Rex L Chisholm

  • 12446 Citations
1976 …2023
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Personal profile

Research Interests

A primary goal of my work is to establish the approaches and benefits of genomics informed personalized medicine. A key element of this is participation in the eMERGE consortium (, where I serve as the steering committee chair. This project uses Electronic Health Records linked biobank samples ( to study the genetics of disease susceptibility, therapeutic outcomes and pharmacogenomics. My group is also interested in genome informatics, particularly genome annotation and visualization technology.

Training Experience

1984Postdoctoral Fellowship, Massachusetts Institute of Technology

Education/Academic qualification

PhD, University of Michigan

… → 1980


  • Bioinformatics
  • Biotechnology
  • Cell Biology
  • Cytoskeleton
  • Genetics
  • Genomics

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Grants 2001 2023

Hypertrophic Cardiomyopathy
Heart Failure
Dilated Cardiomyopathy
Patient Outcome Assessment
Research Personnel
Patient Participation
Electronic Health Records
National Human Genome Research Institute (U.S.)
Genome-Wide Association Study
Practice Guidelines
Electronic Health Records
National Human Genome Research Institute (U.S.)
Genome-Wide Association Study
Practice Guidelines

Research Output 1976 2018

8 Citations

Research Directions in the Clinical Implementation of Pharmacogenomics: An Overview of US Programs and Projects

Volpi, S., Bult, C. J., Chisholm, R. L., Deverka, P. A., Ginsburg, G. S., Jacob, H. J., Kasapi, M., McLeod, H. L., Roden, D. M., Williams, M. S., Green, E. D., Rodriguez, L. L., Aronson, S., Cavallari, L. H., Denny, J. C., Dressler, L. G., Johnson, J. A., Klein, T. E., Leeder, J. S., Piquette-Miller, M. & 12 othersPerera, M., Rasmussen-Torvik, L. J., Rehm, H. L., Ritchie, M. D., Skaar, T. C., Wagle, N., Weinshilboum, R., Weitzel, K. W., Wildin, R., Wilson, J., Manolio, T. A. & Relling, M. V., May 1 2018, In : Clinical pharmacology and therapeutics. 103, 5, p. 778-786 9 p.

Research output: Contribution to journalArticle

Pharmaceutical Preparations
Precision Medicine
Drug-Related Side Effects and Adverse Reactions
1 Citations
Electronic Health Records
Herpes Zoster
Medical Records
8 Citations

Apolipoprotein L1 Variants and Blood Pressure Traits in African Americans

Nadkarni, G. N., Galarneau, G., Ellis, S. B., Nadukuru, R., Zhang, J., Scott, S. A., Schurmann, C., Li, R., Rasmussen-Torvik, L. J., Kho, A. N., Hayes, M. G., Pacheco, J. A., Manolio, T. A., Chisholm, R. L., Roden, D. M., Denny, J. C., Kenny, E. E. & Bottinger, E. P., Mar 28 2017, In : Journal of the American College of Cardiology. 69, 12, p. 1564-1574 11 p.

Research output: Contribution to journalArticle

African Americans
Blood Pressure
30 Citations

Bedside Back to Bench: Building Bridges between Basic and Clinical Genomic Research

Manolio, T. A., Fowler, D. M., Starita, L. M., Haendel, M. A., MacArthur, D. G., Biesecker, L. G., Worthey, E., Chisholm, R. L., Green, E. D., Jacob, H. J., McLeod, H. L., Roden, D., Rodriguez, L. L., Williams, M. S., Cooper, G. M., Cox, N. J., Herman, G. E., Kingsmore, S., Lo, C., Lutz, C. & 11 othersMacRae, C. A., Nussbaum, R. L., Ordovas, J. M., Ramos, E. M., Robinson, P. N., Rubinstein, W. S., Seidman, C., Stranger, B. E., Wang, H., Westerfield, M. & Bult, C., Mar 23 2017, In : Cell. 169, 1, p. 6-12 7 p.

Research output: Contribution to journalComment/debate

Inborn Genetic Diseases
Information Dissemination
276 Citations

Expansion of the gene ontology knowledgebase and resources: The gene ontology consortium

Carbon, S., Dietze, H., Lewis, S. E., Mungall, C. J., Munoz-Torres, M. C., Basu, S., Chisholm, R. L., Dodson, R. J., Fey, P., Thomas, P. D., Mi, H., Muruganujan, A., Huang, X., Poudel, S., Hu, J. C., Aleksander, S. A., McIntosh, B. K., Renfro, D. P., Siegele, D. A., Antonazzo, G. & 31 othersAttrill, H., Brown, N. H., Marygold, S. J., Mc-Quilton, P., Ponting, L., Millburn, G. H., Rey, A. J., Stefancsik, R., Tweedie, S., Falls, K., Schroeder, A. J., Courtot, M., Osumi-Sutherland, D., Parkinson, H., Roncaglia, P., Lovering, R. C., Foulger, R. E., Huntley, R. P., Denny, P., Campbell, N. H., Kramarz, B., Patel, S., Buxton, J. L., Umrao, Z., Deng, A. T., Alrohaif, H., Mitchell, K., Ratnaraj, F., Omer, W., Rodríguez-López, M. & The Gene Ontology Consortium, Jan 1 2017, In : Nucleic acids research. 45, D1, p. D331-D338

Research output: Contribution to journalArticle

Gene Ontology
Knowledge Bases
Biological Models
Systems Biology