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Research Output 1982 2019

2019
1 Citation (Scopus)

Repressive Gene Regulation Synchronizes Development with Cellular Metabolism

Cassidy, J. J., Bernasek, S. M., Bakker, R., Giri, R., Peláez, N., Eder, B., Bobrowska, A., Bagheri, N., Nunes Amaral, L. A. & Carthew, R. W., Aug 8 2019, In : Cell. 178, 4, p. 980-992.e17

Research output: Contribution to journalArticle

Metabolism
Gene expression
Gene Regulatory Networks
Genes
MicroRNAs
2017
7 Citations (Scopus)

Microprocessor Recruitment to Elongating RNA Polymerase II Is Required for Differential Expression of MicroRNAs

Church, V. A., Pressman, S., Isaji, M., Truscott, M., Cizmecioglu, N. T., Buratowski, S., Frolov, M. V. & Carthew, R. W., Sep 26 2017, In : Cell reports. 20, 13, p. 3123-3134 12 p.

Research output: Contribution to journalArticle

RNA Polymerase II
Microcomputers
MicroRNAs
Microprocessor chips
Processing
16 Citations (Scopus)

MicroRNA function in Drosophila melanogaster

Carthew, R. W., Agbu, P. & Giri, R., May 2017, In : Seminars in Cell and Developmental Biology. 65, p. 29-37 9 p.

Research output: Contribution to journalReview article

Drosophila melanogaster
MicroRNAs
Gene Regulatory Networks
Germ Cells
Diptera
3 Citations (Scopus)

MicroRNAs Make a Difference in Cardiovascular Robustness

Bakker, R. & Carthew, R. W., Mar 27 2017, In : Developmental Cell. 40, 6, p. 515-516 2 p.

Research output: Contribution to journalShort survey

MicroRNAs
Zebrafish
Invertebrates
Embryonic Development
1 Citation (Scopus)

Out of the testis: Biological impacts of new genes

Nyberg, K. G. & Carthew, R. W., Sep 15 2017, In : Genes and Development. 31, 18, p. 1825-1826 2 p.

Research output: Contribution to journalArticle

Testis
Clustered Regularly Interspaced Short Palindromic Repeats
Genes
Molecular Dynamics Simulation
Drosophila
2016
9 Citations (Scopus)

Differential masking of natural genetic variation by miR-9a in Drosophila

Cassidy, J. J., Straughan, A. J. & Carthew, R. W., Feb 2016, In : Genetics. 202, 2, p. 675-687 13 p.

Research output: Contribution to journalArticle

MicroRNAs
Drosophila
Temperature
Drosophila MIRN9 microRNA
6 Citations (Scopus)

Hexagonal Patterning of the Insect Compound Eye: Facet Area Variation, Defects, and Disorder

Kim, S., Cassidy, J. J., Yang, B., Carthew, R. W. & Hilgenfeldt, S., Dec 20 2016, In : Biophysical Journal. 111, 12, p. 2735-2746 12 p.

Research output: Contribution to journalArticle

Insects
Body Patterning
Cell Polarity
Wild Animals
Cellular Structures
4 Citations (Scopus)

Spindle-E cycling between nuage and cytoplasm is controlled by Qin and PIWI proteins

Andress, A., Bei, Y., Fonslow, B. R., Giri, R., Wu, Y., Yates, J. R. & Carthew, R. W., Apr 1 2016, In : Journal of Cell Biology. 213, 2, p. 201-211 11 p.

Research output: Contribution to journalArticle

Cytoplasm
Solanum melongena
DNA Transposable Elements
RNA
Proteins
2015
10 Citations (Scopus)

Dynamics and heterogeneity of a fate determinant during transition towards cell differentiation

Peláez, N., Gavalda-Miralles, A., Wang, B., Navarro, H. T., Gudjonson, H., Rebay, I., Dinner, A. R., Katsaggelos, A. K., Amaral, L. A. N. & Carthew, R. W., Nov 19 2015, In : eLife. 4, NOVEMBER2015, e08924.

