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Personal profile

Research Interests

Our laboratory is interested in the role of receptors in the regulation of nerve cell function.We are particularly interested in the role of cytokines in nerve cell biology.The effects of cytokines on neural stem cell development and in the genesis of chronic pain syndromes are of current interest.We study these phenomena using biochemistry,molecular biology,electrophysiology,mouse genetics and imaging.Projects in our laboratory involve the development of drugs that act on cytokine receptors as well as the molecular basis for pain in osteoarthritis and diabetic neuropathy.

Education/Academic qualification

PhD, University of Cambridge

… → 1976

Keywords

  • Cytokines
  • Drug Discovery
  • Electrophysiology
  • Neuroscience
  • Pain
  • Pharmacology
  • Physiology
  • Stem Cells

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Grants 2002 2024

Interleukins
Neurons
Keratinocytes
Histamine Antagonists
G-Protein-Coupled Receptors
CXC Chemokines
MAP Kinase Signaling System
Chemokine Receptors
Chemokines
Prostatic Neoplasms
Diabetic Neuropathies
Neuralgia
Nociceptors
Diagnosis-Related Groups
Therapeutics

Research Output 1974 2018

4 Citations (Scopus)

An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2

Miller, R. E., Ishihara, S., Tran, P. B., Golub, S. B., Last, K., Miller, R. J., Fosang, A. J. & Malfait, A. M., Mar 22 2018, In : JCI insight. 3, 6

Research output: Contribution to journalArticle

Open Access
Aggrecans
Toll-Like Receptor 2
Osteoarthritis
Pain
Amino Acids
3 Citations (Scopus)

Reducing CXCR4-mediated nociceptor hyperexcitability reverses painful diabetic neuropathy

Jayaraj, N. D., Bhattacharyya, B. J., Belmadani, A., Ren, D., Rathwell, C. A., Hackelberg, S., Hopkins, B. E., Gupta, H. R., Miller, R. J. & Menichella, D. M., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2205-2225 21 p.

Research output: Contribution to journalArticle

Nociceptors
Diabetic Neuropathies
Spinal Ganglia
Hyperalgesia
Neurons

TRPV1 and the MCP-1/CCR2 Axis Modulate Post-UTI Chronic Pain

Rosen, J. M., Yaggie, R. E., Woida, P. J., Miller, R. J., Schaeffer, A. J. & Klumpp, D., Dec 1 2018, In : Scientific Reports. 8, 1, 7188.

Research output: Contribution to journalArticle

Urinary Tract Infections
Chronic Pain
Hyperalgesia
Pelvic Pain
Neuralgia
4 Citations (Scopus)

Visualization of Peripheral Neuron Sensitization in a Surgical Mouse Model of Osteoarthritis by In Vivo Calcium Imaging

Miller, R. E., Kim, Y. S., Tran, P. B., Ishihara, S., Dong, X., Miller, R. J. & Malfait, A. M., Jan 1 2018, In : Arthritis and Rheumatology. 70, 1, p. 88-97 10 p.

Research output: Contribution to journalArticle

Anatomic Models
Osteoarthritis
Tibial Meniscus
Calcium
Neurons
12 Citations (Scopus)

Chemogenetic Inhibition of Pain Neurons in a Mouse Model of Osteoarthritis

Miller, R. E., Ishihara, S., Bhattacharyya, B., Delaney, A., Menichella, D. M., Miller, R. J. & Malfait, A. M., Jul 1 2017, In : Arthritis and Rheumatology. 69, 7, p. 1429-1439 11 p.

Research output: Contribution to journalArticle

Hyperalgesia
Osteoarthritis
Tibial Meniscus
Designer Drugs
Neurons