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Research Output

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2020

Challenging Proteostasis: Role of the Chaperone Network to Control Aggregation-Prone Proteins in Human Disease

Sinnige, T., Yu, A. & Morimoto, R. I., Jan 1 2020, Advances in Experimental Medicine and Biology. Springer, p. 53-68 16 p. (Advances in Experimental Medicine and Biology; vol. 1243).

Research output: Chapter in Book/Report/Conference proceedingChapter

2016

Protein aggregation and degradation

Morimoto, R. I. & Kirstein, J., 2016, Molecular and Cellular Biology of Aging. Vigh, J., Campisi, J. & Lithgow, G. (eds.). Gerontological Society of America

Research output: Chapter in Book/Report/Conference proceedingChapter

2012

The regulation and function of the heat shock response

Guisbert, E. & Morimoto, R. I., 2012, Protein Quality Control in Neurodegenerative Diseases. Morimoto, R. & Christen, Y. (eds.). Springer Berlin Heidelberg, p. 1-18 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2010

C. elegans as a Model System to Study the Biology of Protein Aggregation and Toxicity

Kikis, E. A., Ben-Zhi, A. & Morimoto, R. I., 2010, Protein Misfolding Diseases: Current and Emerging Principles and Therapies. Ramirez-Alvarado, M., Kelly, J. & Dobson, C. (eds.). Wiley Press, p. 175-190

Research output: Chapter in Book/Report/Conference proceedingChapter

Caenorhabditis Elegans as a Model System to Study the Biology of Protein Aggregation and Toxicity

Kikis, E. A., Ben-Zvi, A. & Morimoto, R. I., Jul 2 2010, Protein Misfolding Diseases: Current and Emerging Principles and Therapies. John Wiley and Sons, p. 175-190 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Protein homeostasis in models of aging and age-related conformational disease

Kikis, E. A., Gidalevitz, T. & Morimoto, R. I., Dec 1 2010, Protein Metabolism and Homeostasis in Aging. Tavernarakis, N. (ed.). p. 138-159 22 p. (Advances in Experimental Medicine and Biology; vol. 694).

Research output: Chapter in Book/Report/Conference proceedingChapter

107 Scopus citations

The heat shock response and the stress of misfolded proteins

Morimoto, R. I. & Westerheide, S. D., Dec 1 2010, Handbook of Cell Signaling, 2/e. Elsevier Inc, Vol. 3. p. 2231-2239 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2008

Polyglutamine Aggregates as a Model for Protein-misfolding Diseases

Kim, S., Morley, J. F., Ben-Zvi, A. & Morimoto, R. I., Jan 31 2008, Protein Folding Handbook. Wiley-VCH Verlag GmbH, Vol. 3. p. 1175-1199 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2007

Protein Misfolding, Chaperone Networks, and the Heat Shock Response in the Nervous System

Voisine, C., Orton, K. & Morimoto, R. I., Dec 1 2007, Molecular Neurology. Elsevier Inc, p. 59-76 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

The stress of misfolded proteins: C. elegans models for neurodegenerative disease and aging

Brignull, H. R., Morley, J. F. & Morimoto, R. I., Jan 1 2007, Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks. Springer New York, p. 167-189 23 p. (Advances in Experimental Medicine and Biology; vol. 594).

Research output: Chapter in Book/Report/Conference proceedingChapter

51 Scopus citations
2003

The Heat-Shock Response: Sensing the Stress of Misfolded Proteins

Morimoto, R. I. & Nollen, E. A. A., Nov 7 2003, Handbook of Cell Signaling. Elsevier Inc., Vol. 3-3. p. 269-275 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2000

Heat Shock Gene Expression and the Analysis of Heat Shock Factor Activity

Matthew, A., Jolly, C., Shi, Y. & Morimoto, R. I., 2000, Methods in Molecular Biology. Keyse, S. (ed.). Humana Press, p. 217-255

Research output: Chapter in Book/Report/Conference proceedingChapter

1998

Autoregulation of the Heat Shock Transcriptional Response

Shi, Y. D. & Morimoto, R. I., 1998, Handbook of Experimental Pharmacology, Vol. 136: Stress Proteins. Latchman, D. (ed.). Springer-Verlag, p. 225-242

Research output: Chapter in Book/Report/Conference proceedingChapter

Inducible Transcriptional Regulation of Heat Shock Genes: Stress Signal and the Unfolded Protein Response

Morimoto, R. I., 1998, Molecular Chaperones and Folding Catalysts. Bukau, B. (ed.). Harwood Academic Publishers, p. 35-52

Research output: Chapter in Book/Report/Conference proceedingChapter

Stress-Induced Activation of the Heat Shock Response: Cell and Molecular Biology of Heat Shock Factors

Cotto, J. & Morimoto, R. I., 1998, Cellular Reponses to Stress. Downes, C. P., Wolf, C. R. & Lane, D. P. (eds.). London: Portland Press, p. 105-118

Research output: Chapter in Book/Report/Conference proceedingChapter

The Heat Shock Response: Role in the Life and Death of Proteins

Matthew, A. & Morimoto, R. I., 1998, Stress of Life From Molecules to Man. Csermely, P. (ed.). New York Academy of Science Press, p. 99-111

Research output: Chapter in Book/Report/Conference proceedingChapter

1997

The Eukaryotic Heat Shock Transcriptional Response

Morimoto, R. I., 1997, Guidebook to Molecular Chaperones and Protein Folding Catalysts. Gething, M. J. (ed.). Oxford University Press

Research output: Chapter in Book/Report/Conference proceedingChapter

The Heat Shock Response: Regulation and Function of Molecular Chaperones

Morimoto, R. I., Bimston, D., Kline, M. & Cotto, J., 1997, Essays in Biochemistry: Cell Signalling. Bowles, D. J. (ed.). Portland Press, p. 17-29

Research output: Chapter in Book/Report/Conference proceedingChapter

1996

Transcriptional Regulation of Heat Shock Genes: A Plethora of Heat Shock Factors and Regulatory Conditions

Morimoto, R. I., Kroeger, P. & Cotto, J., 1996, Stress Inducible Cellular Responses. Feige, U., Morimoto, R. I., Yahara, I. & Polla, B. (eds.). Birkhauser Press

Research output: Chapter in Book/Report/Conference proceedingChapter

139 Scopus citations
1994

Progress and Perspectives on the Biology and Heat Shock Proteins and Molecular Chaperones

Morimoto, R. I., Tissieres, A. & Georgopoulous, C., 1994, The Biology of Heat Shock Proteins and Molecular Chaperones. Morimoto, R. I., Tissieres, A. & Georgopoulous, C. (eds.). Cold Spring Harbor Press, p. 1-30

Research output: Chapter in Book/Report/Conference proceedingChapter

Regulation of Heat Shock Gene Transcription by a Family of Heat Shock Transcription Factors

Morimoto, R. I., Jurivich, D., Kroeger, P., Mathur, S., Murphy, S., Nakai, A., Sarge, K., Abravaya, K. & Sistonen, L., 1994, The Biology of Heat Shock Proteins and Molecular Chaperones. Morimoto, R. I., Tissieres, A. & Georgopoulous, C. (eds.). Cold Spring Harbor Press, p. 417-455

Research output: Chapter in Book/Report/Conference proceedingChapter

The Heat Shock Transcriptional Response

Kroeger, P. & Morimoto, R. I., 1994, Inducible Gene Expression. Bauerele, P. (ed.). New York: Springer-Verlag, p. 25-61

Research output: Chapter in Book/Report/Conference proceedingChapter

102 Scopus citations
1991

In vivo and In vitro Studies on the Activation and Binding of Human Heat Shock Transcription Factor

Abravaya, K., Phillips, B., Sarge, K. D., Zimarino, V. & Morimoto, R. I., 1991, Heat Shock. Maresca, B. & Lindquist, S. (eds.). Springer Verlag, p. 17-34

Research output: Chapter in Book/Report/Conference proceedingChapter

Transcriptional Regulation of Human HSP70 Genes: Relationship Between Cell Growth, Differentiation, Virus infection and the Stress Response

Phillips, B. & Morimoto, R. I., 1991, Heat Shock and Development. Hightower, L. & Nover, L. (eds.). Berlin: Springer-Verlag, p. 167-187

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations

Transcription of the Human HSP70 gene - Cis Acting Elements and Trans Acting Factors involved in Basal, Adenovirus EIA and Stress Induced Expression

Morimoto, R. I., Mosser, D., Abravaya, K. & Williams, G., 1991, Stress Proteins. Schlesinger, M., Santoro, M. G. & Garaci, E. (eds.). Amsterdam: Elsevier Press, p. 1-17

Research output: Chapter in Book/Report/Conference proceedingChapter

1990

Expression and Function of Vertebrate HSP70 Genes

Morimoto, R. I. & Milarski, K. L., 1990, Stress Proteins in Biology and Medicine. Morimoto, R. I., Tissieres, A. & Georgopoulous, C. (eds.). New York: Cold Spring Harbor Press, p. 323-359

Research output: Chapter in Book/Report/Conference proceedingChapter

Multiple Regulatory Pathways of Human HSP70 Gene Transcription

Williams, G. T., McClanahan, T. K. & Morimoto, R. I., 1990, Recombinant Systems in Protein Expression. Alitalo, K. (ed.). Amsterdam: Elsevier Press, p. 113-124

Research output: Chapter in Book/Report/Conference proceedingChapter

The Stress Response, Function of the Proteins and Perspective

Morimoto, R. I., Tissieres, A. & Georgopoulous, C., 1990, Stress Proteins in Biology and Medicine. Morimoto, R. I., Tissieres, A. & Georgopoulous, C. (eds.). New York: Cold Spring Harbor Press, p. 1-36

Research output: Chapter in Book/Report/Conference proceedingChapter

1982

In Vitro Transcription of Drosophila Actin and Heat Shock Genes in Hela Cell-Free Extracts

Morimoto, R. I., Schaffer, J. & Meselson, M., 1982, Heat Shock: From Bacteria to Man. Schlesinger, M., Tissieres, A. & Ashburner, M. (eds.). Cold Spring Harbor Press, p. 161-166

Research output: Chapter in Book/Report/Conference proceedingChapter

1977

Physical Mapping of Mitochondrial Genes and Transcripts in Saccharomyces cerevisiae

Lewin, A., Morimoto, R. I., Merten, S., Martin, N., Berg, P., Christianson, T., Levens, D. & Rabinowitz, M., 1977, Genetics and Biogenesis of Mitochondria. Kaudewitz, F., Schweyen, R., Bandlow, W. & Wolf, K. (eds.). Berlin: De Gruyer, p. 271-288

Research output: Chapter in Book/Report/Conference proceedingChapter

1976

Transcription and Organization of Yeast Mitochondrial DNA

Rabinowitz, M., Jakovcic, S., Martin, N., Hendler, F., Halbreich, A., Lewin, A. & Morimoto, R. I., 1976, The Genetic Function of Mitochondrial DNA. Saccone, C. & Kroon, A. M. (eds.). Amsterdam: Elsevier/North-Holland Biomedical Press, p. 219

Research output: Chapter in Book/Report/Conference proceedingChapter