Grants per year
Personal profile
Research Interests
Dr. Hashizume's primary research interests in understanding of the molecular mechanisms, that affect the aggressive/ invasive biological behavior of pediatric malignant glioma and would accordingly reveal potential therapeutic targets for glioma therapy.
Training Experience
| 1992 | Residency, St. Marianna University |
| 1997 | Residency, St. Marianna University |
| 1999 | Postdoctoral Fellowship, University of Texas, MD Anderson Cancer Center |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Clinical Pathology, PhD, St. Marianna University School of Medicine
… → 1996
Medicine, MD, St. Marianna University School of Medicine
… → 1990
Research interests
- Neuro-Oncology
- Pediatrics
Fingerprint
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Network
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Grants
- 17 Finished
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Targeted Inhibition of EZH2 and BET BRD4 for the treatment of AT/RT
Hashizume, R. & Zou, L.
7/1/20 → 6/30/21
Project: Research project
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Dual inhibition of DNA damage repair in DIPG
Hashizume, R., Gius, D. R. & Zou, L.
7/1/20 → 6/30/21
Project: Research project
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Targeted Inhibition of EZH2 and BET BRD4 for the treatment of AT/RT
7/1/19 → 8/31/20
Project: Research project
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Epigenetic Targeted Therapy and Resistance in Pediatric Rhabdoid Tumor
2/1/19 → 1/31/21
Project: Research project
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Targeted Inhibition of EZH2 and BET BRD4 for the treatment of AT/RT
Bear Necessities Pediatric Cancer Foundation
7/1/18 → 6/30/19
Project: Research project
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A novel mouse model of diffuse midline glioma initiated in neonatal oligodendrocyte progenitor cells highlights cell-of-origin dependent effects of H3K27M
Tomita, Y., Shimazu, Y., Somasundaram, A., Tanaka, Y., Takata, N., Ishi, Y., Gadd, S., Hashizume, R., Angione, A., Pinero, G., Hambardzumyan, D., Brat, D. J., Hoeman, C. M. & Becher, O. J., Sep 2022, In: Glia. 70, 9, p. 1681-1698 18 p.Research output: Contribution to journal › Article › peer-review
Open Access -
A tumor suppressor role for EZH2 in diffuse midline glioma pathogenesis
Dhar, S., Gadd, S., Patel, P., Vaynshteyn, J., Raju, G. P., Hashizume, R., Brat, D. J. & Becher, O. J., Dec 2022, In: Acta Neuropathologica Communications. 10, 1, 47.Research output: Contribution to journal › Article › peer-review
Open Access -
Therapeutic Targeting of EZH2 and BET BRD4 in Pediatric Rhabdoid Tumors
Ishi, Y., Zhang, Y., Zhang, A., Sasaki, T., Piunti, A., Suri, A., Watanabe, J., Abe, K., He, X., Katagi, H., Bhalla, P., Natsumeda, M., Zou, L., Shilatifard, A. & Hashizume, R., May 2022, In: Molecular cancer therapeutics. 21, 5, p. 715-726 12 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Characterization of distinctive in vivo metabolism between enhancing and non-enhancing gliomas using hyperpolarized carbon-13 mri
Park, S., Rintaro, H., Kim, S. K. & Park, I., Aug 2021, In: Metabolites. 11, 8, 504.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Fifteen-year trends and differences in mortality rates across sex, age, and race/ethnicity in patients with brainstem tumors
Tomita, Y., Tanaka, Y., Takata, N., Hibler, E. A., Hashizume, R. & Becher, O. J., Jan 1 2021, In: Neuro-Oncology Advances. 3, 1, vdab137.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations