Qi Cao

Personal profile

Training Experience

2012	Postdoctoral Fellowship, University of Michigan

Research Interests

I have been working on prostate cancer and epigenetics for over 15 years and published over 30 peer-reviewed publications. My major contributions to the field of prostate cancer and other cancer research include: (1) identification of PcG protein histone methyltransferase EZH2 as a biomarker for aggressive breast and prostate cancer; (2) characterization of EZH2 as an oncogene by repressing multiple tumor suppressors in breast and prostate cancer; (3) discovery of genomic loss of miR-101 in breast and prostate cancer and the upregulation of EZH2 by miR-101 in cancer; and (4) the coordinated regulation between Polycomb Repressive Complexes 1 and 2 in breast and prostate cancer progression. My work has demonstrated EZH2 and BMI1 as valuable therapeutic targets in cancer, and several pharmaceutical companies are developing EZH2- or BMI1- specific inhibitors for cancer therapy.

Education/Academic qualification

PhD, University of Michigan

… → 2008

MS, Peking University

… → 2001

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6 Similar Profiles

Prostatic Neoplasms Medicine & Life Sciences

Gene Fusion Medicine & Life Sciences

Neoplasms Medicine & Life Sciences

Polycomb-Group Proteins Medicine & Life Sciences

Androgen Receptors Medicine & Life Sciences

Long Noncoding RNA Medicine & Life Sciences

MicroRNAs Medicine & Life Sciences

Sarcosine Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2018 2022

1 Finished
5 Active

The role of A-to-I RNA editing in advanced prostate cancer

Thaxton, C. S. & Cao, Q.

U.S. Army Medical Research and Materiel Command

9/30/19 → 9/29/22

Project: Research project

RNA Editing

Prostatic Neoplasms

RNA

Proteins

immune RNA

The EZH2 and Chromosomal Passenger Complex Network in Prostate Cancer

Cao, Q.

American Cancer Society

7/1/18 → 12/31/19

Project: Research project

Prostatic Neoplasms

Aurora Kinases

Polycomb-Group Proteins

Proteins

Neoplasms

The inhibitory network between EZH2 and PARP1 in triple-negative breast cancer

Cao, Q.

National Cancer Institute

7/1/18 → 2/28/22

Project: Research project

Triple Negative Breast Neoplasms

Breast Neoplasms

Polycomb Repressive Complex 2

Polycomb-Group Proteins

DNA Repair

Role of S-nitrosylation in Transdifferentiation

Cao, Q.

Methodist Hospital Research Institute, National Heart, Lung, and Blood Institute

7/1/18 → 3/31/22

Project: Research project

Epigenomics

Nitric Oxide Synthase Type II

Enzymes

Chromatin

Cell Lineage

Computational epigenetics modeling of cell identity genes

Cao, Q.

Methodist Hospital Research Institute, National Institute of General Medical Sciences

7/1/18 → 4/30/20

Project: Research project

Epigenomics

Genes

Computational Biology

Histone Code

Transcription Factors

Research Output 2003 2020

8856 Citations
38 Article
3 Comment/debate
2 Letter
2 Review article

BMI1 is directly regulated by androgen receptor to promote castration-resistance in prostate cancer

Zhu, S., Zhao, D., Li, C., Li, Q., Jiang, W., Liu, Q., Wang, R., Fazli, L., Li, Y., Zhang, L., Yi, Y., Meng, Q., Wang, W., Wang, G., Zhang, M., Zu, X., Zhao, W., Deng, T., Yu, J., Dong, X. & 2 others, Chen, K. & Cao, Q., Jan 2 2020, In : Oncogene. 39, 1, p. 17-29 13 p.

Research output: Contribution to journal › Article

Castration

Androgen Receptors

Lymphoma

Prostatic Neoplasms

Neoplasms

1 Citation (Scopus)

B lymphoma Moloney murine leukemia virus insertion region 1: An oncogenic mediator in prostate cancer

Liu, Q., Li, Q., Zhu, S., Yi, Y. & Cao, Q., May 1 2019, In : Asian Journal of Andrology. 21, 3, p. 224-232 9 p.

Research output: Contribution to journal › Review article

Open Access

Moloney murine leukemia virus

Lymphoma

Prostatic Neoplasms

Neoplasms

Epigenomics

Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression

Vantaku, V., Putluri, V., Bader, D. A., Maity, S., Ma, J., Arnold, J. M., Rajapakshe, K., Donepudi, S. R., von Rundstedt, F. C., Devarakonda, V., Dubrulle, J., Karanam, B., McGuire, S. E., Stossi, F., Jain, A. K., Coarfa, C., Cao, Q., Sikora, A. G., Villanueva, H., Kavuri, S. M. & 3 others, Lotan, Y., Sreekumar, A. & Putluri, N., Jan 1 2019, In : Oncogene.

Research output: Contribution to journal › Article

Urinary Bladder Neoplasms

Epigenomics

NADP

Nucleotides

Aldehyde Oxidase

2 Citations (Scopus)

N⁶-methyladenosine modulates nonsense-mediated mRNA decay in human glioblastoma

Li, F., Yi, Y., Miao, Y., Long, W., Long, T., Chen, S., Cheng, W., Zou, C., Zheng, Y., Wu, X., Ding, J., Zhu, K., Chen, D., Xu, Q., Wang, J., Liu, Q., Zhi, F., Ren, J., Cao, Q. & Zhao, W., Nov 15 2019, In : Cancer Research. 79, 22, p. 5785-5798 14 p.

Research output: Contribution to journal › Article

Nonsense Mediated mRNA Decay

Glioblastoma

Protein Isoforms

Stem Cells

Alternative Splicing

2 Citations (Scopus)

Polycomb group proteins EZH2 and EED directly regulate androgen receptor in advanced prostate cancer

Liu, Q., Wang, G., Li, Q., Jiang, W., Kim, J. S., Wang, R., Zhu, S., Wang, X., Yan, L., Yi, Y., Zhang, L., Meng, Q., Li, C., Zhao, D., Qiao, Y., Li, Y., Gursel, D. B., Chinnaiyan, A. M., Chen, K. & Cao, Q., Jul 15 2019, In : International Journal of Cancer. 145, 2, p. 415-426 12 p.

Research output: Contribution to journal › Article

Polycomb-Group Proteins

Ectoderm

Androgen Receptors

Embryonic Development

Prostatic Neoplasms