Rama K Mishra

  • 1519 Citations
1988 …2020

Research output per year

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Research Output

  • 1519 Citations
  • 69 Article
  • 1 Comment/debate
  • 1 Editorial
  • 1 Review article
2020

In silico analysis of alternative splicing on drug-target gene interactions

Ji, Y., Mishra, R. K. & Davuluri, R. V., Dec 1 2020, In : Scientific reports. 10, 1, 134.

Research output: Contribution to journalArticle

Open Access

Targeted Covalent Inhibition of Telomerase

Betori, R. C., Liu, Y., Mishra, R. K., Cohen, S. B., Kron, S. J. & Scheidt, K. A., Mar 20 2020, In : ACS chemical biology. 15, 3, p. 706-717 12 p.

Research output: Contribution to journalArticle

2 Scopus citations
2019

Development of Tetrahydroindazole-Based Potent and Selective Sigma-2 Receptor Ligands

Iyamu, I. D., Lv, W., Malik, N., Mishra, R. K. & Schiltz, G. E., Jul 3 2019, In : ChemMedChem. 14, 13, p. 1248-1256 9 p.

Research output: Contribution to journalArticle

Discovery of a novel class of potent and selective tetrahydroindazole-based sigma-1 receptor ligands

Iyamu, I. D., Lv, W., Malik, N., Mishra, R. K. & Schiltz, G. E., May 1 2019, In : Bioorganic and Medicinal Chemistry. 27, 9, p. 1824-1835 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Discovery of covalent enzyme inhibitors using virtual docking of covalent fragments

Chowdhury, S. R., Kennedy, S., Zhu, K., Mishra, R., Chuong, P., Nguyen, A. U., Kathman, S. G. & Statsyuk, A. V., Jan 1 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 1, p. 36-39 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Discovery of novel Mnk inhibitors using mutation-based induced-fit virtual high-throughput screening

Mishra, R. K., Clutter, M. R., Blyth, G. T., Kosciuczuk, E. M., Blackburn, A. Z., Beauchamp, E. M., Schiltz, G. E. & Platanias, L. C., Oct 1 2019, In : Chemical Biology and Drug Design. 94, 4, p. 1813-1823 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Modeling MEK4 Kinase Inhibitors through Perturbed Electrostatic Potential (ESP) Charges

Mishra, R. K., Deibler, K. K., Clutter, M. R., Vagadia, P. P., O'Connor, M., Schiltz, G. E., Bergan, R. & Scheidt, K. A., Jan 1 2019, (Accepted/In press) In : Journal of Chemical Information and Modeling.

Research output: Contribution to journalArticle

1 Scopus citations

Small-Molecule MYC Inhibitors Suppress Tumor Growth and Enhance Immunotherapy

Han, H., Jain, A. D., Truica, M. I., Izquierdo-Ferrer, J., Anker, J. F., Lysy, B., Sagar, V., Luan, Y., Chalmers, Z. R., Unno, K., Mok, H., Vatapalli, R., Yoo, Y. A., Rodriguez, Y., Kandela, I., Parker, J. B., Chakravarti, D., Mishra, R. K., Schiltz, G. E. & Abdulkadir, S. A., Nov 11 2019, In : Cancer Cell. 36, 5, p. 483-497.e15

Research output: Contribution to journalArticle

7 Scopus citations

Synthesis and Biological Evaluation of 3-Arylindazoles as Selective MEK4 Inhibitors

Deibler, K. K., Schiltz, G. E., Clutter, M., Mishra, R. K., Vagadia, P. P., O'Connor, M., George, M. D., Gordon, R., Fowler, G., Bergan, R. & Scheidt, K. A., Mar 22 2019, In : ChemMedChem. 14, 6, p. 615-620 6 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Selective disruption of TLR2/MyD88 interaction inhibits inflammation and attenuates Alzheimer's pathology

Rangasamy, S. B., Jana, M., Roy, A., Corbett, G. T., Kundu, M., Chandra, S., Mondal, S., Dasarathi, S., Mufson, E. J., Mishra, R. K., Luan, C-H., Bennett, D. A. & Pahan, K., Jul 10 2018, In : The Journal of clinical investigation.

Research output: Contribution to journalArticle

11 Scopus citations

Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced Cancer Therapy

Liang, K., Smith, E. R., Aoi, Y., Stoltz, K. L., Katagi, H., Woodfin, A. R., Rendleman, E. J., Marshall, S. A., Murray, D. C., Wang, L., Ozark, P. A., Mishra, R. K., Hashizume, R., Schiltz, G. E. & Shilatifard, A., Oct 18 2018, In : Cell. 175, 3, p. 766-779.e17

Research output: Contribution to journalArticle

21 Scopus citations

Tissue tranglutaminase regulates interactions between ovarian cancer stem cells and the tumor niche

Condello, S., Sima, L., Ivan, C., Cardenas, H., Schiltz, G., Mishra, R. K. & Matei, D., Jun 1 2018, In : Cancer Research. 78, 11, p. 2990-3001 12 p.

Research output: Contribution to journalArticle

11 Scopus citations
2017

A Chemical Probe Strategy for Interrogating Inhibitor Selectivity Across the MEK Kinase Family

Deibler, K. K., Mishra, R. K., Clutter, M. R., Antanasijevic, A., Bergan, R., Caffrey, M. & Scheidt, K. A., May 19 2017, In : ACS chemical biology. 12, 5, p. 1245-1256 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation

Calvert, A. E., Chalastanis, A., Wu, Y., Hurley, L. A., Kouri, F., Bi, Y., Kachman, M., May, J. L., Bartom, E. T., Hua, Y., Mishra, R. K., Schiltz, G. E., Dubrovskyi, O., Mazar, A. P., Peter, M. E., Zheng, H., James, C. D., Burant, C. F., Chandel, N., Davuluri, R. V. & 2 others, Horbinski, C. M. & Stegh, A. H., May 30 2017, In : Cell reports. 19, 9, p. 1858-1873 16 p.

Research output: Contribution to journalArticle

43 Scopus citations

Catalytic, Enantioselective β-Protonation through a Cooperative Activation Strategy

Wang, M. H., Barsoum, D., Schwamb, C. B., Cohen, D. T., Goess, B. C., Riedrich, M., Chan, A., Maki, B. E., Mishra, R. K. & Scheidt, K. A., May 5 2017, In : Journal of Organic Chemistry. 82, 9, p. 4689-4702 14 p.

Research output: Contribution to journalArticle

13 Scopus citations

Descriptor spaces for QSAR: Delving into the history of the expanding frontier

Basak, S. C. & Mishra, R. K., Mar 1 2017, In : Current Computer-Aided Drug Design. 13, 1, p. 4-7 4 p.

Research output: Contribution to journalEditorial

Development of GLUT4-selective antagonists for multiple myeloma therapy

Wei, C., Bajpai, R., Sharma, H., Heitmeier, M., Jain, A. D., Matulis, S. M., Nooka, A. K., Mishra, R. K., Hruz, P. W., Schiltz, G. E. & Shanmugam, M., Oct 20 2017, In : European Journal of Medicinal Chemistry. 139, p. 573-586 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

Homology modeling of FFA2 identifies novel agonists that potentiate insulin secretion

Villa, S. R., Mishra, R. K., Zapater, J. L., Priyadarshini, M., Gilchrist, A., Mancebo, H., Schiltz, G. E. & Layden, B. T., Dec 1 2017, In : Journal of Investigative Medicine. 65, 8, p. 1116-1124 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Molecular Mechanism Underlying the Action of Influenza A Virus Fusion Inhibitor MBX2546

Basu, A., Komazin-Meredith, G., McCarthy, C., Antanasijevic, A., Cardinale, S. C., Mishra, R. K., Barnard, D. L., Caffrey, M., Rong, L. & Bowlin, T. L., May 12 2017, In : ACS Infectious Diseases. 3, 5, p. 330-335 6 p.

Research output: Contribution to journalArticle

5 Scopus citations
2016
23 Scopus citations

Identification and characterization of PPARα ligands in the hippocampus

Roy, A., Kundu, M., Jana, M., Mishra, R. K., Yung, Y., Luan, C. H., Gonzalez, F. J. & Pahan, K., Dec 1 2016, In : Nature Chemical Biology. 12, 12, p. 1075-1083 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Stabilization and improvement of a promising influenza antiviral: Making a PAIN PAINless

Antanasijevic, A., Hafeman, N. J., Tundup, S., Kingsley, C., Mishra, R. K., Rong, L., Manicassamy, B., Wardrop, D. & Caffrey, M., Jul 25 2016, In : ACS Infectious Diseases. 2, 9, p. 608-615 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

The role of Fas-associated phosphatase 1 in leukemia stem cell persistence during tyrosine kinase inhibitor treatment of chronic myeloid leukemia

Huang, W., Luan, C. H., Hjort, E. E., Bei, L., Mishra, R., Sakamoto, K. M., Platanias, L. C. & Eklund, E. A., Jul 1 2016, In : Leukemia. 30, 7, p. 1502-1509 8 p.

