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Research Output 1993 2019

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2019
8 Citations (Scopus)

ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis

Hoeman, C. M., Cordero, F. J., Hu, G., Misuraca, K., Romero, M. M., Cardona, H. J., Nazarian, J., Hashizume, R., McLendon, R., Yu, P., Procissi, D., Gadd, S. L. & Becher, O. J., Mar 4 2019, In : Nature communications. 10, 1, 1023.

Research output: Contribution to journalArticle

pathogenesis
Glioma
Tumors
tumors
mutations
2 Citations (Scopus)

Advances in multidisciplinary therapy for meningiomas

International Consortium on Meningiomas, Jan 14 2019, In : Neuro-oncology. 21, p. I18-I31

Research output: Contribution to journalArticle

Open Access
Meningioma
trabectedin
Therapeutics
Radiotherapy
Focal Adhesion Protein-Tyrosine Kinases
6 Citations (Scopus)

DNA methylation profiling to predict recurrence risk in meningioma: Development and validation of a nomogram to optimize clinical management

Nassiri, F., Mamatjan, Y., Suppiah, S., Badhiwala, J. H., Mansouri, S., Karimi, S., Saarela, O., Poisson, L., Gepfner-Tuma, I., Schittenhelm, J., Ng, H. K., Noushmehr, H., Harter, P., Baumgarten, P., Weller, M., Preusser, M., Herold-Mende, C., Tatagiba, M., Tabatabai, G., Sahm, F. & 68 others, Von Deimling, A., Aldape, K., Au, K., Barnhartz-Sloan, J., Bi, W. L., Brastianos, P. K., Butowski, N., Carlotti, C., Cusimano, M. D., Dimeco, F., Drummond, K., Dunn, I. F., Galanis, E., Giannini, C., Goldbrunner, R., Griffith, B., Hashizume, R., Hanemann, C. O., Herold-Mende, C., Horbinski, C., Huang, R. Y., James, D., Jenkinson, M. D., Jungk, C., Kaufman, T. J., Krischek, B., Lachance, D., Lafougère, C., Lee, I., Liu, J. C., Mamatjan, Y., Malta, T. M., Mawrin, C., McDermott, M., Munoz, D., Nassiri, F., Noushmehr, H., Ng, H. K., Perry, A., Pirouzmand, F., Poisson, L. M., Pollo, B., Raleigh, D., Sahm, F., Saladino, A., Santarius, T., Schichor, C., Schultz, D., Schmidt, N. O., Selman, W., Sloan, A., Spears, J., Snyder, J., Suppiah, S., Tabatabai, G., Tatagiba, M., Tirapelli, D., Tonn, J. C., Tsang, D., Vogelbaum, M. A., Von Deimling, A., Wen, P. Y., Walbert, T., Westphal, M., Workewych, A. M., Zadeh, G., Zadeh, G. & Aldape, K. D., Jul 11 2019, In : Neuro-oncology. 21, 7, p. 901-910 10 p., noz061.

Research output: Contribution to journalArticle

Open Access
Nomograms
DNA Fingerprinting
Meningioma
DNA Methylation
Recurrence

Dramatic response of BRAF V600E-mutant epithelioid glioblastoma to combination therapy with BRAF and MEK inhibitor: establishment and xenograft of a cell line to predict clinical efficacy

Kanemaru, Y., Natsumeda, M., Okada, M., Saito, R., Kobayashi, D., Eda, T., Watanabe, J., Saito, S., Tsukamoto, Y., Oishi, M., Saito, H., Nagahashi, M., Sasaki, T., Hashizume, R., Aoyama, H., Wakai, T., Kakita, A. & Fujii, Y., Jul 25 2019, In : Acta Neuropathologica Communications. 7, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Mitogen-Activated Protein Kinase Kinases
Glioblastoma
Heterografts
Cell Line
Mutation

Global Reduction of H3K4me3 Improves Chemotherapeutic Efficacy for Pediatric Ependymomas

Lewis, R., Li, Y. D., Hoffman, L., Hashizume, R., Gravohac, G., Rice, G., Wadhwani, N. R., Jie, C., Pundy, T., Mania-Farnell, B., Mayanil, C. S., Soares, M. B., Lei, T., James, C. D., Foreman, N. K., Tomita, T. & Xi, G., Jun 2019, In : Neoplasia (United States). 21, 6, p. 505-515 11 p.

Research output: Contribution to journalArticle

Open Access
Ependymoma
Pediatrics
Histone Code
Neoplasms
Post Translational Protein Processing

Identification of novel Ras signaling therapeutic vulnerabilities in diffuse intrinsic pontine gliomas

Koncar, R. F., Dey, B. R., Stanton, A. C. J., Agrawal, N., Wassell, M. L., McCarl, L. H., Locke, A. L., Sanders, L., Morozova-Vaske, O., Myers, M. I., Hamilton, R. L., Carcaboso, A. M., Kohanbash, G., Hu, B., Amankulor, N. M., Felker, J., Kambhampati, M., Nazarian, J., Becher, O. J., James, C. D. & 4 others, Hashizume, R., Broniscer, A., Pollack, I. F. & Agnihotri, S., Aug 15 2019, In : Cancer Research. 79, 16, p. 4026-4041 16 p.

Research output: Contribution to journalArticle

Glioma
Mutation
Therapeutics
Brain Stem Neoplasms
Proto-Oncogenes
7 Citations (Scopus)

Imaging and diagnostic advances for intracranial meningiomas

International Consortium on Meningiomas, Jan 14 2019, In : Neuro-oncology. 21, p. I44-I61

Research output: Contribution to journalArticle

Open Access
Meningioma
Diagnostic Imaging
Central Nervous System Neoplasms
Neoplasms
Information Storage and Retrieval
3 Citations (Scopus)

Life after surgical resection of a meningioma: A prospective cross-sectional study evaluating health-related quality of life

International Consortium on Meningiomas, Jan 14 2019, In : Neuro-oncology. 21, p. I32-I43

Research output: Contribution to journalArticle

Open Access
Meningioma
Cross-Sectional Studies
Quality of Life
Fatigue
Sleep
6 Citations (Scopus)

Molecular and translational advances in meningiomas

International Consortium on Meningiomas, Jan 14 2019, In : Neuro-oncology. 21, p. I4-I17

Research output: Contribution to journalArticle

Meningioma
Clinical Trials
Epigenomics
Neoplasms
Therapeutics
1 Citation (Scopus)

Potent antineoplastic effects of combined PI3Kα-MNK inhibition in medulloblastoma

Eckerdt, F., Bell, J. B., Beauchamp, E. M., Clymer, J., Blyth, G. T., Kosciuczuk, E. M., Ma, Q., Chen, D. Z., Horbinski, C., Goldman, S., Munshi, H. G., Hashizume, R. & Platanias, L. C., Jun 1 2019, In : Molecular Cancer Research. 17, 6, p. 1305-1315 11 p.

Research output: Contribution to journalArticle

Medulloblastoma
Mitogen-Activated Protein Kinase Kinases
Phosphatidylinositol 3-Kinases
Antineoplastic Agents
Neoplastic Stem Cells
3 Citations (Scopus)

Radiosensitization by histone H3 demethylase inhibition in diffuse intrinsic pontine glioma

Katagi, H., Louis, N., Unruh, D., Sasaki, T., He, X., Zhang, A., Ma, Q., Piunti, A., Shimazu, Y., Lamano, J. B., Carcaboso, A. M., Tian, X., Seluanov, A., Gorbunova, V., Laurie, K. L., Kondo, A., Wadhwani, N. R., Lulla, R., Goldman, S., Venneti, S. & 4 others, Becher, O. J., Zou, L., Shilatifard, A. & Hashizume, R., Sep 15 2019, In : Clinical Cancer Research. 25, 18, p. 5572-5583 12 p.

Research output: Contribution to journalArticle

Histone Demethylases
Glioma
Histones
Radiotherapy
Double-Stranded DNA Breaks

Tenascin-C expression contributes to pediatric brainstem glioma tumor phenotype and represents a novel biomarker of disease

Qi, J., Esfahani, D. R., Huang, T., Ozark, P., Bartom, E. T., Hashizume, R., Bonner, E. R., An, S., Horbinski, C. M., James, C. D. & Saratsis, A. M., May 15 2019, In : Acta Neuropathologica Communications. 7, 1, 75.

