Grants per year
Personal profile
Research Interests
Dr. Hashizume's primary research interests in understanding of the molecular mechanisms, that affect the aggressive/ invasive biological behavior of pediatric malignant glioma and would accordingly reveal potential therapeutic targets for glioma therapy.
Training Experience
| 1992 | Residency, St. Marianna University |
| 1997 | Residency, St. Marianna University |
| 1999 | Postdoctoral Fellowship, University of Texas, MD Anderson Cancer Center |
Expertise related to UN Sustainable Devlopment Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Clinical Pathology, PhD, St. Marianna University School of Medicine
… → 1996
Medicine, MD, St. Marianna University School of Medicine
… → 1990
Research interests
- Neuro-Oncology
- Pediatrics
Fingerprint
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Network
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Grants
- 17 Finished
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Targeted Inhibition of EZH2 and BET BRD4 for the treatment of AT/RT
7/1/20 → 6/30/21
Project: Research project
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Targeted Inhibition of EZH2 and BET BRD4 for the treatment of AT/RT
7/1/19 → 8/31/20
Project: Research project
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Epigenetic Targeted Therapy and Resistance in Pediatric Rhabdoid Tumor
2/1/19 → 1/31/21
Project: Research project
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Epigenetic targeting and adaptation of EZH2 and BET BRD4 in AT/RT
7/1/18 → 6/30/19
Project: Research project
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Mesenchymal stem cells successfully deliver oncolytic virotherapy to diffuse intrinsic pontine glioma
Chastkofsky, M. I., Pituch, K. C., Katagi, H., Zannikou, M., Ilut, L., Xiao, T., Han, Y., Sonabend, A. M., Curiel, D. T., Bonner, E. R., Nazarian, J., Horbinski, C. M., James, C. D., Saratsis, A. M., Hashizume, R., Lesniak, M. S. & Balyasnikova, I. V., Mar 2021, In: Clinical Cancer Research. 27, 6, p. 1766-1777 12 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
ABC Transporter Inhibition Plus Dexamethasone Enhances the Efficacy of Convection Enhanced Delivery in H3.3K27M Mutant Diffuse Intrinsic Pontine Glioma
Tsvankin, V., Hashizume, R., Katagi, H., Herndon, J. E., Lascola, C., Venkatraman, T. N., Picard, D., Burrus, B., Becher, O. J. & Thompson, E. M., May 1 2020, In: Neurosurgery. 86, 5, p. 742-751 10 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Combined therapy of AXL and HDAC inhibition reverses mesenchymal transition in diffuse intrinsic pontine glioma
Meel, M. H., de Gooijer, M. C., Metselaar, D. S., Sewing, C. P. A., Zwaan, K., Waranecki, P., Breur, M., Buil, L. C. M., Lagerweij, T., Wedekind, L. E., Twisk, J. W. R., Koster, J., Hashizume, R., Raabe, E. H., Carcaboso, Á. M., Bugiani, M., Phoenix, T. N., van Tellingen, O., van Vuurden, D. G., Kaspers, G. J. L. & 1 others, , Jul 2020, In: Clinical Cancer Research. 26, 13, p. 3319-3332 14 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
Convection-enhanced delivery of enhancer of zeste homolog-2 (EZH2) inhibitor for the treatment of diffuse intrinsic pontine glioma
Sasaki, T., Katagi, H., Goldman, S., Becher, O. J. & Hashizume, R., Dec 1 2020, In: Neurosurgery. 87, 6, p. E680-E688Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
LSD1 inhibition in pHGG: The key to unleashing immunotherapy?
Nicolaides, T. P. & Hashizume, R., Sep 1 2020, In: Neuro-oncology. 22, 9, p. 1237-1238 2 p.Research output: Contribution to journal › Editorial › peer-review