Research output: Contribution to journalArticle

9 Scopus citations
2015

A structure guided QSAR: A rapid and accurate technique to predict IC50: A case study

Mishra, R. K. & Singh, J., Sep 1 2015, In : Current Computer-Aided Drug Design. 11, 2, p. 152-163 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Enantioselective β-Protonation by a Cooperative Catalysis Strategy

Wang, M. H., Cohen, D. T., Schwamb, C. B., Mishra, R. K. & Scheidt, K. A., May 13 2015, In : Journal of the American Chemical Society. 137, 18, p. 5891-5894 4 p.

Research output: Contribution to journalArticle

52 Scopus citations

HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice

Roy, A., Jana, M., Kundu, M., Corbett, G. T., Rangaswamy, S. B., Mishra, R. K., Luan, C-H., Gonzalez, F. J. & Pahan, K., Aug 4 2015, In : Cell Metabolism. 22, 2, p. 253-265 13 p.

Research output: Contribution to journalArticle

74 Scopus citations

In Silico Modeling-based Identification of Glucose Transporter 4 (GLUT4)-selective Inhibitors for Cancer Therapy

Mishra, R. K., Wei, C., Hresko, R. C., Bajpai, R., Heitmeier, M., Matulis, S. M., Nooka, A. K., Rosen, S. T., Hruz, P. W., Schiltz, G. E. & Shanmugam, M., Jun 5 2015, In : Journal of Biological Chemistry. 290, 23, p. 14441-14453 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

Virtual High-Throughput Screening to Identify Novel Activin Antagonists

Zhu, J., Mishra, R. K., Schiltz, G. E., Makanji, Y., Scheidt, K. A., Mazar, A. P. & Woodruff, T. K., Jul 23 2015, In : Journal of Medicinal Chemistry. 58, 14, p. 5637-5648 12 p.

Research output: Contribution to journalArticle

8 Scopus citations
2014

Enantioselective annulations for dihydroquinolones by in situ generation of azolium enolates

Lee, A., Younai, A., Price, C. K., Izquierdo, J., Mishra, R. K. & Scheidt, K. A., Jul 30 2014, In : Journal of the American Chemical Society. 136, 30, p. 10589-10592 4 p.

Research output: Contribution to journalArticle

153 Scopus citations

Inhibin at 90: From discovery to clinical application, a historical review

Makanji, Y., Zhu, J., Mishra, R. K., Holmquist, C., Wong, W. P. S., Schwartz, N. B., Mayo, K. E. & Woodruff, T. K., 2014, In : Endocrine reviews. 35, 5, p. 747-794 48 p.

Research output: Contribution to journalReview article

76 Scopus citations

Mutagenesis studies of the H5 influenza hemagglutinin stem loop region

Antanasijevic, A., Basu, A., Bowlin, T. L., Mishra, R. K., Rong, L. & Caffrey, M., Aug 8 2014, In : Journal of Biological Chemistry. 289, 32, p. 22237-22245 9 p.

Research output: Contribution to journalArticle

5 Scopus citations
2013

A fluorescence-based thermal shift assay identifies inhibitors of mitogen activated protein kinase kinase 4

Krishna, S. N., Luan, C. H., Mishra, R. K., Xu, L., Scheidt, K. A., Anderson, W. F. & Bergan, R. C., Dec 5 2013, In : PloS one. 8, 12, e81504.

Research output: Contribution to journalArticle

24 Scopus citations
2012

Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL

Wen, Q., Goldenson, B., Silver, S. J., Schenone, M., Dancik, V., Huang, Z., Wang, L. Z., Lewis, T. A., An, W. F., Li, X., Bray, M. A., Thiollier, C., Diebold, L., Gilles, L., Vokes, M. S., Moore, C. B., Bliss-Moreau, M., Verplank, L., Tolliday, N. J., Mishra, R. & 28 others, Vemula, S., Shi, J., Wei, L., Kapur, R., Lopez, C. K., Gerby, B., Ballerini, P., Pflumio, F., Gilliland, D. G., Goldberg, L., Birger, Y., Izraeli, S., Gamis, A. S., Smith, F. O., Woods, W. G., Taub, J., Scherer, C. A., Bradner, J. E., Goh, B. C., Mercher, T., Carpenter, A. E., Gould, R. J., Clemons, P. A., Carr, S. A., Root, D. E., Schreiber, S. L., Stern, A. M. & Crispino, J. D., Aug 3 2012, In : Cell. 150, 3, p. 575-589 15 p.

