• 461 Citations
20042021
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Research Output 2004 2019

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Article
2019
3 Citations (Scopus)

Activation of JAK/STAT signaling in megakaryocytes sustains myeloproliferation in vivo

Woods, B., Chen, W., Chiu, S., Marinaccio, C., Fu, C., Gu, L., Bulic, M., Yang, Q., Zouak, A., Jia, S., Suraneni, P. K., Xu, K., Levine, R. L., Crispino, J. D. & Wen, Q. J., Oct 1 2019, In : Clinical Cancer Research. 25, 19, p. 5901-5912 12 p.

Research output: Contribution to journalArticle

Megakaryocytes
Erythropoiesis
Neoplasms
Primary Myelofibrosis
Maintenance

AKT activation is a feature of CALR mutant myeloproliferative neoplasms

Fu, C., Wen, Q., Marinaccio, C., Ling, T., Chen, W., Bulic, M., Lasho, T., Tefferi, A., Crispino, J. D. & Xu, K., Jan 1 2019, In : Leukemia. 33, 1, p. 271-274 4 p.

Research output: Contribution to journalArticle

Neoplasms
5 Citations (Scopus)

An activating mutation of the NSD2 histone methyltransferase drives oncogenic reprogramming in acute lymphocytic leukemia

Swaroop, A., Oyer, J. A., Will, C. M., Huang, X., Yu, W., Troche, C., Bulic, M., Durham, B. H., Wen, Q. J., Crispino, J. D., MacKerell, A. D., Bennett, R. L., Kelleher, N. L. & Licht, J. D., Jan 31 2019, In : Oncogene. 38, 5, p. 671-686 16 p.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Mutation
Histones
Methylation
Lysine
8 Citations (Scopus)

Aurora kinase A inhibition provides clinical benefit, normalizes megakaryocytes, and reduces bone marrow fibrosis in patients with myelofibrosis: A phase I trial

Gangat, N., Marinaccio, C., Swords, R., Watts, J. M., Gurbuxani, S., Rademaker, A., Fought, A. J., Frankfurt, O., Altman, J. K., Wen, Q. J., Farnoud, N., Famulare, C. A., Patel, A., Tapia, R., Vallapureddy, R. R., Barath, S., Graf, A., Handlogten, A., Zblewski, D., Patnaik, M. M. & 14 others, Al-Kali, A., Dinh, Y. T., Prahl, K. E., Patel, S., Nobrega, J. C., Tejera, D., Thomassen, A., Gao, J., Ji, P., Rampal, R. K., Giles, F. J., Tefferi, A., Stein, B. & Crispino, J. D., Aug 15 2019, In : Clinical Cancer Research. 25, 16, p. 4898-4906 9 p.

Research output: Contribution to journalArticle

Aurora Kinase A
Primary Myelofibrosis
Megakaryocytes
Fibrosis
Splenomegaly
2018
4 Citations (Scopus)

ANP32A regulates histone H3 acetylation and promotes leukemogenesis

Yang, X., Lu, B., Sun, X., Han, C., Fu, C., Xu, K., Wang, M., Li, D., Chen, Z., Opal, P., Wen, Q., Crispino, J. D., Wang, Q. F. & Huang, Z., Jul 1 2018, In : Leukemia. 32, 7, p. 1587-1597 11 p.

Research output: Contribution to journalArticle

Phosphoproteins
Acetylation
Leucine
Histones
Histone Code
2 Citations (Scopus)

Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2 V617F -positive myeloproliferative neoplasms

Zhao, B., Mei, Y., Cao, L., Zhang, J., Sumagin, R., Yang, J., Gao, J., Schipma, M. J., Wang, Y., Thorsheim, C., Zhao, L., Stalker, T., Stein, B., Wen, Q. J., Crispino, J. D., Abrams, C. S. & Ji, P., Jan 2 2018, In : Journal of Clinical Investigation. 128, 1, p. 125-140 16 p.

Research output: Contribution to journalArticle

Blood Vessels
Neoplasms
Erythrocyte Volume
Thrombocytosis
Philadelphia Chromosome
2017
26 Citations (Scopus)

Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosis

Gilles, L., Arslan, A. D., Marinaccio, C., Wen, Q. J., Arya, P., McNulty, M., Yang, Q., Zhao, J. C., Konstantinoff, K., Lasho, T., Pardanani, A., Stein, B., Plo, I., Sundaravel, S., Wickrema, A., Migliaccio, A., Gurbuxani, S., Vainchenker, W., Platanias, L. C., Tefferi, A. & 1 others, Crispino, J. D., Apr 3 2017, In : Journal of Clinical Investigation. 127, 4, p. 1316-1320 5 p.

Research output: Contribution to journalArticle

Primary Myelofibrosis
Megakaryocytes
Hematopoiesis
Down-Regulation
Extramedullary Hematopoiesis
10 Citations (Scopus)

Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation

Nitulescu, I. I., Meyer, S. C., Wen, Q., Crispino, J. D., Lemieux, M. E., Levine, R. L., Pelish, H. E. & Shair, M. D., Dec 1 2017, In : EBioMedicine. 26, p. 112-125 14 p.

Research output: Contribution to journalArticle

Phosphorylation
Phosphotransferases
Chemical activation
Acute Myeloid Leukemia
Serine
2016

Tyrosine 625 plays a key role and cooperates with tyrosine 630 in MPL W515L-induced signaling and myeloproliferative neoplasms

Yu, C., Yang, Q., Chen, Y., Wang, D., Levine, R., Crispino, J. D., Wen, Q. & Huang, Z., Jan 1 2016, In : Cell and Bioscience. 6, 1, 34.

Research output: Contribution to journalArticle

Tyrosine
Bone
Megakaryocytes
Neoplasms
Blood Group Antigens
2015
15 Citations (Scopus)

Aurora kinase a is required for hematopoiesis but is dispensable for murine megakaryocyte endomitosis and differentiation

Goldenson, B., Kirsammer, G., Stankiewicz, M. J., Wen, Q. J. & Crispino, J. D., Mar 26 2015, In : Blood. 125, 13, p. 2141-2150 10 p.

Research output: Contribution to journalArticle

Aurora Kinases
Megakaryocytes
Hematopoiesis
Cells
Cell Cycle
5 Citations (Scopus)

Des-aspartate-angiotensin i causes specific release of PGE2 and PGI2 in HUVEC via the angiotensin AT1 receptor and biased agonism

Wen, Q., Lee, K. O., Sim, S. Z., Xu, X. G. & Sim, M. K., Dec 5 2015, In : European Journal of Pharmacology. 768, p. 173-181 9 p.

Research output: Contribution to journalArticle

Angiotensin Type 1 Receptor
Angiotensins
Epoprostenol
Dinoprostone
Aspartic Acid
48 Citations (Scopus)

Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition

Jeremy Wen, Q., Yang, Q., Goldenson, B., Malinge, S., Lasho, T., Schneider, R. K., Breyfogle, L. J., Schultz, R., Gilles, L., Koppikar, P., Abdel-Wahab, O., Pardanani, A., Stein, B., Gurbuxani, S., Mullally, A., Levine, R. L., Tefferi, A. & Crispino, J. D., Dec 1 2015, In : Nature Medicine. 21, 12, p. 1473-1480 8 p.

Research output: Contribution to journalArticle

Aurora Kinase A
Primary Myelofibrosis
Fibrosis
Bone
Janus Kinases
2014
8 Citations (Scopus)

PSTPIP2 dysregulation contributes to aberrant terminal differentiation in GATA-1-deficient megakaryocytes by activating LYN

Liu, L., Wen, Q., Gong, R., Gilles, L., Stankiewicz, M. J., Li, W., Guo, M., Li, L., Sun, X., Li, W., Crispino, J. D. & Huang, Z., Jan 1 2014, In : Cell Death and Disease. 5, 1, e988.

Research output: Contribution to journalArticle

Megakaryocytes
src-Family Kinases
Phosphorylation
Phosphoric Monoester Hydrolases
Myeloproliferative Disorders
2013
34 Citations (Scopus)

AKT is a therapeutic target in myeloproliferative neoplasms

Khan, I., Huang, Z., Wen, Q., Stankiewicz, M. J., Gilles, L., Goldenson, B., Schultz, R., Diebold, L., Gurbuxani, S., Finke, C. M., Lasho, T. L., Koppikar, P., Pardanani, A., Stein, B. L., Altman, J. K., Levine, R. L., Tefferi, A. & Crispino, J. D., Sep 1 2013, In : Leukemia. 27, 9, p. 1882-1890 9 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Neoplasms
Primary Myelofibrosis
Megakaryocytes
MAP Kinase Signaling System
2012
51 Citations (Scopus)

Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models

Thiollier, C., Lopez, C. K., Gerby, B., Ignacimouttou, C., Poglio, S., Duffourd, Y., Guégan, J., Rivera-Munoz, P., Bluteau, O., Mabialah, V., Diop, MB., Wen, Q., Petit, A., Bauchet, A. L., Reinhardt, D., Bornhauser, B., Gautheret, D., Lecluse, Y., Landman-Parker, J., Radford, I. & 10 others, Vainchenker, W., Dastugue, N., de Botton, S., Dessen, P., Bourquin, J. P., Crispino, J. D., Ballerini, P., Bernard, O. A., Pflumio, F. & Mercher, T., Oct 1 2012, In : Journal of Experimental Medicine. 209, 11, p. 2017-2031 15 p.

