A. (Co-Investigator), Abdulkadir, S. A. (Co-Investigator), Platanias, L. C. (Co-Investigator), Platanias, L. C. (Co-Investigator), Yi, Y. (Other) & Yi, Y. (Other)
7/15/21 → 6/30/26
Project: Research project
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The regulatory axis of lncRNA PRCAT71-AR in advanced prostate cancer
Cao, Q. (Other) & Schaeffer, E. M. (Other)
U.S. Army Medical Research and Materiel Command
9/1/21 → 8/31/24
Project: Research project
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Androgen receptor–regulated lncRNA PRCAT71 promotes AR signaling through the interaction with KHSRP in prostate cancer
Yang, Y., Wang, T. Y., Li, Q., Lu, J., Ren, Y., Weiner, A. B., Fry, J., Liu, Q., Yum, C., Wang, R., Guo, Q., Wan, Y., Ji, Z., Dong, X., Lotan, T. L., Schaeffer, E. M., Yang, R. & Cao, Q., Apr 11 2025, In: Science Advances. 11, 15, eadk6989.Research output: Contribution to journal › Article › peer-review
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ERRATUM: Roles of the HOXA10 gene during castrate-resistant prostate cancer progression
Long, Z., Li, Y., Gan, Y., Zhao, D., Wang, G., Xie, N., Lovnicki, J. M., Fazli, L., Cao, Q., Chen, K. & Dong, X., Jun 1 2025, In: Endocrine-related cancer. 32, 6Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
The detection, function, and therapeutic potential of RNA 2'-O-methylation
Wu, K., Li, Y., Yi, Y., Yu, Y., Wang, Y., Zhang, L., Cao, Q. & Chen, K., Feb 2025, In: Innovation Life. 3, 1, 100112.Research output: Contribution to journal › Review article › peer-review
1 Scopus citations -
2′-O-methylation at internal sites on mRNA promotes mRNA stability
Li, Y., Yi, Y., Gao, X., Wang, X., Zhao, D., Wang, R., Zhang, L. S., Gao, B., Zhang, Y., Zhang, L., Cao, Q. & Chen, K., Jun 20 2024, In: Molecular cell. 84, 12, p. 2320-2336.e6Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
EZH2 directly methylates PARP1 and regulates its activity in cancer
Meng, Q., Shen, J., Ren, Y., Liu, Q., Wang, R., Li, Q., Jiang, W., Wang, Q., Zhang, Y., Trinidad, J. C., Lu, X., Wang, T., Li, Y., Yum, C., Yi, Y., Yang, Y., Zhao, D., Harris, C., Kalantry, S. & Chen, K. & 3 others, , Nov 29 2024, In: Science Advances. 10, 48, eadl2804.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations
Datasets
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Additional file 2 of LncGSEA: a versatile tool to infer lncRNA associated pathways from large-scale cancer transcriptome sequencing data
Ren, Y. (Creator), Wang, T.-Y. (Creator), Anderton, L. C. (Creator), Cao, Q. (Creator) & Yang, R. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.15064797, https://springernature.figshare.com/articles/dataset/Additional_file_2_of_LncGSEA_a_versatile_tool_to_infer_lncRNA_associated_pathways_from_large-scale_cancer_transcriptome_sequencing_data/15064797
Dataset
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Coordinated regulation of polycomb group complexes through microRNAs in cancer
Cao, Q. (Contributor), Ateeq, B. (Contributor), Jing, X. (Contributor), Cao, X. (Contributor), Wang, R. (Contributor), Li, Y. (Contributor), Dahiya, A. (Contributor), Wang, L. (Contributor), Pandhi, M. (Contributor), Palanisamy, N. (Contributor), Qin, Z. (Contributor), Yu, J. (Contributor) & Varambally, S. (Contributor), ArrayExpress, 2011
https://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-26996
Dataset
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An Integrated Network of Androgen Receptor and TMPRSS2-ERG Gene Fusion in Prostate Cancer Progression (II)
Yu, J. (Contributor), Yu, J. (Contributor), Cao, Q. (Contributor), Cao, X. (Contributor), Wang, X. (Contributor), Wu, L. (Contributor), Li, J. (Contributor), Hu, M. (Contributor), Gong, Y. (Contributor), Cheng, H. (Contributor), Laxman, B. (Contributor), Vellaichamy, A. (Contributor), Shankar, S. (Contributor), Li, Y. (Contributor), Morey, R. (Contributor), Barrette, T. (Contributor) & Varambally, S. (Contributor), ArrayExpress, 2010
https://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-14092
Dataset
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The African swine fever virus protease pS273R inhibits DNA sensing cGAS-STING pathway by targeting IKKε
Luo, J. (Creator), Zhang, J. (Creator), Ni, J. (Creator), Jiang, S. (Creator), Xia, N. (Creator), Guo, Y. (Creator), Shao, Q. (Creator), Cao, Q. (Creator), Zheng, W. (Creator), Chen, N. (Creator), Zhang, Q. (Creator), Chen, H. (Creator), Chen, Q. (Creator), Zhu, H. (Creator), Meurens, F. (Creator) & Zhu, J. (Creator), Taylor & Francis, 2022
DOI: 10.6084/m9.figshare.19612991.v1, https://tandf.figshare.com/articles/dataset/The_African_swine_fever_virus_protease_pS273R_inhibits_DNA_sensing_cGAS-STING_pathway_by_targeting_IKK_/19612991/1
Dataset
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LncGSEA: a versatile tool to infer lncRNA associated pathways from large-scale cancer transcriptome sequencing data
Ren, Y. (Creator), Wang, T.-Y. (Creator), Anderton, L. C. (Creator), Cao, Q. (Creator) & Yang, R. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.c.5531415, https://springernature.figshare.com/collections/LncGSEA_a_versatile_tool_to_infer_lncRNA_associated_pathways_from_large-scale_cancer_transcriptome_sequencing_data/5531415
Dataset