• 34933 Citations
1974 …2020

Research output per year

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Personal profile

Research Interests

Our laboratory is interested in the role of receptors in the regulation of nerve cell function.We are particularly interested in the role of cytokines in nerve cell biology.The effects of cytokines on neural stem cell development and in the genesis of chronic pain syndromes are of current interest.We study these phenomena using biochemistry,molecular biology,electrophysiology,mouse genetics and imaging.Projects in our laboratory involve the development of drugs that act on cytokine receptors as well as the molecular basis for pain in osteoarthritis and diabetic neuropathy.

Education/Academic qualification

PhD, University of Cambridge

… → 1976

Research interests

  • Cytokines
  • Drug Discovery
  • Electrophysiology
  • Neuroscience
  • Pain
  • Pharmacology
  • Physiology
  • Stem Cells

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  • Research Output

    Microarray analyses of the dorsal root ganglia support a role for innate neuro-immune pathways in persistent pain in experimental osteoarthritis

    Miller, R. E., Tran, P. B., Ishihara, S., Syx, D., Ren, D., Miller, R. J., Valdes, A. M. & Malfait, A. M., May 2020, In : Osteoarthritis and Cartilage. 28, 5, p. 581-592 12 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    The innate immune response as a mediator of osteoarthritis pain

    Miller, R. J., Malfait, A. M. & Miller, R. E., May 2020, In : Osteoarthritis and Cartilage. 28, 5, p. 562-571 10 p.

    Research output: Contribution to journalReview article

  • 3 Scopus citations

    The nociceptive innervation of the normal and osteoarthritic mouse knee

    Obeidat, A. M., Miller, R. E., Miller, R. J. & Malfait, A. M., Jan 1 2019, (Accepted/In press) In : Osteoarthritis and Cartilage.

    Research output: Contribution to journalArticle

  • 3 Scopus citations

    An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2

    Miller, R. E., Ishihara, S., Tran, P. B., Golub, S. B., Last, K., Miller, R. J., Fosang, A. J. & Malfait, A. M., Mar 22 2018, In : JCI Insight. 3, 6

    Research output: Contribution to journalArticle

    Open Access
  • 15 Scopus citations

    Reducing CXCR4-mediated nociceptor hyperexcitability reverses painful diabetic neuropathy

    Jayaraj, N. D., Bhattacharyya, B. J., Belmadani, A. A., Ren, D., Rathwell, C. A., Hackelberg, S., Hopkins, B. E., Gupta, H. R., Miller, R. J. & Menichella, D. M., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2205-2225 21 p.

    Research output: Contribution to journalArticle

  • 14 Scopus citations