Grants per year
Personal profile
Research Interests
Our group studies how complex cell and tissue behaviors are elicited within the context of the organism. We work as experimentalists, teaming up with theorists in applied mathematics, physics, and engineering, to apply systematic and quantitative approaches to biological problems. Gene regulation is of particular interest, and we have a long-standing interest in why non-coding RNAs regulate gene expression.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Biology, PhD, Massachusetts Institute of Technology
… → 1987
Botany, MSc, University of Toronto
… → 1980
Biology, BSc, Queen's University Kingston
… → 1978
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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National Institute for Theory and Mathematics in Biology
Carthew, R. W. (PD/PI), Carthew, R. W. (PD/PI), Auffinger, A. (Co-PD/PI), Auffinger, A. (Co-PD/PI), Braun, R. I. (Co-PD/PI), Braun, R. I. (Co-PD/PI), Kath, W. L. (Co-PD/PI) & Kath, W. L. (Co-PD/PI)
9/15/23 → 8/31/28
Project: Research project
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National Institute for Theory and Mathematics in Bilogy
Carthew, R. W. (PD/PI), Carthew, R. W. (PD/PI), Braun, R. I. (Co-Investigator), Braun, R. I. (Co-Investigator), Kath, W. L. (Co-Investigator) & Kath, W. L. (Co-Investigator)
7/1/23 → 6/30/28
Project: Research project
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Non-coding RNAs and their mechanisms and functions
Carthew, R. W. (PD/PI) & Carthew, R. W. (PD/PI)
National Institute of General Medical Sciences
4/1/21 → 3/31/26
Project: Research project
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REU Site: Quantitative Biology REU (QBREU) at Northwestern University
Braun, R. I. (PD/PI), Braun, R. I. (PD/PI), Andersen, E. C. (Co-PD/PI), Andersen, E. C. (Co-PD/PI), Andersen, E. C. (Co-PD/PI), Beitel, G. J. (Co-PD/PI), Allada, R. (Other), Allada, R. (Other), Auffinger, A. (Other), Auffinger, A. (Other), Carthew, R. W. (Other), Carthew, R. W. (Other), Kath, W. L. (Other), Kath, W. L. (Other), Kovacs, I. (Other), Kovacs, I. (Other), LaBonne, C. (Other), LaBonne, C. (Other), Lane, K. M. (Other), Lane, K. M. (Other), Mangan, N. M. (Other), Mangan, N. M. (Other), Mani, M. (Other), Mani, M. (Other), Wang, J. (Other) & Wang, J. (Other)
4/15/22 → 3/31/25
Project: Research project
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Reconstructing positional information in the eye from scRNA-seq and relating it to signal transduction
Carthew, R. W. (PD/PI) & Mani, M. (Co-Investigator)
1/1/21 → 12/31/22
Project: Research project
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Energy metabolism modulates the regulatory impact of activators on gene expression
Qiao, S., Bernasek, S., Gallagher, K. D., Connell, J. O., Yamada, S., Bagheri, N., Amaral, L. A. N. & Carthew, R. W., Jan 2024, In: Development (Cambridge). 151, 1, dev201986.Research output: Contribution to journal › Article › peer-review
Open Access -
Robust and heritable knockdown of gene expression using a self-cleaving ribozyme in Drosophila
Nyberg, K. G., Navales, F. G., Keles, E., Nguyen, J. Q., Hertz, L. M. & Carthew, R. W., Aug 2024, In: Genetics. 227, 4, iyae067.Research output: Contribution to journal › Article › peer-review
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Scaling between cell cycle duration and wing growth is regulated by Fat-Dachsous signaling in Drosophila
Liu, A., O'Connell, J., Wall, F. & Carthew, R. W., Jun 6 2024, In: eLife. 12Research output: Contribution to journal › Article › peer-review
Open Access -
Ratiometric sensing of Pnt and Yan transcription factor levels confers ultrasensitivity to photoreceptor fate transitions in Drosophila
Bernasek, S. M., Hur, S. S. J., Peláez-Restrepo, N., Lachance, J. F. B., Bakker, R., Navarro, H. T., Sanchez-Luege, N., Amaral, L. A. N., Bagheri, N., Rebay, I. & Carthew, R. W., Apr 2023, In: Development (Cambridge). 150, 8, dev201467.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
CRISPR-/Cas9-Mediated Precise and Efficient Genome Editing in Drosophila
Nyberg, K. G. & Carthew, R. W., 2022, Methods in Molecular Biology. Humana Press Inc., p. 135-156 22 p. (Methods in Molecular Biology; vol. 2540).Research output: Chapter in Book/Report/Conference proceeding › Chapter
Open Access3 Scopus citations
Datasets
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A pipeline for precise and efficient genome editing by sgRNA-Cas9 RNPs in Drosophila
Nyberg, K. G. (Creator), Nguyen, J. Q. (Creator), Kwon, Y.-J. (Contributor), Blythe, S. (Creator), Beitel, G. J. (Creator) & Carthew, R. (Creator), Taylor & Francis, 2020
DOI: 10.6084/m9.figshare.13049813, https://tandf.figshare.com/articles/dataset/A_Pipeline_for_Precise_and_Efficient_Genome_Editing_by_sgRNA-Cas9_RNPs_in_i_Drosophila_i_/13049813
Dataset
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Microprocessor recruitment to elongating RNA Polymerase II is required for differential expression of microRNAs
Church, V. A. (Contributor) & Carthew, R. W. (Contributor), Gene Expression Omnibus, Aug 29 2017
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE103234
Dataset