Research output: Contribution to journalArticle

88 Scopus citations

Methylenedioxy- and ethylenedioxy-fused indolocarbazoles: Potent human topoisomerase I inhibitors and antitumor agents

Zembower, D. E., Xie, Y., Koohang, A., Kuffel, M. J., Ames, M. M., Zhou, Y., Mishra, R., Mar, A. A., Flavin, M. T. & Xu, Z. Q., Dec 1 2012, In : Anti-Cancer Agents in Medicinal Chemistry. 12, 9, p. 1117-1131 15 p.

Research output: Contribution to journalArticle

6 Scopus citations
2011

Remarkable stereospecific conjugate additions to the Hsp90 inhibitor celastrol

Klaić, L., Trippier, P. C., Mishra, R. K., Morimoto, R. I. & Silverman, R. B., Dec 14 2011, In : Journal of the American Chemical Society. 133, 49, p. 19634-19637 4 p.

Research output: Contribution to journalArticle

32 Scopus citations
2010

Discovery of 4-[(2S)-2-{[4-(4-Chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl] butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis

Sandanayaka, V., Mamat, B., Mishra, R. K., Winger, J., Krohn, M., Zhou, L. M., Keyvan, M., Enache, L., Sullins, D., Onua, E., Zhang, J., Halldorsdottir, G., Sigthorsdottir, H., Thorlaksdottir, A., Sigthorsson, G., Thorsteinnsdottir, M., Davies, D. R., Stewart, L. J., Zembower, D. E., Andresson, T. & 3 others, Kiselyov, A. S., Singh, J. & Gurney, M. E., Mar 1 2010, In : Journal of Medicinal Chemistry. 53, 2, p. 573-585 13 p.

Research output: Contribution to journalArticle

44 Scopus citations

Erratum: Corrections to discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography (Journal of Medicinal Chemistry (2009) 52 (4694) DOI: 10.1021/jm900259h)

Davies, D. R., Mamat, B., Magnusson, O. T., Christensen, J., Haraldsson, M. H., Mishra, R., Pease, B., Hansen, E., Singh, J., Zembower, D., Kim, H., Kiselyov, A. S., Burgin, A. B., Gurney, M. E. & Stewart, L. J., Mar 11 2010, In : Journal of Medicinal Chemistry. 53, 5, p. 2330-2331 2 p.

Research output: Contribution to journalComment/debate

Generation, validation, and utilization of a three-dimensional pharmacophore model for EP3 antagonists

Mishra, R. K. & Singh, J., Aug 23 2010, In : Journal of Chemical Information and Modeling. 50, 8, p. 1502-1509 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Structure - activity relationship studies leading to the identification of (2E)-3-[l-[(2,4-dichlorophenyl)methyl]-5-fluoro-3-methyl-lH-indol-7-yl]-N-[(4, 5-dichloro-2-thienyl)sulfonyl]-2-propenamide (DG-041), a potent and selective prostanoid EP3 receptor antagonist, as a novel antiplatelet agent that does not prolong bleeding

Singh, J., Zeller, W., Zhou, N., Hategan, G., Mishra, R. K., Polozov, A., Yu, P., Onua, E., Zhang, J., Ramírez, J. L., Sigthorsson, G., Thorsteinnsdottir, M., Kiselyov, A. S., Zembower, D. E., Andrésson, T. & Gurney, M. E., Jan 28 2010, In : Journal of Medicinal Chemistry. 53, 1, p. 18-36 19 p.

Research output: Contribution to journalArticle

33 Scopus citations
2009

Antagonists of the EP3 receptor for prostaglandin e2 are novel antiplatelet agents that do not prolong bleeding

Singh, J., Zeller, W., Zhou, N., Hategen, G., Mishra, R., Polozov, A., Yu, P., Onua, E., Zhang, J., Zembower, D., Kiselyov, A., Ramírez, J. L., Sigthorsson, G., Bjornsson, J. M., Thorsteinsdottir, M., Andresson, T., Bjarnadottir, M., Magnusson, O., Fabre, J. E., Stefansson, K. & 1 others, Gurney, M. E., Feb 20 2009, In : ACS chemical biology. 4, 2, p. 115-126 12 p.

