Grants per year
Personal profile
Research Interests
Our laboratory is interested in the role of receptors in the regulation of nerve cell function.We are particularly interested in the role of cytokines in nerve cell biology.The effects of cytokines on neural stem cell development and in the genesis of chronic pain syndromes are of current interest.We study these phenomena using biochemistry,molecular biology,electrophysiology,mouse genetics and imaging.Projects in our laboratory involve the development of drugs that act on cytokine receptors as well as the molecular basis for pain in osteoarthritis and diabetic neuropathy.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, University of Cambridge
… → 1976
Research interests keywords
- Cytokines
- Drug Discovery
- Electrophysiology
- Neuroscience
- Pain
- Pharmacology
- Physiology
- Stem Cells
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Mapping the joint-nerve interactome of the knee
Miller, R. J. (PD/PI) & Miller, R. J. (PD/PI)
Rush University Medical Center, National Institute of Arthritis and Musculoskeletal and Skin Diseases
9/23/22 → 8/31/25
Project: Research project
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Chicago Center for Translational Research in Musculoskeletal Pain
Miller, R. J. (PD/PI), Miller, R. J. (PD/PI), Belmadani, A. (Co-Investigator) & Belmadani, A. (Co-Investigator)
Rush University Medical Center, National Institute of Arthritis and Musculoskeletal and Skin Diseases
9/14/21 → 8/31/26
Project: Research project
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Molecular Pathways of Pain Generation in Osteoarthritis
Miller, R. J. (PD/PI), Miller, R. J. (PD/PI) & Miller, R. J. (PD/PI)
Rush University Medical Center, National Institute of Arthritis and Musculoskeletal and Skin Diseases
9/1/21 → 6/30/25
Project: Research project
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The Role of Mechanosensation Pathways in Osteoarthritis Joint Damage and Pain
Miller, R. J. (PD/PI) & Miller, R. J. (PD/PI)
Rush University Medical Center, National Institute of Arthritis and Musculoskeletal and Skin Diseases
4/2/21 → 2/28/26
Project: Research project
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Neuron-Keratinocyte Communication in the Epidermis in Normal and Diabetic Wound Healing
Paller, A. (PD/PI), Paller, A. (PD/PI), Paller, A. (PD/PI), Miller, R. J. (Co-Investigator), Miller, R. J. (Co-Investigator) & Miller, R. J. (Co-Investigator)
National Institute of Arthritis and Musculoskeletal and Skin Diseases
9/11/20 → 6/30/25
Project: Research project
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The Mas-related G protein-coupled receptor d (Mrgprd) mediates pain hypersensitivity in painful diabetic neuropathy
George, D. S., Jayaraj, N. D., Pacifico, P., Ren, D., Sriram, N., Miller, R. E., Malfait, A. M., Miller, R. J. & Menichella, D. M., May 1 2024, In: Pain. 165, 5, p. 1154-1168 15 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Peripheral mechanisms of peripheral neuropathic pain
Pacifico, P., Coy-Dibley, J. S., Miller, R. J. & Menichella, D. M., 2023, In: Frontiers in Molecular Neuroscience. 16, 1252442.Research output: Contribution to journal › Review article › peer-review
Open Access3 Scopus citations -
Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis
Obeidat, A. M., Wood, M. J., Adamczyk, N. S., Ishihara, S., Li, J., Wang, L., Ren, D., Bennett, D. A., Miller, R. J., Malfait, A. M. & Miller, R. E., Dec 2023, In: Nature communications. 14, 1, 2479.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
Effects of Small Molecule Ligands on ACKR3 ReceptorsS
Hopkins, B. E., Masuho, I., Ren, D., Iyamu, I. D., Lv, W., Malik, N., Martemyanov, K. A., Schiltz, G. E. & Miller, R. J., Sep 2022, In: Molecular pharmacology. 102, 3, p. 128-138 11 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Mitochondrial calcium uniporter deletion prevents painful diabetic neuropathy by restoring mitochondrial morphology and dynamics
George, D. S., Hackelberg, S., Jayaraj, N. D., Ren, D., Edassery, S. L., Rathwell, C. A., Miller, R. E., Malfait, A. M., Savas, J. N., Miller, R. J. & Menichella, D. M., Mar 1 2022, In: Pain. 163, 3, p. 560-578 19 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations
Datasets
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The role of intra-articular neuronal CCR2 receptors in knee joint pain associated with experimental osteoarthritis in mice
Ishihara, S. (Creator), Obeidat, A. M. (Creator), Wokosin, D. L. (Creator), Ren, D. (Contributor), Miller, R. J. (Creator), Malfait, A.-M. (Creator) & Miller, R. E. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.c.5368555, https://springernature.figshare.com/collections/The_role_of_intra-articular_neuronal_CCR2_receptors_in_knee_joint_pain_associated_with_experimental_osteoarthritis_in_mice/5368555
Dataset
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Evidence for an early innate immune response in the motor cortex of ALS
Jara, J. H. (Creator), Genç, B. (Contributor), Stanford, M. J. (Contributor), Pytel, P. (Creator), Roos, R. P. (Creator), Weintraub, S. (Creator), Mesulam, M. M. (Contributor), Bigio, E. H. (Creator), Miller, R. J. (Creator) & Özdinler, P. H. (Contributor), figshare, 2017
DOI: 10.6084/m9.figshare.c.3812497, https://figshare.com/collections/Evidence_for_an_early_innate_immune_response_in_the_motor_cortex_of_ALS/3812497
Dataset