• 10438 Citations
1986 …2024
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Personal profile

Research Interests

Research in the Longnecker laboratory focuses on herpes simplex virus (HSV) and Epstein-Barr virus (EBV). These viruses typically cause self-limiting disease within the human population but both can be associated with serious complications. EBV is associated with variety of hematopoietic cancers such as African Burkitt lymphoma, Hodgkin Lymphoma and adult T-cell leukemia. EBV-associated lymphoproliferative disease occurs in individuals with congenital or acquired cellular immune deficiencies. The two notable epithelial diseases associated with EBV infection are nasopharyngeal cancer and oral hairy leukoplakia. Similar to EBV, HSV latent infections are very common in humans. HSV typically does not cause severe disease but is associated with localized mucocutaneous lesions, but in some cases can cause meningitis and encephalitis. The Longnecker laboratory focuses on several aspects of EBV and HSV replication and pathogenesis. First, the molecular basis EBV transformation and how it relates to cancer is being investigated. The laboratory is currently screening selective inhibitors that may be beneficial in EBV-associated cancers such as Hodgkin lymphoma, Burkitt lymphoma and proliferative disorders that occur in HIV/AIDS and transplant patients. Second, the laboratory is investigating herpesvirus latency in the human host and pathogenesis associated with infections in humans. In this regard, the laboratory is developing animal models for EBV and HSV infections. Finally, the laboratory is investigating the function of herpesvirus encoded proteins and the cellular receptors that are important for infection both using in vivo culture models as well as animal models. Ultimately, studies by the Longnecker laboratory may provide insight for the development of novel therapeutics for the treatment of herpesvirus infections in humans and better understanding of the herpesvirus life cycle in the human host.

Training Experience

1988Postdoctoral Fellowship, University of Chicago
1992Postdoctoral Fellowship, Harvard University

Education/Academic qualification

PhD, University of Chicago

… → 1987

Research interests

  • Cancer Biology
  • Signal Transduction
  • Systems Biology
  • Viral Oncology
  • Viral Pathogenesis
  • Virology

Fingerprint Dive into the research topics where Richard M Longnecker is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 11 Similar Profiles
Human Herpesvirus 4 Medicine & Life Sciences
B-Lymphocytes Medicine & Life Sciences
Membrane Proteins Medicine & Life Sciences
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Glycoproteins Medicine & Life Sciences
Human Herpesvirus 1 Medicine & Life Sciences
B-lymphocytes Agriculture & Biology
Virus Internalization Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2000 2024

Herpes Simplex Encephalitis
Simplexvirus
Interferon Type I
Viral Encephalitis
Human Herpesvirus 1
Human Herpesvirus 8
Kaposi's Sarcoma
HIV
Neoplasms
Medicine
Human Herpesvirus 4
Virus Internalization
Epithelial Cells
Membrane Fusion
B-Lymphocytes
Herpetic Keratitis
Keratitis
Simplexvirus
Human Herpesvirus 1
Virus Diseases

Research Output 1986 2019

Open Access
Receptors, Tumor Necrosis Factor, Member 14
Herpetic Keratitis
Keratitis
Human Herpesvirus 1
Virus Diseases
5 Citations (Scopus)

Ephrin receptor A4 is a new kaposi’s sarcoma-associated herpesvirus virus entry receptor

Chen, J., Zhang, X., Schaller, S., Jardetzky, T. S. & Longnecker, R. M., Jan 1 2019, In : mBio. 10, 1, e02892-18.

Research output: Contribution to journalArticle

Open Access
EphA4 Receptor
Ephrin-A2
Virus Receptors
Satellite Viruses
Human Herpesvirus 8
Open Access
Receptors, Tumor Necrosis Factor, Member 14
Herpetic Keratitis
Keratitis
Human Herpesvirus 1
Virus Diseases

Gammaherpesvirus entry and fusion: A tale how two human pathogenic viruses enter their host cells

Möhl, B. S., Chen, J. & Longnecker, R. M., Jan 1 2019, Advances in Virus Research. Kielian, M., Mettenleiter, T. C. & Roossinck, M. J. (eds.). Academic Press Inc, p. 313-343 31 p. (Advances in Virus Research; vol. 104).

Research output: Chapter in Book/Report/Conference proceedingChapter

Human Herpesvirus 8
Human Herpesvirus 4
Herpesviridae
Viruses
Tropism

Two pathways of p27kip1 degradation are required for murine lymphoma driven by myc and EBV latent membrane protein 2A

Sora, R. P., Ikeda, M. & Longnecker, R. M., Mar 1 2019, In : mBio. 10, 2, e00548-19.

Research output: Contribution to journalArticle

Open Access
Human Herpesvirus 4
Lymphoma
Membrane Proteins
Burkitt Lymphoma
Neoplasms