Qi Cao

  • 9123 Citations
20032022

Research output per year

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Research Output

  • 9123 Citations
  • 39 Article
  • 3 Comment/debate
  • 2 Letter
  • 2 Review article
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Article
2020

BMI1 is directly regulated by androgen receptor to promote castration-resistance in prostate cancer

Zhu, S., Zhao, D., Li, C., Li, Q., Jiang, W., Liu, Q., Wang, R., Fazli, L., Li, Y., Zhang, L., Yi, Y., Meng, Q., Wang, W., Wang, G., Zhang, M., Zu, X., Zhao, W., Deng, T., Yu, J., Dong, X. & 2 others, Chen, K. & Cao, Q., Jan 2 2020, In : Oncogene. 39, 1, p. 17-29 13 p.

Research output: Contribution to journalArticle

TADsplimer reveals splits and mergers of topologically associating domains for epigenetic regulation of transcription

Wang, G., Meng, Q., Xia, B., Zhang, S., Lv, J., Zhao, D., Li, Y., Wang, X., Zhang, L., Cooke, J. P., Cao, Q. & Chen, K., Apr 2 2020, In : Genome biology. 21, 1, 84.

Research output: Contribution to journalArticle

Open Access
2019

Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression

Vantaku, V., Putluri, V., Bader, D. A., Maity, S., Ma, J., Arnold, J. M., Rajapakshe, K., Donepudi, S. R., von Rundstedt, F. C., Devarakonda, V., Dubrulle, J., Karanam, B., McGuire, S. E., Stossi, F., Jain, A. K., Coarfa, C., Cao, Q., Sikora, A. G., Villanueva, H., Kavuri, S. M. & 3 others, Lotan, Y., Sreekumar, A. & Putluri, N., Jan 1 2019, In : Oncogene.

Research output: Contribution to journalArticle

N6-methyladenosine modulates nonsense-mediated mRNA decay in human glioblastoma

Li, F., Yi, Y., Miao, Y., Long, W., Long, T., Chen, S., Cheng, W., Zou, C., Zheng, Y., Wu, X., Ding, J., Zhu, K., Chen, D., Xu, Q., Wang, J., Liu, Q., Zhi, F., Ren, J., Cao, Q. & Zhao, W., Nov 15 2019, In : Cancer Research. 79, 22, p. 5785-5798 14 p.

Research output: Contribution to journalArticle

11 Scopus citations

Polycomb group proteins EZH2 and EED directly regulate androgen receptor in advanced prostate cancer

Liu, Q., Wang, G., Li, Q., Jiang, W., Kim, J. S., Wang, R., Zhu, S., Wang, X., Yan, L., Yi, Y., Zhang, L., Meng, Q., Li, C., Zhao, D., Qiao, Y., Li, Y., Gursel, D. B., Chinnaiyan, A. M., Chen, K. & Cao, Q., Jul 15 2019, In : International Journal of Cancer. 145, 2, p. 415-426 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Roles of the HOXA10 gene during castrate-resistant prostate cancer progression

Long, Z., Li, Y., Gan, Y., Zhao, D., Wang, G., Xie, N., Lovnicki, J. M., Fazli, L., Cao, Q., Chen, K. & Dong, X., Mar 2019, In : Endocrine-related cancer. 26, 3, p. 279-292 14 p.

Research output: Contribution to journalArticle

3 Scopus citations
2018

BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1

Zhu, S., Zhao, D., Yan, L., Jiang, W., Kim, J. S., Gu, B., Liu, Q., Wang, R., Xia, B., Zhao, J. C., Song, G., Mi, W., Wang, R. F., Shi, X., Lam, H. M., Dong, X., Yu, J., Chen, K. & Cao, Q., Dec 1 2018, In : Nature communications. 9, 1, 500.

Research output: Contribution to journalArticle

20 Scopus citations

Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator

Kim, J., Lee, Y., Lu, X., Song, B., Fong, K. W., Cao, Q., Licht, J. D., Zhao, J. C. & Yu, J., Dec 4 2018, In : Cell reports. 25, 10, p. 2808-2820.e4

Research output: Contribution to journalArticle

20 Scopus citations
2014

PCAT-1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer

Prensner, J. R., Chen, W., Iyer, M. K., Cao, Q., Ma, T., Han, S., Sahu, A., Malik, R., Wilder-Romans, K., Navone, N., Logothetis, C. J., Araujo, J. C., Pisters, L. L., Tewari, A. K., Canman, C. E., Knudsen, K. E., Kitabayashi, N., Rubin, M. A., Demichelis, F., Lawrence, T. S. & 2 others, Chinnaiyan, A. M. & Feng, F. Y., Mar 15 2014, In : Cancer Research. 74, 6, p. 1651-1660 10 p.

Research output: Contribution to journalArticle

161 Scopus citations

The central role of EED in the orchestration of polycomb group complexes

Cao, Q., Wang, X., Zhao, M., Yang, R., Malik, R., Qiao, Y., Poliakov, A., Yocum, A. K., Li, Y., Chen, W., Cao, X., Jiang, X., Dahiya, A., Harris, C., Feng, F. Y., Kalantry, S., Qin, Z. S., Dhanasekaran, S. M. & Chinnaiyan, A. M., Jan 24 2014, In : Nature communications. 5, 3127.

Research output: Contribution to journalArticle

77 Scopus citations

The Long Non-Coding RNA PCAT-1 Promotes Prostate Cancer Cell Proliferation through cMyc

Prensner, J. R., Chen, W., Han, S., Iyer, M. K., Cao, Q., Kothari, V., Evans, J. R., Knudsen, K. E., Paulsen, M. T., Ljungman, M., Lawrence, T. S., Chinnaiyan, A. M. & Feng, F. Y., Jan 1 2014, In : Neoplasia. 16, 11, p. 900-908 9 p.

Research output: Contribution to journalArticle

136 Scopus citations
2013

Characterization of the EZH2-MMSET Histone Methyltransferase Regulatory Axis in Cancer

Asangani, I. A., Ateeq, B., Cao, Q., Dodson, L., Pandhi, M., Kunju, L. P., Mehra, R., Lonigro, R. J., Siddiqui, J., Palanisamy, N., Wu, Y. M., Cao, X., Kim, J. H., Zhao, M., Qin, Z. S., Iyer, M. K., Maher, C. A., Kumar-Sinha, C., Varambally, S. & Chinnaiyan, A. M., Jan 10 2013, In : Molecular cell. 49, 1, p. 80-93 14 p.

Research output: Contribution to journalArticle

90 Scopus citations

MicroRNA expression patterns in indeterminate inflammatory bowel disease

Lin, J., Cao, Q., Zhang, J., Li, Y., Shen, B., Zhao, Z., Chinnaiyan, A. M. & Bronner, M. P., Jan 1 2013, In : Modern Pathology. 26, 1, p. 148-154 7 p.

Research output: Contribution to journalArticle

22 Scopus citations
2012

Role of dutasteride in pre-clinical ETS fusion-positive prostate cancer models

Ateeq, B., Vellaichamy, A., Tomlins, S. A., Wang, R., Cao, Q., Lonigro, R. J., Pienta, K. J. & Varambally, S., Oct 1 2012, In : Prostate. 72, 14, p. 1542-1549 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Role of transcriptional corepressor CtBP1 in prostate cancer progression

Wang, R., Asangani, I. A., Chakravarthi, B. V. S. K., Ateeq, B., Lonigro, R. J., Cao, Q., Mani, R. S., Camacho, D. F., McGregor, N., Schumann, T. E. W., Jing, X., Menawat, R., Tomlins, S. A., Zheng, H., Otte, A. P., Mehra, R., Siddiqui, J., Dhanasekaran, S. M., Nyati, M. K., Pienta, K. J. & 5 others, Palanisamy, N., Kunju, L. P., Rubin, M. A., Chinnaiyan, A. M. & Varambally, S., Oct 2012, In : Neoplasia (United States). 14, 10, p. 905-914 10 p.

Research output: Contribution to journalArticle

42 Scopus citations
2011

Characterization of KRAS rearrangements in metastatic prostate cancer

Wang, X. S., Shankar, S., Dhanasekaran, S. M., Ateeq, B., Sasaki, A. T., Jing, X., Robinson, D., Cao, Q., Prensner, J. R., Yocum, A. K., Wang, R., Fries, D. F., Han, B., Asangani, I. A., Cao, X., Li, Y., Omenn, G. S., Pflueger, D., Gopalan, A., Reuter, V. E. & 6 others, Kahoud, E. R., Cantley, L. C., Rubin, M. A., Palanisamy, N., Varambally, S. & Chinnaiyan, A. M., Jun 1 2011, In : Cancer discovery. 1, 1, p. 35-43 9 p.

Research output: Contribution to journalArticle

68 Scopus citations

Coordinated Regulation of Polycomb Group Complexes through microRNAs in Cancer

Cao, Q., Mani, R. S., Ateeq, B., Dhanasekaran, S. M., Asangani, I. A., Prensner, J. R., Kim, J. H., Brenner, J. C., Jing, X., Cao, X., Wang, R., Li, Y., Dahiya, A., Wang, L., Pandhi, M., Lonigro, R. J., Wu, Y. M., Tomlins, S. A., Palanisamy, N., Qin, Z. & 4 others, Yu, J., Maher, C. A., Varambally, S. & Chinnaiyan, A. M., Aug 16 2011, In : Cancer Cell. 20, 2, p. 187-199 13 p.

Research output: Contribution to journalArticle

157 Scopus citations

Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer

Brenner, J. C., Ateeq, B., Li, Y., Yocum, A. K., Cao, Q., Asangani, I. A., Patel, S., Wang, X., Liang, H., Yu, J., Palanisamy, N., Siddiqui, J., Yan, W., Cao, X., Mehra, R., Sabolch, A., Basrur, V., Lonigro, R. J., Yang, J., Tomlins, S. A. & 8 others, Maher, C. A., Elenitoba-Johnson, K. S. J., Hussain, M., Navone, N. M., Pienta, K. J., Varambally, S., Feng, F. Y. & Chinnaiyan, A. M., May 17 2011, In : Cancer Cell. 19, 5, p. 664-678 15 p.

Research output: Contribution to journalArticle

291 Scopus citations

Targeting of microRNA-142-3p in dendritic cells regulates endotoxin-induced mortality

Sun, Y., Varambally, S., Maher, C. A., Cao, Q., Chockley, P., Toubai, T., Malter, C., Nieves, E., Tawara, I., Wang, Y., Ward, P. A., Chinnaiyan, A. & Reddy, P., Jun 9 2011, In : Blood. 117, 23, p. 6172-6183 12 p.

Research output: Contribution to journalArticle

104 Scopus citations

Therapeutic targeting of SPINK1-positive prostate cancer

Ateeq, B., Tomlins, S. A., Laxman, B., Asangani, I. A., Cao, Q., Cao, X., Li, Y., Wang, X., Feng, F. Y., Pienta, K. J., Varambally, S. & Chinnaiyan, A. M., Mar 2 2011, In : Science translational medicine. 3, 72, 72ra17.

Research output: Contribution to journalArticle

115 Scopus citations

The tumor suppressor gene rap1GAP is silenced by miR-101-mediated EZH2 overexpression in invasive squamous cell carcinoma

Banerjee, R., Mani, R. S., Russo, N., Scanlon, C. S., Tsodikov, A., Jing, X., Cao, Q., Palanisamy, N., Metwally, T., Inglehart, R. C., Tomlins, S., Bradford, C., Carey, T., Wolf, G., Kalyana-Sundaram, S., Chinnaiyan, A. M., Varambally, S. & D'Silva, N. J., Oct 20 2011, In : Oncogene. 30, 42, p. 4339-4349 11 p.

Research output: Contribution to journalArticle

72 Scopus citations

TMPRSS2-ERG-mediated feed-forward regulation of wild-type ERG in human prostate cancers

Mani, R. S., Iyer, M. K., Cao, Q., Brenner, J. C., Wang, L., Ghosh, A., Cao, X., Lonigro, R. J., Tomlins, S. A., Varambally, S. & Chinnaiyan, A. M., Aug 15 2011, In : Cancer Research. 71, 16, p. 5387-5392 6 p.

Research output: Contribution to journalArticle

34 Scopus citations

Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression

Prensner, J. R., Iyer, M. K., Balbin, O. A., Dhanasekaran, S. M., Cao, Q., Brenner, J. C., Laxman, B., Asangani, I. A., Grasso, C. S., Kominsky, H. D., Cao, X., Jing, X., Wang, X., Siddiqui, J., Wei, J. T., Robinson, D., Iyer, H. K., Palanisamy, N., Maher, C. A. & Chinnaiyan, A. M., Aug 1 2011, In : Nature biotechnology. 29, 8, p. 742-749 8 p.

Research output: Contribution to journalArticle

658 Scopus citations
2010

An Integrated Network of Androgen Receptor, Polycomb, and TMPRSS2-ERG Gene Fusions in Prostate Cancer Progression

Yu, J., Yu, J., Mani, R. S., Cao, Q., Brenner, C. J., Cao, X., Wang, X., Wu, L., Li, J., Hu, M., Gong, Y., Cheng, H., Laxman, B., Vellaichamy, A., Shankar, S., Li, Y., Dhanasekaran, S. M., Morey, R., Barrette, T., Lonigro, R. J. & 4 others, Tomlins, S. A., Varambally, S., Qin, Z. S. & Chinnaiyan, A. M., May 18 2010, In : Cancer Cell. 17, 5, p. 443-454 12 p.

