Grants per year
Personal profile
Training Experience
| 2012 | Postdoctoral Fellowship, University of Michigan |
Research Interests
I have been working on prostate cancer and epigenetics for over 15 years and published over 30 peer-reviewed publications. My major contributions to the field of prostate cancer and other cancer research include: (1) identification of PcG protein histone methyltransferase EZH2 as a biomarker for aggressive breast and prostate cancer; (2) characterization of EZH2 as an oncogene by repressing multiple tumor suppressors in breast and prostate cancer; (3) discovery of genomic loss of miR-101 in breast and prostate cancer and the upregulation of EZH2 by miR-101 in cancer; and (4) the coordinated regulation between Polycomb Repressive Complexes 1 and 2 in breast and prostate cancer progression. My work has demonstrated EZH2 and BMI1 as valuable therapeutic targets in cancer, and several pharmaceutical companies are developing EZH2- or BMI1- specific inhibitors for cancer therapy.
Education/Academic qualification
PhD, University of Michigan
… → 2008
MS, Peking University
… → 2001
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Grants
The role of A-to-I RNA editing in advanced prostate cancer
U.S. Army Medical Research and Materiel Command
9/30/19 → 9/29/22
Project: Research project
Role of S-nitrosylation in Transdifferentiation
Methodist Hospital Research Institute, National Heart, Lung, and Blood Institute
7/1/18 → 3/31/22
Project: Research project
The EZH2 and Chromosomal Passenger Complex Network in Prostate Cancer
7/1/18 → 12/31/20
Project: Research project
Combinational Targeting EZH2 and PARP1 in Prostate Cancer
U.S. Army Medical Research and Materiel Command
7/1/18 → 8/31/21
Project: Research project
The inhibitory network between EZH2 and PARP1 in triple-negative breast cancer
7/1/18 → 2/28/22
Project: Research project
Research Output
BMI1 is directly regulated by androgen receptor to promote castration-resistance in prostate cancer
Zhu, S., Zhao, D., Li, C., Li, Q., Jiang, W., Liu, Q., Wang, R., Fazli, L., Li, Y., Zhang, L., Yi, Y., Meng, Q., Wang, W., Wang, G., Zhang, M., Zu, X., Zhao, W., Deng, T., Yu, J., Dong, X. & 2 others, , Jan 2 2020, In : Oncogene. 39, 1, p. 17-29 13 p.Research output: Contribution to journal › Article
Machine learning uncovers cell identity regulator by histone code
Xia, B., Zhao, D., Wang, G., Zhang, M., Lv, J., Tomoiaga, A. S., Li, Y., Wang, X., Meng, S., Cooke, J. P., Cao, Q., Zhang, L. & Chen, K., Dec 1 2020, In : Nature communications. 11, 1, 2696.Research output: Contribution to journal › Article
Open Access
TADsplimer reveals splits and mergers of topologically associating domains for epigenetic regulation of transcription
Wang, G., Meng, Q., Xia, B., Zhang, S., Lv, J., Zhao, D., Li, Y., Wang, X., Zhang, L., Cooke, J. P., Cao, Q. & Chen, K., Apr 2 2020, In : Genome biology. 21, 1, 84.Research output: Contribution to journal › Article
Open Access
B lymphoma Moloney murine leukemia virus insertion region 1: An oncogenic mediator in prostate cancer
Liu, Q., Li, Q., Zhu, S., Yi, Y. & Cao, Q., May 1 2019, In : Asian Journal of Andrology. 21, 3, p. 224-232 9 p.Research output: Contribution to journal › Review article
Open Access
1
Scopus
citations
Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression
Vantaku, V., Putluri, V., Bader, D. A., Maity, S., Ma, J., Arnold, J. M., Rajapakshe, K., Donepudi, S. R., von Rundstedt, F. C., Devarakonda, V., Dubrulle, J., Karanam, B., McGuire, S. E., Stossi, F., Jain, A. K., Coarfa, C., Cao, Q., Sikora, A. G., Villanueva, H., Kavuri, S. M. & 3 others, , Jan 1 2019, In : Oncogene.Research output: Contribution to journal › Article
2
Scopus
citations