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R Kannan Mutharasan

  • 863 Citations
20042020
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Research Output 2004 2019

  • 863 Citations
  • 20 Article
  • 3 Review article
  • 1 Chapter
  • 1 Short survey
2019
3 Citations (Scopus)

Dapagliflozin Effects on Biomarkers, Symptoms, and Functional Status in Patients With Heart Failure With Reduced Ejection Fraction: The DEFINE-HF Trial

Nassif, M. E., Windsor, S. L., Tang, F., Khariton, Y., Husain, M., Inzucchi, S. E., Mc-Guire, D. K., Pitt, B., Scirica, B. M., Austin, B., Drazner, M. H., Fong, M. W., Givertz, M. M., Gordon, R. A., Jermyn, R., Katz, S. D., Lamba, S., Lanfear, D. E., LaRue, S. J., Lindenfeld, J. A. & 7 others, Malone, M., Margulies, K., Mentz, R. J., Mutharasan, R. K., Pursley, M., Umpierrez, G. & Kosiborod, M., Oct 29 2019, In : Circulation. 140, 18, p. 1463-1476 14 p.

Research output: Contribution to journal › Article

Heart Failure
Biomarkers
Natriuretic Peptides
Type 2 Diabetes Mellitus
Sodium-Glucose Transporter 2
1 Citation (Scopus)

Risk Adjusting Health Care Provider Collaboration Networks

Chandler, A. E., Mutharasan, R. K., Amelia, L., Carson, M. B., Scholtens, D. M. & Soulakis, N. D., Jan 1 2019, In : Methods of Information in Medicine. 58, 2-3, p. 71-78 8 p.

Research output: Contribution to journal › Article

Health Personnel
Patient Readmission
Risk Adjustment
Workflow
Patient Discharge
2018

A Prospective Pilot Study of Pocket-Carried Ultrasound Pre- and Postdischarge Inferior Vena Cava Assessment for Prediction of Heart Failure Rehospitalization

Akhabue, E., Pierce, J. B., Davidson, L. J., Prenner, S. B., Mutharasan, R. K., Puthumana, J. J., Shah, S. J., Anderson, A. S. & Thomas, J. D., Sep 2018, In : Journal of Cardiac Failure. 24, 9, p. 614-617 4 p.

Research output: Contribution to journal › Article

Inferior Vena Cava
Heart Failure
Prospective Studies
Brain Natriuretic Peptide
Confidence Intervals
9 Citations (Scopus)

A Targeted, Differential Top-Down Proteomic Methodology for Comparison of ApoA-I Proteoforms in Individuals with High and Low HDL Efflux Capacity

Seckler, H. D. S., Fornelli, L., Mutharasan, R. K., Thaxton, C. S., Fellers, R., Daviglus, M., Sniderman, A., Rader, D., Kelleher, N. L., Lloyd-Jones, D. M., Compton, P. D. & Wilkins, J. T., Jun 1 2018, In : Journal of Proteome Research. 17, 6, p. 2156-2164 9 p.

Research output: Contribution to journal › Article

Apolipoprotein A-I
Proteomics
HDL Cholesterol
Bearings (structural)
Lipoylation

Buffer or suffer: Redesigning heart failure postdischarge clinic using queuing theory

Mutharasan, R. K., Ahmad, F. S., Gurvich, I., Alphs Jackson, H., Van Mieghem, J. A. & Yancy, C. W., Jul 1 2018, In : Circulation: Cardiovascular Quality and Outcomes. 11, 7, e004351.

Research output: Contribution to journal › Article

Systems Theory
Buffers
Hospitalization
Heart Failure
Transitional Care
4 Citations (Scopus)

Electrocardiographic findings in national basketball association athletes

Waase, M. P., Kannan Mutharasan, R., Whang, W., DiTullio, M. R., DiFiori, J. P., Callahan, L., Mancell, J., Phelan, D., Schwartz, A., Homma, S. & Engel, D. J., Jan 2018, In : JAMA cardiology. 3, 1, p. 69-74 6 p.

Research output: Contribution to journal › Article

Basketball
Athletes
Electrocardiography
Sports
Age Groups
1 Citation (Scopus)

Reducing Readmissions in Patients With Both Heart Failure and COPD

Kalhan, R. & Mutharasan, R. K., Nov 2018, In : CHEST. 154, 5, p. 1230-1238 9 p.

