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Research Output

  • 2880 Citations
  • 32 Article
  • 2 Chapter
  • 1 Review article
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Article
2017

Dose-dependent transduction of hedgehog relies on phosphorylation-based feedback between the G-protein-coupled receptor smoothened and the kinase fused

Sanial, M., Bécam, I., Hofmann, L., Behague, J., Argüelles, C., Gourhand, V., Bruzzone, L., Holmgren, R. A. & Plessis, A., May 15 2017, In : Development (Cambridge). 144, 10, p. 1841-1850 10 p.

Research output: Contribution to journalArticle

5 Scopus citations
2015

Control of the dynamics and homeostasis of the Drosophila Hedgehog receptor Patched by two C2-WW-HECT-E3 Ubiquitin ligases

Brigui, A., Hofmann, L., Argüelles, C., Sanial, M., Holmgren, R. A. & Plessis, A., Oct 7 2015, In : Open Biology. 5, 10, 150112.

Research output: Contribution to journalArticle

4 Scopus citations
2013

Chemical map of Schizosaccharomyces pombe reveals species-specific features in nucleosome positioning

Moyle-Heyrman, G., Zaichuk, T., Xi, L., Zhang, Q., Uhlenbeck, O. C., Holmgren, R., Widom, J. & Wang, J. P., Dec 10 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 50, p. 20158-20163 6 p.

Research output: Contribution to journalArticle

55 Scopus citations
2012

Specific inhibition of the transcription factor Ci by a cobalt(III) Schiff base-DNA conjugate

Hurtado, R. R., Harney, A. S., Heffern, M. C., Holbrook, R. J., Holmgren, R. A. & Meade, T. J., Feb 6 2012, In : Molecular Pharmaceutics. 9, 2, p. 325-333 9 p.

Research output: Contribution to journalArticle

33 Scopus citations
2011

A Three-part signal governs differential processing of Gli1 and Gli3 proteins by the proteasome

Schrader, E. K., Harstad, K. G., Holmgren, R. A. & Matouschek, A., Nov 11 2011, In : Journal of Biological Chemistry. 286, 45, p. 39051-39058 8 p.

Research output: Contribution to journalArticle

22 Scopus citations
2006

Regulation of Ci and Su(fu) nuclear import in Drosophila

Sisson, B. E., Ziegenhorn, S. L. & Holmgren, R. A., Jun 1 2006, In : Developmental Biology. 294, 1, p. 258-270 13 p.

Research output: Contribution to journalArticle

28 Scopus citations

Regulation of the Drosophila transcription factor, Cubitus interruptus, by two conserved domains

Croker, J. A., Ziegenhorn, S. L. & Holmgren, R. A., Mar 15 2006, In : Developmental Biology. 291, 2, p. 368-381 14 p.

Research output: Contribution to journalArticle

27 Scopus citations
2005

A conserved processing mechanism regulates the activity of transcription factors Cubitus interruptus and NF-κB

Tian, L., Holmgren, R. A. & Matouschek, A., Dec 27 2005, In : Nature Structural and Molecular Biology. 12, 12, p. 1045-1053 9 p.

Research output: Contribution to journalArticle

92 Scopus citations
2001

Genetic dissection of the Drosophila Cubitus interruptus signaling complex

Lefers, M. A., Wang, Q. T. & Holmgren, R. A., Aug 15 2001, In : Developmental Biology. 236, 2, p. 411-420 10 p.

Research output: Contribution to journalArticle

48 Scopus citations
2000

Nuclear import of Cubitus interruptus is regulated by Hedgehog via a mechanism distinct from Ci stabilization and Ci activation

Wang, Q. T. & Holmgren, R. A., Jul 1 2000, In : Development. 127, 14, p. 3131-3139 9 p.

Research output: Contribution to journalArticle

100 Scopus citations
1999

Cubitus interruptus is necessary but not sufficient for direct activation of a wing-specific decapentaplegic enhancer

Hepker, J., Blackman, R. K. & Holmgren, R., Aug 1999, In : Development. 126, 16, p. 3669-3677 9 p.

Research output: Contribution to journalArticle

41 Scopus citations

The subcellular localization and activity of Drosophila Cubitus interruptus are regulated at multiple levels

Wang, Q. T. & Holmgren, R. A., Dec 1 1999, In : Development. 126, 22, p. 5097-5106 10 p.

Research output: Contribution to journalArticle

114 Scopus citations
1997

Drosophila cubitus interruptus forms a negative feedback loop with and regulates expression of Hedgehog target genes

Hepker, J., Wang, Q. T., Motzny, C. K., Holmgren, R. A. & Orenic, T. V., Jan 1 1997, In : Development. 124, 2, p. 549-558 10 p.

Research output: Contribution to journalArticle

123 Scopus citations
1995

Expression of the Drosophila gooseberry Locus Defines a Subset of Neuroblast Lineages in the Central Nervous System

Buenzow, D. E. & Holmgren, R., Aug 1995, In : Developmental Biology. 170, 2, p. 338-349 12 p.

