Grants per year
Personal profile
Research Interests
Dr. Hashizume's primary research interests in understanding of the molecular mechanisms, that affect the aggressive/ invasive biological behavior of pediatric malignant glioma and would accordingly reveal potential therapeutic targets for glioma therapy.
Training Experience
| 1992 | Residency, St. Marianna University |
| 1997 | Residency, St. Marianna University |
| 1999 | Postdoctoral Fellowship, University of Texas, MD Anderson Cancer Center |
Education/Academic qualification
PhD, St. Marianna University School of Medicine
… → 1996
Clinical Pathology, PhD, St. Marianna University School of Medicine
… → 1996
MD, St. Marianna University School of Medicine
… → 1990
Medicine, MD, St. Marianna University School of Medicine
… → 1990
Research interests
- Neuro-Oncology
- Pediatrics
Fingerprint
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants
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Targeted Inhibition of EZH2 and BET BRD4 for the treatment of AT/RT
Hashizume, R. & Zou, L.
7/1/20 → 6/30/21
Project: Research project
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Dual inhibition of DNA damage repair in DIPG
Hashizume, R., Gius, D. R. & Zou, L.
7/1/20 → 6/30/21
Project: Research project
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Targeting histone demethylase activity for the treatment of pediatric brainstem glioma
Bi, Y. & Hashizume, R.
National Institute of Neurological Disorders and Stroke
9/15/15 → 6/30/21
Project: Research project
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Targeted Inhibition of EZH2 and BET BRD4 for the treatment of AT/RT
7/1/19 → 8/31/20
Project: Research project
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Epigenetic Targeted Therapy and Resistance in Pediatric Rhabdoid Tumor
2/1/19 → 1/31/21
Project: Research project
Research Output
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ABC Transporter Inhibition Plus Dexamethasone Enhances the Efficacy of Convection Enhanced Delivery in H3.3K27M Mutant Diffuse Intrinsic Pontine Glioma
Tsvankin, V., Hashizume, R., Katagi, H., Herndon, J. E., Lascola, C., Venkatraman, T. N., Picard, D., Burrus, B., Becher, O. J. & Thompson, E. M., May 1 2020, In: Neurosurgery. 86, 5, p. 742-751 10 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Combined therapy of AXL and HDAC inhibition reverses mesenchymal transition in diffuse intrinsic pontine glioma
Meel, M. H., de Gooijer, M. C., Metselaar, D. S., Sewing, C. P. A., Zwaan, K., Waranecki, P., Breur, M., Buil, L. C. M., Lagerweij, T., Wedekind, L. E., Twisk, J. W. R., Koster, J., Hashizume, R., Raabe, E. H., Carcaboso, Á. M., Bugiani, M., Phoenix, T. N., van Tellingen, O., van Vuurden, D. G., Kaspers, G. J. L. & 1 others, , Jul 2020, In: Clinical Cancer Research. 26, 13, p. 3319-3332 14 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Convection-enhanced delivery of enhancer of zeste homolog-2 (EZH2) inhibitor for the treatment of diffuse intrinsic pontine glioma
Sasaki, T., Katagi, H., Goldman, S., Becher, O. J. & Hashizume, R., Dec 1 2020, In: Neurosurgery. 87, 6, p. E680-E688Research output: Contribution to journal › Article › peer-review
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LSD1 inhibition in pHGG: The key to unleashing immunotherapy?
Nicolaides, T. P. & Hashizume, R., Sep 1 2020, In: Neuro-oncology. 22, 9, p. 1237-1238 2 p.Research output: Contribution to journal › Editorial › peer-review
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MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas
Abe, H., Natsumeda, M., Okada, M., Watanabe, J., Tsukamoto, Y., Kanemaru, Y., Yoshimura, J., Oishi, M., Hashizume, R., Kakita, A. & Fujii, Y., Jan 21 2020, In: Frontiers in Oncology. 9, 1568.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations