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Richard J Miller

  • 34348 Citations
1974 …2024
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Personal profile

Research Interests

Our laboratory is interested in the role of receptors in the regulation of nerve cell function.We are particularly interested in the role of cytokines in nerve cell biology.The effects of cytokines on neural stem cell development and in the genesis of chronic pain syndromes are of current interest.We study these phenomena using biochemistry,molecular biology,electrophysiology,mouse genetics and imaging.Projects in our laboratory involve the development of drugs that act on cytokine receptors as well as the molecular basis for pain in osteoarthritis and diabetic neuropathy.

Education/Academic qualification

PhD, University of Cambridge

… → 1976

Research interests

  • Cytokines
  • Drug Discovery
  • Electrophysiology
  • Neuroscience
  • Pain
  • Pharmacology
  • Physiology
  • Stem Cells

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Grants 2002 2024

Pelvic Pain and Depression

Flury, S. C., Griffith, J. W., Klumpp, D., Miller, R. J., Parrish, T. B. & Schaeffer, A. J.

National Institute of Diabetes, Digestive and Kidney Diseases

7/1/19 → 8/13/22

Project: Research project

Pelvic Pain
Depression
Chronic Pain
Neuroimaging
Comorbidity

Osteoarthritis Progression And Sensory Pathway Alterations

Miller, R. J.

Rush University Medical Center, National Institute of Arthritis and Musculoskeletal and Skin Diseases

5/14/19 → 3/31/24

Project: Research project

Osteoarthritis
Sensory Receptor Cells
Pain
Diagnosis-Related Groups
Medical Schools

The molecular basis of Interleukin-31 driven itch

McNeil, B. D., Miller, R. J. & Zhang, L.

National Institute of Arthritis and Musculoskeletal and Skin Diseases

4/1/19 → 2/29/24

Project: Research project

Interleukins
Neurons
Keratinocytes
Histamine Antagonists
G-Protein-Coupled Receptors

Center for chronic pain and drug abuse

Apkarian, A., Awatramani, R., Drenan, R. M., Graves, S. M., Griffith, J. W., Huang, L., Jovasevic, V., Martina, M., Miller, R. J., Parrish, T. B., Procissi, D., Radulovic, J., Rodes, M. E., Schnitzer, T. J. & Surmeier Jr, D. J.

National Institute on Drug Abuse

9/1/18 → 6/30/23

Project: Research project

Chronic Pain
Substance-Related Disorders
Opioid Analgesics
Opiate Alkaloids
Brain

"RISK" The nervous joint: New concepts in the development of osteoarthritis.

Miller, R. J.

Rush University Medical Center, National Institute of Arthritis and Musculoskeletal and Skin Diseases

5/1/18 → 4/30/20

Project: Research project

Genetic Techniques
Spinal Ganglia
Osteoarthritis
Anatomy
Joints

Research Output 1974 2019

The nociceptive innervation of the normal and osteoarthritic mouse knee

Obeidat, A. M., Miller, R. E., Miller, R. J. & Malfait, A. M., Jan 1 2019, (Accepted/In press) In : Osteoarthritis and Cartilage.

Research output: Contribution to journal › Article

Ligaments
Knee
Bone
Genes
Proteins
11 Citations (Scopus)

An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2

Miller, R. E., Ishihara, S., Tran, P. B., Golub, S. B., Last, K., Miller, R. J., Fosang, A. J. & Malfait, A. M., Mar 22 2018, In : JCI Insight. 3, 6

Research output: Contribution to journal › Article

Open Access
Aggrecans
Toll-Like Receptor 2
Osteoarthritis
Pain
Amino Acids
9 Citations (Scopus)

Reducing CXCR4-mediated nociceptor hyperexcitability reverses painful diabetic neuropathy

Jayaraj, N. D., Bhattacharyya, B. J., Belmadani, A. A., Ren, D., Rathwell, C. A., Hackelberg, S., Hopkins, B. E., Gupta, H. R., Miller, R. J. & Menichella, D. M., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2205-2225 21 p.

Research output: Contribution to journal › Article

Nociceptors
Diabetic Neuropathies
Spinal Ganglia
Hyperalgesia
Neurons
1 Citation (Scopus)

TRPV1 and the MCP-1/CCR2 Axis Modulate Post-UTI Chronic Pain

Rosen, J. M., Yaggie, R. E., Woida, P. J., Miller, R. J., Schaeffer, A. J. & Klumpp, D., Dec 1 2018, In : Scientific Reports. 8, 1, 7188.

Research output: Contribution to journal › Article

Urinary Tract Infections
Chronic Pain
Hyperalgesia
Pelvic Pain
Neuralgia
6 Citations (Scopus)

Visualization of Peripheral Neuron Sensitization in a Surgical Mouse Model of Osteoarthritis by In Vivo Calcium Imaging

Miller, R. E., Kim, Y. S., Tran, P. B., Ishihara, S., Dong, X., Miller, R. J. & Malfait, A. M., Jan 1 2018, In : Arthritis and Rheumatology. 70, 1, p. 88-97 10 p.

Research output: Contribution to journal › Article

Anatomic Models
Osteoarthritis
Tibial Meniscus
Calcium
Neurons