Research output: Contribution to journalArticle

Open Access
Brain Stem Neoplasms
Tenascin
Glioma
Biomarkers
Pediatrics
2018

Measuring Tumor Metabolism in Pediatric Diffuse Intrinsic Pontine Glioma Using Hyperpolarized Carbon-13 MR Metabolic Imaging

Autry, A. W., Hashizume, R., James, C. D., Larson, P. E. Z., Vigneron, D. B. & Park, I., Jan 1 2018, In : Contrast Media and Molecular Imaging. 2018, 3215658.

Research output: Contribution to journalArticle

Glioma
Carbon
Lactic Acid
Pediatrics
Pyruvic Acid
8 Citations (Scopus)

MeLK inhibition in diffuse intrinsic pontine glioma

Meel, M. H., De Gooijer, M. C., Navarro, M. G., Waranecki, P., Breur, M., Buil, L. C. M., Wedekind, L. E., Twisk, J. W. R., Koster, J., Hashizume, R., Raabe, E. H., Carcaboso, A. M., Bugiani, M., Van Tellingen, O., Van Vuurden, D. G., Kaspers, G. J. L. & Hulleman, E., Nov 15 2018, In : Clinical Cancer Research. 24, 22, p. 5645-5657 13 p.

Research output: Contribution to journalArticle

Glioma
Leucine Zippers
Phosphotransferases
Mothers
Heterografts
4 Citations (Scopus)

New therapeutic approaches for brainstem tumors: a comparison of delivery routes using nanoliposomal irinotecan in an animal model

Louis, N., Liu, S., He, X., Drummond, D. C., Noble, C. O., Goldman, S., Mueller, S., Bankiewicz, K., Gupta, N. & Hashizume, R., Feb 1 2018, In : Journal of Neuro-Oncology. 136, 3, p. 475-484 10 p.

Research output: Contribution to journalArticle

irinotecan
Brain Stem Neoplasms
Convection
Animal Models
Intravenous Injections
26 Citations (Scopus)

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy

Wang, L., Zhao, Z., Ozark, P. A., Fantini, D., Marshall, S. A., Rendleman, E. J., Cozzolino, K. A., Louis, N., He, X., Morgan, M. A., Takahashi, Y. H., Collings, C. K., Smith, E. R., Ntziachristos, P., Savas, J. N., Zou, L., Hashizume, R., Meeks, J. J. & Shilatifard, A., Jun 1 2018, In : Nature Medicine. 24, 6, p. 758-769 12 p.

Research output: Contribution to journalArticle

Epigenomics
Tumors
Methyltransferases
Histones
Mutation
11 Citations (Scopus)

Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced Cancer Therapy

Liang, K., Smith, E. R., Aoi, Y., Stoltz, K. L., Katagi, H., Woodfin, A. R., Rendleman, E. J., Marshall, S. A., Murray, D. C., Wang, L., Ozark, P. A., Mishra, R. K., Hashizume, R., Schiltz, G. E. & Shilatifard, A., Oct 18 2018, In : Cell. 175, 3, p. 766-779.e17

Research output: Contribution to journalArticle

Transcription
Elongation
Positive Transcriptional Elongation Factor B
Neoplasms
Peptidomimetics
2017
16 Citations (Scopus)

A cytoplasmic COMPASS is necessary for cell survival and triple-negative breast cancer pathogenesis by regulating metabolism

Wang, L., Collings, C. K., Zhao, Z., Cozzolino, K. A., Ma, Q., Liang, K., Marshall, S. A., Sze, C. C., Hashizume, R., Savas, J. N. & Shilatifard, A., Oct 15 2017, In : Genes and Development. 31, 20, p. 2056-2066 11 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Cell Survival
Adiponectin Receptors
Proteins
Histone-Lysine N-Methyltransferase
10 Citations (Scopus)

A Sequentially Priming Phosphorylation Cascade Activates the Gliomagenic Transcription Factor Olig2

Zhou, J., Tien, A. C., Alberta, J. A., Ficarro, S. B., Griveau, A., Sun, Y., Deshpande, J. S., Card, J. D., Morgan-Smith, M., Michowski, W., Hashizume, R., James, C. D., Ligon, K. L., Snider, W. D., Sicinski, P., Marto, J. A., Rowitch, D. H. & Stiles, C. D., Mar 28 2017, In : Cell reports. 18, 13, p. 3167-3177 11 p.

Research output: Contribution to journalArticle

Phosphorylation
Transcription Factors
Glioma
Serine
Stem Cells
14 Citations (Scopus)

Combined BRAFV600E and MEK blockade for BRAFV600E-mutant gliomas

Zhang, J., Yao, T. W., Hashizume, R., Hariono, S., Barkovich, K. J., Fan, Q. W., Prados, M., James, C. D., Weiss, W. A. & Nicolaides, T., Feb 1 2017, In : Journal of Neuro-Oncology. 131, 3, p. 495-505 11 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Glioma
Neoplasms
Skin
Receptor Protein-Tyrosine Kinases
11 Citations (Scopus)

Epigenetic modification in chromatin machinery and its deregulation in pediatric brain tumors: Insight into epigenetic therapies

Maury, E. & Hashizume, R., May 4 2017, In : Epigenetics. 12, 5, p. 353-369 17 p.

Research output: Contribution to journalArticle

Histone Code
Epigenomics
Brain Neoplasms
Chromatin
Genetic Epigenesis
31 Citations (Scopus)

Histone H3.3K27M represses p16 to accelerate gliomagenesis in a murine model of DIPG

Cordero, F. J., Huang, Z., Grenier, C., He, X., Hu, G., McLendon, R. E., Murphy, S. K., Hashizume, R. & Becher, O. J., Sep 1 2017, In : Molecular Cancer Research. 15, 9, p. 1243-1254 12 p.

Research output: Contribution to journalArticle

Glioma
Histones
Neoplasms
DNA Methylation
Mutation
7 Citations (Scopus)

Inhibition of polo-like kinase 4 (PLK4): A new therapeutic option for rhabdoid tumors and pediatric medulloblastoma

Sredni, S. T., Bailey, A. W., Suri, A., Hashizume, R., He, X., Louis, N., Gokirmak, T., Piper, D. R., Watterson, D. M. & Tomita, T., Jan 1 2017, In : Oncotarget. 8, 67, p. 111190-111212 23 p.

Research output: Contribution to journalArticle

Rhabdoid Tumor
Medulloblastoma
Phosphotransferases
Pediatrics
Neoplasms
96 Citations (Scopus)

Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas

Piunti, A., Hashizume, R., Morgan, M. A., Bartom, E. T., Horbinski, C. M., Marshall, S. A., Rendleman, E. J., Ma, Q., Takahashi, Y. H., Woodfin, A. R., Misharin, A. V., Abshiru, N. A., Lulla, R. R., Saratsis, A. M., Kelleher, N. L., James, C. D. & Shilatifard, A., Apr 1 2017, In : Nature Medicine. 23, 4, p. 493-500 8 p.

Research output: Contribution to journalArticle

Polycomb Repressive Complex 2
Glioma
Tumors
Proteins
Nucleosomes
2016
3 Citations (Scopus)

Bioluminescence imaging of an immunocompetent animal model for glioblastoma

Clark, A. J., Fakurnejad, S., Ma, Q. & Hashizume, R., Jan 15 2016, In : Journal of Visualized Experiments. 2016, 107, e53287.

Research output: Contribution to journalArticle

Bioluminescence
Glioblastoma
Tumors
Animals
Animal Models
21 Citations (Scopus)

BRAF status in personalizing treatment approaches for pediatric gliomas

Olow, A., Mueller, S., Yang, X., Hashizume, R., Meyerowitz, J., Weiss, W., Resnick, A. C., Waanders, A. J., Stalpers, L. J. A., Berger, M. S., Gupta, N., James, C. D., Petritsch, C. K. & Haas-Kogan, D. A., Nov 1 2016, In : Clinical Cancer Research. 22, 21, p. 5312-5321 10 p.

Research output: Contribution to journalArticle

Glioma
Pediatrics
Heterografts
Cell Survival
Neoplasms
6 Citations (Scopus)

Imidazoquinolines: Recent developments in anticancer activity

Patil, S. A., Patil, S. A., Patil, R. & Hashizume, R., Mar 1 2016, In : Mini-Reviews in Medicinal Chemistry. 16, 4, p. 309-322 14 p.

Research output: Contribution to journalArticle

imiquimod
resiquimod
Neoplasms
1-Phosphatidylinositol 4-Kinase
Sirolimus
25 Citations (Scopus)

Inhibition of DNA damage repair by the CDK4/6 inhibitor palbociclib delays irradiated intracranial atypical teratoid rhabdoid tumor and glioblastoma xenograft regrowth

Hashizume, R., Zhang, A., Mueller, S., Prados, M. D., Lulla, R. R., Goldman, S., Saratsis, A. M., Mazar, A. P., Stegh, A. H., Cheng, S. Y., Horbinski, C., Haas-Kogan, D. A., Sarkaria, J. N., Waldman, T. & James, C. D., Nov 1 2016, In : Neuro-oncology. 18, 11, p. 1519-1528 10 p.

Research output: Contribution to journalArticle

Glioblastoma
Heterografts
DNA Repair
DNA Damage
Radiation
16 Citations (Scopus)

Survival advantage combining a BRAF inhibitor and radiation in BRAF V600E-mutant glioma

Dasgupta, T., Olow, A. K., Yang, X., Hashizume, R., Nicolaides, T. P., Tom, M., Aoki, Y., Berger, M. S., Weiss, W. A., Stalpers, L. J. A., Prados, M., David James, C., Mueller, S. & Haas-Kogan, D. A., Feb 1 2016, In : Journal of Neuro-Oncology. 126, 3, p. 385-393 9 p.

Research output: Contribution to journalArticle

Glioma
Radiation
Survival
Apoptosis
Cell Cycle Checkpoints
2015
27 Citations (Scopus)

EAG2 potassium channel with evolutionarily conserved function as a brain tumor target

Huang, X., He, Y., Dubuc, A. M., Hashizume, R., Zhang, W., Reimand, J., Yang, H., Wang, T. A., Stehbens, S. J., Younger, S., Barshow, S., Zhu, S., Cooper, M. K., Peacock, J., Ramaswamy, V., Garzia, L., Wu, X., Remke, M., Forester, C. M., Kim, C. C. & 8 others, Weiss, W. A., James, C. D., Shuman, M. A., Bader, G. D., Mueller, S., Taylor, M. D., Jan, Y. N. & Jan, L. Y., Aug 26 2015, In : Nature Neuroscience. 18, 9, p. 1236-1246 11 p.

Research output: Contribution to journalArticle

Potassium Channels
Ion Channels
Brain Neoplasms
Ether
Thioridazine
19 Citations (Scopus)

Targeting a Plk1-controlled polarity checkpoint in therapy-resistant glioblastoma-propagating cells

Lerner, R. G., Grossauer, S., Kadkhodaei, B., Meyers, I., Sidorov, M., Koeck, K., Hashizume, R., Ozawa, T., Phillips, J. J., Berger, M. S., Nicolaides, T., James, C. D. & Petritsch, C. K., Dec 15 2015, In : Cancer Research. 75, 24, p. 5355-5366 12 p.

Research output: Contribution to journalArticle

Glioblastoma
temozolomide
Therapeutics
Asymmetric Cell Division
Neoplasms
2014
207 Citations (Scopus)

Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma

Hashizume, R., Andor, N., Ihara, Y., Lerner, R., Gan, H., Chen, X., Fang, D., Huang, X., Tom, M. W., Ngo, V., Solomon, D., Mueller, S., Paris, P. L., Zhang, Z., Petritsch, C., Gupta, N., Waldman, T. A. & James, C. D., Dec 1 2014, In : Nature Medicine. 20, 12, p. 1394-1396 3 p.

Research output: Contribution to journalArticle

Pediatrics
Methylation
Glioma
Histones
Brain Stem
11 Citations (Scopus)

Stable luciferase expression does not alter immunologic or in vivo growth properties of GL261 murine glioma cells

Clark, A. J., Safaee, M., Oh, T., Ivan, M. E., Parimi, V., Hashizume, R., Ozawa, T., James, C. D., Bloch, O. & Parsa, A. T., Dec 3 2014, In : Journal of Translational Medicine. 12, 1, 345.

Research output: Contribution to journalArticle

Luciferases
Glioma
Tumors
Growth
Neoplasms
46 Citations (Scopus)

Targeting wee1 for the treatment of pediatric high-grade gliomas

Mueller, S., Hashizume, R., Yang, X., Kolkowitz, I., Olow, A. K., Phillips, J., Smirnov, I., Tom, M. W., Prados, M. D., James, C. D., Berger, M. S., Gupta, N. & Haas-Kogan, D. A., Mar 1 2014, In : Neuro-oncology. 16, 3, p. 352-360 9 p.

Research output: Contribution to journalArticle

Glioma
Pediatrics
Radiation
Therapeutics
Survival
2013
13 Citations (Scopus)

Convection-enhanced delivery of targeted quantum dot-immunoliposome hybrid nanoparticles to intracranial brain tumor models

Weng, K. C., Hashizume, R., Noble, C. O., Serwer, L. P., Drummond, D. C., Kirpotin, D. B., Kuwabara, A. M., Chao, L. X., Chen, F. F., James, C. D. & Park, J. W., Jan 1 2013, In : Nanomedicine. 8, 12, p. 1913-1925 13 p.

Research output: Contribution to journalArticle

Quantum Dots
Convection
Brain Neoplasms
Nanoparticles
Semiconductor quantum dots
32 Citations (Scopus)

Expression of miR-124 inhibits growth of medulloblastoma cells

Silber, J., Hashizume, R., Felix, T., Hariono, S., Yu, M., Berger, M. S., Huse, J. T., Vandenberg, S. R., David James, C., Graeme Hodgson, J. & Gupta, N., Jan 1 2013, In : Neuro-oncology. 15, 1, p. 83-90 8 p.

Research output: Contribution to journalArticle

Medulloblastoma
MicroRNAs
Growth
Glioblastoma
Heterografts
306 Citations (Scopus)

The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression

Chan, K. M., Fang, D., Gan, H., Hashizume, R., Yu, C., Schroeder, M., Gupta, N., Mueller, S., David James, C., Jenkins, R., Sarkaria, J. & Zhang, Z., May 1 2013, In : Genes and Development. 27, 9, p. 985-990 6 p.

Research output: Contribution to journalArticle

Glioma
Histones
Methylation
Pediatrics
Gene Expression
2012
31 Citations (Scopus)

An experimental xenograft mouse model of diffuse pontine glioma designed for therapeutic testing

Aoki, Y., Hashizume, R., Ozawa, T., Banerjee, A., Prados, M., James, C. D. & Gupta, N., May 1 2012, In : Journal of Neuro-Oncology. 108, 1, p. 29-35 7 p.

Research output: Contribution to journalArticle

Heterografts
Glioma
Brain Stem
temozolomide
Neoplasms
36 Citations (Scopus)

Characterization of a diffuse intrinsic pontine glioma cell line: Implications for future investigations and treatment

Hashizume, R., Smirnov, I., Liu, S., Phillips, J. J., Hyer, J., McKnight, T. R., Wendland, M., Prados, M., Banerjee, A., Nicolaides, T., Mueller, S., James, C. D. & Gupta, N., Dec 1 2012, In : Journal of Neuro-Oncology. 110, 3, p. 305-313 9 p.

Research output: Contribution to journalArticle

Glioma
Cell Line
Ribonucleoproteins
Therapeutics
Brain Stem Neoplasms
52 Citations (Scopus)

Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy

Huillard, E., Hashizume, R., Phillips, J. J., Griveau, A., Ihrie, R. A., Aoki, Y., Nicolaides, T., Perry, A., Waldman, T., McMahon, M., Weiss, W. A., Petritsch, C., James, C. D. & Rowitch, D. H., May 29 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 22, p. 8710-8715 6 p.

Research output: Contribution to journalArticle

Astrocytoma
Phosphotransferases
Pediatrics
Cyclin-Dependent Kinase 6
Tumor Suppressor Protein p14ARF
39 Citations (Scopus)

Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics

Huang, X., Dubuc, A. M., Hashizume, R., Berg, J., He, Y., Wang, J., Chiang, C., Cooper, M. K., Northcott, P. A., Taylor, M. D., Barnes, M. J., Tihan, T., Chen, J., Hackett, C. S., Weiss, W. A., David James, C., Rowitch, D. H., Shuman, M. A., Jan, Y. N. & Jan, L. Y., Aug 15 2012, In : Genes and Development. 26, 16, p. 1780-1796 17 p.

