• 475 Citations
20042021

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Article
2019

Activation of JAK/STAT signaling in megakaryocytes sustains myeloproliferation in vivo

Woods, B., Chen, W., Chiu, S., Marinaccio, C., Fu, C., Gu, L., Bulic, M., Yang, Q., Zouak, A., Jia, S., Suraneni, P. K., Xu, K., Levine, R. L., Crispino, J. D. & Wen, Q. J., Oct 1 2019, In : Clinical Cancer Research. 25, 19, p. 5901-5912 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

AKT activation is a feature of CALR mutant myeloproliferative neoplasms

Fu, C., Wen, Q., Marinaccio, C., Ling, T., Chen, W., Bulic, M., Lasho, T., Tefferi, A., Crispino, J. D. & Xu, K., Jan 1 2019, In : Leukemia. 33, 1, p. 271-274 4 p.

Research output: Contribution to journalArticle

An activating mutation of the NSD2 histone methyltransferase drives oncogenic reprogramming in acute lymphocytic leukemia

Swaroop, A., Oyer, J. A., Will, C. M., Huang, X., Yu, W., Troche, C., Bulic, M., Durham, B. H., Wen, Q. J., Crispino, J. D., MacKerell, A. D., Bennett, R. L., Kelleher, N. L. & Licht, J. D., Jan 31 2019, In : Oncogene. 38, 5, p. 671-686 16 p.

Research output: Contribution to journalArticle

5 Scopus citations

Aurora kinase A inhibition provides clinical benefit, normalizes megakaryocytes, and reduces bone marrow fibrosis in patients with myelofibrosis: A phase I trial

Gangat, N., Marinaccio, C., Swords, R., Watts, J. M., Gurbuxani, S., Rademaker, A., Fought, A. J., Frankfurt, O., Altman, J. K., Wen, Q. J., Farnoud, N., Famulare, C. A., Patel, A., Tapia, R., Vallapureddy, R. R., Barath, S., Graf, A., Handlogten, A., Zblewski, D., Patnaik, M. M. & 14 others, Al-Kali, A., Dinh, Y. T., Prahl, K. E., Patel, S., Nobrega, J. C., Tejera, D., Thomassen, A., Gao, J., Ji, P., Rampal, R. K., Giles, F. J., Tefferi, A., Stein, B. & Crispino, J. D., Aug 15 2019, In : Clinical Cancer Research. 25, 16, p. 4898-4906 9 p.

Research output: Contribution to journalArticle

12 Scopus citations
2018

ANP32A regulates histone H3 acetylation and promotes leukemogenesis

Yang, X., Lu, B., Sun, X., Han, C., Fu, C., Xu, K., Wang, M., Li, D., Chen, Z., Opal, P., Wen, Q., Crispino, J. D., Wang, Q. F. & Huang, Z., Jul 1 2018, In : Leukemia. 32, 7, p. 1587-1597 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2 V617F -positive myeloproliferative neoplasms

Zhao, B., Mei, Y., Cao, L., Zhang, J., Sumagin, R., Yang, J., Gao, J., Schipma, M. J., Wang, Y., Thorsheim, C., Zhao, L., Stalker, T., Stein, B., Wen, Q. J., Crispino, J. D., Abrams, C. S. & Ji, P., Jan 2 2018, In : Journal of Clinical Investigation. 128, 1, p. 125-140 16 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosis

Gilles, L., Arslan, A. D., Marinaccio, C., Wen, Q. J., Arya, P., McNulty, M., Yang, Q., Zhao, J. C., Konstantinoff, K., Lasho, T., Pardanani, A., Stein, B., Plo, I., Sundaravel, S., Wickrema, A., Migliaccio, A., Gurbuxani, S., Vainchenker, W., Platanias, L. C., Tefferi, A. & 1 others, Crispino, J. D., Apr 3 2017, In : Journal of Clinical Investigation. 127, 4, p. 1316-1320 5 p.

Research output: Contribution to journalArticle

27 Scopus citations

Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation

Nitulescu, I. I., Meyer, S. C., Wen, Q. J., Crispino, J. D., Lemieux, M. E., Levine, R. L., Pelish, H. E. & Shair, M. D., Dec 2017, In : EBioMedicine. 26, p. 112-125 14 p.

Research output: Contribution to journalArticle

11 Scopus citations
2016

Tyrosine 625 plays a key role and cooperates with tyrosine 630 in MPL W515L-induced signaling and myeloproliferative neoplasms

Yu, C., Yang, Q., Chen, Y., Wang, D., Levine, R., Crispino, J., Wen, Q. & Huang, Z., Jan 1 2016, In : Cell and Bioscience. 6, 1, 34.

Research output: Contribution to journalArticle

2015

Aurora kinase a is required for hematopoiesis but is dispensable for murine megakaryocyte endomitosis and differentiation

Goldenson, B., Kirsammer, G., Stankiewicz, M. J., Wen, Q. J. & Crispino, J. D., Mar 26 2015, In : Blood. 125, 13, p. 2141-2150 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Des-aspartate-angiotensin i causes specific release of PGE2 and PGI2 in HUVEC via the angiotensin AT1 receptor and biased agonism

Wen, Q., Lee, K. O., Sim, S. Z., Xu, X. G. & Sim, M. K., Dec 5 2015, In : European Journal of Pharmacology. 768, p. 173-181 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition

Jeremy Wen, Q., Yang, Q., Goldenson, B., Malinge, S., Lasho, T., Schneider, R. K., Breyfogle, L. J., Schultz, R., Gilles, L., Koppikar, P., Abdel-Wahab, O., Pardanani, A., Stein, B., Gurbuxani, S., Mullally, A., Levine, R. L., Tefferi, A. & Crispino, J. D., Dec 1 2015, In : Nature Medicine. 21, 12, p. 1473-1480 8 p.

