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Research Output 1979 2017

  • 2852 Citations
  • 32 Article
  • 2 Chapter
  • 1 Review article
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Article
2017
3 Citations (Scopus)

Dose-dependent transduction of hedgehog relies on phosphorylation-based feedback between the G-protein-coupled receptor smoothened and the kinase fused

Sanial, M., Bécam, I., Hofmann, L., Behague, J., Argüelles, C., Gourhand, V., Bruzzone, L., Holmgren, R. A. & Plessis, A., May 15 2017, In : Development (Cambridge). 144, 10, p. 1841-1850 10 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptor Kinases
Hedgehogs
Phosphorylation
Phosphotransferases
Imaginal Discs
2015
4 Citations (Scopus)

Control of the dynamics and homeostasis of the Drosophila Hedgehog receptor Patched by two C2-WW-HECT-E3 Ubiquitin ligases

Brigui, A., Hofmann, L., Argüelles, C., Sanial, M., Holmgren, R. A. & Plessis, A., Oct 7 2015, In : Open Biology. 5, 10, 150112.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Hedgehogs
Homeostasis
Ligases
Ubiquitin
2013
53 Citations (Scopus)

Chemical map of Schizosaccharomyces pombe reveals species-specific features in nucleosome positioning

Moyle-Heyrman, G., Zaichuk, T., Xi, L., Zhang, Q., Uhlenbeck, O. C., Holmgren, R. A., Widom, J. & Wang, J., Dec 10 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 50, p. 20158-20163 6 p.

Research output: Contribution to journalArticle

Schizosaccharomyces
Nucleosomes
Transcription Initiation Site
Saccharomyces cerevisiae
DNA
2012
31 Citations (Scopus)

Specific inhibition of the transcription factor Ci by a cobalt(III) Schiff base-DNA conjugate

Hurtado, R. R., Harney, A. S., Heffern, M. C., Holbrook, R. J., Holmgren, R. A. & Meade, T. J., Feb 6 2012, In : Molecular Pharmaceutics. 9, 2, p. 325-333 9 p.

Research output: Contribution to journalArticle

Schiff Bases
Cobalt
Hedgehogs
Transcription Factors
DNA
2011
21 Citations (Scopus)

A Three-part signal governs differential processing of Gli1 and Gli3 proteins by the proteasome

Schrader, E. K., Harstad, K. G., Holmgren, R. A. & Matouschek, A., Nov 11 2011, In : Journal of Biological Chemistry. 286, 45, p. 39051-39058 8 p.

Research output: Contribution to journalArticle

Zinc Fingers
Proteasome Endopeptidase Complex
Protein Sorting Signals
Processing
Signal processing
2006
28 Citations (Scopus)

Regulation of Ci and Su(fu) nuclear import in Drosophila

Sisson, B. E., Ziegenhorn, S. L. & Holmgren, R. A., Jun 1 2006, In : Developmental Biology. 294, 1, p. 258-270 13 p.

Research output: Contribution to journalArticle

Nuclear Localization Signals
Cell Nucleus Active Transport
Hedgehogs
Drosophila
Vertebrates
25 Citations (Scopus)

Regulation of the Drosophila transcription factor, Cubitus interruptus, by two conserved domains

Croker, J. A., Ziegenhorn, S. L. & Holmgren, R. A., Mar 15 2006, In : Developmental Biology. 291, 2, p. 368-381 14 p.

Research output: Contribution to journalArticle

Imaginal Discs
Cell Nucleus Active Transport
Drosophila
Transcription Factors
Hedgehogs
2005
91 Citations (Scopus)

A conserved processing mechanism regulates the activity of transcription factors Cubitus interruptus and NF-κB

Tian, L., Holmgren, R. A. & Matouschek, A., Dec 27 2005, In : Nature Structural and Molecular Biology. 12, 12, p. 1045-1053 9 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Transcription Factors
Proteins
Amino Acids
2001
48 Citations (Scopus)

Genetic dissection of the Drosophila Cubitus interruptus signaling complex

Lefers, M. A., Wang, Q. T. & Holmgren, R. A., Aug 15 2001, In : Developmental Biology. 236, 2, p. 411-420 10 p.

Research output: Contribution to journalArticle

Cell Nucleus Active Transport
Hedgehogs
Drosophila
Dissection
Kinesin
2000
99 Citations (Scopus)

Nuclear import of Cubitus interruptus is regulated by Hedgehog via a mechanism distinct from Ci stabilization and Ci activation

Wang, Q. T. & Holmgren, R. A., Jul 1 2000, In : Development. 127, 14, p. 3131-3139 9 p.

