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Rintaro Hashizume

  • 2417 Citations
1993 …2021
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Personal profile

Research Interests

Dr. Hashizume's primary research interests in understanding of the molecular mechanisms, that affect the aggressive/ invasive biological behavior of pediatric malignant glioma and would accordingly reveal potential therapeutic targets for glioma therapy.

Training Experience

1992Residency, St. Marianna University
1997Residency, St. Marianna University
1999Postdoctoral Fellowship, University of Texas, MD Anderson Cancer Center

Education/Academic qualification

PhD, St. Marianna University

… → 1996

MD, St. Marianna University

… → 1990

Research interests

  • Neuro-Oncology
  • Pediatrics

Fingerprint Dive into the research topics where Rintaro Hashizume is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 46 Similar Profiles
Glioma Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Heterografts Medicine & Life Sciences
Pediatrics Medicine & Life Sciences
Brain Neoplasms Medicine & Life Sciences
Therapeutics Medicine & Life Sciences
Glioblastoma Medicine & Life Sciences
Medulloblastoma Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2014 2021

Targeted Inhibition of EZH2 and BET BRD4 for the treatment of AT/RT

Hashizume, R.

Rally Foundation, Inc.

7/1/19 → 6/30/20

Project: Research project

Epigenetic Targeted Therapy and Resistance in Pediatric Rhabdoid Tumor

Hashizume, R.

Alex's Lemonade Stand, Inc.

2/1/19 → 1/31/21

Project: Research project

Targeting histone demethylase activity for the treatment of pediatric brainstem glioma

Bi, Y. & Hashizume, R.

National Institute of Neurological Disorders and Stroke

9/15/15 → 6/30/20

Project: Research project

Histone Demethylases
Brain Stem Neoplasms
Glioma
Brain Stem
Pediatrics

Targeted Inhibition of EZH2 and BET BRD4 for the treatment of AT/RT

Hashizume, R.

Rally Foundation, Inc.

7/1/18 → 6/30/19

Project: Research project

Histones
Histone Code
Epigenomics
Proteins
Modifier Genes

Epigenetic targeting and adaptation of EZH2 and BET BRD4 in AT/RT

Hashizume, R.

St. Baldrick's Foundation

7/1/18 → 6/30/19

Project: Research project

Epigenomics
Histone Code
Histones
Neoplasms
Growth

Research Output 1993 2019

8 Citations (Scopus)

ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis

Hoeman, C. M., Cordero, F. J., Hu, G., Misuraca, K., Romero, M. M., Cardona, H. J., Nazarian, J., Hashizume, R., McLendon, R., Yu, P., Procissi, D., Gadd, S. L. & Becher, O. J., Mar 4 2019, In : Nature communications. 10, 1, 1023.

Research output: Contribution to journal › Article

pathogenesis
Glioma
Tumors
tumors
mutations
2 Citations (Scopus)

Advances in multidisciplinary therapy for meningiomas

International Consortium on Meningiomas, Jan 14 2019, In : Neuro-oncology. 21, p. I18-I31

Research output: Contribution to journal › Article

Open Access
Meningioma
trabectedin
Therapeutics
Radiotherapy
Focal Adhesion Protein-Tyrosine Kinases
4 Citations (Scopus)

DNA methylation profiling to predict recurrence risk in meningioma: Development and validation of a nomogram to optimize clinical management

Nassiri, F., Mamatjan, Y., Suppiah, S., Badhiwala, J. H., Mansouri, S., Karimi, S., Saarela, O., Poisson, L., Gepfner-Tuma, I., Schittenhelm, J., Ng, H. K., Noushmehr, H., Harter, P., Baumgarten, P., Weller, M., Preusser, M., Herold-Mende, C., Tatagiba, M., Tabatabai, G., Sahm, F. & 68 others, Von Deimling, A., Aldape, K., Au, K., Barnhartz-Sloan, J., Bi, W. L., Brastianos, P. K., Butowski, N., Carlotti, C., Cusimano, M. D., Dimeco, F., Drummond, K., Dunn, I. F., Galanis, E., Giannini, C., Goldbrunner, R., Griffith, B., Hashizume, R., Hanemann, C. O., Herold-Mende, C., Horbinski, C., Huang, R. Y., James, D., Jenkinson, M. D., Jungk, C., Kaufman, T. J., Krischek, B., Lachance, D., Lafougère, C., Lee, I., Liu, J. C., Mamatjan, Y., Malta, T. M., Mawrin, C., McDermott, M., Munoz, D., Nassiri, F., Noushmehr, H., Ng, H. K., Perry, A., Pirouzmand, F., Poisson, L. M., Pollo, B., Raleigh, D., Sahm, F., Saladino, A., Santarius, T., Schichor, C., Schultz, D., Schmidt, N. O., Selman, W., Sloan, A., Spears, J., Snyder, J., Suppiah, S., Tabatabai, G., Tatagiba, M., Tirapelli, D., Tonn, J. C., Tsang, D., Vogelbaum, M. A., Von Deimling, A., Wen, P. Y., Walbert, T., Westphal, M., Workewych, A. M., Zadeh, G., Zadeh, G. & Aldape, K. D., Jul 11 2019, In : Neuro-oncology. 21, 7, p. 901-910 10 p., noz061.

Research output: Contribution to journal › Article

Open Access
Nomograms
DNA Fingerprinting
Meningioma
DNA Methylation
Recurrence

Dramatic response of BRAF V600E-mutant epithelioid glioblastoma to combination therapy with BRAF and MEK inhibitor: establishment and xenograft of a cell line to predict clinical efficacy

Kanemaru, Y., Natsumeda, M., Okada, M., Saito, R., Kobayashi, D., Eda, T., Watanabe, J., Saito, S., Tsukamoto, Y., Oishi, M., Saito, H., Nagahashi, M., Sasaki, T., Hashizume, R., Aoyama, H., Wakai, T., Kakita, A. & Fujii, Y., Jul 25 2019, In : Acta Neuropathologica Communications. 7, 1, 1 p.

Research output: Contribution to journal › Article

Open Access
Mitogen-Activated Protein Kinase Kinases
Glioblastoma
Heterografts
Cell Line
Mutation

Global Reduction of H3K4me3 Improves Chemotherapeutic Efficacy for Pediatric Ependymomas

Lewis, R., Li, Y. D., Hoffman, L., Hashizume, R., Gravohac, G., Rice, G., Wadhwani, N. R., Jie, C., Pundy, T., Mania-Farnell, B., Mayanil, C. S., Soares, M. B., Lei, T., James, C. D., Foreman, N. K., Tomita, T. & Xi, G., Jun 2019, In : Neoplasia (United States). 21, 6, p. 505-515 11 p.

Research output: Contribution to journal › Article

Open Access
Ependymoma
Pediatrics
Histone Code
Neoplasms
Post Translational Protein Processing