Research output: Contribution to journalArticle

Voltage-Gated Potassium Channels
Medulloblastoma
Cell Size
Interphase
p38 Mitogen-Activated Protein Kinases
2011
114 Citations (Scopus)

Targeted therapy for BRAF V600E malignant astrocytoma

Nicolaides, T. P., Li, H., Solomon, D. A., Hariono, S., Hashizume, R., Barkovich, K., Baker, S. J., Paugh, B. S., Jones, C., Forshew, T., Hindley, G. F., Graeme Hodgson, J., Kim, J. S., Rowitch, D. H., Weiss, W. A., Waldman, T. A. & David James, C., Dec 15 2011, In : Clinical Cancer Research. 17, 24, p. 7595-7604 10 p.

Research output: Contribution to journalArticle

Astrocytoma
Heterografts
Mutation
Pediatrics
Cell Line
2010
42 Citations (Scopus)

A human brainstem glioma xenograft model enabled for bioluminescence imaging

Hashizume, R., Ozawa, T., Dinca, E. B., Banerjee, A., Prados, M. D., James, C. D. & Gupta, N., Jan 1 2010, In : Journal of Neuro-Oncology. 96, 2, p. 151-159 9 p.

Research output: Contribution to journalArticle

Heterografts
Glioma
Brain Stem
temozolomide
Brain Stem Neoplasms
33 Citations (Scopus)

Identification of internalizing human single-chain antibodies targeting brain tumor sphere cells

Zhu, X., Bidlingmaier, S., Hashizume, R., James, C. D., Berger, M. S. & Liu, B., Jul 2010, In : Molecular cancer therapeutics. 9, 7, p. 2131-2141 11 p.

Research output: Contribution to journalArticle

Single-Chain Antibodies
Forensic Anthropology
Brain Neoplasms
Glioblastoma
Neoplasms
18 Citations (Scopus)

Morphologic and molecular characterization of ATRT xenografts adapted for orthotopic therapeutic testing

Hashizume, R., Gupta, N., Berger, M. S., Banerjee, A., Prados, M. D., Ayers-Ringler, J., James, C. D. & VandenBerg, S. R., Apr 1 2010, In : Neuro-oncology. 12, 4, p. 366-376 11 p.

Research output: Contribution to journalArticle

Heterografts
temozolomide
Therapeutics
Neoplasms
Nude Mice
12 Citations (Scopus)
Central Nervous System Diseases
Neurology
Drug delivery
Rodentia
Pharmaceutical Preparations
2008
93 Citations (Scopus)

New therapeutic approach for brain tumors: Intranasal delivery of telomerase inhibitor GRN163

Hashizume, R., Ozawa, T., Gryaznov, S. M., Bollen, A. W., Lamborn, K. R., Frey, W. H. & Deen, D. F., Apr 1 2008, In : Neuro-oncology. 10, 2, p. 112-120 9 p.

Research output: Contribution to journalArticle

Telomerase
Brain Neoplasms
Neoplasms
Blood-Brain Barrier
Therapeutics
2002
1 Citation (Scopus)

Breast cancer

Fukuda, M., Miyamoto, K., Hashizume, R., Okamoto, J., Kawamoto, H., Yabuki, Y., Ogata, H. & Ohta, T., Nov 2002, In : Gan to kagaku ryoho. Cancer & chemotherapy. 29, 11, p. 1900-1906 7 p.

Research output: Contribution to journalArticle

Mammography
Breast Neoplasms
Japan
Breast
Compliance
2001
482 Citations (Scopus)

The RING Heterodimer BRCA1-BARD1 Is a Ubiquitin Ligase Inactivated by a Breast Cancer-derived Mutation

Hashizume, R., Fukuda, M., Maeda, I., Nishikawa, H., Oyake, D., Yabuki, Y., Ogata, H. & Ohta, T., May 4 2001, In : Journal of Biological Chemistry. 276, 18, p. 14537-14540 4 p.

Research output: Contribution to journalArticle

Ligases
Ubiquitin
Breast Neoplasms
Mutation
RING Finger Domains
2000
95 Citations (Scopus)

C-erbB-2/HER-2 upregulates fascin, an actin-bundling protein associated with cell motility, in human breast cancer cell lines

Grothey, A., Hashizume, R., Ji, H., Tubb, B. E., Patrick, C. W., Yu, D., Mooney, E. E. & McCrea, P. D., Oct 5 2000, In : Oncogene. 19, 42, p. 4864-4875 12 p.

Research output: Contribution to journalArticle

Cell Movement
Actins
Up-Regulation
Breast Neoplasms
Cell Line