• 14010 Citations
1982 …2020

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2020

Fly-QMA: Automated analysis of mosaic imaginal discs in Drosophila

Bernasek, S. M., Peláez, N., Carthew, R. W., Bagheri, N. & Amaral, L. A. N., Jan 1 2020, In : PLoS computational biology. 16, 3, e1007406.

Research output: Contribution to journalArticle

Open Access

MicroRNA miR-7 Regulates Secretion of Insulin-Like Peptides

Agbu, P., Cassidy, J. J., Braverman, J., Jacobson, A. & Carthew, R. W., Feb 1 2020, In : Endocrinology (United States). 161, 2, bqz040.

Research output: Contribution to journalArticle

Ordered patterning of the sensory system is susceptible to stochastic features of gene expression

Giri, R., Papadopoulos, D. K., Posadas, D. M., Potluri, H. K., Tomancak, P., Mani, M. & Carthew, R. W., Feb 2020, In : eLife. 9, e53638.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

The effector mechanism of siRNA spherical nucleic acids

Yamankurt, G., Stawicki, R. J., Posadas, D. M., Nguyen, J. Q., Carthew, R. W. & Mirkin, C. A., Jan 21 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 3, p. 1312-1320 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

The WG and DPP morphogens regulate gene expression by modulating the frequency of transcriptional bursts

Bakker, R., Mani, M. & Carthew, R. W., Jun 2020, In : eLife. 9, p. 1-26 26 p., e56076.

Research output: Contribution to journalArticle

Open Access
2019

Repressive Gene Regulation Synchronizes Development with Cellular Metabolism

Cassidy, J. J., Bernasek, S. M., Bakker, R., Giri, R., Peláez, N., Eder, B., Bobrowska, A., Bagheri, N., Nunes Amaral, L. A. & Carthew, R. W., Aug 8 2019, In : Cell. 178, 4, p. 980-992.e17

Research output: Contribution to journalArticle

5 Scopus citations
2017

Microprocessor Recruitment to Elongating RNA Polymerase II Is Required for Differential Expression of MicroRNAs

Church, V. A., Pressman, S., Isaji, M., Truscott, M., Cizmecioglu, N. T., Buratowski, S., Frolov, M. V. & Carthew, R. W., Sep 26 2017, In : Cell reports. 20, 13, p. 3123-3134 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Out of the testis: Biological impacts of new genes

Nyberg, K. G. & Carthew, R. W., Sep 15 2017, In : Genes and Development. 31, 18, p. 1825-1826 2 p.

Research output: Contribution to journalArticle

3 Scopus citations
2016

Differential masking of natural genetic variation by miR-9a in Drosophila

Cassidy, J. J., Straughan, A. J. & Carthew, R. W., Feb 2016, In : Genetics. 202, 2, p. 675-687 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Hexagonal Patterning of the Insect Compound Eye: Facet Area Variation, Defects, and Disorder

Kim, S., Cassidy, J. J., Yang, B., Carthew, R. W. & Hilgenfeldt, S., Dec 20 2016, In : Biophysical Journal. 111, 12, p. 2735-2746 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Spindle-E cycling between nuage and cytoplasm is controlled by Qin and PIWI proteins

Andress, A., Bei, Y., Fonslow, B. R., Giri, R., Wu, Y., Yates, J. R. & Carthew, R. W., Apr 1 2016, In : Journal of Cell Biology. 213, 2, p. 201-211 11 p.

Research output: Contribution to journalArticle

6 Scopus citations
2015

Dynamics and heterogeneity of a fate determinant during transition towards cell differentiation

Peláez, N., Gavalda-Miralles, A., Wang, B., Navarro, H. T., Gudjonson, H., Rebay, I., Dinner, A. R., Katsaggelos, A. K., Amaral, L. A. N. & Carthew, R. W., Nov 19 2015, In : eLife. 4, NOVEMBER2015, e08924.

Research output: Contribution to journalArticle

13 Scopus citations
2014

A comparative study of pointed and yan expression reveals new complexity to the transcriptional networks downstream of receptor tyrosine kinase signaling

Boisclair Lachance, J. F., Peláez, N., Cassidy, J. J., Webber, J. L., Rebay, I. & Carthew, R. W., Jan 15 2014, In : Developmental Biology. 385, 2, p. 263-278 16 p.

