• 14010 Citations
1982 …2020

Research output per year

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Research Output

2020

Fly-QMA: Automated analysis of mosaic imaginal discs in Drosophila

Bernasek, S. M., Peláez, N., Carthew, R. W., Bagheri, N. & Amaral, L. A. N., Jan 1 2020, In : PLoS computational biology. 16, 3, e1007406.

Research output: Contribution to journalArticle

Open Access

MicroRNA miR-7 Regulates Secretion of Insulin-Like Peptides

Agbu, P., Cassidy, J. J., Braverman, J., Jacobson, A. & Carthew, R. W., Feb 1 2020, In : Endocrinology (United States). 161, 2, bqz040.

Research output: Contribution to journalArticle

Ordered patterning of the sensory system is susceptible to stochastic features of gene expression

Giri, R., Papadopoulos, D. K., Posadas, D. M., Potluri, H. K., Tomancak, P., Mani, M. & Carthew, R. W., Feb 2020, In : eLife. 9, e53638.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

The effector mechanism of siRNA spherical nucleic acids

Yamankurt, G., Stawicki, R. J., Posadas, D. M., Nguyen, J. Q., Carthew, R. W. & Mirkin, C. A., Jan 21 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 3, p. 1312-1320 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

The WG and DPP morphogens regulate gene expression by modulating the frequency of transcriptional bursts

Bakker, R., Mani, M. & Carthew, R. W., Jun 2020, In : eLife. 9, p. 1-26 26 p., e56076.

Research output: Contribution to journalArticle

Open Access
2019

Repressive Gene Regulation Synchronizes Development with Cellular Metabolism

Cassidy, J. J., Bernasek, S. M., Bakker, R., Giri, R., Peláez, N., Eder, B., Bobrowska, A., Bagheri, N., Nunes Amaral, L. A. & Carthew, R. W., Aug 8 2019, In : Cell. 178, 4, p. 980-992.e17

Research output: Contribution to journalArticle

5 Scopus citations
2017

Microprocessor Recruitment to Elongating RNA Polymerase II Is Required for Differential Expression of MicroRNAs

Church, V. A., Pressman, S., Isaji, M., Truscott, M., Cizmecioglu, N. T., Buratowski, S., Frolov, M. V. & Carthew, R. W., Sep 26 2017, In : Cell reports. 20, 13, p. 3123-3134 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

MicroRNA function in Drosophila melanogaster

Carthew, R. W., Agbu, P. & Giri, R., May 2017, In : Seminars in Cell and Developmental Biology. 65, p. 29-37 9 p.

Research output: Contribution to journalReview article

22 Scopus citations

MicroRNAs Make a Difference in Cardiovascular Robustness

Bakker, R. & Carthew, R. W., Mar 27 2017, In : Developmental Cell. 40, 6, p. 515-516 2 p.

Research output: Contribution to journalShort survey

3 Scopus citations

Out of the testis: Biological impacts of new genes

Nyberg, K. G. & Carthew, R. W., Sep 15 2017, In : Genes and Development. 31, 18, p. 1825-1826 2 p.

Research output: Contribution to journalArticle

3 Scopus citations
2016

Differential masking of natural genetic variation by miR-9a in Drosophila

Cassidy, J. J., Straughan, A. J. & Carthew, R. W., Feb 2016, In : Genetics. 202, 2, p. 675-687 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Hexagonal Patterning of the Insect Compound Eye: Facet Area Variation, Defects, and Disorder

Kim, S., Cassidy, J. J., Yang, B., Carthew, R. W. & Hilgenfeldt, S., Dec 20 2016, In : Biophysical Journal. 111, 12, p. 2735-2746 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Spindle-E cycling between nuage and cytoplasm is controlled by Qin and PIWI proteins

Andress, A., Bei, Y., Fonslow, B. R., Giri, R., Wu, Y., Yates, J. R. & Carthew, R. W., Apr 1 2016, In : Journal of Cell Biology. 213, 2, p. 201-211 11 p.

Research output: Contribution to journalArticle

6 Scopus citations
2015

Dynamics and heterogeneity of a fate determinant during transition towards cell differentiation

Peláez, N., Gavalda-Miralles, A., Wang, B., Navarro, H. T., Gudjonson, H., Rebay, I., Dinner, A. R., Katsaggelos, A. K., Amaral, L. A. N. & Carthew, R. W., Nov 19 2015, In : eLife. 4, NOVEMBER2015, e08924.

Research output: Contribution to journalArticle

13 Scopus citations
2014

A comparative study of pointed and yan expression reveals new complexity to the transcriptional networks downstream of receptor tyrosine kinase signaling

Boisclair Lachance, J. F., Peláez, N., Cassidy, J. J., Webber, J. L., Rebay, I. & Carthew, R. W., Jan 15 2014, In : Developmental Biology. 385, 2, p. 263-278 16 p.

Research output: Contribution to journalArticle

17 Scopus citations

Erratum: MiR-9a Minimizes the phenotypic impact of genomic diversity by buffering a transcription factor (Cell (2013) 155 (1556-1567))

Cassidy, J. J., Jha, A. R., Posadas, D. M., Giri, R., Venken, K. J. T., Ji, J., Jiang, H., Bellen, H. J., White, K. P. & Carthew, R. W., Apr 24 2014, In : Cell. 157, 3, 1 p.

Research output: Contribution to journalComment/debate

MicroRNAs and their roles in developmental canalization

Posadas, D. M. & Carthew, R. W., Aug 2014, In : Current Opinion in Genetics and Development. 27, p. 1-6 6 p.

Research output: Contribution to journalReview article

44 Scopus citations

microRNAs suppress cellular phenotypic heterogeneity

Giri, R. & Carthew, R. W., May 15 2014, In : Cell Cycle. 13, 10, p. 1517-1518 2 p.

Research output: Contribution to journalEditorial

3 Scopus citations
2013

Compositions and Methods for Altering RNAi

Carthew, R., May 23 2013, Patent No. 8735371

Research output: Patent

Drosophila eye nuclei segmentation based on graph cut and convex shape prior

Qi, J., Wang, B., Pelaez, N., Rebay, L., Carthew, R. W., Katsaggelos, A. K. & Amaral, L. A. N., Dec 1 2013, 2013 IEEE International Conference on Image Processing, ICIP 2013 - Proceedings. p. 670-674 5 p. 6738138. (2013 IEEE International Conference on Image Processing, ICIP 2013 - Proceedings).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

Functionally diverse MicroRNA effector complexes are regulated by extracellular signaling

Wu, P. H., Isaji, M. & Carthew, R. W., Oct 10 2013, In : Molecular cell. 52, 1, p. 113-123 11 p.

Research output: Contribution to journalArticle

35 Scopus citations

Functional Specialization of the Small Interfering RNA Pathway in Response to Virus Infection

Marques, J. T., Wang, J. P., Wang, X., de Oliveira, K. P. V., Gao, C., Aguiar, E. R. G. R., Jafari, N. & Carthew, R. W., Aug 1 2013, In : PLoS pathogens. 9, 8, e1003579.

Research output: Contribution to journalArticle

48 Scopus citations

MiR-9a minimizes the phenotypic impact of genomic diversity by buffering a transcription factor

Cassidy, J. J., Jha, A. R., Posadas, D. M., Giri, R., Venken, K. J. T., Ji, J., Jiang, H., Bellen, H. J., White, K. P. & Carthew, R. W., Dec 19 2013, In : Cell. 155, 7, p. 1556-1567 12 p.

Research output: Contribution to journalArticle

50 Scopus citations

The relationship between long-range chromatin occupancy and polymerization of the drosophila ets family transcriptional repressor yan

Webber, J. L., Zhang, J., Cote, L., Vivekanand, P., Ni, X., Zhou, J., Nègre, N., Carthew, R. W., White, K. P. & Rebay, I., Apr 29 2013, In : Genetics. 193, 2, p. 633-649 17 p.

Research output: Contribution to journalArticle

22 Scopus citations
2012

A systematic genetic screen to dissect the microrna pathway in drosophila

Pressman, S., Reinke, C. A., Wang, X. & Carthew, R. W., Apr 2012, In : G3: Genes, Genomes, Genetics. 2, 4, p. 437-448 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Biological Robustness and the Role of MicroRNAs. A Network Perspective

Peláez, N. & Carthew, R. W., Jan 1 2012, Current Topics in Developmental Biology. Academic Press Inc, p. 237-255 19 p. (Current Topics in Developmental Biology; vol. 99).

Research output: Chapter in Book/Report/Conference proceedingChapter

58 Scopus citations

Tobacco calmodulin-like protein provides secondary defense by binding to and directing degradation of virus RNA silencing suppressors

Nakahara, K. S., Masuta, C., Yamada, S., Shimura, H., Kashihara, Y., Wada, T. S., Meguro, A., Goto, K., Tadamura, K., Sueda, K., Sekiguchi, T., Shao, J., Itchoda, N., Matsumura, T., Igarashi, M., Ito, K., Carthew, R. W. & Uyeda, I., Jun 19 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 25, p. 10113-10118 6 p.

Research output: Contribution to journalArticle

100 Scopus citations
2011

Cadherin-dependent cell morphology in an epithelium: Constructing a quantitative dynamical model

Gemp, I. M., Carthew, R. W. & Hilgenfeldt, S., Jul 1 2011, In : PLoS Computational Biology. 7, 7, e1002115.

Research output: Contribution to journalArticle

12 Scopus citations

Cargo sorting to lysosome-related organelles regulates siRNA-mediated gene silencing

Harris, D. A., Kim, K., Nakahara, K., Vásquez-Doorman, C. & Carthew, R. W., Jul 11 2011, In : Journal of Cell Biology. 194, 1, p. 77-87 11 p.

Research output: Contribution to journalArticle

18 Scopus citations
2010

Loqs and R2D2 act sequentially in the siRNA pathway in Drosophila

Marques, J. T., Kim, K., Wu, P. H., Alleyne, T. M., Jafari, N. & Carthew, R. W., Jan 2010, In : Nature Structural and Molecular Biology. 17, 1, p. 24-31 8 p.

Research output: Contribution to journalArticle

90 Scopus citations

Reply to evolutionary flux of canonical microRNAs and mirtrons in drosophila

Lu, J., Shen, Y., Carthew, R. W., Wang, S. M. & Wu, C. I., Jan 1 2010, In : Nature Genetics. 42, 1, p. 9-10 2 p.

Research output: Contribution to journalLetter

6 Scopus citations
2009

A MicroRNA Imparts Robustness against Environmental Fluctuation during Development

Li, X., Cassidy, J. J., Reinke, C. A., Fischboeck, S. & Carthew, R. W., Apr 17 2009, In : Cell. 137, 2, p. 273-282 10 p.

Research output: Contribution to journalArticle

326 Scopus citations

Erratum: Silencing by small RNAs is linked to endosomal trafficking (Nature Cell Biology (2009) 11 (1150-1156))

Lee, Y. S., Pressman, S., Andress, A. P., Kim, K., White, J. L., Cassidy, J. J., Li, X., Lubell, K., Lim, D. H., Cho, I. S., Nakahara, K., Preall, J. B., Bellare, P., Sontheimer, E. J. & Carthew, R. W., Dec 1 2009, In : Nature Cell Biology. 11, 12, 1 p.

Research output: Contribution to journalComment/debate

Origins and Mechanisms of miRNAs and siRNAs

Carthew, R. W. & Sontheimer, E. J., Feb 20 2009, In : Cell. 136, 4, p. 642-655 14 p.

Research output: Contribution to journalReview article

3105 Scopus citations

Silencing by small RNAs is linked to endosomal trafficking

Lee, Y. S., Pressman, S., Andress, A. P., Kim, K., White, J. L., Cassidy, J. J., Li, X., Lubell, K., Lim, D. H., Cho, I. S., Nakahara, K., Preall, J. B., Bellare, P., Sontheimer, E. J. & Carthew, R. W., Aug 17 2009, In : Nature Cell Biology. 11, 9, p. 1150-1156 7 p.

