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Personal profile

Education/Academic qualification

Organic Chemistry, PhD, Harvard University

… → 1974

Chemistry, BS, Pennsylvania State University

… → 1968

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Nitric Oxide Synthase Type I Medicine & Life Sciences
Aminobutyrates Medicine & Life Sciences
Monoamine Oxidase Medicine & Life Sciences
Transaminases Medicine & Life Sciences
4-Aminobutyrate Transaminase Medicine & Life Sciences
Enzymes Medicine & Life Sciences
Nitric Oxide Synthase Medicine & Life Sciences
gamma-Aminobutyric Acid Medicine & Life Sciences

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Grants 2002 2024

Nitric Oxide Synthase Type I
Nitric Oxide Synthase
Melanoma
Cerebral Palsy
Hydrogen Peroxide
training program
chemistry
transdisciplinary
life sciences
expertise
4-Aminobutyrate Transaminase
Vigabatrin
gamma-Aminobutyric Acid
Epilepsy
Dopamine
Nitric Oxide Synthase Type I
Nitric Oxide Synthase
Melanoma
Cerebral Palsy
Click Chemistry

Research Output 1968 2019

Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase

Zheng, J., Jeon, S., Jiang, W., Burbulla, L., Ysselstein, D., Oevel, K., Krainc, D. & Silverman, R. B., Feb 14 2019, In : Journal of Medicinal Chemistry. 62, 3, p. 1218-1230 13 p.

Research output: Contribution to journalArticle

Glucosylceramidase
Quinazolines
Parkinson Disease
Mutant Proteins
Structure-Activity Relationship
Aminoquinolines
Nitric Oxide Synthase Type I
Nitriles
Pharmaceutical Chemistry
Bistris
Fluorobenzenes
Nitric Oxide Synthase Type I
Pharmaceutical Chemistry
Permeability
alpha-aminopyridine

Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold

Do, H. T., Li, H., Chreifi, G., Poulos, T. L. & Silverman, R. B., Mar 14 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2690-2707 18 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type I
Blood-Brain Barrier
Permeability
Central Nervous System Agents
P-Glycoprotein
6 Citations (Scopus)

Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction

Juncosa, J. I., Takaya, K., Le, H. V., Moschitto, M. J., Weerawarna, P. M., Mascarenhas, R., Liu, D., Dewey, S. L. & Silverman, R. B., Feb 14 2018, In : Journal of the American Chemical Society. 140, 6, p. 2151-2164 14 p.

Research output: Contribution to journalArticle

4-Aminobutyrate Transaminase
Aminobutyrates
Carboxylic Acids
Transaminases
Carboxylic acids