Research output: Contribution to journalArticle

17 Scopus citations
2013

Functionally diverse MicroRNA effector complexes are regulated by extracellular signaling

Wu, P. H., Isaji, M. & Carthew, R. W., Oct 10 2013, In : Molecular cell. 52, 1, p. 113-123 11 p.

Research output: Contribution to journalArticle

35 Scopus citations

Functional Specialization of the Small Interfering RNA Pathway in Response to Virus Infection

Marques, J. T., Wang, J. P., Wang, X., de Oliveira, K. P. V., Gao, C., Aguiar, E. R. G. R., Jafari, N. & Carthew, R. W., Aug 1 2013, In : PLoS pathogens. 9, 8, e1003579.

Research output: Contribution to journalArticle

48 Scopus citations

MiR-9a minimizes the phenotypic impact of genomic diversity by buffering a transcription factor

Cassidy, J. J., Jha, A. R., Posadas, D. M., Giri, R., Venken, K. J. T., Ji, J., Jiang, H., Bellen, H. J., White, K. P. & Carthew, R. W., Dec 19 2013, In : Cell. 155, 7, p. 1556-1567 12 p.

Research output: Contribution to journalArticle

50 Scopus citations

The relationship between long-range chromatin occupancy and polymerization of the drosophila ets family transcriptional repressor yan

Webber, J. L., Zhang, J., Cote, L., Vivekanand, P., Ni, X., Zhou, J., Nègre, N., Carthew, R. W., White, K. P. & Rebay, I., Apr 29 2013, In : Genetics. 193, 2, p. 633-649 17 p.

Research output: Contribution to journalArticle

22 Scopus citations
2012

A systematic genetic screen to dissect the microrna pathway in drosophila

Pressman, S., Reinke, C. A., Wang, X. & Carthew, R. W., Apr 2012, In : G3: Genes, Genomes, Genetics. 2, 4, p. 437-448 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Tobacco calmodulin-like protein provides secondary defense by binding to and directing degradation of virus RNA silencing suppressors

Nakahara, K. S., Masuta, C., Yamada, S., Shimura, H., Kashihara, Y., Wada, T. S., Meguro, A., Goto, K., Tadamura, K., Sueda, K., Sekiguchi, T., Shao, J., Itchoda, N., Matsumura, T., Igarashi, M., Ito, K., Carthew, R. W. & Uyeda, I., Jun 19 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 25, p. 10113-10118 6 p.

Research output: Contribution to journalArticle

100 Scopus citations
2011

Cadherin-dependent cell morphology in an epithelium: Constructing a quantitative dynamical model

Gemp, I. M., Carthew, R. W. & Hilgenfeldt, S., Jul 1 2011, In : PLoS Computational Biology. 7, 7, e1002115.

Research output: Contribution to journalArticle

12 Scopus citations

Cargo sorting to lysosome-related organelles regulates siRNA-mediated gene silencing

Harris, D. A., Kim, K., Nakahara, K., Vásquez-Doorman, C. & Carthew, R. W., Jul 11 2011, In : Journal of Cell Biology. 194, 1, p. 77-87 11 p.

Research output: Contribution to journalArticle

18 Scopus citations
2010

Loqs and R2D2 act sequentially in the siRNA pathway in Drosophila

Marques, J. T., Kim, K., Wu, P. H., Alleyne, T. M., Jafari, N. & Carthew, R. W., Jan 2010, In : Nature Structural and Molecular Biology. 17, 1, p. 24-31 8 p.

Research output: Contribution to journalArticle

90 Scopus citations
2009

A MicroRNA Imparts Robustness against Environmental Fluctuation during Development

Li, X., Cassidy, J. J., Reinke, C. A., Fischboeck, S. & Carthew, R. W., Apr 17 2009, In : Cell. 137, 2, p. 273-282 10 p.