Research output: Contribution to journalArticle

244 Scopus citations

The Endo-siRNA pathway is essential for robust development of the Drosophila embryo

Lucchetta, E. M., Carthew, R. W. & Ismagilov, R. F., Oct 23 2009, In : PloS one. 4, 10, e7576.

Research output: Contribution to journalArticle

24 Scopus citations
2008

Adaptive evolution of newly emerged micro-RNA genes in Drosophila

Lu, J., Fu, Y., Kumar, S., Shen, Y., Zeng, K., Xu, A., Carthew, R. & Wu, C. I., May 1 2008, In : Molecular biology and evolution. 25, 5, p. 929-938 10 p.

Research output: Contribution to journalArticle

58 Scopus citations

BMP Signaling Goes Posttranscriptional in a microRNA Sort of Way

Reinke, C. A. & Carthew, R. W., Aug 12 2008, In : Developmental Cell. 15, 2, p. 174-175 2 p.

Research output: Contribution to journalShort survey

5 Scopus citations

Cell-type-specific transcription of prospero is controlled by combinatorial signaling in the Drosophila eye

Hayashi, T., Xu, C. & Carthew, R. W., Aug 1 2008, In : Development. 135, 16, p. 2787-2796 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Functional analysis of dicer-2 missense mutations in the siRNA pathway of Drosophila

Lim, D. H., Kim, J., Kim, S., Carthew, R. W. & Lee, Y. S., Jul 4 2008, In : Biochemical and Biophysical Research Communications. 371, 3, p. 525-530 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Lola regulates cell fate by antagonizing Notch induction in the Drosophila eye

Zheng, L. & Carthew, R. W., Jan 1 2008, In : Mechanisms of Development. 125, 1-2, p. 18-29 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Physical modeling of cell geometric order in an epithelial tissue

Hilgenfeldt, S., Erisken, S. & Carthew, R. W., Jan 22 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 3, p. 907-911 5 p.

Research output: Contribution to journalArticle

81 Scopus citations

The birth and death of microRNA genes in Drosophila

Lu, J., Shen, Y., Wu, Q., Kumar, S., He, B., Shi, S., Carthew, R. W., Wang, S. M. & Wu, C. I., Mar 1 2008, In : Nature Genetics. 40, 3, p. 351-355 5 p.

Research output: Contribution to journalArticle

190 Scopus citations
2007

A call to arms: coevolution of animal viruses and host innate immune responses

Marques, J. T. & Carthew, R. W., Jul 1 2007, In : Trends in Genetics. 23, 7, p. 359-364 6 p.

Research output: Contribution to journalReview article

59 Scopus citations

Cell adhesion and cortex contractility determine cell patterning in the Drosophila retina

Käfer, J., Hayashi, T., Marée, A. F. M., Carthew, R. W. & Graner, F., Nov 20 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 47, p. 18549-18554 6 p.

Research output: Contribution to journalArticle

131 Scopus citations

Compositions and Methods for Altering RNAi

Carthew, R., Oct 25 2007, Patent No. 8318688

Research output: Patent

Conversion of pre-RISC to holo-RISC by Ago2 during assembly of RNAi complexes

Kim, K., Lee, Y. S. & Carthew, R. W., Jan 5 2007, In : RNA. 13, 1, p. 22-29 8 p.

Research output: Contribution to journalArticle

64 Scopus citations

Pattern formation in the Drosophila eye

Carthew, R. W., Aug 1 2007, In : Current Opinion in Genetics and Development. 17, 4, p. 309-313 5 p.

Research output: Contribution to journalReview article

48 Scopus citations

Posttranscriptional gene silencing.

Pressman, S., Bei, Y. & Carthew, R., Aug 10 2007, In : Cell. 130, 3, 1 p.

Research output: Contribution to journalArticle

5 Scopus citations

SnapShot: Small RNA-Mediated Epigenetic Modifications

Bei, Y., Pressman, S. & Carthew, R., Aug 24 2007, In : Cell. 130, 4, p. 756.e1-756.e2

Research output: Contribution to journalShort survey

2 Scopus citations