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Personal profile

Research Interests

Professor Morimoto is interested in cell stress regulatory pathways and protein homeostasis (proteostasis) that ensures the stability of the proteome in health and when challenged by cell stress and the expression of metastable, misfolded, and aggregated proteins.  Using C. elegans and human iPS cells, his lab employs genetic, molecular, small molecule, proteomic and genomic methods and systems level analyses to identify changes during aging and age-associated diseases including metabolic diseases, cancer, and neurodegeneration.

Education/Academic qualification

PhD, The University of Chicago

… → 1978

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Grants

  • Research Output

    Amplifiers co-translationally enhance CFTR biosynthesis via PCBP1-mediated regulation of CFTR mRNA

    Dukovski, D., Villella, A., Bastos, C., King, R., Finley, D., Kelly, J. W., Morimoto, R. I., Hartl, F. U., Munoz, B., Lee, P. S., Zecevic, M. & Miller, J. P., Jan 1 2020, (Accepted/In press) In : Journal of Cystic Fibrosis.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    Cell-nonautonomous regulation of proteostasis in aging and disease

    Morimoto, R. I., Apr 2020, In : Cold Spring Harbor Perspectives in Biology. 12, 4, a034074.

    Research output: Contribution to journalArticle

    Open Access
  • 5 Scopus citations

    Challenging Proteostasis: Role of the Chaperone Network to Control Aggregation-Prone Proteins in Human Disease

    Sinnige, T., Yu, A. & Morimoto, R. I., Jan 1 2020, Advances in Experimental Medicine and Biology. Springer, p. 53-68 16 p. (Advances in Experimental Medicine and Biology; vol. 1243).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • Embryo integrity regulates maternal proteostasis and stress resilience

    Sala, A. J., Bott, L. C., Brielmann, R. M. & Morimoto, R. I., May 1 2020, In : Genes and Development. 34, 9-10, p. 678-687 10 p.

    Research output: Contribution to journalArticle

    Open Access
  • ERdj8 governs the size of autophagosomes during the formation process

    Yamamoto, Y. H., Kasai, A., Omori, H., Takino, T., Sugihara, M., Umemoto, T., Hamasaki, M., Hatta, T., Natsume, T., Morimoto, R. I., Arai, R., Waguri, S., Sato, M., Sato, K., Bar-Nun, S., Yoshimori, T., Noda, T. & Nagata, K., Aug 3 2020, In : The Journal of cell biology. 219, 8

    Research output: Contribution to journalArticle

    Open Access