Rex L Chisholm

  • 13623 Citations
1976 …2023
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Personal profile

Research Interests

A primary goal of my work is to establish the approaches and benefits of genomics informed personalized medicine. A key element of this is participation in the eMERGE consortium (, where I serve as the steering committee chair. This project uses Electronic Health Records linked biobank samples ( to study the genetics of disease susceptibility, therapeutic outcomes and pharmacogenomics. My group is also interested in genome informatics, particularly genome annotation and visualization technology.

Training Experience

1984Postdoctoral Fellowship, Massachusetts Institute of Technology

Education/Academic qualification

PhD, University of Michigan

… → 1980


  • Bioinformatics
  • Biotechnology
  • Cell Biology
  • Cytoskeleton
  • Genetics
  • Genomics

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Grants 2001 2023

Hypertrophic Cardiomyopathy
Heart Failure
Dilated Cardiomyopathy
Electronic Health Records
National Human Genome Research Institute (U.S.)
Genome-Wide Association Study
Practice Guidelines
Electronic Health Records
National Human Genome Research Institute (U.S.)
Genome-Wide Association Study
Practice Guidelines
Electronic Health Records
National Human Genome Research Institute (U.S.)
Genome-Wide Association Study
Practice Guidelines

Research Output 1976 2019

An ancillary genomics system to support the return of pharmacogenomic results

Rasmussen, L. V., Smith, M. E., Almaraz, F., Persell, S. D., Rasmussen-Torvik, L. J., Pacheco, J. A., Chisholm, R. L., Christensen, C., Herr, T. M., Wehbe, F. & Starren, J. B., Feb 19 2019, In : Journal of the American Medical Informatics Association. 26, 4, p. 306-310 5 p.

Research output: Contribution to journalArticle

Clinical Decision Support Systems
Electronic Health Records
Information Storage and Retrieval
1 Citation (Scopus)
Electronic Health Records
Herpes Zoster
Medical Records
9 Citations (Scopus)

The Gene Ontology Resource: 20 years and still GOing strong

Carbon, S., Douglass, E., Dunn, N., Good, B., Harris, N. L., Lewis, S. E., Mungall, C. J., Basu, S., Chisholm, R. L., Dodson, R. J., Hartline, E., Fey, P., Thomas, P. D., Albou, L. P., Ebert, D., Kesling, M. J., Mi, H., Muruganujan, A., Huang, X., Poudel, S. & 173 othersMushayahama, T., Hu, J. C., LaBonte, S. A., Siegele, D. A., Antonazzo, G., Attrill, H., Brown, N. H., Fexova, S., Garapati, P., Jones, T. E. M., Marygold, S. J., Millburn, G. H., Rey, A. J., Trovisco, V., Dos Santos, G., Emmert, D. B., Falls, K., Zhou, P., Goodman, J. L., Strelets, V. B., Thurmond, J., Courtot, M., Osumi, D. S., Parkinson, H., Roncaglia, P., Acencio, M. L., Kuiper, M., Lreid, A., Logie, C., Lovering, R. C., Huntley, R. P., Denny, P., Campbell, N. H., Kramarz, B., Acquaah, V., Ahmad, S. H., Chen, H., Rawson, J. H., Chibucos, M. C., Giglio, M., Nadendla, S., Tauber, R., Duesbury, M. J., Del, N. T., Meldal, B. H. M., Perfetto, L., Porras, P., Orchard, S., Shrivastava, A., Xie, Z., Chang, H. Y., Finn, R. D., Mitchell, A. L., Rawlings, N. D., Richardson, L., Sangrador-Vegas, A., Blake, J. A., Christie, K. R., Dolan, M. E., Drabkin, H. J., Hill, D. P., Ni, L., Sitnikov, D., Harris, M. A., Oliver, S. G., Rutherford, K., Wood, V., Hayles, J., Bahler, J., Lock, A., Bolton, E. R., De Pons, J., Dwinell, M., Hayman, G. T., Laulederkind, S. J. F., Shimoyama, M., Tutaj, M., Wang, S. J., D'Eustachio, P., Matthews, L., Balhoff, J. P., Aleksander, S. A., Binkley, G., Dunn, B. L., Cherry, J. M., Engel, S. R., Gondwe, F., Karra, K., MacPherson, K. A., Miyasato, S. R., Nash, R. S., Ng, P. C., Sheppard, T. K., Shrivatsav Vp, A., Simison, M., Skrzypek, M. S., Weng, S., Wong, E. D., Feuermann, M., Gaudet, P., Bakker, E., Berardini, T. Z., Reiser, L., Subramaniam, S., Huala, E., Arighi, C., Auchincloss, A., Axelsen, K., Argoud, G. P., Bateman, A., Bely, B., Blatter, M. C., Boutet, E., Breuza, L., Bridge, A., Britto, R., Bye-A-Jee, H., Casals-Casas, C., Coudert, E., Estreicher, A., Famiglietti, L., Garmiri, P., Georghiou, G., Gos, A., Gruaz-Gumowski, N., Hatton-Ellis, E., Hinz, U., Hulo, C., Ignatchenko, A., Jungo, F., Keller, G., Laiho, K., Lemercier, P., Lieberherr, D., Lussi, Y., Mac-Dougall, A., Magrane, M., Martin, M. J., Masson, P., Natale, D. A., Hyka, N. N., Pedruzzi, I., Pichler, K., Poux, S., Rivoire, C., Rodriguez-Lopez, M., Sawford, T., Speretta, E., Shypitsyna, A., Stutz, A., Sundaram, S., Tognolli, M., Tyagi, N., Warner, K., Zaru, R., Wu, C., Chan, J., Cho, J., Gao, S., Grove, C., Harrison, M. C., Howe, K., Lee, R., Mendel, J., Muller, H. M., Raciti, D., Van Auken, K., Berriman, M., Stein, L., Sternberg, P. W., Howe, D., Toro, S. & Westerfield, M., Jan 8 2019, In : Nucleic acids research. 47, D1, p. D330-D338

Research output: Contribution to journalArticle

Open Access
Gene Ontology
Biological Science Disciplines
9 Citations (Scopus)

Research Directions in the Clinical Implementation of Pharmacogenomics: An Overview of US Programs and Projects

Volpi, S., Bult, C. J., Chisholm, R. L., Deverka, P. A., Ginsburg, G. S., Jacob, H. J., Kasapi, M., McLeod, H. L., Roden, D. M., Williams, M. S., Green, E. D., Rodriguez, L. L., Aronson, S., Cavallari, L. H., Denny, J. C., Dressler, L. G., Johnson, J. A., Klein, T. E., Leeder, J. S., Piquette-Miller, M. & 12 othersPerera, M., Rasmussen-Torvik, L. J., Rehm, H. L., Ritchie, M. D., Skaar, T. C., Wagle, N., Weinshilboum, R., Weitzel, K. W., Wildin, R., Wilson, J., Manolio, T. A. & Relling, M. V., May 1 2018, In : Clinical pharmacology and therapeutics. 103, 5, p. 778-786 9 p.

Research output: Contribution to journalArticle

Pharmaceutical Preparations
Precision Medicine
Drug-Related Side Effects and Adverse Reactions
8 Citations (Scopus)

Apolipoprotein L1 Variants and Blood Pressure Traits in African Americans

Nadkarni, G. N., Galarneau, G., Ellis, S. B., Nadukuru, R., Zhang, J., Scott, S. A., Schurmann, C., Li, R., Rasmussen-Torvik, L. J., Kho, A. N., Hayes, M. G., Pacheco, J. A., Manolio, T. A., Chisholm, R. L., Roden, D. M., Denny, J. C., Kenny, E. E. & Bottinger, E. P., Mar 28 2017, In : Journal of the American College of Cardiology. 69, 12, p. 1564-1574 11 p.

Research output: Contribution to journalArticle

Blood Pressure
African Americans