Robert A Holmgren

Professor, Molecular Biosciences
Interdisciplinary Biological Sciences PhD Program
Northwestern University Interdepartmental Neuroscience PhD Program (NUIN)
Program Director (Academic), Program in Biological Sciences

Phone847/491-5460
Emailr-holmgren@northwestern.edu

2883 Citations

Research output per year

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Personal profile

Research Interests

Professor Holmgren’s research studies how cells in a developing organism signal to one another to pattern tissues. Drosophila is primarily used as a model system and the role of the Hedgehog signal transduction cascade in the patterning of the wing is studied. Of particular interest is how the range of Hedgehog signaling is regulated, how different modes of regulation lead to robust, reproducible outcomes, and how Hedgehog signaling is integrated with other cellular processes. The approach is to identify new components in the pathway using various genetic interaction screens and to then characterize the function of the encoded proteins.

Education/Academic qualification

Biochemistry and Molecular Biology, PhD, Harvard University

… → 1980

Biology, BA, Cornell University

… → 1975

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Grants

2 Active
15 Finished

Specific inhibition of transcription factors with Cobalt-Schiff Base Complexes

Holmgren, R. A., Meade, T. J. & Perez-White, B. E.

National Institute of General Medical Sciences

7/15/17 → 4/30/21

Project: Research project

Holmgren: Specific inhibition of transcription factors with Cobalt-Schiff Base Complexes

Holmgren, R. A.

National Institute of General Medical Sciences

7/15/17 → 4/30/21

Project: Research project

Carcinogenesis Training Program

Chandel, N., Chisholm, R. L., Crispino, J. D., Green, K. J., Holmgren, R. A., LaBonne, C., McGee, R., O'Halloran, T. V., Woloschak, G. E., Woodruff, T. K. & Gottardi, C.

National Cancer Institute

7/1/16 → 6/30/17

Project: Research project

Cellular and Molecular Basis of Disease Training Program

Brickner, J. H., Carthew, R. W., Holmgren, R. A. & Smith, G. A.

National Institute of General Medical Sciences

7/1/16 → 6/30/18

Project: Research project

Cellular and Molecular Basis of Disease Training Program

Brickner, J. H., Brickner, J. H., Holmgren, R. A. & Seifert, H.

National Institute of General Medical Sciences

7/1/13 → 6/30/16

Project: Research project

Research Output

2883 Citations
32 Article
2 Chapter
1 Review article

Dose-dependent transduction of hedgehog relies on phosphorylation-based feedback between the G-protein-coupled receptor smoothened and the kinase fused

Sanial, M., Bécam, I., Hofmann, L., Behague, J., Argüelles, C., Gourhand, V., Bruzzone, L., Holmgren, R. A. & Plessis, A., May 15 2017, In : Development (Cambridge). 144, 10, p. 1841-1850 10 p.