Grants per year
Personal profile
Training Experience
| 2012 | Postdoctoral Fellowship, University of Michigan |
Research Interests
I have been working on prostate cancer and epigenetics for over 15 years and published over 30 peer-reviewed publications. My major contributions to the field of prostate cancer and other cancer research include: (1) identification of PcG protein histone methyltransferase EZH2 as a biomarker for aggressive breast and prostate cancer; (2) characterization of EZH2 as an oncogene by repressing multiple tumor suppressors in breast and prostate cancer; (3) discovery of genomic loss of miR-101 in breast and prostate cancer and the upregulation of EZH2 by miR-101 in cancer; and (4) the coordinated regulation between Polycomb Repressive Complexes 1 and 2 in breast and prostate cancer progression. My work has demonstrated EZH2 and BMI1 as valuable therapeutic targets in cancer, and several pharmaceutical companies are developing EZH2- or BMI1- specific inhibitors for cancer therapy.
Education/Academic qualification
PhD, University of Michigan
… → 2008
MS, Peking University
… → 2001
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Grants
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The role of BMI1-associated lncRNAs in advanced prostate cancer
U.S. Army Medical Research and Materiel Command
9/30/20 → 9/29/23
Project: Research project
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Effects of Epigenetic Regulation in Chronic Pelvic Pain Syndrome
Flury, S. C., Schaeffer, A. J., Thumbikat, P. & Cao, Q.
National Institute of Diabetes and Digestive and Kidney Diseases
9/15/20 → 7/31/23
Project: Research project
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The role of A-to-I RNA editing in advanced prostate cancer
U.S. Army Medical Research and Materiel Command
9/30/19 → 9/29/22
Project: Research project
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The EZH2 and Chromosomal Passenger Complex Network in Prostate Cancer
7/1/18 → 6/30/21
Project: Research project
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Role of S-nitrosylation in Transdifferentiation
Methodist Hospital Research Institute, National Heart, Lung, and Blood Institute
7/1/18 → 3/31/22
Project: Research project
Research Output
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BMI1 is directly regulated by androgen receptor to promote castration-resistance in prostate cancer
Zhu, S., Zhao, D., Li, C., Li, Q., Jiang, W., Liu, Q., Wang, R., Fazli, L., Li, Y., Zhang, L., Yi, Y., Meng, Q., Wang, W., Wang, G., Zhang, M., Zu, X., Zhao, W., Deng, T., Yu, J., Dong, X. & 2 others, , Jan 2 2020, In: Oncogene. 39, 1, p. 17-29 13 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Broad genic repression domains signify enhanced silencing of oncogenes
Zhao, D., Zhang, L., Zhang, M., Xia, B., Lv, J., Gao, X., Wang, G., Meng, Q., Yi, Y., Zhu, S., Tomoiaga, A. S., Lee, M. G., Cooke, J. P., Cao, Q. & Chen, K., Dec 1 2020, In: Nature communications. 11, 1, 5560.Research output: Contribution to journal › Article › peer-review
Open Access -
Correction: Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression (Oncogene, (2020), 39, 40, (6265-6285), 10.1038/s41388-019-0902-7)
Vantaku, V., Putluri, V., Bader, D. A., Maity, S., Ma, J., Arnold, J. M., Rajapakshe, K., Donepudi, S. R., von Rundstedt, F. C., Devarakonda, V., Dubrulle, J., Karanam, B., McGuire, S. E., Stossi, F., Jain, A. K., Coarfa, C., Cao, Q., Sikora, A. G., Villanueva, H., Kavuri, S. M. & 3 others, , Oct 1 2020, In: Oncogene. 39, 40, p. 6387-6392 6 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression
Vantaku, V., Putluri, V., Bader, D. A., Maity, S., Ma, J., Arnold, J. M., Rajapakshe, K., Donepudi, S. R., von Rundstedt, F. C., Devarakonda, V., Dubrulle, J., Karanam, B., McGuire, S. E., Stossi, F., Jain, A. K., Coarfa, C., Cao, Q., Sikora, A. G., Villanueva, H., Kavuri, S. M. & 3 others, , Oct 1 2020, In: Oncogene. 39, 40, p. 6265-6285 21 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Machine learning uncovers cell identity regulator by histone code
Xia, B., Zhao, D., Wang, G., Zhang, M., Lv, J., Tomoiaga, A. S., Li, Y., Wang, X., Meng, S., Cooke, J. P., Cao, Q., Zhang, L. & Chen, K., Dec 1 2020, In: Nature communications. 11, 1, 2696.Research output: Contribution to journal › Article › peer-review
Open Access