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Personal profile

Research Interests

Professor Holmgren’s research studies how cells in a developing organism signal to one another to pattern tissues. Drosophila is primarily used as a model system and the role of the Hedgehog signal transduction cascade in the patterning of the wing is studied. Of particular interest is how the range of Hedgehog signaling is regulated, how different modes of regulation lead to robust, reproducible outcomes, and how Hedgehog signaling is integrated with other cellular processes. The approach is to identify new components in the pathway using various genetic interaction screens and to then characterize the function of the encoded proteins.

Education/Academic qualification

Biochemistry and Molecular Biology, PhD, Harvard University

… → 1980

Biology, BA, Cornell University

… → 1975

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Grants

Research Output

  • 2883 Citations
  • 32 Article
  • 2 Chapter
  • 1 Review article

Dose-dependent transduction of hedgehog relies on phosphorylation-based feedback between the G-protein-coupled receptor smoothened and the kinase fused

Sanial, M., Bécam, I., Hofmann, L., Behague, J., Argüelles, C., Gourhand, V., Bruzzone, L., Holmgren, R. A. & Plessis, A., May 15 2017, In : Development (Cambridge). 144, 10, p. 1841-1850 10 p.

Research output: Contribution to journalArticle

  • 6 Scopus citations

    Control of the dynamics and homeostasis of the Drosophila Hedgehog receptor Patched by two C2-WW-HECT-E3 Ubiquitin ligases

    Brigui, A., Hofmann, L., Argüelles, C., Sanial, M., Holmgren, R. A. & Plessis, A., Oct 7 2015, In : Open Biology. 5, 10, 150112.

    Research output: Contribution to journalArticle

  • 4 Scopus citations

    Chemical map of Schizosaccharomyces pombe reveals species-specific features in nucleosome positioning

    Moyle-Heyrman, G., Zaichuk, T., Xi, L., Zhang, Q., Uhlenbeck, O. C., Holmgren, R., Widom, J. & Wang, J. P., Dec 10 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 50, p. 20158-20163 6 p.

    Research output: Contribution to journalArticle

  • 55 Scopus citations

    Specific inhibition of the transcription factor Ci by a cobalt(III) Schiff base-DNA conjugate

    Hurtado, R. R., Harney, A. S., Heffern, M. C., Holbrook, R. J., Holmgren, R. A. & Meade, T. J., Feb 6 2012, In : Molecular Pharmaceutics. 9, 2, p. 325-333 9 p.

    Research output: Contribution to journalArticle

  • 33 Scopus citations

    A Three-part signal governs differential processing of Gli1 and Gli3 proteins by the proteasome

    Schrader, E. K., Harstad, K. G., Holmgren, R. A. & Matouschek, A., Nov 11 2011, In : Journal of Biological Chemistry. 286, 45, p. 39051-39058 8 p.

    Research output: Contribution to journalArticle

  • 24 Scopus citations