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Research Output 1982 2019

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Article
2019
1 Citation (Scopus)

Repressive Gene Regulation Synchronizes Development with Cellular Metabolism

Cassidy, J. J., Bernasek, S. M., Bakker, R., Giri, R., Peláez, N., Eder, B., Bobrowska, A., Bagheri, N., Nunes Amaral, L. A. & Carthew, R. W., Aug 8 2019, In : Cell. 178, 4, p. 980-992.e17

Research output: Contribution to journalArticle

Metabolism
Gene expression
Gene Regulatory Networks
Genes
MicroRNAs
2017
7 Citations (Scopus)

Microprocessor Recruitment to Elongating RNA Polymerase II Is Required for Differential Expression of MicroRNAs

Church, V. A., Pressman, S., Isaji, M., Truscott, M., Cizmecioglu, N. T., Buratowski, S., Frolov, M. V. & Carthew, R. W., Sep 26 2017, In : Cell reports. 20, 13, p. 3123-3134 12 p.

Research output: Contribution to journalArticle

RNA Polymerase II
Microcomputers
MicroRNAs
Microprocessor chips
Processing
1 Citation (Scopus)

Out of the testis: Biological impacts of new genes

Nyberg, K. G. & Carthew, R. W., Sep 15 2017, In : Genes and Development. 31, 18, p. 1825-1826 2 p.

Research output: Contribution to journalArticle

Testis
Clustered Regularly Interspaced Short Palindromic Repeats
Genes
Molecular Dynamics Simulation
Drosophila
2016
9 Citations (Scopus)

Differential masking of natural genetic variation by miR-9a in Drosophila

Cassidy, J. J., Straughan, A. J. & Carthew, R. W., Feb 2016, In : Genetics. 202, 2, p. 675-687 13 p.

Research output: Contribution to journalArticle

MicroRNAs
Drosophila
Temperature
Drosophila MIRN9 microRNA
6 Citations (Scopus)

Hexagonal Patterning of the Insect Compound Eye: Facet Area Variation, Defects, and Disorder

Kim, S., Cassidy, J. J., Yang, B., Carthew, R. W. & Hilgenfeldt, S., Dec 20 2016, In : Biophysical Journal. 111, 12, p. 2735-2746 12 p.

Research output: Contribution to journalArticle

Insects
Body Patterning
Cell Polarity
Wild Animals
Cellular Structures
4 Citations (Scopus)

Spindle-E cycling between nuage and cytoplasm is controlled by Qin and PIWI proteins

Andress, A., Bei, Y., Fonslow, B. R., Giri, R., Wu, Y., Yates, J. R. & Carthew, R. W., Apr 1 2016, In : Journal of Cell Biology. 213, 2, p. 201-211 11 p.

Research output: Contribution to journalArticle

Cytoplasm
Solanum melongena
DNA Transposable Elements
RNA
Proteins
2015
10 Citations (Scopus)

Dynamics and heterogeneity of a fate determinant during transition towards cell differentiation

Peláez, N., Gavalda-Miralles, A., Wang, B., Navarro, H. T., Gudjonson, H., Rebay, I., Dinner, A. R., Katsaggelos, A. K., Amaral, L. A. N. & Carthew, R. W., Nov 19 2015, In : eLife. 4, NOVEMBER2015, e08924.

Research output: Contribution to journalArticle

Cell Differentiation
Transition Elements
Noise abatement
Epidermal Growth Factor Receptor
Transcription Factors
2014
16 Citations (Scopus)

A comparative study of pointed and yan expression reveals new complexity to the transcriptional networks downstream of receptor tyrosine kinase signaling

Boisclair Lachance, J. F., Peláez, N., Cassidy, J. J., Webber, J. L., Rebay, I. & Carthew, R. W., Jan 15 2014, In : Developmental Biology. 385, 2, p. 263-278 16 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Receptor Protein-Tyrosine Kinases
Transgenes
Drosophila
Proteins
2013
33 Citations (Scopus)

Functionally diverse MicroRNA effector complexes are regulated by extracellular signaling

Wu, P. H., Isaji, M. & Carthew, R. W., Oct 10 2013, In : Molecular cell. 52, 1, p. 113-123 11 p.

Research output: Contribution to journalArticle

MicroRNAs
Gene Expression
Polyribosomes
Recycling
Organelles
45 Citations (Scopus)

Functional Specialization of the Small Interfering RNA Pathway in Response to Virus Infection

Marques, J. T., Wang, J. P., Wang, X., de Oliveira, K. P. V., Gao, C., Aguiar, E. R. G. R., Jafari, N. & Carthew, R. W., Aug 1 2013, In : PLoS pathogens. 9, 8, e1003579.

Research output: Contribution to journalArticle

Virus Diseases
Small Interfering RNA
RNA Viruses
Viral RNA
Drosophila
46 Citations (Scopus)

MiR-9a minimizes the phenotypic impact of genomic diversity by buffering a transcription factor

Cassidy, J. J., Jha, A. R., Posadas, D. M., Giri, R., Venken, K. J. T., Ji, J., Jiang, H., Bellen, H. J., White, K. P. & Carthew, R. W., Dec 19 2013, In : Cell. 155, 7, p. 1556-1567 12 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Transcription Factors
Genes
Metagenomics
Human Genome
22 Citations (Scopus)

The relationship between long-range chromatin occupancy and polymerization of the drosophila ets family transcriptional repressor yan

Webber, J. L., Zhang, J., Cote, L., Vivekanand, P., Ni, X., Zhou, J., Nègre, N., Carthew, R. W., White, K. P. & Rebay, I., Apr 29 2013, In : Genetics. 193, 2, p. 633-649 17 p.

Research output: Contribution to journalArticle

Polymerization
Drosophila
Chromatin
Drosophila melanogaster
Point Mutation
2012
10 Citations (Scopus)

A systematic genetic screen to dissect the microrna pathway in drosophila

Pressman, S., Reinke, C. A., Wang, X. & Carthew, R. W., Apr 1 2012, In : G3: Genes, Genomes, Genetics. 2, 4, p. 437-448 12 p.

Research output: Contribution to journalArticle

MicroRNAs
Drosophila
Genes
Genetic Pleiotropy
Mutation
89 Citations (Scopus)

Tobacco calmodulin-like protein provides secondary defense by binding to and directing degradation of virus RNA silencing suppressors

Nakahara, K. S., Masuta, C., Yamada, S., Shimura, H., Kashihara, Y., Wada, T. S., Meguro, A., Goto, K., Tadamura, K., Sueda, K., Sekiguchi, T., Shao, J., Itchoda, N., Matsumura, T., Igarashi, M., Ito, K., Carthew, R. W. & Uyeda, I., Jun 19 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 25, p. 10113-10118 6 p.

Research output: Contribution to journalArticle

Calmodulin
RNA Interference
Tobacco
Viruses
Proteins
2011
12 Citations (Scopus)

Cadherin-dependent cell morphology in an epithelium: Constructing a quantitative dynamical model

Gemp, I. M., Carthew, R. W. & Hilgenfeldt, S., Jul 1 2011, In : PLoS Computational Biology. 7, 7, e1002115.

Research output: Contribution to journalArticle

cadherins
Dynamical Model
Cadherins
adhesion
epithelium
16 Citations (Scopus)

Cargo sorting to lysosome-related organelles regulates siRNA-mediated gene silencing

Harris, D. A., Kim, K., Nakahara, K., Vásquez-Doorman, C. & Carthew, R. W., Jul 11 2011, In : Journal of Cell Biology. 194, 1, p. 77-87 11 p.

Research output: Contribution to journalArticle

Gene Silencing
Lysosomes
Organelles
Small Interfering RNA
Argonaute Proteins
2010
86 Citations (Scopus)

Loqs and R2D2 act sequentially in the siRNA pathway in Drosophila

Marques, J. T., Kim, K., Wu, P. H., Alleyne, T. M., Jafari, N. & Carthew, R. W., Jan 2010, In : Nature Structural and Molecular Biology. 17, 1, p. 24-31 8 p.

Research output: Contribution to journalArticle

Double-Stranded RNA
Small Interfering RNA
Drosophila
RNA-Binding Proteins
Virus Diseases
2009
313 Citations (Scopus)

A MicroRNA Imparts Robustness against Environmental Fluctuation during Development

Li, X., Cassidy, J. J., Reinke, C. A., Fischboeck, S. & Carthew, R. W., Apr 17 2009, In : Cell. 137, 2, p. 273-282 10 p.

Research output: Contribution to journalArticle

MicroRNAs
Drosophila
Buffers
Mammals
Genes
237 Citations (Scopus)

Silencing by small RNAs is linked to endosomal trafficking

Lee, Y. S., Pressman, S., Andress, A. P., Kim, K., White, J. L., Cassidy, J. J., Li, X., Lubell, K., Lim, D. H., Cho, I. S., Nakahara, K., Preall, J. B., Bellare, P., Sontheimer, E. J. & Carthew, R. W., Aug 17 2009, In : Nature Cell Biology. 11, 9, p. 1150-1156 7 p.

Research output: Contribution to journalArticle

RNA-Induced Silencing Complex
Multivesicular Bodies
RNA Interference
RNA
MicroRNAs
23 Citations (Scopus)

The Endo-siRNA pathway is essential for robust development of the Drosophila embryo

Lucchetta, E. M., Carthew, R. W. & Ismagilov, R. F., Oct 23 2009, In : PloS one. 4, 10, e7576.

Research output: Contribution to journalArticle

small interfering RNA
Small Interfering RNA
Drosophila
Embryonic Development
embryo (animal)
2008
56 Citations (Scopus)

Adaptive evolution of newly emerged micro-RNA genes in Drosophila

Lu, J., Fu, Y., Kumar, S., Shen, Y., Zeng, K., Xu, A., Carthew, R. & Wu, C. I., May 1 2008, In : Molecular biology and evolution. 25, 5, p. 929-938 10 p.

Research output: Contribution to journalArticle

MicroRNAs
microRNA
Drosophila
RNA
gene
33 Citations (Scopus)

Cell-type-specific transcription of prospero is controlled by combinatorial signaling in the Drosophila eye

Hayashi, T., Xu, C. & Carthew, R. W., Aug 1 2008, In : Development. 135, 16, p. 2787-2796 10 p.

Research output: Contribution to journalArticle

Drosophila
Retinal Cone Photoreceptor Cells
Glass
Transcription Factors
Salts
16 Citations (Scopus)

Functional analysis of dicer-2 missense mutations in the siRNA pathway of Drosophila

Lim, D. H., Kim, J., Kim, S., Carthew, R. W. & Lee, Y. S., Jul 4 2008, In : Biochemical and Biophysical Research Communications. 371, 3, p. 525-530 6 p.

Research output: Contribution to journalArticle

Functional analysis
Double-Stranded RNA
Ribonuclease III
Missense Mutation
Small Interfering RNA
15 Citations (Scopus)

Lola regulates cell fate by antagonizing Notch induction in the Drosophila eye

Zheng, L. & Carthew, R. W., Jan 1 2008, In : Mechanisms of Development. 125, 1-2, p. 18-29 12 p.

Research output: Contribution to journalArticle

Drosophila
Retinal Cone Photoreceptor Cells
Nervous System
Genes
Gene Expression
80 Citations (Scopus)

Physical modeling of cell geometric order in an epithelial tissue

Hilgenfeldt, S., Erisken, S. & Carthew, R. W., Jan 22 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 3, p. 907-911 5 p.

Research output: Contribution to journalArticle

Epithelium
Elasticity
Cadherins
Adhesives
Drosophila
190 Citations (Scopus)

The birth and death of microRNA genes in Drosophila

Lu, J., Shen, Y., Wu, Q., Kumar, S., He, B., Shi, S., Carthew, R. W., Wang, S. M. & Wu, C. I., Mar 1 2008, In : Nature Genetics. 40, 3, p. 351-355 5 p.

Research output: Contribution to journalArticle

MicroRNAs
Drosophila
Parturition
Genes
Birth Rate
2007
130 Citations (Scopus)

Cell adhesion and cortex contractility determine cell patterning in the Drosophila retina

Käfer, J., Hayashi, T., Marée, A. F. M., Carthew, R. W. & Graner, F., Nov 20 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 47, p. 18549-18554 6 p.

Research output: Contribution to journalArticle

Cadherins
Cell Adhesion
Drosophila
Retina
Cell Shape
62 Citations (Scopus)

Conversion of pre-RISC to holo-RISC by Ago2 during assembly of RNAi complexes

Kim, K., Lee, Y. S. & Carthew, R. W., Jan 5 2007, In : RNA. 13, 1, p. 22-29 8 p.

Research output: Contribution to journalArticle

RNA-Induced Silencing Complex
RNA Interference
Small Interfering RNA
Drosophila
Endonucleases
5 Citations (Scopus)

Posttranscriptional gene silencing.

Pressman, S., Bei, Y. & Carthew, R., Aug 10 2007, In : Cell. 130, 3, 1 p.