Research output: Contribution to journal › Review article

Patient Readmission
Chronic Obstructive Pulmonary Disease
Heart Failure
Costs and Cost Analysis
Accountable Care Organizations
2017
16 Citations (Scopus)

HDL efflux capacity, HDL particle size, & high-risk carotid atherosclerosis in a cohort of asymptomatic older adults: The Chicago Healthy Aging Study

Mutharasan, R. K., Thaxton, C. S., Berry, J., Daviglus, M. L., Yuan, C., Sun, J., Ayers, C., Lloyd-Jones, D. M. & Wilkins, J. T., Jan 1 2017, In : Journal of lipid research. 58, 3, p. 600-606 7 p.

Research output: Contribution to journal › Article

Carotid Artery Diseases
Particle Size
Aging of materials
Particle size
Lipids
3 Citations (Scopus)

Leveraging electronic health record documentation for Failure Mode and Effects Analysis team identification

Kricke, G. S., Carson, M. B., Lee, Y. J., Benacka, C., Mutharasan, R. K., Ahmad, F., Kansal, P., Yancy, C. W., Anderson, A. S. & Soulakis, N. D., Mar 1 2017, In : Journal of the American Medical Informatics Association. 24, 2, p. 288-294 7 p., ocw083.

Research output: Contribution to journal › Article

Electronic Health Records
Documentation
Quality Improvement
Workflow
Observation
3 Citations (Scopus)

Targeting the correct population when designing transitional care programs for medicare patients hospitalized with heart failure

Ahmad, F., Wehbe, R. M., Kansal, P., Jackson, H. A., Anderson, A. S., Yancy, C. W. & Mutharasan, R. K., Nov 1 2017, In : JAMA cardiology. 2, 11, p. 1274-1275 2 p.

Research output: Contribution to journal › Article

Medicare
Heart Failure
Population
Transitional Care
2016
6 Citations (Scopus)

Characterizing Teamwork in Cardiovascular Care Outcomes: A Network Analytics Approach

Carson, M. B., Scholtens, D. M., Frailey, C. N., Gravenor, S. J., Powell, E. S., Wang, A. Y., Kricke, G. S., Ahmad, F. S., Mutharasan, R. K. & Soulakis, N. D., Nov 1 2016, In : Circulation: Cardiovascular Quality and Outcomes. 9, 6, p. 670-678 9 p.

Research output: Contribution to journal › Article

Patient Satisfaction
Inpatients
Aptitude
Quality Improvement
Cardiology
2015
9 Citations (Scopus)

High-density lipoproteins for therapeutic delivery systems

Kannan Mutharasan, R., Foit, L. & Shad Thaxton, C., Jan 1 2015, In : Journal of Materials Chemistry B. 4, 2, p. 188-197 10 p.

Research output: Contribution to journal › Article

Lipoproteins
HDL Lipoproteins
Drug delivery
Lipids
Oligonucleotides
36 Citations (Scopus)

Nanoparticle targeting and cholesterol flux through scavenger receptor type B-1 inhibits cellular exosome uptake

Plebanek, M. P., Mutharasan, R. K., Volpert, O., Matov, A., Gatlin, J. C. & Thaxton, C. S., Oct 29 2015, In : Scientific reports. 5, 15724.

Research output: Contribution to journal › Article

Exosomes
Scavenger Receptors
Nanoparticles
Cholesterol
HDL Lipoproteins
5 Citations (Scopus)

Reducing protein oxidation in low-flow electrospray enables deeper investigation of proteoforms by top down proteomics

Kim, K., Compton, P. D., Toby, T. K., Thomas, P. M., Wilkins, J. T., Mutharasan, R. K. & Kelleher, N. L., Sep 1 2015, In : EuPA Open Proteomics. 8, p. 40-47 8 p.

Research output: Contribution to journal › Article

Proteomics
Oxidation
Proteins
Liquid chromatography
Sanitary Engineering
2014
281 Citations (Scopus)

Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation

Ichikawa, Y., Ghanefar, M., Bayeva, M., Wu, R., Khechaduri, A., Naga Prasad, S. V., Mutharasan, R. K., Jairaj Naik, T. & Ardehali, H., Feb 3 2014, In : Journal of Clinical Investigation. 124, 2, p. 617-630 14 p.

Research output: Contribution to journal › Article

Doxorubicin
Iron
Cardiomyopathies
Mitochondria
Dexrazoxane
2013
21 Citations (Scopus)

MicroRNA-210 decreases heme levels by targeting ferrochelatase in cardiomyocytes.