Research output: Contribution to journalArticle

Cell Differentiation
Transition Elements
Noise abatement
Epidermal Growth Factor Receptor
Transcription Factors
2014
16 Citations (Scopus)

A comparative study of pointed and yan expression reveals new complexity to the transcriptional networks downstream of receptor tyrosine kinase signaling

Boisclair Lachance, J. F., Peláez, N., Cassidy, J. J., Webber, J. L., Rebay, I. & Carthew, R. W., Jan 15 2014, In : Developmental Biology. 385, 2, p. 263-278 16 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Receptor Protein-Tyrosine Kinases
Transgenes
Drosophila
Proteins

Erratum: MiR-9a Minimizes the phenotypic impact of genomic diversity by buffering a transcription factor (Cell (2013) 155 (1556-1567))

Cassidy, J. J., Jha, A. R., Posadas, D. M., Giri, R., Venken, K. J. T., Ji, J., Jiang, H., Bellen, H. J., White, K. P. & Carthew, R. W., Apr 24 2014, In : Cell. 157, 3, 1 p.

Research output: Contribution to journalComment/debate

Transcription Factors
42 Citations (Scopus)

MicroRNAs and their roles in developmental canalization

Posadas, D. M. & Carthew, R. W., Aug 2014, In : Current Opinion in Genetics and Development. 27, p. 1-6 6 p.

Research output: Contribution to journalReview article

MicroRNAs
Proteins
2 Citations (Scopus)

microRNAs suppress cellular phenotypic heterogeneity

Giri, R. & Carthew, R. W., May 15 2014, In : Cell Cycle. 13, 10, p. 1517-1518 2 p.

Research output: Contribution to journalEditorial

Drosophila Proteins
Gene Regulatory Networks
Nuclear Proteins
Drosophila melanogaster
MicroRNAs
2013

Compositions and Methods for Altering RNAi

Carthew, R., May 23 2013, Patent No. 8735371

Research output: Patent

RNA Interference
Gene Silencing
Proteins
Genetically Modified Organisms
RNA
4 Citations (Scopus)

Drosophila eye nuclei segmentation based on graph cut and convex shape prior

Qi, J., Wang, B., Pelaez, N., Rebay, L., Carthew, R. W., Katsaggelos, A. K. & Amaral, L. A. N., Dec 1 2013, 2013 IEEE International Conference on Image Processing, ICIP 2013 - Proceedings. p. 670-674 5 p. 6738138. (2013 IEEE International Conference on Image Processing, ICIP 2013 - Proceedings).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Fruits
Cells
Availability
Imaging techniques
33 Citations (Scopus)

Functionally diverse MicroRNA effector complexes are regulated by extracellular signaling

Wu, P. H., Isaji, M. & Carthew, R. W., Oct 10 2013, In : Molecular cell. 52, 1, p. 113-123 11 p.

Research output: Contribution to journalArticle

MicroRNAs
Gene Expression
Polyribosomes
Recycling
Organelles
45 Citations (Scopus)

Functional Specialization of the Small Interfering RNA Pathway in Response to Virus Infection

Marques, J. T., Wang, J. P., Wang, X., de Oliveira, K. P. V., Gao, C., Aguiar, E. R. G. R., Jafari, N. & Carthew, R. W., Aug 1 2013, In : PLoS pathogens. 9, 8, e1003579.

Research output: Contribution to journalArticle

Virus Diseases
Small Interfering RNA
RNA Viruses
Viral RNA
Drosophila
46 Citations (Scopus)

MiR-9a minimizes the phenotypic impact of genomic diversity by buffering a transcription factor

Cassidy, J. J., Jha, A. R., Posadas, D. M., Giri, R., Venken, K. J. T., Ji, J., Jiang, H., Bellen, H. J., White, K. P. & Carthew, R. W., Dec 19 2013, In : Cell. 155, 7, p. 1556-1567 12 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Transcription Factors
Genes
Metagenomics
Human Genome
22 Citations (Scopus)

The relationship between long-range chromatin occupancy and polymerization of the drosophila ets family transcriptional repressor yan

Webber, J. L., Zhang, J., Cote, L., Vivekanand, P., Ni, X., Zhou, J., Nègre, N., Carthew, R. W., White, K. P. & Rebay, I., Apr 29 2013, In : Genetics. 193, 2, p. 633-649 17 p.

