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Personal profile

Research Interests

Our laboratory is interested in the role of receptors in the regulation of nerve cell function.We are particularly interested in the role of cytokines in nerve cell biology.The effects of cytokines on neural stem cell development and in the genesis of chronic pain syndromes are of current interest.We study these phenomena using biochemistry,molecular biology,electrophysiology,mouse genetics and imaging.Projects in our laboratory involve the development of drugs that act on cytokine receptors as well as the molecular basis for pain in osteoarthritis and diabetic neuropathy.

Education/Academic qualification

PhD, University of Cambridge

… → 1976

Research interests

  • Cytokines
  • Drug Discovery
  • Electrophysiology
  • Neuroscience
  • Pain
  • Pharmacology
  • Physiology
  • Stem Cells

Fingerprint Dive into the research topics where Richard J Miller is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Neurons Medicine & Life Sciences
Enkephalins Medicine & Life Sciences
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Chemokines Medicine & Life Sciences
Chemokine Receptors Medicine & Life Sciences
Spinal Ganglia Medicine & Life Sciences
Calcium Medicine & Life Sciences
Brain Medicine & Life Sciences

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Grants 2002 2024

Pelvic Pain
Depression
Chronic Pain
Neuroimaging
Comorbidity
Osteoarthritis
Sensory Receptor Cells
Pain
Diagnosis-Related Groups
Medical Schools
Interleukins
Neurons
Keratinocytes
Histamine Antagonists
G-Protein-Coupled Receptors
Chronic Pain
Substance-Related Disorders
Opioid Analgesics
Opiate Alkaloids
Brain

Research Output 1974 2019

The nociceptive innervation of the normal and osteoarthritic mouse knee

Obeidat, A. M., Miller, R. E., Miller, R. J. & Malfait, A. M., Jan 1 2019, (Accepted/In press) In : Osteoarthritis and Cartilage.

Research output: Contribution to journalArticle

Ligaments
Knee
Bone
Genes
Proteins
6 Citations (Scopus)

An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2

Miller, R. E., Ishihara, S., Tran, P. B., Golub, S. B., Last, K., Miller, R. J., Fosang, A. J. & Malfait, A. M., Mar 22 2018, In : JCI insight. 3, 6

Research output: Contribution to journalArticle

Open Access
Aggrecans
Toll-Like Receptor 2
Osteoarthritis
Pain
Amino Acids
6 Citations (Scopus)

Reducing CXCR4-mediated nociceptor hyperexcitability reverses painful diabetic neuropathy

Jayaraj, N. D., Bhattacharyya, B. J., Belmadani, A., Ren, D., Rathwell, C. A., Hackelberg, S., Hopkins, B. E., Gupta, H. R., Miller, R. J. & Menichella, D. M., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2205-2225 21 p.

Research output: Contribution to journalArticle

Nociceptors
Diabetic Neuropathies
Spinal Ganglia
Hyperalgesia
Neurons
1 Citation (Scopus)

TRPV1 and the MCP-1/CCR2 Axis Modulate Post-UTI Chronic Pain

Rosen, J. M., Yaggie, R. E., Woida, P. J., Miller, R. J., Schaeffer, A. J. & Klumpp, D., Dec 1 2018, In : Scientific Reports. 8, 1, 7188.

Research output: Contribution to journalArticle

Urinary Tract Infections
Chronic Pain
Hyperalgesia
Pelvic Pain
Neuralgia
6 Citations (Scopus)

Visualization of Peripheral Neuron Sensitization in a Surgical Mouse Model of Osteoarthritis by In Vivo Calcium Imaging

Miller, R. E., Kim, Y. S., Tran, P. B., Ishihara, S., Dong, X., Miller, R. J. & Malfait, A. M., Jan 1 2018, In : Arthritis and Rheumatology. 70, 1, p. 88-97 10 p.

Research output: Contribution to journalArticle

Anatomic Models
Osteoarthritis
Tibial Meniscus
Calcium
Neurons