Grants per year
Personal profile
Research Interests
A primary goal of my work is to establish the approaches and benefits of genomics informed personalized medicine. A key element of this is participation in the eMERGE consortium (http://gwas.net), where I serve as the steering committee chair. This project uses Electronic Health Records linked biobank samples (www.nugene.org) to study the genetics of disease susceptibility, therapeutic outcomes and pharmacogenomics. My group is also interested in genome informatics, particularly genome annotation and visualization technology.
Training Experience
1984 | Postdoctoral Fellowship, Massachusetts Institute of Technology |
Education/Academic qualification
PhD, Microbiology, University of Michigan
… → 1980
Research interests keywords
- Bioinformatics
- Biotechnology
- Cell Biology
- Cytoskeleton
- Genetics
- Genomics
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Collaborations and top research areas from the last five years
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Dictyostelium Community Resource
National Institute of General Medical Sciences
9/1/20 → 8/31/25
Project: Research project
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Northwestern Genomic Risk Assessment and Management Program
Chisholm, R. L., McNally, E. M., Rasmussen-Torvik, L. J., Gordon, A. S., Kho, A. N., Luo, Y., Perera, M., Roy-Puckelwartz, M. J., Scherr, C. E. L., Scholtens, D. M., Smith, M. E., Starren, J., Walunas, T. L., Wehbe, F., Aufox, S. A. & Hoell, C.
National Human Genome Research Institute
7/1/20 → 4/30/25
Project: Research project
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The Dictyostelium Stock Center
National Institute of General Medical Sciences
9/15/19 → 8/31/20
Project: Research project
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Development of dictyBase, an online informatics resource
National Institute of General Medical Sciences
9/15/19 → 8/31/21
Project: Research project
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Education and electronic medical records and genomics network, challenges, and lessons learned from a large-scale clinical trial using polygenic risk scores
Connolly, J. J., Berner, E. S., Smith, M., Levy, S., Terek, S., Harr, M., Karavite, D., Suckiel, S., Holm, I. A., Dufendach, K., Nelson, C., Khan, A., Chisholm, R. L., Allworth, A., Wei, W. Q., Bland, H. T., Clayton, E. W., Soper, E. R., Linder, J. E., Limdi, N. A., & 15 others , Sep 2023, In: Genetics in Medicine. 25, 9, 100906.Research output: Contribution to journal › Review article › peer-review
1 Scopus citations -
Multi-ancestry genome- and phenome-wide association studies of diverticular disease in electronic health records with natural language processing enriched phenotyping algorithm
Joo, Y. Y., Pacheco, J. A., Thompson, W. K., Rasmussen-Torvik, L. J., Rasmussen, L. V., Lin, F. T. J., de Andrade, M., Borthwick, K. M., Bottinger, E., Cagan, A., Carrell, D. S., Denny, J. C., Ellis, S. B., Gottesman, O., Linneman, J. G., Pathak, J., Peissig, P. L., Shang, N., Tromp, G., Veerappan, A., & 5 others , May 2023, In: PloS one. 18, 5 MAY, e0283553.Research output: Contribution to journal › Article › peer-review
Open Access -
Returning integrated genomic risk and clinical recommendations: The eMERGE study
eMERGE Consortium, Apr 2023, In: Genetics in Medicine. 25, 4, 100006.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
A research agenda to support the development and implementation of genomics-based clinical informatics tools and resources
Wiley, K., Findley, L., Goldrich, M., Rakhra-Burris, T. K., Stevens, A., Williams, P., Bult, C. J., Chisholm, R., Deverka, P., Ginsburg, G. S., Green, E. D., Jarvik, G., Mensah, G. A., Ramos, E., Relling, M. V., Roden, D. M., Rowley, R., Alterovitz, G., Aronson, S., Bastarache, L., & 19 others , Aug 1 2022, In: Journal of the American Medical Informatics Association. 29, 8, p. 1342-1349 8 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries
Banday, A. R., Stanifer, M. L., Florez-Vargas, O., Onabajo, O. O., Papenberg, B. W., Zahoor, M. A., Mirabello, L., Ring, T. J., Lee, C. H., Albert, P. S., Andreakos, E., Arons, E., Barsh, G., Biesecker, L. G., Boyle, D. L., Brahier, M. S., Burnett-Hartman, A., Carrington, M., Chang, E., Choe, P. G., & 50 others , Aug 2022, In: Nature Genetics. 54, 8, p. 1103-1116 14 p.Research output: Contribution to journal › Article › peer-review
Open Access24 Scopus citations
Datasets
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Additional file 3 of Mutant resources for functional genomics in Dictyostelium discoideum using REMI-seq technology
Gruenheit, N. (Creator), Baldwin, A. (Creator), Stewart, B. (Creator), Jaques, S. (Creator), Keller, T. (Creator), Parkinson, K. (Creator), Salvidge, W. (Creator), Baines, R. (Creator), Brimson, C. (Creator), Wolf, J. B. (Creator), Chisholm, R. L. (Creator), Harwood, A. J. (Creator) & Thompson, C. R. L. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.16435986, https://springernature.figshare.com/articles/dataset/Additional_file_3_of_Mutant_resources_for_functional_genomics_in_Dictyostelium_discoideum_using_REMI-seq_technology/16435986
Dataset
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Additional file 10 of Mutant resources for functional genomics in Dictyostelium discoideum using REMI-seq technology
Gruenheit, N. (Creator), Baldwin, A. (Creator), Stewart, B. (Creator), Jaques, S. (Creator), Keller, T. (Creator), Parkinson, K. (Creator), Salvidge, W. (Creator), Baines, R. (Creator), Brimson, C. (Creator), Wolf, J. B. (Creator), Chisholm, R. L. (Creator), Harwood, A. J. (Creator) & Thompson, C. R. L. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.16435965, https://springernature.figshare.com/articles/dataset/Additional_file_10_of_Mutant_resources_for_functional_genomics_in_Dictyostelium_discoideum_using_REMI-seq_technology/16435965
Dataset
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Additional file 14 of Mutant resources for functional genomics in Dictyostelium discoideum using REMI-seq technology
Gruenheit, N. (Creator), Baldwin, A. (Creator), Stewart, B. (Creator), Jaques, S. (Creator), Keller, T. (Creator), Parkinson, K. (Creator), Salvidge, W. (Creator), Baines, R. (Creator), Brimson, C. (Creator), Wolf, J. B. (Creator), Chisholm, R. L. (Creator), Harwood, A. J. (Creator) & Thompson, C. R. L. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.16435977, https://springernature.figshare.com/articles/dataset/Additional_file_14_of_Mutant_resources_for_functional_genomics_in_Dictyostelium_discoideum_using_REMI-seq_technology/16435977
Dataset
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Additional file 13 of Mutant resources for functional genomics in Dictyostelium discoideum using REMI-seq technology
Gruenheit, N. (Creator), Baldwin, A. (Creator), Stewart, B. (Creator), Jaques, S. (Creator), Keller, T. (Creator), Parkinson, K. (Creator), Salvidge, W. (Creator), Baines, R. (Creator), Brimson, C. (Creator), Wolf, J. B. (Creator), Chisholm, R. L. (Creator), Harwood, A. J. (Creator) & Thompson, C. R. L. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.16435974, https://springernature.figshare.com/articles/dataset/Additional_file_13_of_Mutant_resources_for_functional_genomics_in_Dictyostelium_discoideum_using_REMI-seq_technology/16435974
Dataset
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Additional file 1 of Mutant resources for functional genomics in Dictyostelium discoideum using REMI-seq technology
Gruenheit, N. (Creator), Baldwin, A. (Creator), Stewart, B. (Creator), Jaques, S. (Creator), Keller, T. (Creator), Parkinson, K. (Creator), Salvidge, W. (Creator), Baines, R. (Creator), Brimson, C. (Creator), Wolf, J. B. (Creator), Chisholm, R. L. (Creator), Harwood, A. J. (Creator) & Thompson, C. R. L. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.16435980, https://springernature.figshare.com/articles/dataset/Additional_file_1_of_Mutant_resources_for_functional_genomics_in_Dictyostelium_discoideum_using_REMI-seq_technology/16435980
Dataset