Research output: Contribution to journalArticle

519 Scopus citations

Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma

Palanisamy, N., Ateeq, B., Kalyana-Sundaram, S., Pflueger, D., Ramnarayanan, K., Shankar, S., Han, B., Cao, Q., Cao, X., Suleman, K., Kumar-Sinha, C., Dhanasekaran, S. M., Chen, Y. B., Esgueva, R., Banerjee, S., Lafargue, C. J., Siddiqui, J., Demichelis, F., Moeller, P., Bismar, T. A. & 11 others, Kuefer, R., Fullen, D. R., Johnson, T. M., Greenson, J. K., Giordano, T. J., Tan, P., Tomlins, S. A., Varambally, S., Rubin, M. A., Maher, C. A. & Chinnaiyan, A. M., Jul 1 2010, In : Nature Medicine. 16, 7, p. 793-798 6 p.

Research output: Contribution to journalArticle

338 Scopus citations

The neuronal repellent SLIT2 is a target for repression by EZH2 in prostate cancer

Yu, J., Cao, Q., Yu, J., Wu, L., Dallol, A., Li, J., Chen, G., Grasso, C., Cao, X., Lonigro, R. J., Varambally, S., Mehra, R., Palanisamy, N., Wu, J. Y., Latif, F. & Chinnaiyan, A. M., Sep 30 2010, In : Oncogene. 29, 39, p. 5370-5380 11 p.

Research output: Contribution to journalArticle

56 Scopus citations
2009

AGTR1 overexpression defines a subset of breast cancer and confers sensitivity to losartan, an AGTR1 antagonist

Rhodes, D. R., Ateeq, B., Cao, Q., Tomlins, S. A., Mehra, R., Laxman, B., Kalyana-Sundaram, S., Lonigro, R. J., Helgeson, B. E., Bhojani, M. S., Rehemtulla, A., Kleer, C. G., Hayes, D. F., Lucas, P. C., Varambally, S. & Chinnaiyan, A. M., Jun 23 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 25, p. 10284-10289 6 p.

Research output: Contribution to journalArticle

99 Scopus citations

An integrative approach to reveal driver gene fusions from paired-end sequencing data in cancer

Wang, X. S., Prensner, J. R., Chen, G., Cao, Q., Han, B., Dhanasekaran, S. M., Ponnala, R., Cao, X., Varambally, S., Thomas, D. G., Giordano, T. J., Beer, D. G., Palanisamy, N., Sartor, M. A., Omenn, G. S. & Chinnaiyan, A. M., Nov 1 2009, In : Nature biotechnology. 27, 11, p. 1005-1011 7 p.

Research output: Contribution to journalArticle

53 Scopus citations

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression

Sreekumar, A., Poisson, L. M., Rajendiran, T. M., Khan, A. P., Cao, Q., Yu, J., Laxman, B., Mehra, R., Lonigro, R. J., Li, Y., Nyati, M. K., Ahsan, A., Kalyana-Sundaram, S., Han, B., Cao, X., Byun, J., Omenn, G. S., Ghosh, D., Pennathur, S., Alexander, D. C. & 6 others, Berger, A., Shuster, J. R., Wei, J. T., Varambally, S., Beecher, C. & Chinnaiyan, A. M., Feb 12 2009, In : Nature. 457, 7231, p. 910-914 5 p.

Research output: Contribution to journalArticle

1444 Scopus citations
2008

Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer

Helgeson, B. E., Tomlins, S. A., Shah, N., Laxman, B., Cao, Q., Prensner, J. R., Cao, X., Singla, N., Montie, J. E., Varambally, S., Mehra, R. & Chinnaiyan, A. M., Jan 1 2008, In : Cancer Research. 68, 1, p. 73-80 8 p.

Research output: Contribution to journalArticle

196 Scopus citations

Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer

Varambally, S., Cao, Q., Mani, R. S., Shankar, S., Wang, X., Ateeq, B., Laxman, B., Cao, X., Jing, X., Ramnarayanan, K., Brenner, J. C., Yu, J., Kim, J. H., Han, B., Tan, P., Kumar-Sinha, C., Lonigro, R. J., Palanisamy, N., Maher, C. A. & Chinnaiyan, A. M., Dec 12 2008, In : Science. 322, 5908, p. 1695-1699 5 p.

Research output: Contribution to journalArticle

793 Scopus citations

Golgi protein GOLM1 is a tissue and urine biomarker of prostate cancer

Varambally, S., Laxman, B., Mehra, R., Cao, Q., Dhanasekaran, S. M., Tomlins, S. A., Granger, J., Vellaichamy, A., Sreekumar, A., Yu, J., Gu, W., Shen, R., Ghosh, D., Wright, L. M., Kladney, R. D., Kuefer, R., Rubin, M. A., Fimmel, C. J. & Chinnaiyan, A. M., Nov 2008, In : Neoplasia. 10, 11, p. 1285-1294 10 p.

Research output: Contribution to journalArticle

64 Scopus citations

Repression of E-cadherin by the polycomb group protein EZH2 in cancer

Cao, Q., Yu, J., Dhanasekaran, S. M., Kim, J. H., Mani, R. S., Tomlins, S. A., Mehra, R., Laxman, B., Cao, X., Yu, J., Kleer, C. G., Varambally, S. & Chinnaiyan, A. M., Dec 11 2008, In : Oncogene. 27, 58, p. 7274-7284 11 p.

Research output: Contribution to journalArticle

402 Scopus citations

Role of the TMPRSS2-ERG gene fusion in prostate cancer

Tomlins, S. A., Laxman, B., Varambally, S., Cao, X., Yu, J., Helgeson, B. E., Cao, Q., Prensner, J. R., Rubin, M. A., Shah, R. B., Mehra, R. & Chinnaiyan, A. M., Feb 2008, In : Neoplasia. 10, 2, p. 177-188 12 p.

Research output: Contribution to journalArticle

443 Scopus citations

The Role of SPINK1 in ETS Rearrangement-Negative Prostate Cancers

Tomlins, S. A., Rhodes, D. R., Yu, J., Varambally, S., Mehra, R., Perner, S., Demichelis, F., Helgeson, B. E., Laxman, B., Morris, D. S., Cao, Q., Cao, X., Andrén, O., Fall, K., Johnson, L., Wei, J. T., Shah, R. B., Al-Ahmadie, H., Eastham, J. A., Eggener, S. E. & 12 others, Fine, S. W., Hotakainen, K., Stenman, U. H., Tsodikov, A., Gerald, W. L., Lilja, H., Reuter, V. E., Kantoff, P. W., Scardino, P. T., Rubin, M. A., Bjartell, A. S. & Chinnaiyan, A. M., Jun 10 2008, In : Cancer Cell. 13, 6, p. 519-528 10 p.

Research output: Contribution to journalArticle

228 Scopus citations
2007

Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer

Tomlins, S. A., Laxman, B., Dhanasekaran, S. M., Helgeson, B. E., Cao, X., Morris, D. S., Menon, A., Jing, X., Cao, Q., Han, B., Yu, J., Wang, L., Montie, J. E., Rubin, M. A., Pienta, K. J., Roulston, D., Shah, R. B., Varambally, S., Mehra, R. & Chinnaiyan, A. M., Aug 2 2007, In : Nature. 448, 7153, p. 595-599 5 p.

Research output: Contribution to journalArticle

581 Scopus citations

Integrative Genomics Analysis Reveals Silencing of β-Adrenergic Signaling by Polycomb in Prostate Cancer

Yu, J., Cao, Q., Mehra, R., Laxman, B., Yu, J., Tomlins, S. A., Creighton, C. J., Dhanasekaran, S. M., Shen, R., Chen, G., Morris, D. S., Marquez, V. E., Shah, R. B., Ghosh, D., Varambally, S. & Chinnaiyan, A. M., Nov 13 2007, In : Cancer Cell. 12, 5, p. 419-431 13 p.

Research output: Contribution to journalArticle

156 Scopus citations
2005

The polycomb group protein EZH2 impairs DNA repair in breast epithelial cells

Zeidler, M., Varambally, S., Cao, Q., Chinnaiyan, A. M., Ferguson, D. O., Merajver, S. D. & Kleer, C. G., Nov 2005, In : Neoplasia. 7, 11, p. 1011-1019 9 p.

Research output: Contribution to journalArticle

71 Scopus citations
2003

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

Kleer, C. G., Cao, Q., Varambally, S., Shen, R., Ota, I., Tomlins, S. A., Ghosh, D., Sewalt, R. G. A. B., Otte, A. P., Hayes, D. F., Sabel, M. S., Livant, D., Weiss, S. J., Rubin, M. A. & Chinnaiyan, A. M., Sep 30 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 20, p. 11606-11611 6 p.

Research output: Contribution to journalArticle

1161 Scopus citations