Research output: Contribution to journalArticle

Polymerization
Drosophila
Chromatin
Drosophila melanogaster
Point Mutation
2012
10 Citations (Scopus)

A systematic genetic screen to dissect the microrna pathway in drosophila

Pressman, S., Reinke, C. A., Wang, X. & Carthew, R. W., Apr 1 2012, In : G3: Genes, Genomes, Genetics. 2, 4, p. 437-448 12 p.

Research output: Contribution to journalArticle

MicroRNAs
Drosophila
Genes
Genetic Pleiotropy
Mutation
56 Citations (Scopus)

Biological Robustness and the Role of MicroRNAs. A Network Perspective

Peláez, N. & Carthew, R. W., Jan 1 2012, Current Topics in Developmental Biology. Academic Press Inc, p. 237-255 19 p. (Current Topics in Developmental Biology; vol. 99).

Research output: Chapter in Book/Report/Conference proceedingChapter

MicroRNAs
Genome
89 Citations (Scopus)

Tobacco calmodulin-like protein provides secondary defense by binding to and directing degradation of virus RNA silencing suppressors

Nakahara, K. S., Masuta, C., Yamada, S., Shimura, H., Kashihara, Y., Wada, T. S., Meguro, A., Goto, K., Tadamura, K., Sueda, K., Sekiguchi, T., Shao, J., Itchoda, N., Matsumura, T., Igarashi, M., Ito, K., Carthew, R. W. & Uyeda, I., Jun 19 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 25, p. 10113-10118 6 p.

Research output: Contribution to journalArticle

Calmodulin
RNA Interference
Tobacco
Viruses
Proteins
2011
12 Citations (Scopus)

Cadherin-dependent cell morphology in an epithelium: Constructing a quantitative dynamical model

Gemp, I. M., Carthew, R. W. & Hilgenfeldt, S., Jul 1 2011, In : PLoS Computational Biology. 7, 7, e1002115.

Research output: Contribution to journalArticle

cadherins
Dynamical Model
Cadherins
adhesion
epithelium
16 Citations (Scopus)

Cargo sorting to lysosome-related organelles regulates siRNA-mediated gene silencing

Harris, D. A., Kim, K., Nakahara, K., Vásquez-Doorman, C. & Carthew, R. W., Jul 11 2011, In : Journal of Cell Biology. 194, 1, p. 77-87 11 p.

Research output: Contribution to journalArticle

Gene Silencing
Lysosomes
Organelles
Small Interfering RNA
Argonaute Proteins
2010
86 Citations (Scopus)

Loqs and R2D2 act sequentially in the siRNA pathway in Drosophila

Marques, J. T., Kim, K., Wu, P. H., Alleyne, T. M., Jafari, N. & Carthew, R. W., Jan 2010, In : Nature Structural and Molecular Biology. 17, 1, p. 24-31 8 p.

Research output: Contribution to journalArticle

Double-Stranded RNA
Small Interfering RNA
Drosophila
RNA-Binding Proteins
Virus Diseases
6 Citations (Scopus)

Reply to evolutionary flux of canonical microRNAs and mirtrons in drosophila

Lu, J., Shen, Y., Carthew, R. W., Wang, S. M. & Wu, C. I., Jan 1 2010, In : Nature Genetics. 42, 1, p. 9-10 2 p.

Research output: Contribution to journalLetter

MicroRNAs
Drosophila
2009
313 Citations (Scopus)

A MicroRNA Imparts Robustness against Environmental Fluctuation during Development

Li, X., Cassidy, J. J., Reinke, C. A., Fischboeck, S. & Carthew, R. W., Apr 17 2009, In : Cell. 137, 2, p. 273-282 10 p.

Research output: Contribution to journalArticle

MicroRNAs
Drosophila
Buffers
Mammals
Genes

Erratum: Silencing by small RNAs is linked to endosomal trafficking (Nature Cell Biology (2009) 11 (1150-1156))

Lee, Y. S., Pressman, S., Andress, A. P., Kim, K., White, J. L., Cassidy, J. J., Li, X., Lubell, K., Lim, D. H., Cho, I. S., Nakahara, K., Preall, J. B., Bellare, P., Sontheimer, E. J. & Carthew, R. W., Dec 1 2009, In : Nature Cell Biology. 11, 12, 1 p.

