Grants per year
Personal profile
Education/Academic qualification
Organic Chemistry, PhD, Harvard University
… → 1974
Chemistry, BS, Pennsylvania State University
… → 1968
Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
Nitric Oxide Synthase Type I
Medicine & Life Sciences
Aminobutyrates
Medicine & Life Sciences
Monoamine Oxidase
Medicine & Life Sciences
Transaminases
Medicine & Life Sciences
4-Aminobutyrate Transaminase
Medicine & Life Sciences
Enzymes
Medicine & Life Sciences
Nitric Oxide Synthase
Medicine & Life Sciences
gamma-Aminobutyric Acid
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2002 2024
Selective inhibition of nitric oxide synthase for multiple indications
Silverman, R. B. & Surmeier Jr, D. J.
National Institute of General Medical Sciences
5/1/19 → 4/30/24
Project: Research project
Nitric Oxide Synthase Type I
Nitric Oxide Synthase
Melanoma
Cerebral Palsy
Hydrogen Peroxide
Chemistry of Life Processes Predoctoral Training Program
Kelleher, N. L. & Silverman, R. B.
National Institute of General Medical Sciences
7/1/18 → 6/30/23
Project: Research project
training program
chemistry
transdisciplinary
life sciences
expertise
A-005: Novel Drug for Hepatocellular Carcinoma
Searle Funds at The Chicago Community Trust
1/1/17 → 12/31/21
Project: Research project
New Inactivators of GABA Aminotransferase for Addiction and Epilepsy
National Institute on Drug Abuse
5/1/16 → 4/30/21
Project: Research project
4-Aminobutyrate Transaminase
Vigabatrin
gamma-Aminobutyric Acid
Epilepsy
Dopamine
Selective inhibition of nitric oxide synthase for multiple indications
National Institute of General Medical Sciences
9/1/15 → 7/31/19
Project: Research project
Nitric Oxide Synthase Type I
Nitric Oxide Synthase
Melanoma
Cerebral Palsy
Click Chemistry
Research Output 1968 2019
Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase
Zheng, J., Jeon, S., Jiang, W., Burbulla, L., Ysselstein, D., Oevel, K., Krainc, D. & Silverman, R. B., Feb 14 2019, In : Journal of Medicinal Chemistry. 62, 3, p. 1218-1230 13 p.Research output: Contribution to journal › Article
Glucosylceramidase
Quinazolines
Parkinson Disease
Mutant Proteins
Structure-Activity Relationship
Correction: Nitrile in the hole: Discovery of a small auxiliary pocket in neuronal nitric oxide synthase leading to the development of potent and selective 2-aminoquinoline inhibitors (Journal of Medicinal Chemistry (2017) 60 (3958-3978) DOI: 10.1021/acs.jmedchem.7b00259)
Cinelli, M. A., Li, H., Chreifi, G., Poulos, T. L. & Silverman, R. B., Jan 24 2019, In : Journal of Medicinal Chemistry. 62, 2, 1 p.Research output: Contribution to journal › Comment/debate
Aminoquinolines
Nitric Oxide Synthase Type I
Nitriles
Pharmaceutical Chemistry
Bistris
Correction to: Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker (Journal of Medicinal Chemistry (2017) 60 (9360-9375) DOI: 10.1021/acs.jmedchem.7b01356)
Do, H. T., Wang, H. Y., Li, H., Chreifi, G., Poulos, T. L. & Silverman, R. B., Jan 24 2019, In : Journal of Medicinal Chemistry. 62, 2, 1 p.Research output: Contribution to journal › Comment/debate
Fluorobenzenes
Nitric Oxide Synthase Type I
Pharmaceutical Chemistry
Permeability
alpha-aminopyridine
Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold
Do, H. T., Li, H., Chreifi, G., Poulos, T. L. & Silverman, R. B., Mar 14 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2690-2707 18 p.Research output: Contribution to journal › Article
Nitric Oxide Synthase Type I
Blood-Brain Barrier
Permeability
Central Nervous System Agents
P-Glycoprotein
6
Citations
(Scopus)
Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction
Juncosa, J. I., Takaya, K., Le, H. V., Moschitto, M. J., Weerawarna, P. M., Mascarenhas, R., Liu, D., Dewey, S. L. & Silverman, R. B., Feb 14 2018, In : Journal of the American Chemical Society. 140, 6, p. 2151-2164 14 p.Research output: Contribution to journal › Article
4-Aminobutyrate Transaminase
Aminobutyrates
Carboxylic Acids
Transaminases
Carboxylic acids