Grants per year
Personal profile
Education/Academic qualification
Organic Chemistry, PhD, Harvard University
… → 1974
Chemistry, BS, Pennsylvania State University
… → 1968
Fingerprint Dive into the research topics where Richard B Silverman is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
Nitric Oxide Synthase Type I
Medicine & Life Sciences
Aminobutyrates
Medicine & Life Sciences
Monoamine Oxidase
Medicine & Life Sciences
Transaminases
Medicine & Life Sciences
4-Aminobutyrate Transaminase
Medicine & Life Sciences
Enzymes
Medicine & Life Sciences
Nitric Oxide Synthase
Medicine & Life Sciences
gamma-Aminobutyric Acid
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2002 2024
Novel Protein Aggregation Inhibitors and Upper Motor Neuron Stabilizers for ALS and other Neurodegenerative Diseases
Ozdinler, P. H. & Silverman, R. B.
8/1/19 → 4/30/24
Project: Research project
Amyotrophic Lateral Sclerosis
Motor Neurons
Neurodegenerative Diseases
Motor Neuron Disease
Drug Discovery
Motor Neuron Disease
Amyotrophic Lateral Sclerosis
Drug Discovery
Neurodegenerative Diseases
Health
Selective inhibition of nitric oxide synthase for multiple indications
Silverman, R. B. & Surmeier Jr, D. J.
National Institute of General Medical Sciences
5/1/19 → 4/30/24
Project: Research project
Nitric Oxide Synthase Type I
Nitric Oxide Synthase
Melanoma
Cerebral Palsy
Hydrogen Peroxide
Chemistry of Life Processes Predoctoral Training Program
Kelleher, N. L. & Silverman, R. B.
National Institute of General Medical Sciences
7/1/18 → 6/30/23
Project: Research project
training program
chemistry
transdisciplinary
life sciences
expertise
A-005: Novel Drug for Hepatocellular Carcinoma
Searle Funds at The Chicago Community Trust
1/1/17 → 12/31/21
Project: Research project
Research Output 1968 2019
A modulator of wild-type glucocerebrosidase improves pathogenic phenotypes in dopaminergic neuronal models of Parkinson's disease
Burbulla, L. F., Jeon, S., Zheng, J., Song, P., Silverman, R. B. & Krainc, D., Oct 16 2019, In : Science translational medicine. 11, 514Research output: Contribution to journal › Article
Glucosylceramidase
Parkinson Disease
Phenotype
Mutation
Dopaminergic Neurons
Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase
Zheng, J., Jeon, S., Jiang, W., Burbulla, L., Ysselstein, D., Oevel, K., Krainc, D. & Silverman, R. B., Feb 14 2019, In : Journal of Medicinal Chemistry. 62, 3, p. 1218-1230 13 p.Research output: Contribution to journal › Article
Glucosylceramidase
Quinazolines
Parkinson Disease
Mutant Proteins
Structure-Activity Relationship
Correction: Nitrile in the hole: Discovery of a small auxiliary pocket in neuronal nitric oxide synthase leading to the development of potent and selective 2-aminoquinoline inhibitors (Journal of Medicinal Chemistry (2017) 60 (3958-3978) DOI: 10.1021/acs.jmedchem.7b00259)
Cinelli, M. A., Li, H., Chreifi, G., Poulos, T. L. & Silverman, R. B., Jan 24 2019, In : Journal of Medicinal Chemistry. 62, 2, 1 p.Research output: Contribution to journal › Comment/debate
Aminoquinolines
Nitric Oxide Synthase Type I
Nitriles
Pharmaceutical Chemistry
Bistris
Correction to: Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker (Journal of Medicinal Chemistry (2017) 60 (9360-9375) DOI: 10.1021/acs.jmedchem.7b01356)
Do, H. T., Wang, H. Y., Li, H., Chreifi, G., Poulos, T. L. & Silverman, R. B., Jan 24 2019, In : Journal of Medicinal Chemistry. 62, 2, 1 p.Research output: Contribution to journal › Comment/debate
Fluorobenzenes
Nitric Oxide Synthase Type I
Pharmaceutical Chemistry
Permeability
alpha-aminopyridine
Correction to: Conversion of quinazoline modulators from inhibitors to activators of β-glucocerebrosidase (Journal of Medical Chemistry (2019) 62: 3 (1218-1230) DOI: 10.1021/acs.jmedchem.8b01294)
Zheng, J., Jeon, S., Jiang, W., Burbulla, L. F., Ysselstein, D., Oevel, K., Krainc, D. & Silverman, R. B., Mar 14 2019, In : Journal of Medicinal Chemistry. 62, 5, 1 p.Research output: Contribution to journal › Comment/debate
Glucosylceramidase
Quinazolines