If you made any changes in Pure, your changes will be visible here soon.

Research Output 1968 2020

Filter
Review article
2020
8 Citations (Scopus)

Inducible nitric oxide synthase: Regulation, structure, and inhibition

Cinelli, M. A., Do, H. T., Miley, G. P. & Silverman, R. B., Jan 1 2020, In : Medicinal Research Reviews. 40, 1, p. 158-189 32 p.

Research output: Contribution to journalReview article

Nitric Oxide Synthase Type II
Sepsis
Nitric Oxide
Protein Isoforms
Inhibition (Psychology)
2018
5 Citations (Scopus)

Design and mechanism of GABA aminotransferase inactivators. Treatments for epilepsies and addictions

Silverman, R. B., Apr 11 2018, In : Chemical Reviews. 118, 7, p. 4037-4070 34 p.

Research output: Contribution to journalReview article

4-Aminobutyrate Transaminase
gamma-Aminobutyric Acid
Aminobutyrates
Enzymes
Neurotransmitter Agents
2014
68 Citations (Scopus)

Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain

Mukherjee, P., Cinelli, M. A., Kang, S. & Silverman, R. B., Jan 1 2014, In : Chemical Society Reviews. 43, 19, p. 6814-6838 25 p.

Research output: Contribution to journalReview article

Nitric Oxide Synthase
Nitric Oxide
Protein Isoforms
Molecules
Pharmacokinetics
2013
82 Citations (Scopus)

Target- and mechanism-based therapeutics for neurodegenerative diseases: Strength in numbers

Trippier, P. C., Jansen Labby, K., Hawker, D. D., Mataka, J. J. & Silverman, R. B., Apr 25 2013, In : Journal of Medicinal Chemistry. 56, 8, p. 3121-3147 27 p.

Research output: Contribution to journalReview article

Drug Discovery
Neurodegenerative Diseases
Nitric Oxide Synthase Type I
Calcium Channels
Reactive Oxygen Species
2012
25 Citations (Scopus)
4-Aminobutyrate Transaminase
Vigabatrin
Infantile Spasms
Cocaine-Related Disorders
Molecular Models
2008
85 Citations (Scopus)

From basic science to blockbuster drug: The discovery of lyrica

Silverman, R. B., Apr 28 2008, In : Angewandte Chemie - International Edition. 47, 19, p. 3500-3504 5 p.

Research output: Contribution to journalReview article

Drug Discovery
Neurotransmitter Agents
Acids
Glutamic Acid
Pharmaceutical Preparations
82 Citations (Scopus)

Revisiting heme mechanisms. A perspective on the mechanisms of nitric oxide synthase (NOS), heme oxygenase (HO), and cytochrome P450s (CYP450s)

Zhu, Y. & Silverman, R. B., Feb 26 2008, In : Biochemistry. 47, 8, p. 2231-2243 13 p.

Research output: Contribution to journalReview article

Heme Oxygenase (Decyclizing)
Cytochromes
Heme
Nitric Oxide Synthase
Amidines
2005
54 Citations (Scopus)

Selective neuronal nitric oxide synthase inhibitors

Erdal, E. P., Litzinger, E. A., Seo, J., Zhu, Y., Ji, H. & Silverman, R. B., Aug 31 2005, In : Current topics in medicinal chemistry. 5, 7, p. 603-624 22 p.

Research output: Contribution to journalReview article

Nitric Oxide Synthase Type I
Inhibitory Concentration 50
Enzyme Inhibitors
Nitric Oxide Synthase Type II
Isoenzymes
1987
27 Citations (Scopus)

The potential use of mechanism-based enzyme inactivators in medicine

Silverman, R. B., Dec 1 1987, In : Journal of Enzyme Inhibition. 2, 2, p. 73-90 18 p.

Research output: Contribution to journalReview article

Bioelectric potentials
Enzyme Inhibitors
Structure-Activity Relationship
Medicine
Enzymes