Grants per year
Personal profile
Research Interests
Our laboratory is interested in the role of receptors in the regulation of nerve cell function.We are particularly interested in the role of cytokines in nerve cell biology.The effects of cytokines on neural stem cell development and in the genesis of chronic pain syndromes are of current interest.We study these phenomena using biochemistry,molecular biology,electrophysiology,mouse genetics and imaging.Projects in our laboratory involve the development of drugs that act on cytokine receptors as well as the molecular basis for pain in osteoarthritis and diabetic neuropathy.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, University of Cambridge
… → 1976
Research interests keywords
- Cytokines
- Drug Discovery
- Electrophysiology
- Neuroscience
- Pain
- Pharmacology
- Physiology
- Stem Cells
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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SyncroPatch 384 Automated Patch Clamp Instrument
George, A. L., Burridge, P., DeCaen, P. G., Horvath, C. M., Kearney, J. A., Kiskinis, E., McNally, E. M., Miller, R. J., Prakriya, M., Smith, R. S., Surmeier Jr, D. J. & Vanoye, C. G.
Office of the Director, National Institutes of Health
3/1/23 → 2/29/24
Project: Research project
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Mapping the joint-nerve interactome of the knee
Rush University Medical Center, National Institute of Arthritis and Musculoskeletal and Skin Diseases
9/23/22 → 8/31/25
Project: Research project
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Peripheral mechanisms of peripheral neuropathic pain
Pacifico, P., Coy-Dibley, J. S., Miller, R. J. & Menichella, D. M., 2023, In: Frontiers in Molecular Neuroscience. 16, 1252442.Research output: Contribution to journal › Review article › peer-review
Open Access -
Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis
Obeidat, A. M., Wood, M. J., Adamczyk, N. S., Ishihara, S., Li, J., Wang, L., Ren, D., Bennett, D. A., Miller, R. J., Malfait, A. M. & Miller, R. E., Dec 2023, In: Nature communications. 14, 1, 2479.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Effects of Small Molecule Ligands on ACKR3 ReceptorsS
Hopkins, B. E., Masuho, I., Ren, D., Iyamu, I. D., Lv, W., Malik, N., Martemyanov, K. A., Schiltz, G. E. & Miller, R. J., Sep 2022, In: Molecular pharmacology. 102, 3, p. 128-138 11 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Mitochondrial calcium uniporter deletion prevents painful diabetic neuropathy by restoring mitochondrial morphology and dynamics
George, D. S., Hackelberg, S., Jayaraj, N. D., Ren, D., Edassery, S. L., Rathwell, C. A., Miller, R. E., Malfait, A. M., Savas, J. N., Miller, R. J. & Menichella, D. M., Mar 1 2022, In: Pain. 163, 3, p. 560-578 19 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
An autophagy-related protein Becn2 regulates cocaine reward behaviors in the dopaminergic system
Kim, Y. J., Kong, Q., Yamamoto, S., Kuramoto, K., Huang, M., Wang, N., Hwa, J., Xiao, T., Levine, B., Qiu, X., Zhao, Y., Miller, R. J., Dong, H., Meltzer, H. Y., Xu, M. & He, C., Feb 19 2021, In: Science Advances. 7, 8, eabc8310.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations
Datasets
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Evidence for an early innate immune response in the motor cortex of ALS
Jara, J. H. (Creator), Genç, B. (Contributor), Stanford, M. J. (Contributor), Pytel, P. (Creator), Roos, R. P. (Creator), Weintraub, S. (Creator), Mesulam, M. (Contributor), Bigio, E. H. (Creator), Miller, R. J. (Creator), Ozdinler, H. (Contributor) & Roos, R. (Creator), figshare, 2017
DOI: 10.6084/m9.figshare.c.3812497.v1, https://figshare.com/collections/Evidence_for_an_early_innate_immune_response_in_the_motor_cortex_of_ALS/3812497/1
Dataset
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The role of intra-articular neuronal CCR2 receptors in knee joint pain associated with experimental osteoarthritis in mice
Ishihara, S. (Creator), Obeidat, A. M. (Creator), Wokosin, D. L. (Creator), Ren, D. (Contributor), Miller, R. J. (Creator), Malfait, A. (Creator) & Miller, R. E. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.c.5368555.v1, https://springernature.figshare.com/collections/The_role_of_intra-articular_neuronal_CCR2_receptors_in_knee_joint_pain_associated_with_experimental_osteoarthritis_in_mice/5368555/1
Dataset