Grants per year
Personal profile
Research Interests
Professor Morimoto is interested in cell stress regulatory pathways and protein homeostasis (proteostasis) that ensures the stability of the proteome in health and when challenged by cell stress and the expression of metastable, misfolded, and aggregated proteins. Using C. elegans and human iPS cells, his lab employs genetic, molecular, small molecule, proteomic and genomic methods and systems level analyses to identify changes during aging and age-associated diseases including metabolic diseases, cancer, and neurodegeneration.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, The University of Chicago
… → 1978
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Dissecting the role of polyglutamine aggregation in shaping the proteasome conformational landscape in aging
Morimoto, R. I. (PD/PI)
10/8/24 → 10/7/26
Project: Research project
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The Metastable Subproteome: Sensor, Risk-Factor and Predictor of Healthy Aging
Morimoto, R. I. (PD/PI)
4/1/24 → 3/31/28
Project: Research project
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Proteostasis Rejuvenation for Healthy Human Aging
Morimoto, R. I. (PD/PI)
2/15/24 → 2/14/29
Project: Research project
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Proteostasis Rejuvenation for Healthy Human Aging
Morimoto, R. I. (PD/PI)
2/15/24 → 2/14/29
Project: Research project
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Transition to Aging Research for Predoctoral Students (F99/K00 Clinical Trial Not Allowed)
Morimoto, R. I. (PD/PI) & Morimoto, R. I. (PD/PI)
1/15/23 → 12/31/26
Project: Research project
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HaloTag as a substrate-based macroautophagy reporter
Xiao, Q., Cruz, G., Botham, R., Fox, S. G., Yu, A., Allen, S., Morimoto, R. I. & Kelly, J. W., Aug 6 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 32, e2322500121.Research output: Contribution to journal › Article › peer-review
Open Access -
Hetero-oligomerization of TDP-43 carboxy-terminal fragments with cellular proteins contributes to proteotoxicity
Kitamura, A., Fujimoto, A., Kawashima, R., Lyu, Y., Sasaki, K., Hamada, Y., Moriya, K., Kurata, A., Takahashi, K., Brielmann, R., Bott, L. C., Morimoto, R. I. & Kinjo, M., Dec 2024, In: Communications Biology. 7, 1, 743.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Nuclear receptor signaling via NHR-49/ MDT-15 regulates stress resilience and proteostasis in response to reproductive and metabolic cues
Sala, A. J., Grant, R. A., Imran, G., Morton, C., Brielmann, R. M., Gorgon, S., Watts, J., Bott, L. C. & Morimoto, R. I., 2024, In: Genes and Development. 38, 9-10, p. 380-392 13 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Proteostasis in health and disease: a conversation with Professor Rick Morimoto
Morimoto, R. I. & Ktistakis, N. T., 2024, In: Autophagy. 20, 9, p. 1909-1915 7 p.Research output: Contribution to journal › Editorial › peer-review
Open Access -
Target Identification of a Class of Pyrazolone Protein Aggregation Inhibitor Therapeutics for Amyotrophic Lateral Sclerosis
Weerawarna, P. M., Schiefer, I. T., Soares, P., Fox, S., Morimoto, R. I., Melani, R. D., Kelleher, N. L., Luan, C. H. & Silverman, R. B., Jan 24 2024, In: ACS Central Science. 10, 1, p. 87-103 17 p.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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The crystal structure of the human Hsp70 ATPase domain
Sriram (Contributor), Osipiuk, J. (Contributor), Freeman, B. C. (Contributor), Morimoto, R. I. (Contributor) & Joachimiak, A. (Contributor), Protein Data Bank (PDB), Jan 20 2004
DOI: 10.2210/pdb1S3X/pdb, https://www.wwpdb.org/pdb?id=pdb_00001s3x
Dataset
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MOESM1 of A metastable subproteome underlies inclusion formation in muscle proteinopathies
Ciryam, P. (Contributor), Antalek, M. (Creator), Cid, F. (Creator), Tartaglia, G. G. (Creator), Dobson, C. M. (Creator), Guettsches, A.-K. (Contributor), Eggers, B. (Creator), Vorgerd, M. (Creator), Marcus, K. (Creator), Kley, R. A. (Creator), Morimoto, R. I. (Creator), Vendruscolo, M. (Creator) & Weihl, C. C. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.11315579, https://springernature.figshare.com/articles/MOESM1_of_A_metastable_subproteome_underlies_inclusion_formation_in_muscle_proteinopathies/11315579
Dataset
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A metastable subproteome underlies inclusion formation in muscle proteinopathies
Ciryam, P. (Contributor), Antalek, M. (Creator), Cid, F. (Creator), Tartaglia, G. G. (Creator), Dobson, C. M. (Creator), Guettsches, A.-K. (Contributor), Eggers, B. (Creator), Vorgerd, M. (Creator), Marcus, K. (Creator), Kley, R. A. (Creator), Morimoto, R. I. (Creator), Vendruscolo, M. (Creator) & Weihl, C. C. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.c.4768538, https://springernature.figshare.com/collections/A_metastable_subproteome_underlies_inclusion_formation_in_muscle_proteinopathies/4768538
Dataset
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1S3X : The crystal structure of the human Hsp70 ATPase domain
Sriram (Contributor), Osipiuk, J. (Contributor), Freeman, B. C. (Contributor), Morimoto, R. I. (Contributor) & Joachimiak, A. (Contributor), RCSB-PDB, 2004
DOI: 10.2210/pdb1s3x/pdb, https://www.rcsb.org/structure/1S3X
Dataset
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2OCH : J-domain of dnj-12 from Caenorhabditis elegans
Osipiuk, J. (Contributor), Joachimiak, A. (Contributor) & Morimoto, R. I. (Contributor), RCSB-PDB, 2007
DOI: 10.2210/pdb2och/pdb, https://www.rcsb.org/structure/2OCH
Dataset