Grants per year
Personal profile
Research Interests
The research in Professor Silverman’s group can be summarized as investigations of the molecular mechanisms of action, rational design, and syntheses of potential medicinal agents. The primary focus is basic research into central nervous system disorders, including Parkinson’s disease, cerebral palsy, amyotrophic lateral sclerosis, addiction, and epilepsy. Other therapeutic areas include cancer (melanoma and hepatocellular carcinoma), lysosomal storage diseases, such as Gaucher’s disease, and bacterial infection. Numerous drugs are known to function as specific inhibitors of particular enzymes. For some enzyme targets, where potent reversible inhibitors are desired, computer modeling based on X-ray crystal structures initiates the research (high-throughput screening also may be used). For enzyme targets where inactivators are desired and when little is known about the enzyme’s molecular mechanism of action, chemical model studies are designed to determine reasonable nonenzymatic pathways applicable to the enzyme. For those enzymes, mechanism-based inactivators are designed and synthesized and inactivation mechanisms investigated. The enzymes are isolated from either mammalian tissue or from overexpressed cells containing recombinant enzymes. Collaborations are developed in X-ray crystallography and preclinical studies.
Education/Academic qualification
Organic Chemistry, PhD, Harvard University
… → 1974
Chemistry, BS, Pennsylvania State University
… → 1968
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants
CardioExcyte 96 System for Pharmacology Research at Northwestern University
Abdulkadir, S. A., Ardehali, H., Arora, R. K., Burridge, P., George Jr, A. L., Kearney, J. A., McNally, E. M., Schiltz, G. E., Silverman, R. B., Watterson, D. M. & Wilsbacher, L. D.
Office of the Director, National Institutes of Health
6/15/20 → 6/14/21
Project: Research project
Novel Protein Aggregation Inhibitors and Upper Motor Neuron Stabilizers for ALS and other Neurodegenerative Diseases
Ozdinler, P. H. & Silverman, R. B.
8/1/19 → 4/30/24
Project: Research project
Equipment Supplement for Selective inhibition of nitric oxide synthase for multiple indications
National Institute of General Medical Sciences
5/1/19 → 4/30/24
Project: Research project
Selective inhibition of nitric oxide synthase for multiple indications
Silverman, R. B. & Surmeier Jr, D. J.
National Institute of General Medical Sciences
5/1/19 → 4/30/24
Project: Research project
Research Output
A Remarkable Difference That One Fluorine Atom Confers on the Mechanisms of Inactivation of Human Ornithine Aminotransferase by Two Cyclohexene Analogues of γ-Aminobutyric Acid
Zhu, W., Doubleday, P. F., Catlin, D. S., Weerawarna, P. M., Butrin, A., Shen, S., Wawrzak, Z., Kelleher, N. L., Liu, D. & Silverman, R. B., Mar 11 2020, In : Journal of the American Chemical Society. 142, 10, p. 4892-4903 12 p.Research output: Contribution to journal › Article
First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate
Cinelli, M. A., Reidl, C. T., Li, H., Chreifi, G., Poulos, T. L. & Silverman, R. B., May 14 2020, In : Journal of Medicinal Chemistry. 63, 9, p. 4528-4554 27 p.Research output: Contribution to journal › Article
Inducible nitric oxide synthase: Regulation, structure, and inhibition
Cinelli, M. A., Do, H. T., Miley, G. P. & Silverman, R. B., Jan 1 2020, In : Medicinal Research Reviews. 40, 1, p. 158-189 32 p.Research output: Contribution to journal › Review article
18
Scopus
citations
Mechanism-Based Design of 3-Amino-4-Halocyclopentenecarboxylic Acids as Inactivators of GABA Aminotransferase
Shen, S., Doubleday, P. F., Weerawarna, P. M., Zhu, W., Kelleher, N. L. & Silverman, R. B., Jan 1 2020, (Accepted/In press) In : ACS Medicinal Chemistry Letters.Research output: Contribution to journal › Article
Physiological involvement of presynaptic L-type voltage-dependent calcium channels in GABA release of cerebellar molecular layer interneurons
Rey, S., Maton, G., Satake, SI., Llano, I., Kang, S., Surmeier, D. J., Silverman, R. B. & Collin, T., 2020, (Accepted/In press) In : Journal of neurochemistry.Research output: Contribution to journal › Article