Research output: Contribution to journalArticle

59 Scopus citations

Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography

Davies, D. R., Mamat, B., Magnusson, O. T., Christensen, J., Haraldsson, M. H., Mishra, R., Pease, B., Hansen, E., Singh, J., Zembower, D., Kim, H., Kiselyov, A. S., Burgin, A. B., Gurney, M. E. & Stewart, L. J., Aug 13 2009, In : Journal of Medicinal Chemistry. 52, 15, p. 4694-4715 22 p.

Research output: Contribution to journalArticle

85 Scopus citations

Heterocyclic 1,7-disubstituted indole sulfonamides are potent and selective human EP3 receptor antagonists

Hategan, G., Polozov, A. M., Zeller, W., Cao, H., Mishra, R. K., Kiselyov, A. S., Ramirez, J., Halldorsdottir, G., Andrésson, T., Gurney, M. E. & Singh, J., Dec 1 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 23, p. 6797-6800 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Peri-substituted hexahydro-indolones as novel, potent and selective human EP3 receptor antagonists

O'Connell, M., Zeller, W., Burgeson, J., Mishra, R. K., Ramirez, J., Kiselyov, A. S., Andrésson, T., Gurney, M. E. & Singh, J., Feb 1 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 3, p. 778-782 5 p.

Research output: Contribution to journalArticle

14 Scopus citations
2008

DcpS as a therapeutic target for spinal muscular atrophy

Singh, J., Salcius, M., Liu, S. W., Staker, B. L., Mishra, R., Thurmond, J., Michaud, G., Mattoon, D. R., Printen, J., Christensen, J., Bjornsson, J. M., Pollok, B. A., Kiledjian, M., Stewart, L., Jarecki, J. & Gurney, M. E., Nov 21 2008, In : ACS chemical biology. 3, 11, p. 711-722 12 p.

Research output: Contribution to journalArticle

92 Scopus citations

Synthesis and biological evaluation of novel 2,4-diaminoquinazoline derivatives as SMN2 promoter activators for the potential treatment of spinal muscular atrophy

Thurmond, J., Butchbach, M. E. R., Palomo, M., Pease, B., Rao, M., Bedell, L., Keyvan, M., Pai, G., Mishra, R., Haraldsson, M., Andresson, T., Bragason, G., Thosteinsdottir, M., Bjornsson, J. M., Coovert, D. D., Burghes, A. H. M., Gurney, M. E. & Singh, J., Feb 14 2008, In : Journal of Medicinal Chemistry. 51, 3, p. 449-469 21 p.

Research output: Contribution to journalArticle

76 Scopus citations
2005

A density functional theory study for the hydrogen-bonded nucleic acid base pair: Cytosine dimer

Sahu, P. K., Mishra, R. K. & Lee, S. L., Mar 31 2005, In : Journal of Physical Chemistry A. 109, 12, p. 2887-2893 7 p.

Research output: Contribution to journalArticle

15 Scopus citations
2003

Computational studies of the growth mechanism of small fullerenes: A ring-stacking model

Lin, W. H., Mishra, R. K., Lin, Y. T. & Lee, S. L., Jan 1 2003, In : Journal of the Chinese Chemical Society. 50, 3 B, p. 575-582 8 p.

Research output: Contribution to journalArticle

1 Scopus citations
2002

Predicting blood-brain barrier partitioning of organic molecules using membrane-interaction QSAR analysis

Iyer, M., Mishra, R., Han, Y. & Hopfinger, A. J., Nov 1 2002, In : Pharmaceutical Research. 19, 11, p. 1611-1621 11 p.

Research output: Contribution to journalArticle

124 Scopus citations
2001

C28 (D2): Fullerene growth mechanism

Mishra, R. K., Lin, Y. T. & Lee, S. L., Sep 20 2001, In : International Journal of Quantum Chemistry. 84, 6, p. 642-648 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Free energy force field (FEFF) 3D-QSAR analysis of a set of Plasmodium falciparum dihydrofolate reductase inhibitors

Santos-Filho, O. A., Mishra, R. K. & Hopfinger, A. J., Dec 24 2001, In : Journal of Computer-Aided Molecular Design. 15, 9, p. 787-810 24 p.

Research output: Contribution to journalArticle

35 Scopus citations