Grants per year
Personal profile
Research Interests
A primary goal of my work is to establish the approaches and benefits of genomics informed personalized medicine. A key element of this is participation in the eMERGE consortium (http://gwas.net), where I serve as the steering committee chair. This project uses Electronic Health Records linked biobank samples (www.nugene.org) to study the genetics of disease susceptibility, therapeutic outcomes and pharmacogenomics. My group is also interested in genome informatics, particularly genome annotation and visualization technology.
Training Experience
| 1984 | Postdoctoral Fellowship, Massachusetts Institute of Technology |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Microbiology, University of Michigan
… → 1980
Research interests keywords
- Bioinformatics
- Biotechnology
- Cell Biology
- Cytoskeleton
- Genetics
- Genomics
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Transforming health at the intersection of implementation science, learning health systems, and genomics at Northwestern Medicine
Beidas, R. S. (PD/PI), Beidas, R. S. (PD/PI), Franklin, P. D. (PD/PI), Franklin, P. D. (PD/PI), Godley, L. A. (PD/PI), Godley, L. A. (PD/PI), McNally, E. M. (PD/PI), McNally, E. M. (PD/PI), Ahmad, F. S. (Co-Investigator), Ahmad, F. S. (Co-Investigator), Bass, M. (Co-Investigator), Bass, M. (Co-Investigator), Beach, L. B. (Co-Investigator), Beach, L. B. (Co-Investigator), Becker, S. (Co-Investigator), Becker, S. (Co-Investigator), Bradley, C. D. (Co-Investigator), Bradley, C. D. (Co-Investigator), Chisholm, R. L. (Co-Investigator), Chisholm, R. L. (Co-Investigator), Chorniy, A. (Co-Investigator), Chorniy, A. (Co-Investigator), Holmes, K. (Co-Investigator), Holmes, K. (Co-Investigator), Rasmussen-Torvik, L. J. (Co-Investigator), Rasmussen-Torvik, L. J. (Co-Investigator), Rini, C. (Co-Investigator), Rini, C. (Co-Investigator), Scott, K. (Co-Investigator), Scott, K. (Co-Investigator), Skolarus, L. E. (Co-Investigator), Skolarus, L. E. (Co-Investigator), Walunas, T. L. (Co-Investigator), Walunas, T. L. (Co-Investigator), Young, J. L. (Co-Investigator) & Young, J. L. (Co-Investigator)
National Human Genome Research Institute
9/1/24 → 7/31/29
Project: Research project
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The Illinois Precision Medicine Consortium (IPMC)
Ho, J. (PD/PI), Ho, J. (PD/PI), Chisholm, R. L. (Co-Investigator), Greenland, P. (Co-Investigator), Greenland, P. (Co-Investigator), Patel, R. B. (Co-Investigator), Patel, R. B. (Co-Investigator), Rasmussen-Torvik, L. J. (Co-Investigator) & Simon, M. A. (Co-Investigator)
The University of Chicago, Office of the Director, National Institutes of Health
9/1/23 → 8/31/25
Project: Research project
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WashU-Northwestern Genomic Variation and Function Data and Administrative Coordinating Center
Yue, F. (PD/PI), Yue, F. (PD/PI), Chisholm, R. L. (Co-Investigator), Chisholm, R. L. (Co-Investigator), Luo, Y. (Co-Investigator), Luo, Y. (Co-Investigator), Stranger, B. E. (Co-Investigator) & Stranger, B. E. (Co-Investigator)
Washington University in St. Louis, National Human Genome Research Institute
8/24/21 → 5/31/26
Project: Research project
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Dictyostelium Community Resource
Chisholm, R. L. (PD/PI) & Chisholm, R. L. (PD/PI)
National Institute of General Medical Sciences
9/1/20 → 8/31/25
Project: Research project
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WashU-Northwestern Genomic Variation and Function Data and Administrative Coordinating Center
Yue, F. (PD/PI), Chisholm, R. L. (Co-Investigator), Luo, Y. (Co-Investigator) & Stranger, B. E. (Co-Investigator)
Washington University in St. Louis, National Human Genome Research Institute
6/1/22 → 5/31/23
Project: Research project
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A compendium of human gene functions derived from evolutionary modelling
Gene Ontology Consortium, Zebrafish Information Network (ZFIN), Xenbase, WormBase, UniProt Consortium (EMBL-EBI), UniProt Consortium (Swiss-Prot Group), The Arabidopsis Information Resource (TAIR), SynGO Consortium, Saccharomyces Genome Database, Rat Genome Database, Reactome, PomBase, Mouse Genome Informatics, Functional Gene Annotation UCL, FlyBase, Evidence and Conclusion Ontology, dictyBase & CACAO/EcoliWiki, 2025, (Accepted/In press) In: Nature. 244.Research output: Contribution to journal › Article › peer-review
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A genomic mutational constraint map using variation in 76,156 human genomes
Genome Aggregation Database Consortium, Jan 4 2024, In: Nature. 625, 7993, p. 92-100 9 p.Research output: Contribution to journal › Article › peer-review
483 Scopus citations -
Author Correction: A genomic mutational constraint map using variation in 76,156 human genomes (Nature, (2024), 625, 7993, (92-100), 10.1038/s41586-023-06045-0)
Genome Aggregation Database Consortium, Feb 1 2024, In: Nature. 626, 7997, p. E1Research output: Contribution to journal › Comment/debate › peer-review
9 Scopus citations -
Deciphering the impact of genomic variation on function
UM1HG011969, UM1HG011966, Single Cell, QTL/Statgen, Phenotypic Impact and Function, Neuro, Noncoding Variants, MPRA, iPSC, Impact on Diverse Populations, Immune, Imaging, Evolution, Enumerating Variants, Defining and Systematizing Function, CRISPR, Coding Variants, Cellular Programs and Networks, Cardiometabolic & Standards and Pipelines & 60 others, , Sep 5 2024, In: Nature. 633, 8028, p. 47-57 11 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
From Calculation to Communication: Using Risk Score Calculators to Inform Clinical Decision Making and Facilitate Patient Engagement
Fakhari, H., Scherr, C. L., Moe, S., Hoell, C., Smith, M. E., Rasmussen-Torvik, L. J., Chisholm, R. L. & McNally, E. M., Nov 2024, In: Medical Decision Making. 44, 8, p. 900-913 14 p.Research output: Contribution to journal › Article › peer-review
Datasets
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Mutant resources for functional genomics in Dictyostelium discoideum using REMI-seq technology
Gruenheit, N. (Creator), Baldwin, A. (Creator), Stewart, B. (Creator), Jaques, S. (Creator), Keller, T. (Creator), Parkinson, K. (Creator), Salvidge, W. (Creator), Baines, R. (Creator), Brimson, C. (Creator), Wolf, J. B. (Creator), Chisholm, R. (Creator), Harwood, A. J. (Creator) & Thompson, C. R. L. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.c.5580699, https://springernature.figshare.com/collections/Mutant_resources_for_functional_genomics_in_Dictyostelium_discoideum_using_REMI-seq_technology/5580699
Dataset
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Additional file 7 of Mutant resources for functional genomics in Dictyostelium discoideum using REMI-seq technology
Gruenheit, N. (Creator), Baldwin, A. (Creator), Stewart, B. (Creator), Jaques, S. (Creator), Keller, T. (Creator), Parkinson, K. (Creator), Salvidge, W. (Creator), Baines, R. (Creator), Brimson, C. (Creator), Wolf, J. B. (Creator), Chisholm, R. (Creator), Harwood, A. J. (Creator) & Thompson, C. R. L. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.16436001, https://springernature.figshare.com/articles/dataset/Additional_file_7_of_Mutant_resources_for_functional_genomics_in_Dictyostelium_discoideum_using_REMI-seq_technology/16436001
Dataset
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Additional file 12 of Mutant resources for functional genomics in Dictyostelium discoideum using REMI-seq technology
Gruenheit, N. (Creator), Baldwin, A. (Creator), Stewart, B. (Creator), Jaques, S. (Creator), Keller, T. (Creator), Parkinson, K. (Creator), Salvidge, W. (Creator), Baines, R. (Creator), Brimson, C. (Creator), Wolf, J. B. (Creator), Chisholm, R. (Creator), Harwood, A. J. (Creator) & Thompson, C. R. L. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.16435971, https://springernature.figshare.com/articles/dataset/Additional_file_12_of_Mutant_resources_for_functional_genomics_in_Dictyostelium_discoideum_using_REMI-seq_technology/16435971
Dataset
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Additional file 10 of Mutant resources for functional genomics in Dictyostelium discoideum using REMI-seq technology
Gruenheit, N. (Creator), Baldwin, A. (Creator), Stewart, B. (Creator), Jaques, S. (Creator), Keller, T. (Creator), Parkinson, K. (Creator), Salvidge, W. (Creator), Baines, R. (Creator), Brimson, C. (Creator), Wolf, J. B. (Creator), Chisholm, R. (Creator), Harwood, A. J. (Creator) & Thompson, C. R. L. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.16435965, https://springernature.figshare.com/articles/dataset/Additional_file_10_of_Mutant_resources_for_functional_genomics_in_Dictyostelium_discoideum_using_REMI-seq_technology/16435965
Dataset
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Additional file 14 of Mutant resources for functional genomics in Dictyostelium discoideum using REMI-seq technology
Gruenheit, N. (Creator), Baldwin, A. (Creator), Stewart, B. (Creator), Jaques, S. (Creator), Keller, T. (Creator), Parkinson, K. (Creator), Salvidge, W. (Creator), Baines, R. (Creator), Brimson, C. (Creator), Wolf, J. B. (Creator), Chisholm, R. (Creator), Harwood, A. J. (Creator) & Thompson, C. R. L. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.16435977, https://springernature.figshare.com/articles/dataset/Additional_file_14_of_Mutant_resources_for_functional_genomics_in_Dictyostelium_discoideum_using_REMI-seq_technology/16435977
Dataset