Grants per year
Personal profile
Research Interests
My research interest lies in identification and characterization of cell surface carbohydrates and proteins required for herpes simplex virus (HSV) viral entry and cell fusion. I have been focusing on glycoprotein B (gB) and gL, two of four glycoproteins essential for HSV entry and cell fusion. I have been studying the interaction between gB and gB entry receptor, paired immunoglobulin like-type 2 receptor (PILRa). I am also interested in the interactions among gB, gD, gH and gL.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Plant Physiology, Chinese Academy of Sciences
… → 1998
Research interests keywords
- Virology
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Grants
- 2 Finished
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Herpesvirus Gene Expression in Transformed Cells
Longnecker, R. M. (PD/PI) & Fan, Q. (Other)
2/1/16 → 1/31/19
Project: Research project
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Herpesvirus Gene Expression in Transformed Cells
Longnecker, R. M. (PD/PI) & Fan, Q. (Other)
2/1/13 → 1/31/16
Project: Research project
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Human TMEFF1 is a restriction factor for herpes simplex virus in the brain
Chan, Y. H., Liu, Z., Bastard, P., Khobrekar, N., Hutchison, K. M., Yamazaki, Y., Fan, Q., Matuozzo, D., Harschnitz, O., Kerrouche, N., Nakajima, K., Amin, P., Yatim, A., Rinchai, D., Chen, J., Zhang, P., Ciceri, G., Chen, J., Dobbs, K. & Belkaya, S. & 29 others, , Aug 8 2024, In: Nature. 632, 8024, p. 390-400 11 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Leveraging biotin-based proximity labeling to identify cellular factors governing early alphaherpesvirus infection
Quan, J., Fan, Q., Simons, L. M., Smukowski, S. N., Pegg, C., Longnecker, R., Savas, J. N., Hultquist, J. F. & Smith, G. A., Aug 2024, In: mBio. 15, 8Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Multiple Sites on Glycoprotein H (gH) Functionally Interact with the gB Fusion Protein to Promote Fusion during Herpes Simplex Virus (HSV) Entry
Fan, Q., Hippler, D. P., Yang, Y., Longnecker, R. & Connolly, S. A., Jan 2023, In: mBio. 14, 1Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Herpes simplex virus glycoprotein B mutations define structural sites in domain I, the membrane proximal region, and the cytodomain that regulate entry
Fan, Q., Longnecker, R. & Connolly, S. A., Nov 2021, In: Journal of virology. 95, 22, e01050-21.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Natural selection of glycoprotein B mutations that rescue the small-plaque phenotype of a fusion-impaired herpes simplex virus mutant
Fan, Q., Kopp, S. J., Byskosh, N. C., Connolly, S. A. & Longnecker, R., Sep 1 2018, In: mBio. 9, 5, e01948-18.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations