• 371 Citations
20042021
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Personal profile

Education/Academic qualification

PhD, National University of Singapore

… → 2003

MD, China Medical University

… → 1995

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  • 17 Similar Profiles
Megakaryocytes Medicine & Life Sciences
Leukemia, Megakaryoblastic, Acute Medicine & Life Sciences
Primary Myelofibrosis Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Aurora Kinase A Medicine & Life Sciences
Hematopoiesis Medicine & Life Sciences
Platelets Chemical Compounds
Phosphotransferases Medicine & Life Sciences

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Grants 2012 2021

Leukemia, Megakaryoblastic, Acute
Primary Myelofibrosis
Polyploidy
Neoplasms
Megakaryocytes
Aurora Kinase A
Leukemia, Megakaryoblastic, Acute
Primary Myelofibrosis
Neoplasms
Animal Models
Aurora Kinase A
Primary Myelofibrosis
Essential Thrombocythemia
Polycythemia Vera
Phosphotransferases
Thrombocytosis
Primary Myelofibrosis
Polycythemia Vera
Mutation
Neoplasms

Research Output 2004 2019

AKT activation is a feature of CALR mutant myeloproliferative neoplasms

Fu, C., Wen, Q., Marinaccio, C., Ling, T., Chen, W., Bulic, M., Lasho, T., Tefferi, A., Crispino, J. D. & Xu, K., Jan 1 2019, In : Leukemia. 33, 1, p. 271-274 4 p.

Research output: Contribution to journalArticle

Neoplasms
2 Citations (Scopus)

An activating mutation of the NSD2 histone methyltransferase drives oncogenic reprogramming in acute lymphocytic leukemia

Swaroop, A., Oyer, J. A., Will, C. M., Huang, X., Yu, W., Troche, C., Bulic, M., Durham, B. H., Wen, Q., Crispino, J. D., MacKerell, A. D., Bennett, R. L., Kelleher, N. L. & Licht, J. D., Jan 31 2019, In : Oncogene. 38, 5, p. 671-686 16 p.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Mutation
Histones
Methylation
Lysine

ANP32A regulates histone H3 acetylation and promotes leukemogenesis

Yang, X., Lu, B., Sun, X., Han, C., Fu, C., Xu, K., Wang, M., Li, D., Chen, Z., Opal, P., Wen, Q., Crispino, J. D., Wang, Q. F. & Huang, Z., Jul 1 2018, In : Leukemia. 32, 7, p. 1587-1597 11 p.

Research output: Contribution to journalArticle

Phosphoproteins
Acetylation
Leucine
Histones
Histone Code

Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2 V617F -positive myeloproliferative neoplasms

Zhao, B., Mei, Y., Cao, L., Zhang, J., Sumagin, R., Yang, J., Gao, J., Schipma, M. J., Wang, Y., Thorsheim, C., Zhao, L., Stalker, T., Stein, B., Wen, Q. J., Crispino, J. D., Abrams, C. S. & Ji, P., Jan 2 2018, In : Journal of Clinical Investigation. 128, 1, p. 125-140 16 p.

Research output: Contribution to journalArticle

Blood Vessels
Neoplasms
Erythrocyte Volume
Thrombocytosis
Philadelphia Chromosome

ANP32A dysregulation contributes to abnormal megakaryopoiesis in acute megakaryoblastic leukemia

Sun, X., Lu, B., Han, C., Qiu, W., Jin, Q., Li, D., Li, Q., Yang, Q., Wen, Q., Opal, P., Kini, A. R., Crispino, J. D. & Huang, Z., Dec 1 2017, In : Blood cancer journal. 7, 12, 31.

Research output: Contribution to journalLetter

Leukemia, Megakaryoblastic, Acute