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Rex L Chisholm

  • 13623 Citations
1976 …2023
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Personal profile

Research Interests

A primary goal of my work is to establish the approaches and benefits of genomics informed personalized medicine. A key element of this is participation in the eMERGE consortium (http://gwas.net), where I serve as the steering committee chair. This project uses Electronic Health Records linked biobank samples (www.nugene.org) to study the genetics of disease susceptibility, therapeutic outcomes and pharmacogenomics. My group is also interested in genome informatics, particularly genome annotation and visualization technology.

Training Experience

1984Postdoctoral Fellowship, Massachusetts Institute of Technology

Education/Academic qualification

PhD, University of Michigan

… → 1980

Keywords

  • Bioinformatics
  • Biotechnology
  • Cell Biology
  • Cytoskeleton
  • Genetics
  • Genomics

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Grants 2001 2023

Genomic context alters disease manifestation of cardiomyopathies

Chisholm, R. L., George Jr, A. L., McNally, E. M., Roy-Puckelwartz, M. J. & Shah, S. J.

American Heart Association

7/1/18 → 6/30/21

Project: Research project

Cardiomyopathies
Mutation
Hypertrophic Cardiomyopathy
Heart Failure
Dilated Cardiomyopathy

Infrastructure: Illinois Precision Medicine Consortium (IPMC)

Ackermann, R. T., Chisholm, R. L., Cristofanilli, M., Greenland, P., Kho, A. N., Ho, J., Simon, M. A., Smith, M. E. & Wehbe, F.

Office of the Director, National Institutes of Health

6/1/18 → 5/31/23

Project: Research project

Precision Medicine
Health Personnel
Organizations
Research
Biomedical Technology

Subproject for Genomic Medicine at Northwestern: Discovery and Implementation

Chisholm, R. L.

National Human Genome Research Institute

9/1/15 → 5/31/19

Project: Research project

Electronic Health Records
Medicine
National Human Genome Research Institute (U.S.)
Genome-Wide Association Study
Practice Guidelines

SUPPLEMENT: Genomic Medicine at Northwestern: Discovery and Implementation

Chisholm, R. L.

National Human Genome Research Institute

9/1/15 → 5/31/19

Project: Research project

Electronic Health Records
Medicine
National Human Genome Research Institute (U.S.)
Genome-Wide Association Study
Practice Guidelines

Genomic Medicine at Northwestern: Discovery and Implementation

Aufox, S. A., Chisholm, R. L., George Jr, A. L., Hayes, M. G., Kho, A. N., McNally, E. M., Rasmussen-Torvik, L. J., Roy-Puckelwartz, M. J., Smith, M. E. & Starren, J. B.

National Human Genome Research Institute

9/1/15 → 5/31/19

Project: Research project

Electronic Health Records
Medicine
National Human Genome Research Institute (U.S.)
Genome-Wide Association Study
Practice Guidelines

Research Output 1976 2019

An ancillary genomics system to support the return of pharmacogenomic results

Rasmussen, L. V., Smith, M. E., Almaraz, F., Persell, S. D., Rasmussen-Torvik, L. J., Pacheco, J. A., Chisholm, R. L., Christensen, C., Herr, T. M., Wehbe, F. & Starren, J. B., Feb 19 2019, In : Journal of the American Medical Informatics Association. 26, 4, p. 306-310 5 p.

Research output: Contribution to journal › Article

Clinical Decision Support Systems
Electronic Health Records
Pharmacogenetics
Genomics
Information Storage and Retrieval
1 Citation (Scopus)

The eMERGE genotype set of 83,717 subjects imputed to ~40 million variants genome wide and association with the herpes zoster medical record phenotype

The eMERGE Network, Feb 1 2019, In : Genetic Epidemiology. 43, 1, p. 63-81 19 p.

Research output: Contribution to journal › Article

Electronic Health Records
Herpes Zoster
Genomics
Medical Records
Genotype
9 Citations (Scopus)

The Gene Ontology Resource: 20 years and still GOing strong

Carbon, S., Douglass, E., Dunn, N., Good, B., Harris, N. L., Lewis, S. E., Mungall, C. J., Basu, S., Chisholm, R. L., Dodson, R. J., Hartline, E., Fey, P., Thomas, P. D., Albou, L. P., Ebert, D., Kesling, M. J., Mi, H., Muruganujan, A., Huang, X., Poudel, S. & 173 othersMushayahama, T., Hu, J. C., LaBonte, S. A., Siegele, D. A., Antonazzo, G., Attrill, H., Brown, N. H., Fexova, S., Garapati, P., Jones, T. E. M., Marygold, S. J., Millburn, G. H., Rey, A. J., Trovisco, V., Dos Santos, G., Emmert, D. B., Falls, K., Zhou, P., Goodman, J. L., Strelets, V. B., Thurmond, J., Courtot, M., Osumi, D. S., Parkinson, H., Roncaglia, P., Acencio, M. L., Kuiper, M., Lreid, A., Logie, C., Lovering, R. C., Huntley, R. P., Denny, P., Campbell, N. H., Kramarz, B., Acquaah, V., Ahmad, S. H., Chen, H., Rawson, J. H., Chibucos, M. C., Giglio, M., Nadendla, S., Tauber, R., Duesbury, M. J., Del, N. T., Meldal, B. H. M., Perfetto, L., Porras, P., Orchard, S., Shrivastava, A., Xie, Z., Chang, H. Y., Finn, R. D., Mitchell, A. L., Rawlings, N. D., Richardson, L., Sangrador-Vegas, A., Blake, J. A., Christie, K. R., Dolan, M. E., Drabkin, H. J., Hill, D. P., Ni, L., Sitnikov, D., Harris, M. A., Oliver, S. G., Rutherford, K., Wood, V., Hayles, J., Bahler, J., Lock, A., Bolton, E. R., De Pons, J., Dwinell, M., Hayman, G. T., Laulederkind, S. J. F., Shimoyama, M., Tutaj, M., Wang, S. J., D'Eustachio, P., Matthews, L., Balhoff, J. P., Aleksander, S. A., Binkley, G., Dunn, B. L., Cherry, J. M., Engel, S. R., Gondwe, F., Karra, K., MacPherson, K. A., Miyasato, S. R., Nash, R. S., Ng, P. C., Sheppard, T. K., Shrivatsav Vp, A., Simison, M., Skrzypek, M. S., Weng, S., Wong, E. D., Feuermann, M., Gaudet, P., Bakker, E., Berardini, T. Z., Reiser, L., Subramaniam, S., Huala, E., Arighi, C., Auchincloss, A., Axelsen, K., Argoud, G. P., Bateman, A., Bely, B., Blatter, M. C., Boutet, E., Breuza, L., Bridge, A., Britto, R., Bye-A-Jee, H., Casals-Casas, C., Coudert, E., Estreicher, A., Famiglietti, L., Garmiri, P., Georghiou, G., Gos, A., Gruaz-Gumowski, N., Hatton-Ellis, E., Hinz, U., Hulo, C., Ignatchenko, A., Jungo, F., Keller, G., Laiho, K., Lemercier, P., Lieberherr, D., Lussi, Y., Mac-Dougall, A., Magrane, M., Martin, M. J., Masson, P., Natale, D. A., Hyka, N. N., Pedruzzi, I., Pichler, K., Poux, S., Rivoire, C., Rodriguez-Lopez, M., Sawford, T., Speretta, E., Shypitsyna, A., Stutz, A., Sundaram, S., Tognolli, M., Tyagi, N., Warner, K., Zaru, R., Wu, C., Chan, J., Cho, J., Gao, S., Grove, C., Harrison, M. C., Howe, K., Lee, R., Mendel, J., Muller, H. M., Raciti, D., Van Auken, K., Berriman, M., Stein, L., Sternberg, P. W., Howe, D., Toro, S. & Westerfield, M., Jan 8 2019, In : Nucleic acids research. 47, D1, p. D330-D338

Research output: Contribution to journal › Article

Open Access
Gene Ontology
Genes
Biological Science Disciplines
9 Citations (Scopus)

Research Directions in the Clinical Implementation of Pharmacogenomics: An Overview of US Programs and Projects

Volpi, S., Bult, C. J., Chisholm, R. L., Deverka, P. A., Ginsburg, G. S., Jacob, H. J., Kasapi, M., McLeod, H. L., Roden, D. M., Williams, M. S., Green, E. D., Rodriguez, L. L., Aronson, S., Cavallari, L. H., Denny, J. C., Dressler, L. G., Johnson, J. A., Klein, T. E., Leeder, J. S., Piquette-Miller, M. & 12 othersPerera, M., Rasmussen-Torvik, L. J., Rehm, H. L., Ritchie, M. D., Skaar, T. C., Wagle, N., Weinshilboum, R., Weitzel, K. W., Wildin, R., Wilson, J., Manolio, T. A. & Relling, M. V., May 1 2018, In : Clinical pharmacology and therapeutics. 103, 5, p. 778-786 9 p.

Research output: Contribution to journal › Article

Pharmacogenetics
Research
Pharmaceutical Preparations
Precision Medicine
Drug-Related Side Effects and Adverse Reactions
8 Citations (Scopus)

Apolipoprotein L1 Variants and Blood Pressure Traits in African Americans

Nadkarni, G. N., Galarneau, G., Ellis, S. B., Nadukuru, R., Zhang, J., Scott, S. A., Schurmann, C., Li, R., Rasmussen-Torvik, L. J., Kho, A. N., Hayes, M. G., Pacheco, J. A., Manolio, T. A., Chisholm, R. L., Roden, D. M., Denny, J. C., Kenny, E. E. & Bottinger, E. P., Mar 28 2017, In : Journal of the American College of Cardiology. 69, 12, p. 1564-1574 11 p.

Research output: Contribution to journal › Article

Apolipoproteins
Blood Pressure
Alleles
Meta-Analysis
African Americans