• 10761 Citations
1986 …2020

Research output per year

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Personal profile

Research Interests

Research in the Longnecker laboratory focuses on herpes simplex virus (HSV) and Epstein-Barr virus (EBV). These viruses typically cause self-limiting disease within the human population but both can be associated with serious complications. EBV is associated with variety of hematopoietic cancers such as African Burkitt lymphoma, Hodgkin Lymphoma and adult T-cell leukemia. EBV-associated lymphoproliferative disease occurs in individuals with congenital or acquired cellular immune deficiencies. The two notable epithelial diseases associated with EBV infection are nasopharyngeal cancer and oral hairy leukoplakia. Similar to EBV, HSV latent infections are very common in humans. HSV typically does not cause severe disease but is associated with localized mucocutaneous lesions, but in some cases can cause meningitis and encephalitis. The Longnecker laboratory focuses on several aspects of EBV and HSV replication and pathogenesis. First, the molecular basis EBV transformation and how it relates to cancer is being investigated. The laboratory is currently screening selective inhibitors that may be beneficial in EBV-associated cancers such as Hodgkin lymphoma, Burkitt lymphoma and proliferative disorders that occur in HIV/AIDS and transplant patients. Second, the laboratory is investigating herpesvirus latency in the human host and pathogenesis associated with infections in humans. In this regard, the laboratory is developing animal models for EBV and HSV infections. Finally, the laboratory is investigating the function of herpesvirus encoded proteins and the cellular receptors that are important for infection both using in vivo culture models as well as animal models. Ultimately, studies by the Longnecker laboratory may provide insight for the development of novel therapeutics for the treatment of herpesvirus infections in humans and better understanding of the herpesvirus life cycle in the human host.

Training Experience

1988Postdoctoral Fellowship, University of Chicago
1992Postdoctoral Fellowship, Harvard University

Education/Academic qualification

PhD, The University of Chicago

… → 1987

Research interests

  • Cancer Biology
  • Signal Transduction
  • Systems Biology
  • Viral Oncology
  • Viral Pathogenesis
  • Virology

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  • Research Output

    Herpesvirus entry mediator binding partners mediate immunopathogenesis of ocular herpes simplex virus 1 infection

    Park, S. J., Riccio, R. E., Kopp, S. J., Ifergan, I., Miller, S. D. & Longnecker, R., Jan 1 2020, In : mBio. 11, 3, e00790-20.

    Research output: Contribution to journalArticle

    Open Access
  • The innate immune response to herpes simplex virus 1 infection is dampened in the newborn brain and can be modulated by exogenous interferon beta to improve survival

    Giraldo, D., Wilcox, D. R., Longnecker, R. & Shenk, T., May 1 2020, In : mBio. 11, 3, e00921-20.

    Research output: Contribution to journalArticle

    Open Access
  • Open Access
  • 1 Scopus citations

    Ephrin receptor A4 is a new kaposi’s sarcoma-associated herpesvirus virus entry receptor

    Chen, J., Zhang, X., Schaller, S., Jardetzky, T. S. & Longnecker, R. M., Jan 1 2019, In : mBio. 10, 1, e02892-18.

    Research output: Contribution to journalArticle

    Open Access
  • 7 Scopus citations

    Epithelial cell infection by Epstein-Barr virus

    Chen, J. & Longnecker, R., Aug 6 2019, In : FEMS microbiology reviews. 43, 6, p. 674-683 10 p.

    Research output: Contribution to journalReview article

  • 1 Scopus citations