Research output: Contribution to journalComment/debate

RNA Interference
Cell Biology
2980 Citations (Scopus)

Origins and Mechanisms of miRNAs and siRNAs

Carthew, R. W. & Sontheimer, E. J., Feb 20 2009, In : Cell. 136, 4, p. 642-655 14 p.

Research output: Contribution to journalReview article

MicroRNAs
Small Interfering RNA
Genes
Genome
RNA
237 Citations (Scopus)

Silencing by small RNAs is linked to endosomal trafficking

Lee, Y. S., Pressman, S., Andress, A. P., Kim, K., White, J. L., Cassidy, J. J., Li, X., Lubell, K., Lim, D. H., Cho, I. S., Nakahara, K., Preall, J. B., Bellare, P., Sontheimer, E. J. & Carthew, R. W., Aug 17 2009, In : Nature Cell Biology. 11, 9, p. 1150-1156 7 p.

Research output: Contribution to journalArticle

RNA-Induced Silencing Complex
Multivesicular Bodies
RNA Interference
RNA
MicroRNAs
23 Citations (Scopus)

The Endo-siRNA pathway is essential for robust development of the Drosophila embryo

Lucchetta, E. M., Carthew, R. W. & Ismagilov, R. F., Oct 23 2009, In : PloS one. 4, 10, e7576.

Research output: Contribution to journalArticle

small interfering RNA
Small Interfering RNA
Drosophila
Embryonic Development
embryo (animal)
2008
56 Citations (Scopus)

Adaptive evolution of newly emerged micro-RNA genes in Drosophila

Lu, J., Fu, Y., Kumar, S., Shen, Y., Zeng, K., Xu, A., Carthew, R. & Wu, C. I., May 1 2008, In : Molecular biology and evolution. 25, 5, p. 929-938 10 p.

Research output: Contribution to journalArticle

MicroRNAs
microRNA
Drosophila
RNA
gene
5 Citations (Scopus)

BMP Signaling Goes Posttranscriptional in a microRNA Sort of Way

Reinke, C. A. & Carthew, R. W., Aug 12 2008, In : Developmental Cell. 15, 2, p. 174-175 2 p.

Research output: Contribution to journalShort survey

MicroRNAs
Heart Neoplasms
Cell Differentiation
Therapeutics
33 Citations (Scopus)

Cell-type-specific transcription of prospero is controlled by combinatorial signaling in the Drosophila eye

Hayashi, T., Xu, C. & Carthew, R. W., Aug 1 2008, In : Development. 135, 16, p. 2787-2796 10 p.

Research output: Contribution to journalArticle

Drosophila
Retinal Cone Photoreceptor Cells
Glass
Transcription Factors
Salts
16 Citations (Scopus)

Functional analysis of dicer-2 missense mutations in the siRNA pathway of Drosophila

Lim, D. H., Kim, J., Kim, S., Carthew, R. W. & Lee, Y. S., Jul 4 2008, In : Biochemical and Biophysical Research Communications. 371, 3, p. 525-530 6 p.

Research output: Contribution to journalArticle

Functional analysis
Double-Stranded RNA
Ribonuclease III
Missense Mutation
Small Interfering RNA
15 Citations (Scopus)

Lola regulates cell fate by antagonizing Notch induction in the Drosophila eye

Zheng, L. & Carthew, R. W., Jan 1 2008, In : Mechanisms of Development. 125, 1-2, p. 18-29 12 p.

Research output: Contribution to journalArticle

Drosophila
Retinal Cone Photoreceptor Cells
Nervous System
Genes
Gene Expression
80 Citations (Scopus)

Physical modeling of cell geometric order in an epithelial tissue

Hilgenfeldt, S., Erisken, S. & Carthew, R. W., Jan 22 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 3, p. 907-911 5 p.

Research output: Contribution to journalArticle

Epithelium
Elasticity
Cadherins
Adhesives
Drosophila
190 Citations (Scopus)

The birth and death of microRNA genes in Drosophila

Lu, J., Shen, Y., Wu, Q., Kumar, S., He, B., Shi, S., Carthew, R. W., Wang, S. M. & Wu, C. I., Mar 1 2008, In : Nature Genetics. 40, 3, p. 351-355 5 p.

Research output: Contribution to journalArticle

MicroRNAs
Drosophila
Parturition
Genes
Birth Rate
2007
59 Citations (Scopus)

A call to arms: coevolution of animal viruses and host innate immune responses

Marques, J. T. & Carthew, R. W., Jul 1 2007, In : Trends in Genetics. 23, 7, p. 359-364 6 p.

Research output: Contribution to journalReview article

RNA Interference
Innate Immunity
Antiviral Agents
Virus Diseases
Viruses
130 Citations (Scopus)

Cell adhesion and cortex contractility determine cell patterning in the Drosophila retina

Käfer, J., Hayashi, T., Marée, A. F. M., Carthew, R. W. & Graner, F., Nov 20 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 47, p. 18549-18554 6 p.

Research output: Contribution to journalArticle

Cadherins
Cell Adhesion
Drosophila
Retina
Cell Shape

Compositions and Methods for Altering RNAi

Carthew, R., Oct 25 2007, Patent No. 8318688

Research output: Patent

RNA Interference
Gene Silencing
Proteins
Genetically Modified Organisms
RNA
62 Citations (Scopus)

Conversion of pre-RISC to holo-RISC by Ago2 during assembly of RNAi complexes

Kim, K., Lee, Y. S. & Carthew, R. W., Jan 5 2007, In : RNA. 13, 1, p. 22-29 8 p.

Research output: Contribution to journalArticle

RNA-Induced Silencing Complex
RNA Interference
Small Interfering RNA
Drosophila
Endonucleases
47 Citations (Scopus)

Pattern formation in the Drosophila eye

Carthew, R. W., Aug 1 2007, In : Current Opinion in Genetics and Development. 17, 4, p. 309-313 5 p.

Research output: Contribution to journalReview article

Drosophila
Notch Receptors
Epidermal Growth Factor Receptor
Insects
Epithelium
5 Citations (Scopus)

Posttranscriptional gene silencing.

Pressman, S., Bei, Y. & Carthew, R., Aug 10 2007, In : Cell. 130, 3, 1 p.

Research output: Contribution to journalArticle

Animals
Genes

SnapShot: Posttranscriptional Gene Silencing

Pressman, S., Bei, Y. & Carthew, R., Aug 10 2007, In : Cell. 130, 3, p. 570.e1-570.e2

Research output: Contribution to journalShort survey

Open Access
RNA Interference
Genes
2 Citations (Scopus)

SnapShot: Small RNA-Mediated Epigenetic Modifications

Bei, Y., Pressman, S. & Carthew, R., Aug 24 2007, In : Cell. 130, 4, p. 756.e1-756.e2

Research output: Contribution to journalShort survey

RNA
2006
35 Citations (Scopus)

A new RNA dimension to genome control

Carthew, R. W., Jul 21 2006, In : Science. 313, 5785, p. 305-306 2 p.

Research output: Contribution to journalReview article

Genetic Transcription
Antisense RNA
Untranslated RNA
Retroelements
germ cell
351 Citations (Scopus)

Gene regulation by microRNAs

Carthew, R. W., Apr 1 2006, In : Current Opinion in Genetics and Development. 16, 2, p. 203-208 6 p.

Research output: Contribution to journalReview article

MicroRNAs
Genes
Protein Biosynthesis
RNA
Gene Expression
36 Citations (Scopus)

Par-1 kinase establishes cell polarity and functions in Notch signaling in the Drosophila embryo

Bayraktar, J., Zygmunt, D. & Carthew, R. W., Feb 15 2006, In : Journal of cell science. 119, 4, p. 711-721 11 p.

Research output: Contribution to journalArticle

Cell Polarity
Drosophila
Phosphotransferases
Embryonic Structures
Drosophila Proteins
485 Citations (Scopus)

RNA interference directs innate immunity against viruses in adult Drosophila

Wang, X. H., Aliyari, R., Li, W. X., Li, H. W., Kim, K., Carthew, R., Atkinson, P. & Ding, S. W., Apr 21 2006, In : Science. 312, 5772, p. 452-454 3 p.

Research output: Contribution to journalArticle

RNA Interference
Innate Immunity
Drosophila
Viruses
Double-Stranded RNA