• 2663 Citations
1993 …2020

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ABC Transporter Inhibition Plus Dexamethasone Enhances the Efficacy of Convection Enhanced Delivery in H3.3K27M Mutant Diffuse Intrinsic Pontine Glioma

Tsvankin, V., Hashizume, R., Katagi, H., Herndon, J. E., Lascola, C., Venkatraman, T. N., Picard, D., Burrus, B., Becher, O. J. & Thompson, E. M., May 1 2020, In : Neurosurgery. 86, 5, p. 742-751 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis

Hoeman, C. M., Cordero, F. J., Hu, G., Misuraca, K., Romero, M. M., Cardona, H. J., Nazarian, J., Hashizume, R., McLendon, R., Yu, P., Procissi, D., Gadd, S. L. & Becher, O. J., Mar 4 2019, In : Nature communications. 10, 1, 1023.

Research output: Contribution to journalArticle

16 Scopus citations

A cytoplasmic COMPASS is necessary for cell survival and triple-negative breast cancer pathogenesis by regulating metabolism

Wang, L., Collings, C. K., Zhao, Z., Cozzolino, K. A., Ma, Q., Liang, K., Marshall, S. A., Sze, C. C., Hashizume, R., Savas, J. N. & Shilatifard, A., Oct 15 2017, In : Genes and Development. 31, 20, p. 2056-2066 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Advances in multidisciplinary therapy for meningiomas

International Consortium on Meningiomas, Jan 14 2019, In : Neuro-oncology. 21, p. I18-I31

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

A human brainstem glioma xenograft model enabled for bioluminescence imaging

Hashizume, R., Ozawa, T., Dinca, E. B., Banerjee, A., Prados, M. D., James, C. D. & Gupta, N., Jan 1 2010, In : Journal of Neuro-Oncology. 96, 2, p. 151-159 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Analysis of Cdc2 and cyclin D1 expression in breast cancer by immunoblotting

Ohta, T., Fukuda, M., Arima, K., Kawamoto, H., Hashizume, R., Arimura, T. & Yamaguchi, S., Mar 1 1997, In : Breast Cancer. 4, 1, p. 17-24 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

An experimental xenograft mouse model of diffuse pontine glioma designed for therapeutic testing

Aoki, Y., Hashizume, R., Ozawa, T., Banerjee, A., Prados, M., James, C. D. & Gupta, N., May 1 2012, In : Journal of Neuro-Oncology. 108, 1, p. 29-35 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

A Sequentially Priming Phosphorylation Cascade Activates the Gliomagenic Transcription Factor Olig2

Zhou, J., Tien, A. C., Alberta, J. A., Ficarro, S. B., Griveau, A., Sun, Y., Deshpande, J. S., Card, J. D., Morgan-Smith, M., Michowski, W., Hashizume, R., James, C. D., Ligon, K. L., Snider, W. D., Sicinski, P., Marto, J. A., Rowitch, D. H. & Stiles, C. D., Mar 28 2017, In : Cell reports. 18, 13, p. 3167-3177 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

A True Splenic Cyst –An Immunohistologic Study of Lining Cell of the Cyst–

Ihara, A., Hashizume, R., Katayama, K., Komoriyama, H., Yokose, H., Ehira, T., Yamaguchi, S. & Shinagawa, T., Jan 1 1993, In : the japanese journal of gastroenterological surgery. 26, 4, p. 1090-1094 5 p.

Research output: Contribution to journalArticle

Bioluminescence imaging of an immunocompetent animal model for glioblastoma

Clark, A. J., Fakurnejad, S., Ma, Q. & Hashizume, R., Jan 15 2016, In : Journal of Visualized Experiments. 2016, 107, e53287.

Research output: Contribution to journalArticle

3 Scopus citations

BRAF status in personalizing treatment approaches for pediatric gliomas

Olow, A., Mueller, S., Yang, X., Hashizume, R., Meyerowitz, J., Weiss, W., Resnick, A. C., Waanders, A. J., Stalpers, L. J. A., Berger, M. S., Gupta, N., James, C. D., Petritsch, C. K. & Haas-Kogan, D. A., Nov 1 2016, In : Clinical Cancer Research. 22, 21, p. 5312-5321 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Breast cancer

Fukuda, M., Miyamoto, K., Hashizume, R., Okamoto, J., Kawamoto, H., Yabuki, Y., Ogata, H. & Ohta, T., Nov 2002, In : Gan to kagaku ryoho. Cancer & chemotherapy. 29, 11, p. 1900-1906 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

C-erbB-2/HER-2 upregulates fascin, an actin-bundling protein associated with cell motility, in human breast cancer cell lines

Grothey, A., Hashizume, R., Ji, H., Tubb, B. E., Patrick, C. W., Yu, D., Mooney, E. E. & McCrea, P. D., Oct 5 2000, In : Oncogene. 19, 42, p. 4864-4875 12 p.

Research output: Contribution to journalArticle

98 Scopus citations

Characterization of a diffuse intrinsic pontine glioma cell line: Implications for future investigations and treatment

Hashizume, R., Smirnov, I., Liu, S., Phillips, J. J., Hyer, J., McKnight, T. R., Wendland, M., Prados, M., Banerjee, A., Nicolaides, T., Mueller, S., James, C. D. & Gupta, N., Dec 1 2012, In : Journal of Neuro-Oncology. 110, 3, p. 305-313 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

Combined BRAFV600E and MEK blockade for BRAFV600E-mutant gliomas

Zhang, J., Yao, T. W., Hashizume, R., Hariono, S., Barkovich, K. J., Fan, Q. W., Prados, M., James, C. D., Weiss, W. A. & Nicolaides, T., Feb 1 2017, In : Journal of Neuro-Oncology. 131, 3, p. 495-505 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Convection-enhanced delivery of targeted quantum dot-immunoliposome hybrid nanoparticles to intracranial brain tumor models

Weng, K. C., Hashizume, R., Noble, C. O., Serwer, L. P., Drummond, D. C., Kirpotin, D. B., Kuwabara, A. M., Chao, L. X., Chen, F. F., James, C. D. & Park, J. W., Jan 1 2013, In : Nanomedicine. 8, 12, p. 1913-1925 13 p.

Research output: Contribution to journalArticle

16 Scopus citations

Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy

Huillard, E., Hashizume, R., Phillips, J. J., Griveau, A., Ihrie, R. A., Aoki, Y., Nicolaides, T., Perry, A., Waldman, T., McMahon, M., Weiss, W. A., Petritsch, C., James, C. D. & Rowitch, D. H., May 29 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 22, p. 8710-8715 6 p.

Research output: Contribution to journalArticle

54 Scopus citations

DNA methylation profiling to predict recurrence risk in meningioma: Development and validation of a nomogram to optimize clinical management

Nassiri, F., Mamatjan, Y., Suppiah, S., Badhiwala, J. H., Mansouri, S., Karimi, S., Saarela, O., Poisson, L., Gepfner-Tuma, I., Schittenhelm, J., Ng, H. K., Noushmehr, H., Harter, P., Baumgarten, P., Weller, M., Preusser, M., Herold-Mende, C., Tatagiba, M., Tabatabai, G., Sahm, F. & 68 others, Von Deimling, A., Aldape, K., Au, K., Barnhartz-Sloan, J., Bi, W. L., Brastianos, P. K., Butowski, N., Carlotti, C., Cusimano, M. D., Dimeco, F., Drummond, K., Dunn, I. F., Galanis, E., Giannini, C., Goldbrunner, R., Griffith, B., Hashizume, R., Hanemann, C. O., Herold-Mende, C., Horbinski, C., Huang, R. Y., James, D., Jenkinson, M. D., Jungk, C., Kaufman, T. J., Krischek, B., Lachance, D., Lafougère, C., Lee, I., Liu, J. C., Mamatjan, Y., Malta, T. M., Mawrin, C., McDermott, M., Munoz, D., Nassiri, F., Noushmehr, H., Ng, H. K., Perry, A., Pirouzmand, F., Poisson, L. M., Pollo, B., Raleigh, D., Sahm, F., Saladino, A., Santarius, T., Schichor, C., Schultz, D., Schmidt, N. O., Selman, W., Sloan, A., Spears, J., Snyder, J., Suppiah, S., Tabatabai, G., Tatagiba, M., Tirapelli, D., Tonn, J. C., Tsang, D., Vogelbaum, M. A., Von Deimling, A., Wen, P. Y., Walbert, T., Westphal, M., Workewych, A. M., Zadeh, G., Zadeh, G. & Aldape, K. D., Jul 11 2019, In : Neuro-oncology. 21, 7, p. 901-910 10 p., noz061.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Dramatic response of BRAF V600E-mutant epithelioid glioblastoma to combination therapy with BRAF and MEK inhibitor: establishment and xenograft of a cell line to predict clinical efficacy

Kanemaru, Y., Natsumeda, M., Okada, M., Saito, R., Kobayashi, D., Eda, T., Watanabe, J., Saito, S., Tsukamoto, Y., Oishi, M., Saito, H., Nagahashi, M., Sasaki, T., Hashizume, R., Aoyama, H., Wakai, T., Kakita, A. & Fujii, Y., Jul 25 2019, In : Acta Neuropathologica Communications. 7, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

EAG2 potassium channel with evolutionarily conserved function as a brain tumor target

Huang, X., He, Y., Dubuc, A. M., Hashizume, R., Zhang, W., Reimand, J., Yang, H., Wang, T. A., Stehbens, S. J., Younger, S., Barshow, S., Zhu, S., Cooper, M. K., Peacock, J., Ramaswamy, V., Garzia, L., Wu, X., Remke, M., Forester, C. M., Kim, C. C. & 8 others, Weiss, W. A., James, C. D., Shuman, M. A., Bader, G. D., Mueller, S., Taylor, M. D., Jan, Y. N. & Jan, L. Y., Aug 26 2015, In : Nature neuroscience. 18, 9, p. 1236-1246 11 p.

Research output: Contribution to journalArticle

31 Scopus citations

Epigenetic modification in chromatin machinery and its deregulation in pediatric brain tumors: Insight into epigenetic therapies

Maury, E. & Hashizume, R., May 4 2017, In : Epigenetics. 12, 5, p. 353-369 17 p.

Research output: Contribution to journalArticle

16 Scopus citations

Expression of epithelial cadherin and α- and β-catenins in nontumoral livers and hepatocellular carcinomas

Ihara, A., Koizumi, H., Hashizume, R. & Uchikoshi, T., Jan 1 1996, In : Hepatology. 23, 6, p. 1441-1447 7 p.

Research output: Contribution to journalArticle

126 Scopus citations

Expression of miR-124 inhibits growth of medulloblastoma cells

Silber, J., Hashizume, R., Felix, T., Hariono, S., Yu, M., Berger, M. S., Huse, J. T., Vandenberg, S. R., David James, C., Graeme Hodgson, J. & Gupta, N., Jan 1 2013, In : Neuro-oncology. 15, 1, p. 83-90 8 p.

Research output: Contribution to journalArticle

34 Scopus citations

Expression of β-catenin in normal breast tissue and breast carcinoma: A comparative study with epithelial cadherin and α-catenin

Hashizume, R., Koizumi, H., Ihara, A., Ohta, T. & Uchikoshi, T., Jan 1 1996, In : Histopathology. 29, 2, p. 139-146 8 p.

Research output: Contribution to journalArticle

75 Scopus citations

Fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breast cancer

Grothey, A., Hashizume, R., Sahin, A. A. & McCrea, P. D., Jan 1 2000, In : British Journal of Cancer. 83, 7, p. 870-873 4 p.

Research output: Contribution to journalArticle

124 Scopus citations

Global Reduction of H3K4me3 Improves Chemotherapeutic Efficacy for Pediatric Ependymomas

Lewis, R., Li, Y. D., Hoffman, L., Hashizume, R., Gravohac, G., Rice, G., Wadhwani, N. R., Jie, C., Pundy, T., Mania-Farnell, B., Mayanil, C. S., Soares, M. B., Lei, T., James, C. D., Foreman, N. K., Tomita, T. & Xi, G., Jun 2019, In : Neoplasia (United States). 21, 6, p. 505-515 11 p.

Research output: Contribution to journalArticle

Open Access

Histone H3.3K27M represses p16 to accelerate gliomagenesis in a murine model of DIPG

Cordero, F. J., Huang, Z., Grenier, C., He, X., Hu, G., McLendon, R. E., Murphy, S. K., Hashizume, R. & Becher, O. J., Sep 1 2017, In : Molecular Cancer Research. 15, 9, p. 1243-1254 12 p.

Research output: Contribution to journalArticle

33 Scopus citations

Identification of internalizing human single-chain antibodies targeting brain tumor sphere cells

Zhu, X., Bidlingmaier, S., Hashizume, R., James, C. D., Berger, M. S. & Liu, B., Jul 2010, In : Molecular cancer therapeutics. 9, 7, p. 2131-2141 11 p.

Research output: Contribution to journalArticle

34 Scopus citations

Identification of novel Ras signaling therapeutic vulnerabilities in diffuse intrinsic pontine gliomas

Koncar, R. F., Dey, B. R., Stanton, A. C. J., Agrawal, N., Wassell, M. L., McCarl, L. H., Locke, A. L., Sanders, L., Morozova-Vaske, O., Myers, M. I., Hamilton, R. L., Carcaboso, A. M., Kohanbash, G., Hu, B., Amankulor, N. M., Felker, J., Kambhampati, M., Nazarian, J., Becher, O. J., James, C. D. & 4 others, Hashizume, R., Broniscer, A., Pollack, I. F. & Agnihotri, S., Aug 15 2019, In : Cancer Research. 79, 16, p. 4026-4041 16 p.

Research output: Contribution to journalArticle

1 Scopus citations

Imaging and diagnostic advances for intracranial meningiomas

International Consortium on Meningiomas, Jan 14 2019, In : Neuro-oncology. 21, p. I44-I61

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Imidazoquinolines: Recent developments in anticancer activity

Patil, S. A., Patil, S. A., Patil, R. & Hashizume, R., Mar 1 2016, In : Mini-Reviews in Medicinal Chemistry. 16, 4, p. 309-322 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Inhibition of DNA damage repair by the CDK4/6 inhibitor palbociclib delays irradiated intracranial atypical teratoid rhabdoid tumor and glioblastoma xenograft regrowth

Hashizume, R., Zhang, A., Mueller, S., Prados, M. D., Lulla, R. R., Goldman, S., Saratsis, A. M., Mazar, A. P., Stegh, A. H., Cheng, S. Y., Horbinski, C., Haas-Kogan, D. A., Sarkaria, J. N., Waldman, T. & James, C. D., Nov 1 2016, In : Neuro-oncology. 18, 11, p. 1519-1528 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

Inhibition of polo-like kinase 4 (PLK4): A new therapeutic option for rhabdoid tumors and pediatric medulloblastoma

Sredni, S. T., Bailey, A. W., Suri, A., Hashizume, R., He, X., Louis, N., Gokirmak, T., Piper, D. R., Watterson, D. M. & Tomita, T., Jan 1 2017, In : Oncotarget. 8, 67, p. 111190-111212 23 p.

Research output: Contribution to journalArticle

8 Scopus citations

Life after surgical resection of a meningioma: A prospective cross-sectional study evaluating health-related quality of life

International Consortium on Meningiomas, Jan 14 2019, In : Neuro-oncology. 21, p. I32-I43

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Measuring Tumor Metabolism in Pediatric Diffuse Intrinsic Pontine Glioma Using Hyperpolarized Carbon-13 MR Metabolic Imaging

Autry, A. W., Hashizume, R., James, C. D., Larson, P. E. Z., Vigneron, D. B. & Park, I., Jan 1 2018, In : Contrast Media and Molecular Imaging. 2018, 3215658.

Research output: Contribution to journalArticle

MeLK inhibition in diffuse intrinsic pontine glioma

Meel, M. H., De Gooijer, M. C., Navarro, M. G., Waranecki, P., Breur, M., Buil, L. C. M., Wedekind, L. E., Twisk, J. W. R., Koster, J., Hashizume, R., Raabe, E. H., Carcaboso, A. M., Bugiani, M., Van Tellingen, O., Van Vuurden, D. G., Kaspers, G. J. L. & Hulleman, E., Nov 15 2018, In : Clinical Cancer Research. 24, 22, p. 5645-5657 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas

Abe, H., Natsumeda, M., Okada, M., Watanabe, J., Tsukamoto, Y., Kanemaru, Y., Yoshimura, J., Oishi, M., Hashizume, R., Kakita, A. & Fujii, Y., Jan 21 2020, In : Frontiers in Oncology. 9, 1568.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Molecular and translational advances in meningiomas

International Consortium on Meningiomas, Jan 14 2019, In : Neuro-oncology. 21, p. I4-I17

Research output: Contribution to journalArticle

10 Scopus citations

Morphologic and molecular characterization of ATRT xenografts adapted for orthotopic therapeutic testing

Hashizume, R., Gupta, N., Berger, M. S., Banerjee, A., Prados, M. D., Ayers-Ringler, J., James, C. D. & VandenBerg, S. R., Apr 1 2010, In : Neuro-oncology. 12, 4, p. 366-376 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

New therapeutic approaches for brainstem tumors: a comparison of delivery routes using nanoliposomal irinotecan in an animal model

Louis, N., Liu, S., He, X., Drummond, D. C., Noble, C. O., Goldman, S., Mueller, S., Bankiewicz, K., Gupta, N. & Hashizume, R., Feb 1 2018, In : Journal of Neuro-Oncology. 136, 3, p. 475-484 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

New therapeutic approach for brain tumors: Intranasal delivery of telomerase inhibitor GRN163

Hashizume, R., Ozawa, T., Gryaznov, S. M., Bollen, A. W., Lamborn, K. R., Frey, W. H. & Deen, D. F., Apr 1 2008, In : Neuro-oncology. 10, 2, p. 112-120 9 p.

Research output: Contribution to journalArticle

97 Scopus citations

Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma

Hashizume, R., Andor, N., Ihara, Y., Lerner, R., Gan, H., Chen, X., Fang, D., Huang, X., Tom, M. W., Ngo, V., Solomon, D., Mueller, S., Paris, P. L., Zhang, Z., Petritsch, C., Gupta, N., Waldman, T. A. & James, C. D., Dec 1 2014, In : Nature Medicine. 20, 12, p. 1394-1396 3 p.

Research output: Contribution to journalArticle

232 Scopus citations

Potent antineoplastic effects of combined PI3Kα-MNK inhibition in medulloblastoma

Eckerdt, F., Bell, J. B., Beauchamp, E. M., Clymer, J., Blyth, G. T., Kosciuczuk, E. M., Ma, Q., Chen, D. Z., Horbinski, C., Goldman, S., Munshi, H. G., Hashizume, R. & Platanias, L. C., Jun 1 2019, In : Molecular Cancer Research. 17, 6, p. 1305-1315 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Radiosensitization by histone H3 demethylase inhibition in diffuse intrinsic pontine glioma

Katagi, H., Louis, N., Unruh, D., Sasaki, T., He, X., Zhang, A., Ma, Q., Piunti, A., Shimazu, Y., Lamano, J. B., Carcaboso, A. M., Tian, X., Seluanov, A., Gorbunova, V., Laurie, K. L., Kondo, A., Wadhwani, N. R., Lulla, R. R., Goldman, S., Venneti, S. & 4 others, Becher, O. J., Zou, L., Shilatifard, A. & Hashizume, R., Sep 15 2019, In : Clinical Cancer Research. 25, 18, p. 5572-5583 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy

Wang, L., Zhao, Z., Ozark, P. A., Fantini, D., Marshall, S. A., Rendleman, E. J., Cozzolino, K. A., Louis, N., He, X., Morgan, M. A., Takahashi, Y. H., Collings, C. K., Smith, E. R., Ntziachristos, P., Savas, J. N., Zou, L., Hashizume, R., Meeks, J. J. & Shilatifard, A., Jun 1 2018, In : Nature Medicine. 24, 6, p. 758-769 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

Stable luciferase expression does not alter immunologic or in vivo growth properties of GL261 murine glioma cells

Clark, A. J., Safaee, M., Oh, T., Ivan, M. E., Parimi, V., Hashizume, R., Ozawa, T., James, C. D., Bloch, O. & Parsa, A. T., Dec 3 2014, In : Journal of Translational Medicine. 12, 1, 345.

Research output: Contribution to journalArticle

11 Scopus citations

Survival advantage combining a BRAF inhibitor and radiation in BRAF V600E-mutant glioma

Dasgupta, T., Olow, A. K., Yang, X., Hashizume, R., Nicolaides, T. P., Tom, M., Aoki, Y., Berger, M. S., Weiss, W. A., Stalpers, L. J. A., Prados, M., David James, C., Mueller, S. & Haas-Kogan, D. A., Feb 1 2016, In : Journal of Neuro-Oncology. 126, 3, p. 385-393 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
14 Scopus citations

Targeted therapy for BRAF V600E malignant astrocytoma

Nicolaides, T. P., Li, H., Solomon, D. A., Hariono, S., Hashizume, R., Barkovich, K., Baker, S. J., Paugh, B. S., Jones, C., Forshew, T., Hindley, G. F., Graeme Hodgson, J., Kim, J. S., Rowitch, D. H., Weiss, W. A., Waldman, T. A. & David James, C., Dec 15 2011, In : Clinical Cancer Research. 17, 24, p. 7595-7604 10 p.

Research output: Contribution to journalArticle

116 Scopus citations

Targeting a Plk1-controlled polarity checkpoint in therapy-resistant glioblastoma-propagating cells

Lerner, R. G., Grossauer, S., Kadkhodaei, B., Meyers, I., Sidorov, M., Koeck, K., Hashizume, R., Ozawa, T., Phillips, J. J., Berger, M. S., Nicolaides, T., James, C. D. & Petritsch, C. K., Dec 15 2015, In : Cancer Research. 75, 24, p. 5355-5366 12 p.

Research output: Contribution to journalArticle

22 Scopus citations