Research output: Contribution to journalArticle

50 Scopus citations

Mutations that alter the timing and pattern of cubitus interruptus gene expression in Drosophila melanogaster

Slusarski, D. C., Motzny, C. K. & Holmgren, R., Jan 1 1995, In : Genetics. 139, 1, p. 229-240 12 p.

Research output: Contribution to journalArticle

94 Scopus citations

Specification of neuroblast identity in the drosophila embryonic central nervous system by gooseberry-distal

Skeath, J. B., Zhang, Y., Holmgren, R. A., Carroll, S. B. & Doe, C. Q., Aug 3 1995, In : Nature. 376, 6539, p. 427-430 4 p.

Research output: Contribution to journalArticle

76 Scopus citations

The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways

Motzny, C. K. & Holmgren, R., Jul 1995, In : Mechanisms of Development. 52, 1, p. 137-150 14 p.

Research output: Contribution to journalArticle

245 Scopus citations
1994

Ectopic expression of either the Drosophila gooseberry-distal or proximal gene causes alterations of cell fate in the epidermis and central nervous system

Zhang, Y., Ungar, A., Fresquez, C. & Holmgren, R., May 1 1994, In : Development. 120, 5, p. 1151-1161 11 p.

Research output: Contribution to journalArticle

57 Scopus citations
384 Scopus citations

Invariant tryptophan at a shielded site promotes folding of the conformational unit of spectrin

Macdonald, R. I., Musacchio, A., Holmgren, R. A. & Saraste, M., Feb 15 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 4, p. 1299-1303 5 p.

Research output: Contribution to journalArticle

40 Scopus citations
1993

A GATA family transcription factor is expressed along the embryonic dorsoventral axis in Drosophila melanogaster

Winick, J., Abel, T., Leonard, M. W., Michelson, A. M., Chardon-Loriauxl, I., Holmgren, R. A., Maniatis, T. & Engel, J. D., Jan 1 1993, In : Development. 119, 4, p. 1055-1065 11 p.

Research output: Contribution to journalArticle

80 Scopus citations

gli, a zinc finger transcription factor and oncogene, is expressed during normal mouse development

Walterhouse, D. O., Ahmed, M., Slusarski, D., Kalamaras, J., Boucher, D., Holmgren, R. A. & Iannaccone, P. M., Jan 1 1993, In : Developmental Dynamics. 196, 2, p. 91-102 12 p.

Research output: Contribution to journalArticle

87 Scopus citations
1992

Developmental potential

Holmgren, R. A. & Engel, J. D., Jan 1 1992, In : Genes and Development. 6, 2, p. 161-165 5 p.

Research output: Contribution to journalArticle

2 Scopus citations
1990

Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila

Orenic, T. V., Slusarski, D. C., Kroll, K. L. & Holmgren, R. A., Jan 1 1990, In : Genes and Development. 4, 6, p. 1053-1067 15 p.

Research output: Contribution to journalArticle

219 Scopus citations
1989

The isolation and in situ location of adligin: the microtubule cross-linking protein from Caenorhabditis elegans.

Aamodt, E., Holmgren, R. A. & Culotti, J., Jan 1 1989, In : The Journal of cell biology. 108, 3, p. 955-963 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

The role of segment polarity genes during Drosophila neurogenesis.

Patel, N. H., Schafer, B., Goodman, C. S. & Holmgren, R., Jun 1989, In : Genes & development. 3, 6, p. 890-904 15 p.

Research output: Contribution to journalArticle

176 Scopus citations
1987

Cell and cubitus interruptus Dominant: Two segment polarity genes on the fourth chromosome in Drosophila

Orenic, T., Chidsey, J. & Holmgren, R. A., Jan 1 1987, In : Developmental Biology. 124, 1, p. 50-56 7 p.

Research output: Contribution to journalArticle

34 Scopus citations
1984

Cloning sequences from the hairy gene of Drosophila.

Holmgren, R., Mar 1 1984, In : EMBO Journal. 3, 3, p. 569-573 5 p.

Research output: Contribution to journalArticle

11 Scopus citations
1981

Sequence homologies in the 5' regions of four Drosophila heat-shock genes

Holmgren, R., Corces, V., Morimoto, R., Blackman, R. & Meselson, M., Dec 1 1981, In : Proceedings of the National Academy of Sciences of the United States of America. 78, 6 I, p. 3775-3778 4 p.

Research output: Contribution to journalArticle

112 Scopus citations
1980
111 Scopus citations
1979

Studies of cloned sequences from four drosophila heat shock loci

Holmgren, R., Livak, K., Morimoto, R., Freund, R. & Meselson, M., Dec 1979, In : Cell. 18, 4, p. 1359-1370 12 p.

Research output: Contribution to journalArticle

133 Scopus citations

The chromatin structure of specific genes: I. Evidence for higher order domains of defined DNA sequence

Wu, C., M. Bingham, P., Livak, K. J., Holmgren, R. & Elgin, S. C. R., Apr 1979, In : Cell. 16, 4, p. 797-806 10 p.

Research output: Contribution to journalArticle

264 Scopus citations