Research output: Contribution to journalArticle

326 Scopus citations

Silencing by small RNAs is linked to endosomal trafficking

Lee, Y. S., Pressman, S., Andress, A. P., Kim, K., White, J. L., Cassidy, J. J., Li, X., Lubell, K., Lim, D. H., Cho, I. S., Nakahara, K., Preall, J. B., Bellare, P., Sontheimer, E. J. & Carthew, R. W., Aug 17 2009, In : Nature Cell Biology. 11, 9, p. 1150-1156 7 p.

Research output: Contribution to journalArticle

244 Scopus citations

The Endo-siRNA pathway is essential for robust development of the Drosophila embryo

Lucchetta, E. M., Carthew, R. W. & Ismagilov, R. F., Oct 23 2009, In : PloS one. 4, 10, e7576.

Research output: Contribution to journalArticle

24 Scopus citations
2008

Adaptive evolution of newly emerged micro-RNA genes in Drosophila

Lu, J., Fu, Y., Kumar, S., Shen, Y., Zeng, K., Xu, A., Carthew, R. & Wu, C. I., May 1 2008, In : Molecular biology and evolution. 25, 5, p. 929-938 10 p.

Research output: Contribution to journalArticle

58 Scopus citations

Cell-type-specific transcription of prospero is controlled by combinatorial signaling in the Drosophila eye

Hayashi, T., Xu, C. & Carthew, R. W., Aug 1 2008, In : Development. 135, 16, p. 2787-2796 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Functional analysis of dicer-2 missense mutations in the siRNA pathway of Drosophila

Lim, D. H., Kim, J., Kim, S., Carthew, R. W. & Lee, Y. S., Jul 4 2008, In : Biochemical and Biophysical Research Communications. 371, 3, p. 525-530 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Lola regulates cell fate by antagonizing Notch induction in the Drosophila eye

Zheng, L. & Carthew, R. W., Jan 1 2008, In : Mechanisms of Development. 125, 1-2, p. 18-29 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Physical modeling of cell geometric order in an epithelial tissue

Hilgenfeldt, S., Erisken, S. & Carthew, R. W., Jan 22 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 3, p. 907-911 5 p.

Research output: Contribution to journalArticle

81 Scopus citations

The birth and death of microRNA genes in Drosophila

Lu, J., Shen, Y., Wu, Q., Kumar, S., He, B., Shi, S., Carthew, R. W., Wang, S. M. & Wu, C. I., Mar 1 2008, In : Nature Genetics. 40, 3, p. 351-355 5 p.

Research output: Contribution to journalArticle

190 Scopus citations
2007

Cell adhesion and cortex contractility determine cell patterning in the Drosophila retina

Käfer, J., Hayashi, T., Marée, A. F. M., Carthew, R. W. & Graner, F., Nov 20 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 47, p. 18549-18554 6 p.

Research output: Contribution to journalArticle

131 Scopus citations

Conversion of pre-RISC to holo-RISC by Ago2 during assembly of RNAi complexes

Kim, K., Lee, Y. S. & Carthew, R. W., Jan 5 2007, In : RNA. 13, 1, p. 22-29 8 p.

Research output: Contribution to journalArticle

64 Scopus citations

Posttranscriptional gene silencing.

Pressman, S., Bei, Y. & Carthew, R., Aug 10 2007, In : Cell. 130, 3, 1 p.

Research output: Contribution to journalArticle

5 Scopus citations
2006

Par-1 kinase establishes cell polarity and functions in Notch signaling in the Drosophila embryo

Bayraktar, J., Zygmunt, D. & Carthew, R. W., Feb 15 2006, In : Journal of cell science. 119, 4, p. 711-721 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

RNA interference directs innate immunity against viruses in adult Drosophila

Wang, X. H., Aliyari, R., Li, W. X., Li, H. W., Kim, K., Carthew, R., Atkinson, P. & Ding, S. W., Apr 21 2006, In : Science. 312, 5772, p. 452-454 3 p.

Research output: Contribution to journalArticle

496 Scopus citations

The RNAi pathway initiated by Dicer-2 in Drosophila

Kim, K., Lee, Y. S., Harris, D., Nakahara, K. & Carthew, R. W., Dec 1 2006, In : Cold Spring Harbor symposia on quantitative biology. 71, p. 39-44 6 p.

