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Rintaro Hashizume

  • 2526 Citations
1993 …2021

Research output per year

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Personal profile

Research Interests

Dr. Hashizume's primary research interests in understanding of the molecular mechanisms, that affect the aggressive/ invasive biological behavior of pediatric malignant glioma and would accordingly reveal potential therapeutic targets for glioma therapy.

Training Experience

1992Residency, St. Marianna University
1997Residency, St. Marianna University
1999Postdoctoral Fellowship, University of Texas, MD Anderson Cancer Center

Education/Academic qualification

PhD, St. Marianna University School of Medicine

… → 1996

MD, St. Marianna University School of Medicine

… → 1990

Research interests

  • Neuro-Oncology
  • Pediatrics

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Grants

Targeted Inhibition of EZH2 and BET BRD4 for the treatment of AT/RT

Hashizume, R.

Rally Foundation, Inc.

7/1/19 → 6/30/20

Project: Research project

Epigenetic Targeted Therapy and Resistance in Pediatric Rhabdoid Tumor

Hashizume, R.

Alex's Lemonade Stand, Inc.

2/1/19 → 1/31/21

Project: Research project

Targeting histone demethylase activity for the treatment of pediatric brainstem glioma

Bi, Y. & Hashizume, R.

National Institute of Neurological Disorders and Stroke

9/15/15 → 6/30/20

Project: Research project

    • Targeted Inhibition of EZH2 and BET BRD4 for the treatment of AT/RT

    Hashizume, R.

    Bear Necessities Pediatric Cancer Foundation

    7/1/18 → 6/30/19

    Project: Research project

    Targeted Inhibition of EZH2 and BET BRD4 for the treatment of AT/RT

    Hashizume, R.

    Rally Foundation, Inc.

    7/1/18 → 6/30/19

    Project: Research project

    • Research Output

    ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis

    Hoeman, C. M., Cordero, F. J., Hu, G., Misuraca, K., Romero, M. M., Cardona, H. J., Nazarian, J., Hashizume, R., McLendon, R., Yu, P., Procissi, D., Gadd, S. L. & Becher, O. J., Mar 4 2019, In : Nature communications. 10, 1, 1023.

    Research output: Contribution to journal › Article

    • 11 Scopus citations

    Advances in multidisciplinary therapy for meningiomas

    International Consortium on Meningiomas, Jan 14 2019, In : Neuro-oncology. 21, p. I18-I31

    Research output: Contribution to journal › Article

    Open Access
    • 3 Scopus citations

    DNA methylation profiling to predict recurrence risk in meningioma: Development and validation of a nomogram to optimize clinical management

    Nassiri, F., Mamatjan, Y., Suppiah, S., Badhiwala, J. H., Mansouri, S., Karimi, S., Saarela, O., Poisson, L., Gepfner-Tuma, I., Schittenhelm, J., Ng, H. K., Noushmehr, H., Harter, P., Baumgarten, P., Weller, M., Preusser, M., Herold-Mende, C., Tatagiba, M., Tabatabai, G., Sahm, F. & 68 others, Von Deimling, A., Aldape, K., Au, K., Barnhartz-Sloan, J., Bi, W. L., Brastianos, P. K., Butowski, N., Carlotti, C., Cusimano, M. D., Dimeco, F., Drummond, K., Dunn, I. F., Galanis, E., Giannini, C., Goldbrunner, R., Griffith, B., Hashizume, R., Hanemann, C. O., Herold-Mende, C., Horbinski, C., Huang, R. Y., James, D., Jenkinson, M. D., Jungk, C., Kaufman, T. J., Krischek, B., Lachance, D., Lafougère, C., Lee, I., Liu, J. C., Mamatjan, Y., Malta, T. M., Mawrin, C., McDermott, M., Munoz, D., Nassiri, F., Noushmehr, H., Ng, H. K., Perry, A., Pirouzmand, F., Poisson, L. M., Pollo, B., Raleigh, D., Sahm, F., Saladino, A., Santarius, T., Schichor, C., Schultz, D., Schmidt, N. O., Selman, W., Sloan, A., Spears, J., Snyder, J., Suppiah, S., Tabatabai, G., Tatagiba, M., Tirapelli, D., Tonn, J. C., Tsang, D., Vogelbaum, M. A., Von Deimling, A., Wen, P. Y., Walbert, T., Westphal, M., Workewych, A. M., Zadeh, G., Zadeh, G. & Aldape, K. D., Jul 11 2019, In : Neuro-oncology. 21, 7, p. 901-910 10 p., noz061.

    Research output: Contribution to journal › Article

    Open Access
    • 9 Scopus citations

    Dramatic response of BRAF V600E-mutant epithelioid glioblastoma to combination therapy with BRAF and MEK inhibitor: establishment and xenograft of a cell line to predict clinical efficacy

    Kanemaru, Y., Natsumeda, M., Okada, M., Saito, R., Kobayashi, D., Eda, T., Watanabe, J., Saito, S., Tsukamoto, Y., Oishi, M., Saito, H., Nagahashi, M., Sasaki, T., Hashizume, R., Aoyama, H., Wakai, T., Kakita, A. & Fujii, Y., Jul 25 2019, In : Acta Neuropathologica Communications. 7, 1, 1 p.

    Research output: Contribution to journal › Article

    Open Access
    • 1 Scopus citations

    Global Reduction of H3K4me3 Improves Chemotherapeutic Efficacy for Pediatric Ependymomas

    Lewis, R., Li, Y. D., Hoffman, L., Hashizume, R., Gravohac, G., Rice, G., Wadhwani, N. R., Jie, C., Pundy, T., Mania-Farnell, B., Mayanil, C. S., Soares, M. B., Lei, T., James, C. D., Foreman, N. K., Tomita, T. & Xi, G., Jun 2019, In : Neoplasia (United States). 21, 6, p. 505-515 11 p.

    Research output: Contribution to journal › Article

    Open Access