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Qi Cao

  • 9016 Citations
20032022

Research output per year

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Personal profile

Training Experience

2012Postdoctoral Fellowship, University of Michigan

Research Interests

I have been working on prostate cancer and epigenetics for over 15 years and published over 30 peer-reviewed publications. My major contributions to the field of prostate cancer and other cancer research include: (1) identification of PcG protein histone methyltransferase EZH2 as a biomarker for aggressive breast and prostate cancer; (2) characterization of EZH2 as an oncogene by repressing multiple tumor suppressors in breast and prostate cancer; (3) discovery of genomic loss of miR-101 in breast and prostate cancer and the upregulation of EZH2 by miR-101 in cancer; and (4) the coordinated regulation between Polycomb Repressive Complexes 1 and 2 in breast and prostate cancer progression. My work has demonstrated EZH2 and BMI1 as valuable therapeutic targets in cancer, and several pharmaceutical companies are developing EZH2- or BMI1- specific inhibitors for cancer therapy.

Education/Academic qualification

PhD, University of Michigan

… → 2008

MS, Peking University

… → 2001

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Grants

The role of A-to-I RNA editing in advanced prostate cancer

Thaxton, C. S. & Cao, Q.

U.S. Army Medical Research and Materiel Command

9/30/19 → 9/29/22

Project: Research project

    • The EZH2 and Chromosomal Passenger Complex Network in Prostate Cancer

    Cao, Q.

    American Cancer Society

    7/1/18 → 12/31/20

    Project: Research project

    • Role of S-nitrosylation in Transdifferentiation

    Cao, Q.

    Methodist Hospital Research Institute, National Heart, Lung, and Blood Institute

    7/1/18 → 3/31/22

    Project: Research project

    • Computational epigenetics modeling of cell identity genes

    Cao, Q.

    Methodist Hospital Research Institute, National Institute of General Medical Sciences

    7/1/18 → 4/30/20

    Project: Research project

    • The inhibitory network between EZH2 and PARP1 in triple-negative breast cancer

    Cao, Q.

    National Cancer Institute

    7/1/18 → 2/28/22

    Project: Research project

    • Research Output

    • 9016 Citations
    • 38 Article
    • 3 Comment/debate
    • 2 Letter
    • 2 Review article

    BMI1 is directly regulated by androgen receptor to promote castration-resistance in prostate cancer

    Zhu, S., Zhao, D., Li, C., Li, Q., Jiang, W., Liu, Q., Wang, R., Fazli, L., Li, Y., Zhang, L., Yi, Y., Meng, Q., Wang, W., Wang, G., Zhang, M., Zu, X., Zhao, W., Deng, T., Yu, J., Dong, X. & 2 others, Chen, K. & Cao, Q., Jan 2 2020, In : Oncogene. 39, 1, p. 17-29 13 p.

    Research output: Contribution to journal › Article

    • B lymphoma Moloney murine leukemia virus insertion region 1: An oncogenic mediator in prostate cancer

    Liu, Q., Li, Q., Zhu, S., Yi, Y. & Cao, Q., May 1 2019, In : Asian Journal of Andrology. 21, 3, p. 224-232 9 p.

    Research output: Contribution to journal › Review article

    Open Access
    • 1 Scopus citations

    Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression

    Vantaku, V., Putluri, V., Bader, D. A., Maity, S., Ma, J., Arnold, J. M., Rajapakshe, K., Donepudi, S. R., von Rundstedt, F. C., Devarakonda, V., Dubrulle, J., Karanam, B., McGuire, S. E., Stossi, F., Jain, A. K., Coarfa, C., Cao, Q., Sikora, A. G., Villanueva, H., Kavuri, S. M. & 3 others, Lotan, Y., Sreekumar, A. & Putluri, N., Jan 1 2019, In : Oncogene.

    Research output: Contribution to journal › Article

    • N6-methyladenosine modulates nonsense-mediated mRNA decay in human glioblastoma

    Li, F., Yi, Y., Miao, Y., Long, W., Long, T., Chen, S., Cheng, W., Zou, C., Zheng, Y., Wu, X., Ding, J., Zhu, K., Chen, D., Xu, Q., Wang, J., Liu, Q., Zhi, F., Ren, J., Cao, Q. & Zhao, W., Nov 15 2019, In : Cancer Research. 79, 22, p. 5785-5798 14 p.

    Research output: Contribution to journal › Article

    • 5 Scopus citations

    Polycomb group proteins EZH2 and EED directly regulate androgen receptor in advanced prostate cancer

    Liu, Q., Wang, G., Li, Q., Jiang, W., Kim, J. S., Wang, R., Zhu, S., Wang, X., Yan, L., Yi, Y., Zhang, L., Meng, Q., Li, C., Zhao, D., Qiao, Y., Li, Y., Gursel, D. B., Chinnaiyan, A. M., Chen, K. & Cao, Q., Jul 15 2019, In : International Journal of Cancer. 145, 2, p. 415-426 12 p.

    Research output: Contribution to journal › Article

    • 5 Scopus citations