Grants per year
Personal profile
Research Interests
Dr. Hashizume's primary research interests in understanding of the molecular mechanisms, that affect the aggressive/ invasive biological behavior of pediatric malignant glioma and would accordingly reveal potential therapeutic targets for glioma therapy.
Training Experience
| 1992 | Residency, St. Marianna University |
| 1997 | Residency, St. Marianna University |
| 1999 | Postdoctoral Fellowship, University of Texas, MD Anderson Cancer Center |
Education/Academic qualification
PhD, St. Marianna University
… → 1996
MD, St. Marianna University
… → 1990
Research interests
- Neuro-Oncology
- Pediatrics
Fingerprint Dive into the research topics where Rintaro Hashizume is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 24 Similar Profiles
Glioma
Medicine & Life Sciences
Neoplasms
Medicine & Life Sciences
Heterografts
Medicine & Life Sciences
Pediatrics
Medicine & Life Sciences
Brain Neoplasms
Medicine & Life Sciences
Therapeutics
Medicine & Life Sciences
Glioblastoma
Medicine & Life Sciences
Medulloblastoma
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2014 2021
Targeted Inhibition of EZH2 and BET BRD4 for the treatment of AT/RT
7/1/19 → 6/30/20
Project: Research project
Epigenetic Targeted Therapy and Resistance in Pediatric Rhabdoid Tumor
2/1/19 → 1/31/21
Project: Research project
Targeting histone demethylase activity for the treatment of pediatric brainstem glioma
Bi, Y. & Hashizume, R.
National Institute of Neurological Disorders and Stroke
9/15/15 → 6/30/20
Project: Research project
Histone Demethylases
Brain Stem Neoplasms
Glioma
Brain Stem
Pediatrics
Targeted Inhibition of EZH2 and BET BRD4 for the treatment of AT/RT
7/1/18 → 6/30/19
Project: Research project
Histones
Histone Code
Epigenomics
Proteins
Modifier Genes
Targeted Inhibition of EZH2 and BET BRD4 for the treatment of AT/RT
Bear Necessities Pediatric Cancer Foundation
7/1/18 → 6/30/19
Project: Research project
Research Output 1993 2019
3
Citations
(Scopus)
ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis
Hoeman, C. M., Cordero, F. J., Hu, G., Misuraca, K., Romero, M. M., Cardona, H. J., Nazarian, J., Hashizume, R., McLendon, R., Yu, P., Procissi, D., Gadd, S. L. & Becher, O. J., Dec 1 2019, In : Nature communications. 10, 1, 1023.Research output: Contribution to journal › Article
pathogenesis
Glioma
Tumors
tumors
mutations
1
Citation
(Scopus)
Advances in multidisciplinary therapy for meningiomas
International Consortium on Meningiomas, Jan 14 2019, In : Neuro-oncology. 21, p. I18-I31Research output: Contribution to journal › Article
Open Access
Meningioma
trabectedin
Therapeutics
Radiotherapy
Focal Adhesion Protein-Tyrosine Kinases
Dramatic response of BRAF V600E-mutant epithelioid glioblastoma to combination therapy with BRAF and MEK inhibitor: establishment and xenograft of a cell line to predict clinical efficacy
Kanemaru, Y., Natsumeda, M., Okada, M., Saito, R., Kobayashi, D., Eda, T., Watanabe, J., Saito, S., Tsukamoto, Y., Oishi, M., Saito, H., Nagahashi, M., Sasaki, T., Hashizume, R., Aoyama, H., Wakai, T., Kakita, A. & Fujii, Y., Jul 25 2019, In : Acta Neuropathologica Communications. 7, 1, 1 p.Research output: Contribution to journal › Article
Open Access
Mitogen-Activated Protein Kinase Kinases
Glioblastoma
Heterografts
Cell Line
Mutation
Global Reduction of H3K4me3 Improves Chemotherapeutic Efficacy for Pediatric Ependymomas
Lewis, R., Li, Y. D., Hoffman, L., Hashizume, R., Gravohac, G., Rice, G., Wadhwani, N. R., Jie, C., Pundy, T., Mania-Farnell, B., Mayanil, C. S. K., Soares, M. B., Lei, T., James, C. D., Foreman, N. K., Tomita, T. & Xi, G., Jun 1 2019, In : Neoplasia (United States). 21, 6, p. 505-515 11 p.Research output: Contribution to journal › Article
Open Access
Ependymoma
Pediatrics
Histone Code
Neoplasms
Post Translational Protein Processing
Identification of novel Ras signaling therapeutic vulnerabilities in diffuse intrinsic pontine gliomas
Koncar, R. F., Dey, B. R., Stanton, A. C. J., Agrawal, N., Wassell, M. L., McCarl, L. H., Locke, A. L., Sanders, L., Morozova-Vaske, O., Myers, M. I., Hamilton, R. L., Carcaboso, A. M., Kohanbash, G., Hu, B., Amankulor, N. M., Felker, J., Kambhampati, M., Nazarian, J., Becher, O. J., James, C. D. & 4 others, , Aug 15 2019, In : Cancer Research. 79, 16, p. 4026-4041 16 p.Research output: Contribution to journal › Article
Glioma
Mutation
Therapeutics
Brain Stem Neoplasms
Proto-Oncogenes