Grants per year
Personal profile
Research Interests
Professor Holmgren’s research studies how cells in a developing organism signal to one another to pattern tissues. Drosophila is primarily used as a model system and the role of the Hedgehog signal transduction cascade in the patterning of the wing is studied. Of particular interest is how the range of Hedgehog signaling is regulated, how different modes of regulation lead to robust, reproducible outcomes, and how Hedgehog signaling is integrated with other cellular processes. The approach is to identify new components in the pathway using various genetic interaction screens and to then characterize the function of the encoded proteins.
Education/Academic qualification
Biochemistry and Molecular Biology, PhD, Harvard University
… → 1980
Biology, BA, Cornell University
… → 1975
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Grants
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Specific inhibition of transcription factors with Cobalt-Schiff Base Complexes
Holmgren, R. A., Meade, T. J. & Perez-White, B. E.
National Institute of General Medical Sciences
7/15/17 → 4/30/21
Project: Research project
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Holmgren: Specific inhibition of transcription factors with Cobalt-Schiff Base Complexes
National Institute of General Medical Sciences
7/15/17 → 4/30/21
Project: Research project
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Carcinogenesis Training Program
Chandel, N., Chisholm, R. L., Crispino, J. D., Green, K. J., Holmgren, R. A., LaBonne, C., McGee, R., O'Halloran, T. V., Woloschak, G. E., Woodruff, T. K. & Gottardi, C.
7/1/16 → 6/30/17
Project: Research project
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Cellular and Molecular Basis of Disease Training Program
Brickner, J. H., Carthew, R. W., Holmgren, R. A. & Smith, G. A.
National Institute of General Medical Sciences
7/1/16 → 6/30/18
Project: Research project
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Cellular and Molecular Basis of Disease Training Program
Brickner, J. H., Brickner, J. H., Holmgren, R. A. & Seifert, H.
National Institute of General Medical Sciences
7/1/13 → 6/30/16
Project: Research project
Research Output
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Regulation of the RNA-binding protein Smaug by the GPCR Smoothened via the kinase Fused
Bruzzone, L., Argüelles, C., Sanial, M., Miled, S., Alvisi, G., Gonçalves-Antunes, M., Qasrawi, F., Holmgren, R. A., Smibert, C. A., Lipshitz, H. D., Boccaccio, G. L., Plessis, A. & Bécam, I., Jul 3 2020, In: EMBO Reports. 21, 7, e48425.Research output: Contribution to journal › Article › peer-review
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Dose-dependent transduction of hedgehog relies on phosphorylation-based feedback between the G-protein-coupled receptor smoothened and the kinase fused
Sanial, M., Bécam, I., Hofmann, L., Behague, J., Argüelles, C., Gourhand, V., Bruzzone, L., Holmgren, R. A. & Plessis, A., May 15 2017, In: Development (Cambridge). 144, 10, p. 1841-1850 10 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Control of the dynamics and homeostasis of the Drosophila Hedgehog receptor Patched by two C2-WW-HECT-E3 Ubiquitin ligases
Brigui, A., Hofmann, L., Argüelles, C., Sanial, M., Holmgren, R. A. & Plessis, A., Oct 7 2015, In: Open Biology. 5, 10, 150112.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Chemical map of Schizosaccharomyces pombe reveals species-specific features in nucleosome positioning
Moyle-Heyrman, G., Zaichuk, T., Xi, L., Zhang, Q., Uhlenbeck, O. C., Holmgren, R., Widom, J. & Wang, J. P., Dec 10 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 50, p. 20158-20163 6 p.Research output: Contribution to journal › Article › peer-review
58 Scopus citations -
Specific inhibition of the transcription factor Ci by a cobalt(III) Schiff base-DNA conjugate
Hurtado, R. R., Harney, A. S., Heffern, M. C., Holbrook, R. J., Holmgren, R. A. & Meade, T. J., Feb 6 2012, In: Molecular Pharmaceutics. 9, 2, p. 325-333 9 p.Research output: Contribution to journal › Article › peer-review
37 Scopus citations