Rama K Mishra

  • 1392 Citations
1988 …2024
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Personal profile

Education/Academic qualification

PhD, Sambalpur University

… → 2006

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Fullerenes Chemical Compounds
Molecules Chemical Compounds
Quantitative Structure-Activity Relationship Medicine & Life Sciences
Ligands Medicine & Life Sciences
Phosphotransferases Chemical Compounds
Hydrocarbons Chemical Compounds
Hemagglutinins Medicine & Life Sciences
Polynomials Chemical Compounds

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Grants 2012 2024

Neoplasms
Therapeutics
Bone Marrow Diseases
Mutation
Hematopoiesis
Antidepressive Agents
High-Throughput Screening Assays
Manuscripts
Organized Financing
Research
Astemizole
Castration
Nuclear Factor 90 Proteins
Prostatic Neoplasms
Zinc Compounds

Research Output 1988 2019

  • 1392 Citations
  • 67 Article
  • 1 Comment/debate
  • 1 Editorial
  • 1 Review article

Development of Tetrahydroindazole-Based Potent and Selective Sigma-2 Receptor Ligands

Iyamu, I. D., Lv, W., Malik, N., Mishra, R. K. & Schiltz, G. E., Jul 3 2019, In : ChemMedChem. 14, 13, p. 1248-1256 9 p.

Research output: Contribution to journalArticle

Drug Discovery
Ligands
Central Nervous System Diseases
Neurology
Solubility
2 Citations (Scopus)

Discovery of a novel class of potent and selective tetrahydroindazole-based sigma-1 receptor ligands

Iyamu, I. D., Lv, W., Malik, N., Mishra, R. K. & Schiltz, G. E., May 1 2019, In : Bioorganic and Medicinal Chemistry. 27, 9, p. 1824-1835 12 p.

Research output: Contribution to journalArticle

Protein Transport
Ligands
Molecular modeling
Central Nervous System Diseases
Structure-Activity Relationship
2 Citations (Scopus)

Discovery of covalent enzyme inhibitors using virtual docking of covalent fragments

Chowdhury, S. R., Kennedy, S., Zhu, K., Mishra, R. K., Chuong, P., Nguyen, A. U., Kathman, S. G. & Statsyuk, A. V., Jan 1 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 1, p. 36-39 4 p.

Research output: Contribution to journalArticle

Cysteine Proteinase Inhibitors
Cathepsin L
Cathepsin B
Enzyme Inhibitors
Peptide Hydrolases

Discovery of novel Mnk inhibitors using mutation-based induced-fit virtual high-throughput screening

Mishra, R. K., Clutter, M. R., Blyth, G. T., Kosciuczuk, E. M., Blackburn, A. Z., Beauchamp, E. M., Schiltz, G. E. & Platanias, L. C., Oct 1 2019, In : Chemical Biology and Drug Design. 94, 4, p. 1813-1823 11 p.

Research output: Contribution to journalArticle

Screening
Phosphotransferases
Throughput
Acute Myeloid Leukemia
Mutation

Modeling MEK4 Kinase Inhibitors through Perturbed Electrostatic Potential (ESP) Charges

Mishra, R. K., Deibler, K. K., Clutter, M. R., Vagadia, P. P., O'Connor, M., Schiltz, G. E., Bergan, R. & Scheidt, K. A., Jan 1 2019, (Accepted/In press) In : Journal of Chemical Information and Modeling.

Research output: Contribution to journalArticle

Electrostatics
activity structure
Phosphotransferases
non-alignment
predictive model