Research output: Contribution to journalArticle

Leukemia, Megakaryoblastic, Acute
Heterografts
Gene Fusion
Transcriptome
Aurora Kinase A
82 Citations (Scopus)

Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL

Wen, Q., Goldenson, B., Silver, S. J., Schenone, M., Dancik, V., Huang, Z., Wang, L. Z., Lewis, T. A., An, W. F., Li, X., Bray, M. A., Thiollier, C., Diebold, L., Gilles, L., Vokes, M. S., Moore, C. B., Bliss-Moreau, M., Verplank, L., Tolliday, N. J., Mishra, R. & 28 others, Vemula, S., Shi, J., Wei, L., Kapur, R., Lopez, C. K., Gerby, B., Ballerini, P., Pflumio, F., Gilliland, D. G., Goldberg, L., Birger, Y., Izraeli, S., Gamis, A. S., Smith, F. O., Woods, W. G., Taub, J., Scherer, C. A., Bradner, J. E., Goh, B. C., Mercher, T., Carpenter, A. E., Gould, R. J., Clemons, P. A., Carr, S. A., Root, D. E., Schreiber, S. L., Stern, A. M. & Crispino, J. D., Aug 3 2012, In : Cell. 150, 3, p. 575-589 15 p.

Research output: Contribution to journalArticle

Leukemia, Megakaryoblastic, Acute
Aurora Kinase A
Polyploidy
Megakaryocytes
Small Interfering RNA
2011
8 Citations (Scopus)

Effects of des-aspartate-angiotensin I on myocardial ischemia-reperfusion injury in rats

Wen, Q. & Sim, M. K., May 11 2011, In : European Journal of Pharmacology. 658, 2-3, p. 193-199 7 p.

Research output: Contribution to journalArticle

Myocardial Reperfusion Injury
Reperfusion Injury
Myocardial Ischemia
Cardiomegaly
Intercellular Adhesion Molecule-1
55 Citations (Scopus)

Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL

Mali, R. S., Ramdas, B., Ma, P., Shi, J., Munugalavadla, V., Sims, E., Wei, L., Vemula, S., Nabinger, S. C., Goodwin, C. B., Chan, R. J., Traina, F., Visconte, V., Tiu, R. V., Lewis, T. A., Stern, A. M., Wen, Q., Crispino, J. D., Boswell, H. S. & Kapur, R., Sep 1 2011, In : Cancer Cell. 20, 3, p. 357-369 13 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Cell Survival
Phosphatidylinositol 3-Kinases
Oncogenes
Acute Myeloid Leukemia
2009
19 Citations (Scopus)

Survivin is not required for the endomitotic cell cycle of megakaryocytes

Wen, Q., Leung, C., Huang, Z., Small, S., Reddi, A. L., Licht, J. D. & Crispino, J. D., Nov 18 2009, In : Blood. 114, 1, p. 153-156 4 p.

Research output: Contribution to journalArticle

Megakaryocytes
Chromosomes
Cell Cycle
Cells
Megakaryocyte Progenitor Cells
2008
10 Citations (Scopus)

Survivin overexpression alone does not alter megakaryocyte ploidy nor interfere with erythroid/megakaryocytic lineage development in transgenic mice

McCrann, D. J., Yezefski, T., Nguyen, H. G., Papadantonakis, N., Liu, H., Wen, Q., Crispino, J. D. & Ravid, K., Apr 15 2008, In : Blood. 111, 8, p. 4092-4095 4 p.

Research output: Contribution to journalArticle

Megakaryocytes
Ploidies
Platelets
Transgenic Mice
Tissue
2004
21 Citations (Scopus)

Reduction of infarct size by orally administered des-aspartate-angiotensin I in the ischemic reperfused rat heart

Wen, Q., Sim, M. K. & Tang, F. R., Aug 15 2004, In : Regulatory Peptides. 120, 1-3, p. 149-153 5 p.

Research output: Contribution to journalArticle

Rats
Reperfusion
Angiotensins
Indomethacin
Angiotensin Type 1 Receptor