Research output: Contribution to journalArticle

Animals
Genes
2006
36 Citations (Scopus)

Par-1 kinase establishes cell polarity and functions in Notch signaling in the Drosophila embryo

Bayraktar, J., Zygmunt, D. & Carthew, R. W., Feb 15 2006, In : Journal of cell science. 119, 4, p. 711-721 11 p.

Research output: Contribution to journalArticle

Cell Polarity
Drosophila
Phosphotransferases
Embryonic Structures
Drosophila Proteins
485 Citations (Scopus)

RNA interference directs innate immunity against viruses in adult Drosophila

Wang, X. H., Aliyari, R., Li, W. X., Li, H. W., Kim, K., Carthew, R., Atkinson, P. & Ding, S. W., Apr 21 2006, In : Science. 312, 5772, p. 452-454 3 p.

Research output: Contribution to journalArticle

RNA Interference
Innate Immunity
Drosophila
Viruses
Double-Stranded RNA
33 Citations (Scopus)

The RNAi pathway initiated by Dicer-2 in Drosophila

Kim, K., Lee, Y. S., Harris, D., Nakahara, K. & Carthew, R. W., Dec 1 2006, In : Cold Spring Harbor symposia on quantitative biology. 71, p. 39-44 6 p.

Research output: Contribution to journalArticle

RNA-Induced Silencing Complex
RNA Interference
Drosophila
RNA
Messenger RNA
2005
264 Citations (Scopus)

A microRNA mediates EGF receptor signaling and promotes photoreceptor differentiation in the Drosophila eye

Li, X. & Carthew, R. W., Dec 29 2005, In : Cell. 123, 7, p. 1267-1277 11 p.

Research output: Contribution to journalArticle

MicroRNAs
Epidermal Growth Factor Receptor
Drosophila
Signal transduction
Gene expression
535 Citations (Scopus)

Stem cell division is regulated by the microRNA pathway

Hatfield, S. D., Shcherbata, H. R., Fischer, K. A., Nakahara, K., Carthew, R. W. & Ruohola-Baker, H., Jun 16 2005, In : Nature. 435, 7044, p. 974-978 5 p.

Research output: Contribution to journalArticle

MicroRNAs
Cell Division
Stem Cells
Cell Cycle
Cyclin-Dependent Kinases
67 Citations (Scopus)

Targets of microRNA regulation in the Drosophila oocyte proteome

Nakahara, K., Kim, K., Sciulli, C., Dowd, S. R., Minden, J. S. & Carthew, R. W., Aug 23 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 34, p. 12023-12028 6 p.

Research output: Contribution to journalArticle

Proteome
MicroRNAs
Drosophila
Oocytes
Genes
2004
327 Citations (Scopus)

A Dicer-2-dependent 80S complex cleaves targeted mRNAs during RNAi in Drosophila

Pham, J. W., Pellino, J. L., Lee, Y. S., Carthew, R. W. & Sontheimer, E. J., Apr 2 2004, In : Cell. 117, 1, p. 83-94 12 p.

Research output: Contribution to journalArticle

RNA Interference
Small Interfering RNA
Drosophila
RNA
Messenger RNA
887 Citations (Scopus)

Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways

Lee, Y. S., Nakahara, K., Pham, J. W., Kim, K., He, Z., Sontheimer, E. J. & Carthew, R. W., Apr 2 2004, In : Cell. 117, 1, p. 69-81 13 p.

Research output: Contribution to journalArticle

Ribonuclease III
MicroRNAs
Small Interfering RNA
Drosophila
RNA-Induced Silencing Complex
271 Citations (Scopus)

Genome-wide survey of protein kinases required for cell cycle progression

Bettencourt-Dias, M., Giet, R., Sinka, R., Mazumdar, A., Lock, W. G., Balloux, F., Zafiropoulos, P. J., Yamaguchi, S., Winter, S., Carthew, R. W., Cooper, M., Jones, D., Fronz, L. & Glover, D. M., Dec 23 2004, In : Nature. 432, 7020, p. 980-987 8 p.

Research output: Contribution to journalArticle

Protein Kinases
Cell Cycle
Genome
Phosphotransferases
Drosophila Proteins
211 Citations (Scopus)

Surface mechanics mediate pattern formation in the developing retina

Hayashi, T. & Carthew, R. W., Oct 7 2004, In : Nature. 431, 7009, p. 647-652 6 p.

Research output: Contribution to journalArticle

Mechanics
Retina
Cadherins
Retinal Cone Photoreceptor Cells
Soaps
2003
208 Citations (Scopus)

Chibby, a nuclear β-catenin-associated antagonist of the Wnt/Wingless pathway

Takemaru, K. I., Yamaguchi, S., Sik Lee, Y., Zhang, Y., Carthew, R. W. & Moon, R. T., Apr 24 2003, In : Nature. 422, 6934, p. 905-909 5 p.

Research output: Contribution to journalArticle

Catenins
Wnt Signaling Pathway
Armadillos
Oncogene Proteins
Human Development
291 Citations (Scopus)

Making a better RNAi vector for Drosophila: Use of intron spacers

Lee, Y. S. & Carthew, R. W., Aug 1 2003, In : Methods. 30, 4, p. 322-329 8 p.

Research output: Contribution to journalArticle

RNA Interference
Transgenes
Introns
Drosophila
Genes
2002
47 Citations (Scopus)

Phyllopod acts as an adaptor protein to link the Sina ubiquitin ligase to the substrate protein Tramtrack

Li, S., Xu, C. & Carthew, R. W., Oct 1 2002, In : Molecular and Cellular Biology. 22, 19, p. 6854-6865 12 p.

Research output: Contribution to journalArticle

Ligases
Ubiquitin
Ubiquitin-Protein Ligases
F-Box Proteins
Photoreceptor Cells
147 Citations (Scopus)

RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-E

Kennerdell, J. R., Yamaguchi, S. & Carthew, R. W., Aug 1 2002, In : Genes and Development. 16, 15, p. 1884-1889 6 p.

Research output: Contribution to journalArticle

Solanum melongena
RNA Interference
Drosophila
Oocytes
Gene Silencing
2001

Construction and assay of radiation hybrids.

Richard, C. W. & Washington, S. S., May 1 2001, In : Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.]. Chapter 3

Research output: Contribution to journalArticle

Radiation Hybrid Mapping
Agar Gel Electrophoresis
Cell Fusion
Human Chromosomes
Polymerase Chain Reaction
2000
391 Citations (Scopus)

Heritable gene silencing in Drosophila using double-stranded RNA

Kennerdell, J. R. & Carthew, R. W., Sep 2 2000, In : Nature biotechnology. 18, 8, p. 896-898 3 p.

Research output: Contribution to journalArticle

Genetically Modified Animals
Lac Operon
Double-Stranded RNA
Gene Silencing
Drosophila
128 Citations (Scopus)

Overlapping activators and repressors delimit transcriptional response to receptor tyrosine kinase signals in the drosophila eye

Xu, C., Kauffmann, R. C., Zhang, J., Kladny, S. & Carthew, R. W., Sep 29 2000, In : Cell. 103, 1, p. 87-97 11 p.

Research output: Contribution to journalArticle

Receptor Protein-Tyrosine Kinases
Transcription
Drosophila
Chemical activation
Epidermal Growth Factor Receptor
1999
76 Citations (Scopus)

ebi regulates epidermal growth factor receptor signaling pathways in Drosophila

Dong, X., Tsuda, L., Zavitz, K. H., Lin, M., Li, S., Carthew, R. W. & Zipursky, S. L., Apr 15 1999, In : Genes and Development. 13, 8, p. 954-965 12 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Drosophila
Torso
Fungal Proteins
Terminal Repeat Sequences
1998
73 Citations (Scopus)

Interactions between Wingless and DFz2 during Drosophila wing development

Zhang, J. & Carthew, R. W., Aug 1 1998, In : Development. 125, 16, p. 3075-3085 11 p.

Research output: Contribution to journalArticle

Frizzled Receptors
Drosophila
Wnt Proteins
Wnt Signaling Pathway
Diptera
183 Citations (Scopus)

Proteasomal regulation of nuclear receptor corepressor-mediated repression

Zhang, J., Guenther, M. G., Carthew, R. W. & Lazar, M. A., Jun 15 1998, In : Genes and Development. 12, 12, p. 1775-1780 6 p.

Research output: Contribution to journalArticle

Co-Repressor Proteins
Cytoplasmic and Nuclear Receptors
Proteolysis
Genes
Drosophila
887 Citations (Scopus)

Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway

Kennerdell, J. R. & Carthew, R. W., Dec 23 1998, In : Cell. 95, 7, p. 1017-1026 10 p.

Research output: Contribution to journalArticle

Genes
Drosophila
Double-Stranded RNA
Embryonic Structures
RNA