Research output: Contribution to journalArticle

51 Scopus citations
2014

PSTPIP2 dysregulation contributes to aberrant terminal differentiation in GATA-1-deficient megakaryocytes by activating LYN

Liu, L., Wen, Q., Gong, R., Gilles, L., Stankiewicz, M. J., Li, W., Guo, M., Li, L., Sun, X., Li, W., Crispino, J. D. & Huang, Z., Jan 1 2014, In : Cell Death and Disease. 5, 1, e988.

Research output: Contribution to journalArticle

8 Scopus citations
2013

AKT is a therapeutic target in myeloproliferative neoplasms

Khan, I., Huang, Z., Wen, Q., Stankiewicz, M. J., Gilles, L., Goldenson, B., Schultz, R., Diebold, L., Gurbuxani, S., Finke, C. M., Lasho, T. L., Koppikar, P., Pardanani, A., Stein, B. L., Altman, J. K., Levine, R. L., Tefferi, A. & Crispino, J. D., Sep 1 2013, In : Leukemia. 27, 9, p. 1882-1890 9 p.

Research output: Contribution to journalArticle

35 Scopus citations
2012

Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models

Thiollier, C., Lopez, C. K., Gerby, B., Ignacimouttou, C., Poglio, S., Duffourd, Y., Guégan, J., Rivera-Munoz, P., Bluteau, O., Mabialah, V., Diop, MB., Wen, Q., Petit, A., Bauchet, A. L., Reinhardt, D., Bornhauser, B., Gautheret, D., Lecluse, Y., Landman-Parker, J., Radford, I. & 10 others, Vainchenker, W., Dastugue, N., de Botton, S., Dessen, P., Bourquin, J. P., Crispino, J. D., Ballerini, P., Bernard, O. A., Pflumio, F. & Mercher, T., Oct 1 2012, In : Journal of Experimental Medicine. 209, 11, p. 2017-2031 15 p.

Research output: Contribution to journalArticle

53 Scopus citations

Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL

Wen, Q., Goldenson, B., Silver, S. J., Schenone, M., Dancik, V., Huang, Z., Wang, L. Z., Lewis, T. A., An, W. F., Li, X., Bray, M. A., Thiollier, C., Diebold, L., Gilles, L., Vokes, M. S., Moore, C. B., Bliss-Moreau, M., Verplank, L., Tolliday, N. J., Mishra, R. & 28 others, Vemula, S., Shi, J., Wei, L., Kapur, R., Lopez, C. K., Gerby, B., Ballerini, P., Pflumio, F., Gilliland, D. G., Goldberg, L., Birger, Y., Izraeli, S., Gamis, A. S., Smith, F. O., Woods, W. G., Taub, J., Scherer, C. A., Bradner, J. E., Goh, B. C., Mercher, T., Carpenter, A. E., Gould, R. J., Clemons, P. A., Carr, S. A., Root, D. E., Schreiber, S. L., Stern, A. M. & Crispino, J. D., Aug 3 2012, In : Cell. 150, 3, p. 575-589 15 p.

Research output: Contribution to journalArticle

84 Scopus citations
2011

Effects of des-aspartate-angiotensin I on myocardial ischemia-reperfusion injury in rats

Wen, Q. & Sim, M. K., May 11 2011, In : European Journal of Pharmacology. 658, 2-3, p. 193-199 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL

Mali, R. S., Ramdas, B., Ma, P., Shi, J., Munugalavadla, V., Sims, E., Wei, L., Vemula, S., Nabinger, S. C., Goodwin, C. B., Chan, R. J., Traina, F., Visconte, V., Tiu, R. V., Lewis, T. A., Stern, A. M., Wen, Q., Crispino, J. D., Boswell, H. S. & Kapur, R., Sep 1 2011, In : Cancer Cell. 20, 3, p. 357-369 13 p.

Research output: Contribution to journalArticle

55 Scopus citations
2009

Survivin is not required for the endomitotic cell cycle of megakaryocytes

Wen, Q., Leung, C., Huang, Z., Small, S., Reddi, A. L., Licht, J. D. & Crispino, J. D., Nov 18 2009, In : Blood. 114, 1, p. 153-156 4 p.

Research output: Contribution to journalArticle

19 Scopus citations
2008

Survivin overexpression alone does not alter megakaryocyte ploidy nor interfere with erythroid/megakaryocytic lineage development in transgenic mice

McCrann, D. J., Yezefski, T., Nguyen, H. G., Papadantonakis, N., Liu, H., Wen, Q., Crispino, J. D. & Ravid, K., Apr 15 2008, In : Blood. 111, 8, p. 4092-4095 4 p.

Research output: Contribution to journalArticle

10 Scopus citations
2004

Reduction of infarct size by orally administered des-aspartate-angiotensin I in the ischemic reperfused rat heart

Wen, Q., Sim, M. K. & Tang, F. R., Aug 15 2004, In : Regulatory Peptides. 120, 1-3, p. 149-153 5 p.

Research output: Contribution to journalArticle

21 Scopus citations