Grants per year
Personal profile
Research Interests
Dr. Hashizume's primary research interests in understanding of the molecular mechanisms, that affect the aggressive/ invasive biological behavior of pediatric malignant glioma and would accordingly reveal potential therapeutic targets for glioma therapy.
Training Experience
| 1992 | Residency, St. Marianna University |
| 1997 | Residency, St. Marianna University |
| 1999 | Postdoctoral Fellowship, University of Texas, MD Anderson Cancer Center |
Education/Academic qualification
PhD, St. Marianna University
… → 1996
MD, St. Marianna University
… → 1990
Keywords
- Neuro-Oncology
- Pediatrics
Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
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Therapeutics
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Glioblastoma
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Epigenomics
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2014 2021
Epigenetic Targeted Therapy and Resistance in Pediatric Rhabdoid Tumor
2/1/19 → 1/31/21
Project: Research project
Targeted Inhibition of EZH2 and BET BRD4 for the treatment of AT/RT
7/1/18 → 6/30/19
Project: Research project
Histones
Histone Code
Epigenomics
Proteins
Modifier Genes
Targeted Inhibition of EZH2 and BET BRD4 for the treatment of AT/RT
Bear Necessities Pediatric Cancer Foundation
7/1/18 → 6/30/19
Project: Research project
Epigenetic targeting and adaptation of EZH2 and BET BRD4 in AT/RT
7/1/18 → 6/30/19
Project: Research project
Epigenomics
Histone Code
Histones
Neoplasms
Growth
Targeting histone demethylase activity for the treatment of pediatric brainstem glioma
Bi, Y. & Hashizume, R.
National Institute of Neurological Disorders and Stroke
9/15/15 → 6/30/20
Project: Research project
Histone Demethylases
Brain Stem Neoplasms
Glioma
Brain Stem
Pediatrics
Research Output 1993 2019
ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis
Hoeman, C. M., Cordero, F. J., Hu, G., Misuraca, K., Romero, M. M., Cardona, H. J., Nazarian, J., Hashizume, R., McLendon, R., Yu, P., Procissi, D., Gadd, S. L. & Becher, O. J., Dec 1 2019, In : Nature communications. 10, 1, 1023.Research output: Contribution to journal › Article
pathogenesis
Glioma
Tumors
tumors
mutations
Global Reduction of H3K4me3 Improves Chemotherapeutic Efficacy for Pediatric Ependymomas
Lewis, R., Li, Y. D., Hoffman, L., Hashizume, R., Gravohac, G., Rice, G., Wadhwani, N. R., Jie, C., Pundy, T., Mania-Farnell, B., Mayanil, C. S. K., Soares, M. B., Lei, T., James, C. D., Foreman, N. K., Tomita, T. & Xi, G., Jun 1 2019, In : Neoplasia (United States). 21, 6, p. 505-515 11 p.Research output: Contribution to journal › Article
Open Access
Ependymoma
Pediatrics
Histone Code
Neoplasms
Post Translational Protein Processing
Molecular and translational advances in meningiomas
International Consortium on Meningiomas, Jan 14 2019, In : Neuro-oncology. 21, p. I4-I17Research output: Contribution to journal › Article
Meningioma
Clinical Trials
Epigenomics
Neoplasms
Therapeutics
1
Citation
(Scopus)
CSF H3F3A K27M circulating tumor DNA copy number quantifies tumor growth and in vitro treatment response
Stallard, S., Savelieff, M. G., Wierzbicki, K., Mullan, B., Miklja, Z., Bruzek, A., Garcia, T., Siada, R., Anderson, B., Singer, B. H., Hashizume, R., Carcaboso, A. M., McMurray, K. Q., Heth, J., Muraszko, K., Robertson, P. L., Mody, R., Venneti, S., Garton, H. & Koschmann, C., Aug 15 2018, In : Acta Neuropathologica Communications. 6, 1, 1 p.Research output: Contribution to journal › Letter
DNA
Growth
Neoplasms
In Vitro Techniques
Measuring Tumor Metabolism in Pediatric Diffuse Intrinsic Pontine Glioma Using Hyperpolarized Carbon-13 MR Metabolic Imaging
Autry, A. W., Hashizume, R., James, C. D., Larson, P. E. Z., Vigneron, D. B. & Park, I., Jan 1 2018, In : Contrast Media and Molecular Imaging. 2018, 3215658.Research output: Contribution to journal › Article
Glioma
Carbon
Lactic Acid
Pediatrics
Pyruvic Acid