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Personal profile

Research Interests

Professor Morimoto is interested in cell stress regulatory pathways and protein homeostasis (proteostasis) that ensures the stability of the proteome in health and when challenged by cell stress and the expression of metastable, misfolded, and aggregated proteins.  Using C. elegans and human iPS cells, his lab employs genetic, molecular, small molecule, proteomic and genomic methods and systems level analyses to identify changes during aging and age-associated diseases including metabolic diseases, cancer, and neurodegeneration.

Education/Academic qualification

PhD, The University of Chicago

… → 1978

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Grants

  • Research Output

    Amplifiers co-translationally enhance CFTR biosynthesis via PCBP1-mediated regulation of CFTR mRNA

    Dukovski, D., Villella, A., Bastos, C., King, R., Finley, D., Kelly, J. W., Morimoto, R. I., Hartl, F. U., Munoz, B., Lee, P. S., Zecevic, M. & Miller, J. P., Jan 1 2020, (Accepted/In press) In : Journal of Cystic Fibrosis.

    Research output: Contribution to journalArticle

    Open Access
  • A metastable subproteome underlies inclusion formation in muscle proteinopathies

    Ciryam, P., Antalek, M., Cid, F., Tartaglia, G. G., Dobson, C. M., Guettsches, A. K., Eggers, B., Vorgerd, M., Marcus, K., Kley, R. A., Morimoto, R. I., Vendruscolo, M. & Weihl, C. C., Dec 3 2019, In : Acta Neuropathologica Communications. 7, 1, 197.

    Research output: Contribution to journalArticle

    Open Access
  • Deconvoluting Stress-Responsive Proteostasis Signaling Pathways for Pharmacologic Activation Using Targeted RNA Sequencing

    Grandjean, J. M. D., Plate, L., Morimoto, R. I., Bollong, M. J., Powers, E. T. & Luke Wiseman, R., Apr 19 2019, In : ACS chemical biology. 14, 4, p. 784-795 12 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Erratum: Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis (Cell Metabolism (2019) 29(2) (335–347.e5), (S1550413118305862) (10.1016/j.cmet.2018.09.019))

    Soberanes, S., Misharin, A. V., Jairaman, A., Morales-Nebreda, L., McQuattie-Pimentel, A. C., Cho, T., Hamanaka, R. B., Meliton, A. Y., Reyfman, P. A., Walter, J. M., Chen, C. I., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Antalek, M., Abdala-Valencia, H., Chiarella, S. E., Sun, K. A., Woods, P. S., Ghio, A. J. & 12 others, Jain, M., Perlman, H., Ridge, K. M., Morimoto, R. I., Sznajder, J. I., Balch, W. E., Bhorade, S. M., Bharat, A., Prakriya, M., Chandel, N. S., Mutlu, G. M. & Budinger, G. R. S., Feb 5 2019, In : Cell Metabolism. 29, 2, 1 p.

    Research output: Contribution to journalComment/debate

  • Tau protein aggregates inhibit the protein-folding and vesicular trafficking arms of the cellular proteostasis network

    Yu, A., Fox, S. G., Cavallini, A., Kerridge, C., O'Neill, M. J., Wolak, J., Bose, S. & Morimoto, R. I., Jan 1 2019, In : Journal of Biological Chemistry. 294, 19, p. 7917-7930 14 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations