Qi Cao

  • 9189 Citations
20032020

Research output per year

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Personal profile

Training Experience

2012Postdoctoral Fellowship, University of Michigan

Research Interests

I have been working on prostate cancer and epigenetics for over 15 years and published over 30 peer-reviewed publications. My major contributions to the field of prostate cancer and other cancer research include: (1) identification of PcG protein histone methyltransferase EZH2 as a biomarker for aggressive breast and prostate cancer; (2) characterization of EZH2 as an oncogene by repressing multiple tumor suppressors in breast and prostate cancer; (3) discovery of genomic loss of miR-101 in breast and prostate cancer and the upregulation of EZH2 by miR-101 in cancer; and (4) the coordinated regulation between Polycomb Repressive Complexes 1 and 2 in breast and prostate cancer progression. My work has demonstrated EZH2 and BMI1 as valuable therapeutic targets in cancer, and several pharmaceutical companies are developing EZH2- or BMI1- specific inhibitors for cancer therapy.

Education/Academic qualification

PhD, University of Michigan

… → 2008

MS, Peking University

… → 2001

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Grants

  • Research Output

    • 9189 Citations
    • 40 Article
    • 3 Comment/debate
    • 2 Letter
    • 2 Review article

    BMI1 is directly regulated by androgen receptor to promote castration-resistance in prostate cancer

    Zhu, S., Zhao, D., Li, C., Li, Q., Jiang, W., Liu, Q., Wang, R., Fazli, L., Li, Y., Zhang, L., Yi, Y., Meng, Q., Wang, W., Wang, G., Zhang, M., Zu, X., Zhao, W., Deng, T., Yu, J., Dong, X. & 2 others, Chen, K. & Cao, Q., Jan 2 2020, In : Oncogene. 39, 1, p. 17-29 13 p.

    Research output: Contribution to journalArticle

  • Machine learning uncovers cell identity regulator by histone code

    Xia, B., Zhao, D., Wang, G., Zhang, M., Lv, J., Tomoiaga, A. S., Li, Y., Wang, X., Meng, S., Cooke, J. P., Cao, Q., Zhang, L. & Chen, K., Dec 1 2020, In : Nature communications. 11, 1, 2696.

    Research output: Contribution to journalArticle

    Open Access
  • TADsplimer reveals splits and mergers of topologically associating domains for epigenetic regulation of transcription

    Wang, G., Meng, Q., Xia, B., Zhang, S., Lv, J., Zhao, D., Li, Y., Wang, X., Zhang, L., Cooke, J. P., Cao, Q. & Chen, K., Apr 2 2020, In : Genome biology. 21, 1, 84.

    Research output: Contribution to journalArticle

    Open Access
  • B lymphoma Moloney murine leukemia virus insertion region 1: An oncogenic mediator in prostate cancer

    Liu, Q., Li, Q., Zhu, S., Yi, Y. & Cao, Q., May 1 2019, In : Asian Journal of Andrology. 21, 3, p. 224-232 9 p.

    Research output: Contribution to journalReview article

    Open Access
  • 1 Scopus citations

    Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression

    Vantaku, V., Putluri, V., Bader, D. A., Maity, S., Ma, J., Arnold, J. M., Rajapakshe, K., Donepudi, S. R., von Rundstedt, F. C., Devarakonda, V., Dubrulle, J., Karanam, B., McGuire, S. E., Stossi, F., Jain, A. K., Coarfa, C., Cao, Q., Sikora, A. G., Villanueva, H., Kavuri, S. M. & 3 others, Lotan, Y., Sreekumar, A. & Putluri, N., Jan 1 2019, In : Oncogene.

    Research output: Contribution to journalArticle

  • 2 Scopus citations