Research output: Contribution to journalArticle

37 Scopus citations
2005

A microRNA mediates EGF receptor signaling and promotes photoreceptor differentiation in the Drosophila eye

Li, X. & Carthew, R. W., Dec 29 2005, In : Cell. 123, 7, p. 1267-1277 11 p.

Research output: Contribution to journalArticle

268 Scopus citations

Stem cell division is regulated by the microRNA pathway

Hatfield, S. D., Shcherbata, H. R., Fischer, K. A., Nakahara, K., Carthew, R. W. & Ruohola-Baker, H., Jun 16 2005, In : Nature. 435, 7044, p. 974-978 5 p.

Research output: Contribution to journalArticle

541 Scopus citations

Targets of microRNA regulation in the Drosophila oocyte proteome

Nakahara, K., Kim, K., Sciulli, C., Dowd, S. R., Minden, J. S. & Carthew, R. W., Aug 23 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 34, p. 12023-12028 6 p.

Research output: Contribution to journalArticle

68 Scopus citations
2004

A Dicer-2-dependent 80S complex cleaves targeted mRNAs during RNAi in Drosophila

Pham, J. W., Pellino, J. L., Lee, Y. S., Carthew, R. W. & Sontheimer, E. J., Apr 2 2004, In : Cell. 117, 1, p. 83-94 12 p.

Research output: Contribution to journalArticle

330 Scopus citations

Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways

Lee, Y. S., Nakahara, K., Pham, J. W., Kim, K., He, Z., Sontheimer, E. J. & Carthew, R. W., Apr 2 2004, In : Cell. 117, 1, p. 69-81 13 p.

Research output: Contribution to journalArticle

911 Scopus citations

Genome-wide survey of protein kinases required for cell cycle progression

Bettencourt-Dias, M., Giet, R., Sinka, R., Mazumdar, A., Lock, W. G., Balloux, F., Zafiropoulos, P. J., Yamaguchi, S., Winter, S., Carthew, R. W., Cooper, M., Jones, D., Fronz, L. & Glover, D. M., Dec 23 2004, In : Nature. 432, 7020, p. 980-987 8 p.

Research output: Contribution to journalArticle

278 Scopus citations

Surface mechanics mediate pattern formation in the developing retina

Hayashi, T. & Carthew, R. W., Oct 7 2004, In : Nature. 431, 7009, p. 647-652 6 p.

Research output: Contribution to journalArticle

217 Scopus citations
2003

Chibby, a nuclear β-catenin-associated antagonist of the Wnt/Wingless pathway

Takemaru, K. I., Yamaguchi, S., Sik Lee, Y., Zhang, Y., Carthew, R. W. & Moon, R. T., Apr 24 2003, In : Nature. 422, 6934, p. 905-909 5 p.

Research output: Contribution to journalArticle

212 Scopus citations

Making a better RNAi vector for Drosophila: Use of intron spacers

Lee, Y. S. & Carthew, R. W., Aug 1 2003, In : Methods. 30, 4, p. 322-329 8 p.

Research output: Contribution to journalArticle

294 Scopus citations
2002

Phyllopod acts as an adaptor protein to link the Sina ubiquitin ligase to the substrate protein Tramtrack

Li, S., Xu, C. & Carthew, R. W., Oct 1 2002, In : Molecular and cellular biology. 22, 19, p. 6854-6865 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-E

Kennerdell, J. R., Yamaguchi, S. & Carthew, R. W., Aug 1 2002, In : Genes and Development. 16, 15, p. 1884-1889 6 p.

Research output: Contribution to journalArticle

149 Scopus citations
2001

Construction and assay of radiation hybrids.

Richard, C. W. & Washington, S. S., May 1 2001, In : Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.]. Chapter 3

Research output: Contribution to journalArticle

2000

Heritable gene silencing in Drosophila using double-stranded RNA

Kennerdell, J. R. & Carthew, R. W., Sep 2 2000, In : Nature biotechnology. 18, 8, p. 896-898 3 p.

Research output: Contribution to journalArticle

396 Scopus citations