Grants per year
Personal profile
Research Interests
Professor Morimoto is interested in cell stress regulatory pathways and protein homeostasis (proteostasis) that ensures the stability of the proteome in health and when challenged by cell stress and the expression of metastable, misfolded, and aggregated proteins. Using C. elegans and human iPS cells, his lab employs genetic, molecular, small molecule, proteomic and genomic methods and systems level analyses to identify changes during aging and age-associated diseases including metabolic diseases, cancer, and neurodegeneration.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, The University of Chicago
… → 1978
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Transition to Aging Research for Predoctoral Students (F99/K00 Clinical Trial Not Allowed)
Morimoto, R. I. & Morimoto, R. I.
1/15/23 → 12/31/26
Project: Research project
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Chicago Biomedical Consortium Phase 3
Searle Funds at The Chicago Community Trust
1/1/23 → 12/31/25
Project: Research project
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Comprehensive identification of the metastable subproteome dysregulated in aging and Alzheimer's Disease
10/1/22 → 9/30/24
Project: Research project
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Predoctoral and Postdoctoral Training Program in Aging and Dementia
Vassar, R. J., Vassar, R. J., Weintraub, S., Weintraub, S., Allada, R., Allada, R., Bevan, M. D., Bevan, M. D., Caraveo Piso, G., Caraveo Piso, G., Carvill, G. L., Carvill, G. L., Chan, S., Chan, S., Contractor, A., Contractor, A., Disterhoft, J. F., Disterhoft, J. F., Dombeck, D. A., Dombeck, D. A., Dong, H., Dong, H., Ferreira, A. B., Ferreira, A. B., Flanagan, M. E., Flanagan, M. E., Gefen, T. D., Gefen, T. D., Geula, C., Geula, C., Gratton, C., Gratton, C., He, C., He, C., Kahnt, T., Kahnt, T., Kalb, R. G., Kalb, R. G., Kennedy, A., Kennedy, A., Kessler, J., Kessler, J., Kiskinis, E., Kiskinis, E., Klein, W. L., Klein, W. L., Kozorovitskiy, Y., Kozorovitskiy, Y., Krainc, D., Krainc, D., Li, L., Li, L., Mazzulli, J., Mazzulli, J., Mesulam, M., Mesulam, M., Miller, R. J., Miller, R. J., Morimoto, R. I., Morimoto, R. I., Opal, P., Opal, P., Ozdinler, H., Ozdinler, H., Paller, K., Paller, K., Parisiadou, L., Parisiadou, L., Penzes, P., Penzes, P., Pinto, L., Pinto, L., Prakriya, M., Prakriya, M., Reber, P. J., Reber, P. J., Roberts, A. L., Roberts, A. L., Rogalski, E., Rogalski, E., Savas, J. N., Savas, J. N., Surmeier Jr, D. J., Surmeier Jr, D. J., Swanson, G. T., Swanson, G. T., Voss, J. L., Voss, J. L., Zee, P. C., Zee, P. C., Zelano, C. & Zelano, C.
5/1/22 → 4/30/27
Project: Research project
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Chicago Biomedical Consortium for the Entrepreneurial Fellows Program
3/30/22 → 3/31/25
Project: Research project
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Takashi Yura-sensei
Morimoto, R. I., Jul 1 2023, In: Cell Stress and Chaperones. 28, 4, p. 359-360 2 p.Research output: Contribution to journal › Editorial › peer-review
Open Access -
Aging is associated with a systemic length-associated transcriptome imbalance
Stoeger, T., Grant, R. A., McQuattie-Pimentel, A. C., Anekalla, K. R., Liu, S. S., Tejedor-Navarro, H., Singer, B. D., Abdala-Valencia, H., Schwake, M., Tetreault, M. P., Perlman, H., Balch, W. E., Chandel, N. S., Ridge, K. M., Sznajder, J. I., Morimoto, R. I., Misharin, A. V., Budinger, G. R. S. & Nunes Amaral, L. A., Dec 2022, In: Nature Aging. 2, 12, p. 1191-1206 16 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Protecting the future: balancing proteostasis for reproduction
Sala, A. J. & Morimoto, R. I., Mar 2022, In: Trends in Cell Biology. 32, 3, p. 202-215 14 p.Research output: Contribution to journal › Review article › peer-review
7 Scopus citations -
Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons
Capano, L. S., Sato, C., Ficulle, E., Yu, A., Horie, K., Kwon, J. S., Burbach, K. F., Barthélemy, N. R., Fox, S. G., Karch, C. M., Bateman, R. J., Houlden, H., Morimoto, R. I., Holtzman, D. M., Duff, K. E. & Yoo, A. S., Jun 2 2022, In: Cell stem cell. 29, 6, p. 918-932.e8Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Autophagy in healthy aging and disease
Aman, Y., Schmauck-Medina, T., Hansen, M., Morimoto, R. I., Simon, A. K., Bjedov, I., Palikaras, K., Simonsen, A., Johansen, T., Tavernarakis, N., Rubinsztein, D. C., Partridge, L., Kroemer, G., Labbadia, J. & Fang, E. F., Aug 2021, In: Nature Aging. 1, 8, p. 634-650 17 p.Research output: Contribution to journal › Review article › peer-review
Open Access335 Scopus citations
Datasets
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1S3X : The crystal structure of the human Hsp70 ATPase domain
Sriram (Contributor), Osipiuk, J. (Contributor), Freeman, B. C. (Contributor), Morimoto, R. I. (Contributor) & Joachimiak, A. (Contributor), RCSB-PDB, 2004
DOI: 10.2210/pdb1s3x/pdb, https://www.rcsb.org/structure/1S3X
Dataset
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A metastable subproteome underlies inclusion formation in muscle proteinopathies
Ciryam, P. (Contributor), Antalek, M. (Creator), Cid, F. (Creator), Tartaglia, G. G. (Creator), Dobson, C. M. (Creator), Guettsches, A. (Contributor), Eggers, B. (Creator), Vorgerd, M. (Creator), Marcus, K. (Creator), Kley, R. A. (Creator), Morimoto, R. I. (Creator), Vendruscolo, M. (Creator) & Weihl, C. C. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.c.4768538.v1, https://springernature.figshare.com/collections/A_metastable_subproteome_underlies_inclusion_formation_in_muscle_proteinopathies/4768538/1
Dataset
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2OCH : J-domain of dnj-12 from Caenorhabditis elegans
Osipiuk, J. (Contributor), Joachimiak, A. (Contributor) & Morimoto, R. I. (Contributor), RCSB-PDB, 2007
DOI: 10.2210/pdb2och/pdb, https://www.rcsb.org/structure/2OCH
Dataset
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MOESM1 of A metastable subproteome underlies inclusion formation in muscle proteinopathies
Ciryam, P. (Contributor), Antalek, M. (Creator), Cid, F. (Creator), Tartaglia, G. G. (Creator), Dobson, C. M. (Creator), Guettsches, A. (Contributor), Eggers, B. (Creator), Vorgerd, M. (Creator), Marcus, K. (Creator), Kley, R. A. (Creator), Morimoto, R. I. (Creator), Vendruscolo, M. (Creator) & Weihl, C. C. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.11315579, https://springernature.figshare.com/articles/MOESM1_of_A_metastable_subproteome_underlies_inclusion_formation_in_muscle_proteinopathies/11315579
Dataset