Grants per year
Personal profile
Training Experience
| 2012 | Postdoctoral Fellowship, University of Michigan |
Research Interests
I have been working on prostate cancer and epigenetics for over 15 years and published over 30 peer-reviewed publications. My major contributions to the field of prostate cancer and other cancer research include: (1) identification of PcG protein histone methyltransferase EZH2 as a biomarker for aggressive breast and prostate cancer; (2) characterization of EZH2 as an oncogene by repressing multiple tumor suppressors in breast and prostate cancer; (3) discovery of genomic loss of miR-101 in breast and prostate cancer and the upregulation of EZH2 by miR-101 in cancer; and (4) the coordinated regulation between Polycomb Repressive Complexes 1 and 2 in breast and prostate cancer progression. My work has demonstrated EZH2 and BMI1 as valuable therapeutic targets in cancer, and several pharmaceutical companies are developing EZH2- or BMI1- specific inhibitors for cancer therapy.
Expertise related to UN Sustainable Devlopment Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, University of Michigan
… → 2008
MS, Peking University
… → 2001
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The regulatory axis of lncRNA PRCAT71-AR in advanced prostate cancer
U.S. Army Medical Research and Materiel Command
9/1/21 → 8/31/23
Project: Research project
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A non-canonical role for EZH2 in rRNA methtlation
Cao, Q., Abdulkadir, S. A., Platanias, L. C. & Yi, Y.
7/15/21 → 6/30/26
Project: Research project
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The role of BMI1-associated lncRNAs in advanced prostate cancer
U.S. Army Medical Research and Materiel Command
9/30/20 → 9/29/23
Project: Research project
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Effects of Epigenetic Regulation in Chronic Pelvic Pain Syndrome
Thumbikat, P., Cao, Q. & Schaeffer, A. J.
National Institute of Diabetes and Digestive and Kidney Diseases
9/15/20 → 7/31/23
Project: Research project
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The role of A-to-I RNA editing in advanced prostate cancer
U.S. Army Medical Research and Materiel Command
9/30/19 → 9/29/22
Project: Research project
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Androgen Receptor-Related Non-coding RNAs in Prostate Cancer
Yang, Y., Liu, K. Y., Liu, Q. & Cao, Q., Apr 1 2021, In: Frontiers in Cell and Developmental Biology. 9, 660853.Research output: Contribution to journal › Review article › peer-review
Open Access -
A pan-cancer transcriptome analysis of exitron splicing identifies novel cancer driver genes and neoepitopes
Wang, T. Y., Liu, Q., Ren, Y., Alam, S. K., Wang, L., Zhu, Z., Hoeppner, L. H., Dehm, S. M., Cao, Q. & Yang, R., May 20 2021, In: Molecular cell. 81, 10, p. 2246-2260.e12Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
A PRC2-independent function for EZH2 in regulating rRNA 2′-O methylation and IRES-dependent translation
Yi, Y., Li, Y., Meng, Q., Li, Q., Li, F., Lu, B., Shen, J., Fazli, L., Zhao, D., Li, C., Jiang, W., Wang, R., Liu, Q., Szczepanski, A., Li, Q., Qin, W., Weiner, A. B., Lotan, T. L., Ji, Z., Kalantry, S. & 7 others, , Apr 2021, In: Nature Cell Biology. 23, 4, p. 341-354 14 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Antihistamine drug ebastine inhibits cancer growth by targeting polycomb group protein EZH2
Li, Q., Liu, K. Y., Liu, Q., Wang, G., Jiang, W., Meng, Q., Yi, Y., Yang, Y., Wang, R., Zhu, S., Li, C., Wu, L., Zhao, D., Yan, L., Zhang, L., Kim, J. S., Zu, X., Kozielski, A. J., Qian, W., Chang, J. C. & 3 others, , Oct 1 2020, In: Molecular cancer therapeutics. 19, 10, p. 2023-2033 11 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
BMI1 is directly regulated by androgen receptor to promote castration-resistance in prostate cancer
Zhu, S., Zhao, D., Li, C., Li, Q., Jiang, W., Liu, Q., Wang, R., Fazli, L., Li, Y., Zhang, L., Yi, Y., Meng, Q., Wang, W., Wang, G., Zhang, M., Zu, X., Zhao, W., Deng, T., Yu, J., Dong, X. & 2 others, , Jan 2 2020, In: Oncogene. 39, 1, p. 17-29 13 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations