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Richard J Miller

  • 33828 Citations
1974 …2024
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Personal profile

Research Interests

Our laboratory is interested in the role of receptors in the regulation of nerve cell function.We are particularly interested in the role of cytokines in nerve cell biology.The effects of cytokines on neural stem cell development and in the genesis of chronic pain syndromes are of current interest.We study these phenomena using biochemistry,molecular biology,electrophysiology,mouse genetics and imaging.Projects in our laboratory involve the development of drugs that act on cytokine receptors as well as the molecular basis for pain in osteoarthritis and diabetic neuropathy.

Education/Academic qualification

PhD, University of Cambridge

… → 1976

Keywords

  • Cytokines
  • Drug Discovery
  • Electrophysiology
  • Neuroscience
  • Pain
  • Pharmacology
  • Physiology
  • Stem Cells

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Grants 2002 2024

The molecular basis of Interleukin-31 driven itch

McNeil, B. D., Miller, R. J. & Zhang, L.

National Institute of Arthritis and Musculoskeletal and Skin Diseases

4/1/19 → 2/29/24

Project: Research project

Interleukins
Neurons
Keratinocytes
Histamine Antagonists
G-Protein-Coupled Receptors

Center for chronic pain and drug abuse

Apkarian, A., Awatramani, R., Drenan, R. M., Graves, S. M., Griffith, J. W., Huang, L., Jovasevic, V., Martina, M., Miller, R. J., Parrish, T. B., Procissi, D., Radulovic, J., Rodes, M. E., Schnitzer, T. J. & Surmeier Jr, D. J.

National Institute on Drug Abuse

9/1/18 → 6/30/23

Project: Research project

Chronic Pain
Substance-Related Disorders
Opioid Analgesics
Opiate Alkaloids
Brain

Targeting chemokine signaling and MAPK/ERK pathway in advanced prostate cancer

Yu, J., Cristofanilli, M., Hussain, M., Miller, R. J., Schiltz, G. E., Yang, X. J., Zhang, B. & Zhao, C.

Prostate Cancer Foundation

12/31/17 → 12/31/19

Project: Research project

CXC Chemokines
MAP Kinase Signaling System
Chemokine Receptors
Chemokines
Prostatic Neoplasms

Cellular and Molecular Role of CXCR4 signaling in Painful Diabetic Neuropathy

Menichella, D. M. & Miller, R. J.

National Institute of Neurological Disorders and Stroke

12/1/17 → 11/30/22

Project: Research project

Diabetic Neuropathies
Neuralgia
Nociceptors
Diagnosis-Related Groups
Therapeutics

Northwestern University Interdepartmental Neuroscience Postbaccalaureate Research Education Program

Acosta, A., Allada, R., Apkarian, A., Awatramani, R., Beeman, M., Bevan, M. D., Bozza, T. C., Cang, J., Chetkovich, D. M., Cobia, D. J., Contractor, A., Corcos, D. M., DeVries, S. H., Dewald, J. P. A., Dhar, S., Disterhoft, J. F., Dombeck, D. A., Elliott, J. M., Feng, Y., Ferreira, A. B., Gallio, M., Garcia-Anoveros, J., George Jr, A. L., Geula, C., Gordon, K. E., Gottfried, J. A., Grafman, J. H., Hartmann, M. J. Z., Heckman, C., Hespos, S. J., Jayaraman, A., Kahnt, T., Kearney, J. A., Kessler, J., Kiskinis, E., Kohtz, J., Kording, K. P., Kozorovitskiy, Y., Krainc, D., Larson, C., Lee, S. S. M., Li, L., Losh, M. C., Maccaferri, G., MacIver, M. A., Martina, M., Mazzulli, J., McLean, D., Mesulam, M., Miller, L. E., Miller, R. J., Mussa-Ivaldi, F., Nusslock, R., Opal, P., Ozdinler, P. H., Paller, K., Parrish, T. B., Prakriya, M., Radulovic, J., Raman, I. M., Reber, P. J., Redei, E., Rogalski, E., Sanchez, J. T., Sanz-Clemente, A., Savas, J. N., Schmidt, T. M., Schwartz, G. W., Segraves, M., Shepherd, G. M. G., Siddique, T., Solla, S. A., Surmeier Jr, D. J., Swanson, G. T., Topczewski, J., Tresch, M. C., Tysseling, V. M., Vassar, R. J., Voss, J. L., Wainwright, D. A., Wang, L., Weintraub, S., Woolley, C. S. & Wright, B. A.

National Institute of General Medical Sciences

5/1/17 → 4/30/22

Project: Research project

neurosciences
graduate
university
education

Research Output 1974 2018

4 Citations (Scopus)

An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2

Miller, R. E., Ishihara, S., Tran, P. B., Golub, S. B., Last, K., Miller, R. J., Fosang, A. J. & Malfait, A. M., Mar 22 2018, In : JCI insight. 3, 6

Research output: Contribution to journal › Article

Open Access
Aggrecans
Toll-Like Receptor 2
Osteoarthritis
Pain
Amino Acids
3 Citations (Scopus)

Reducing CXCR4-mediated nociceptor hyperexcitability reverses painful diabetic neuropathy

Jayaraj, N. D., Bhattacharyya, B. J., Belmadani, A., Ren, D., Rathwell, C. A., Hackelberg, S., Hopkins, B. E., Gupta, H. R., Miller, R. J. & Menichella, D. M., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2205-2225 21 p.

Research output: Contribution to journal › Article

Nociceptors
Diabetic Neuropathies
Spinal Ganglia
Hyperalgesia
Neurons

TRPV1 and the MCP-1/CCR2 Axis Modulate Post-UTI Chronic Pain

Rosen, J. M., Yaggie, R. E., Woida, P. J., Miller, R. J., Schaeffer, A. J. & Klumpp, D., Dec 1 2018, In : Scientific Reports. 8, 1, 7188.

Research output: Contribution to journal › Article

Urinary Tract Infections
Chronic Pain
Hyperalgesia
Pelvic Pain
Neuralgia
4 Citations (Scopus)

Visualization of Peripheral Neuron Sensitization in a Surgical Mouse Model of Osteoarthritis by In Vivo Calcium Imaging

Miller, R. E., Kim, Y. S., Tran, P. B., Ishihara, S., Dong, X., Miller, R. J. & Malfait, A. M., Jan 1 2018, In : Arthritis and Rheumatology. 70, 1, p. 88-97 10 p.

Research output: Contribution to journal › Article

Anatomic Models
Osteoarthritis
Tibial Meniscus
Calcium
Neurons
12 Citations (Scopus)

Chemogenetic Inhibition of Pain Neurons in a Mouse Model of Osteoarthritis

Miller, R. E., Ishihara, S., Bhattacharyya, B., Delaney, A., Menichella, D. M., Miller, R. J. & Malfait, A. M., Jul 1 2017, In : Arthritis and Rheumatology. 69, 7, p. 1429-1439 11 p.

Research output: Contribution to journal › Article

Hyperalgesia
Osteoarthritis
Tibial Meniscus
Designer Drugs
Neurons