Qiao, A., Khechaduri, A., Kannan Mutharasan, R., Wu, R., Nagpal, V. & Ardehali, H., Apr 2013, In : Unknown Journal. 2, 2, p. e000121

Research output: Contribution to journal › Article

Ferrochelatase
MicroRNAs
Heme
Cardiac Myocytes
Iron
72 Citations (Scopus)

Templated high density lipoprotein nanoparticles as potential therapies and for molecular delivery

Damiano, M. G., Mutharasan, R. K., Tripathy, S., McMahon, K. M. & Thaxton, C. S., May 1 2013, In : Advanced Drug Delivery Reviews. 65, 5, p. 649-662 14 p.

Research output: Contribution to journal › Review article

HDL Lipoproteins
Nanoparticles
Therapeutics
Apolipoprotein A-I
Pharmaceutical Preparations
2012

Cell therapy for cardiac disease

Mutharasan, R. K. & Losordo, D. W., Dec 1 2012, Muscle. Elsevier Inc, Vol. 1. p. 697-705 9 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

60 Citations (Scopus)

Disruption of ATP-binding cassette B8 in mice leads to cardiomyopathy through a decrease in mitochondrial iron export

Ichikawa, Y., Bayeva, M., Ghanefar, M., Potini, V., Sun, L., Mutharasan, R. K., Wu, R., Khechaduri, A., Naik, T. J. & Ardehali, H., Mar 13 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 11, p. 4152-4157 6 p.

Research output: Contribution to journal › Article

Cardiomyopathies
Iron
Adenosine Triphosphate
Protein S
Mitochondria
2011
93 Citations (Scopus)

Biomimetic high density lipoprotein nanoparticles for nucleic acid delivery

McMahon, K. M., Mutharasan, R. K., Tripathy, S., Veliceasa, D., Bobeica, M., Shumaker, D. K., Luthi, A. J., Helfand, B. T., Ardehali, H., Mirkin, C. A., Volpert, O. & Thaxton, C. S., Mar 9 2011, In : Nano letters. 11, 3, p. 1208-1214 7 p.

Research output: Contribution to journal › Article

lipoproteins
hardware description languages
Lipoproteins
Nucleic acids
biomimetics
111 Citations (Scopus)

microRNA-210 is upregulated in hypoxic cardiomyocytes through Akt- and p53-dependent pathways and exerts cytoprotective effects

Mutharasan, R. K., Nagpal, V., Ichikawa, Y. & Ardehali, H., Oct 1 2011, In : American Journal of Physiology - Heart and Circulatory Physiology. 301, 4, p. H1519-H1530

Research output: Contribution to journal › Article

MicroRNAs
Cardiac Myocytes
Apoptosis Inducing Factor
Aryl Hydrocarbon Receptor Nuclear Translocator
Mitochondria
2010
19 Citations (Scopus)

Nanotechnology for synthetic high-density lipoproteins

Luthi, A. J., Patel, P. C., Ko, C. H., Mutharasan, R. K., Mirkin, C. A. & Thaxton, C. S., Dec 1 2010, In : Trends in Molecular Medicine. 16, 12, p. 553-560 8 p.

Research output: Contribution to journal › Short survey

Nanotechnology
HDL Lipoproteins
Coronary Disease
Atherosclerosis
Cholesterol
2008
89 Citations (Scopus)

The sulfonylurea receptor, an atypical ATP-binding cassette protein, and its regulation of the KATP channel

Burke, M. A., Mutharasan, R. K. & Ardehali, H., Feb 1 2008, In : Circulation research. 102, 2, p. 164-176 13 p.

Research output: Contribution to journal › Review article

Sulfonylurea Receptors
KATP Channels
Carrier Proteins
Adenosine Triphosphate
Heart Failure
2004
3 Citations (Scopus)

Computer three-dimensional reconstruction of the atrioventricular conduction system

Mutharasan, R. K., Nagaraj, A., Hamilton, A. J., McPherson, D. D. & Bharati, S., Jun 1 2004, In : PACE - Pacing and Clinical Electrophysiology. 27, 6 PART I, p. 740-748 9 p.

Research output: Contribution to journal › Article

Atrioventricular Node
Canidae
Microscopy
Software
Color
18 Citations (Scopus)

Identification of hydrophobic interactions between proteins and lipids: Free fatty acids activate phospholipase C δ1 via allosterism

Kobayashi, M., Mutharasan, R. K., Feng, J., Roberts, M. F. & Lomasney, J. W., Jun 15 2004, In : Biochemistry. 43, 23, p. 7522-7533 12 p.

Research output: Contribution to journal › Article

Type C Phospholipases
Hydrophobic and Hydrophilic Interactions
Nonesterified Fatty Acids
Arachidonic Acid
Lipids