Grants per year
Personal profile
Research Interests
The focus of our lab is to acquire a quantitative mechanistic characterization of synaptic players at different length scales, from a single protein to the synapse level, to describe this complexity and towards understanding of the molecular nature of information processing in the brain. We do so by developing quantitative biophysical and cell biology analyses using cutting edge single molecule and high throughput approaches that draw from cell biology, chemistry, physics and engineering.
Education/Academic qualification
PhD, University of Illinois at Urbana-Champaign
… → 2012
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Grants
- 2 Active
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Quantitative analysis of metabotropic glutamate receptor activation and modulation
National Institute of General Medical Sciences
9/15/20 → 8/31/25
Project: Research project
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C-093: Visualizing the dynamic process of activation and modulation of adhesion GPCRs
Searle Funds at The Chicago Community Trust
1/1/17 → 12/31/21
Project: Research project
Research Output
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Conformational rearrangement during activation of a metabotropic glutamate receptor
Liauw, B. W. H., Afsari, H. S. & Vafabakhsh, R., Mar 2021, In: Nature Chemical Biology. 17, 3, p. 291-297 7 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices
Lerner, E., Barth, A., Hendrix, J., Ambrose, B., Birkedal, V., Blanchard, S. C., Börner, R., Chung, H. S., Cordes, T., Craggs, T. D., Deniz, A. A., Diao, J., Fei, J., Gonzalez, R. L., Gopich, I. V., Ha, T., Hanke, C. A., Haran, G., Hatzakis, N. S., Hohng, S. & 27 others, , Mar 2021, In: eLife. 10, e60416.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations -
Mechanism of Assembly and Cooperativity of Homomeric and Heteromeric Metabotropic Glutamate Receptors
Levitz, J., Habrian, C., Bharill, S., Fu, Z., Vafabakhsh, R. & Isacoff, E. Y., Oct 5 2016, In: Neuron. 92, 1, p. 143-159 17 p.Research output: Contribution to journal › Article › peer-review
73 Scopus citations -
Structural dynamics of potassium-channel gating revealed by single-molecule FRET
Wang, S., Vafabakhsh, R., Borschel, W. F., Ha, T. & Nichols, C. G., Jan 1 2016, In: Nature Structural and Molecular Biology. 23, 1, p. 31-36 6 p.Research output: Contribution to journal › Article › peer-review
42 Scopus citations -
Conformational dynamics of a class C G-protein-coupled receptor
Vafabakhsh, R., Levitz, J. & Isacoff, E. Y., Aug 27 2015, In: Nature. 524, 7566, p. 497-501 5 p.Research output: Contribution to journal › Article › peer-review
95 Scopus citations