Research output: Contribution to journalArticle

Cell Nucleus Active Transport
Hedgehogs
Cell Nucleus
Proteolysis
Drosophila
1999
39 Citations (Scopus)

Cubitus interruptus is necessary but not sufficient for direct activation of a wing-specific decapentaplegic enhancer

Hepker, J., Blackman, R. K. & Holmgren, R. A., Jan 1 1999, In : Development. 126, 16, p. 3669-3677 9 p.

Research output: Contribution to journalArticle

Imaginal Discs
Hedgehogs
Transcriptional Activation
Drosophila
Nucleic Acid Regulatory Sequences
114 Citations (Scopus)

The subcellular localization and activity of Drosophila Cubitus interruptus are regulated at multiple levels

Wang, Q. T. & Holmgren, R. A., Dec 1 1999, In : Development. 126, 22, p. 5097-5106 10 p.

Research output: Contribution to journalArticle

Hedgehogs
Drosophila
Nuclear Localization Signals
Proteolysis
Imaginal Discs
1997
123 Citations (Scopus)

Drosophila cubitus interruptus forms a negative feedback loop with and regulates expression of Hedgehog target genes

Hepker, J., Wang, Q. T., Motzny, C. K., Holmgren, R. A. & Orenic, T. V., Jan 1 1997, In : Development. 124, 2, p. 549-558 10 p.

Research output: Contribution to journalArticle

Hedgehogs
Drosophila
Zinc Fingers
Imaginal Discs
Genes
1995
49 Citations (Scopus)

Expression of the Drosophila gooseberry Locus Defines a Subset of Neuroblast Lineages in the Central Nervous System

Buenzow, D. E. & Holmgren, R. A., Jan 1 1995, In : Developmental Biology. 170, 2, p. 338-349 12 p.

Research output: Contribution to journalArticle

Ribes
Drosophila
Central Nervous System
Polyadenylation
Cell Lineage
94 Citations (Scopus)

Mutations that alter the timing and pattern of cubitus interruptus gene expression in Drosophila melanogaster

Slusarski, D. C., Motzny, C. K. & Holmgren, R. A., Jan 1 1995, In : Genetics. 139, 1, p. 229-240 12 p.

Research output: Contribution to journalArticle

Drosophila melanogaster
Gene Expression
Mutation
Embryonic Development
Veins
76 Citations (Scopus)

Specification of neuroblast identity in the drosophila embryonic central nervous system by gooseberry-distal

Skeath, J. B., Zhang, Y., Holmgren, R. A., Carroll, S. B. & Doe, C. Q., Aug 3 1995, In : Nature. 376, 6539, p. 427-430 4 p.

Research output: Contribution to journalArticle

Ribes
Drosophila
Central Nervous System
Cell Lineage
Genes
243 Citations (Scopus)

The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways

Motzny, C. K. & Holmgren, R. A., Jan 1 1995, In : Mechanisms of Development. 52, 1, p. 137-150 14 p.

Research output: Contribution to journalArticle

Signal Transduction
Proteins
Gene Expression
Drosophila ci protein
Antibodies
1994
57 Citations (Scopus)

Ectopic expression of either the Drosophila gooseberry-distal or proximal gene causes alterations of cell fate in the epidermis and central nervous system

Zhang, Y., Ungar, A., Fresquez, C. & Holmgren, R. A., May 1 1994, In : Development. 120, 5, p. 1151-1161 11 p.

Research output: Contribution to journalArticle

Ribes
Epidermis
Drosophila
Central Nervous System
Genes
382 Citations (Scopus)
Ectoderm
Mesoderm
Drosophila
Genes
Gastrulation
40 Citations (Scopus)

Invariant tryptophan at a shielded site promotes folding of the conformational unit of spectrin

Macdonald, R. I., Musacchio, A., Holmgren, R. A. & Saraste, M., Feb 15 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 4, p. 1299-1303 5 p.

Research output: Contribution to journalArticle

Spectrin
Tryptophan
Peptides
Acrylamide
Pancreatic Elastase
1993
78 Citations (Scopus)

A GATA family transcription factor is expressed along the embryonic dorsoventral axis in Drosophila melanogaster

Winick, J., Abel, T., Leonard, M. W., Michelson, A. M., Chardon-Loriauxl, I., Holmgren, R. A., Maniatis, T. & Engel, J. D., Jan 1 1993, In : Development. 119, 4, p. 1055-1065 11 p.

Research output: Contribution to journalArticle

GATA Transcription Factors
Drosophila melanogaster
Zinc Fingers
Drosophila
Vertebrates
87 Citations (Scopus)

gli, a zinc finger transcription factor and oncogene, is expressed during normal mouse development

Walterhouse, D. O., Ahmed, M., Slusarski, D., Kalamaras, J., Boucher, D., Holmgren, R. A. & Iannaccone, P. M., Jan 1 1993, In : Developmental Dynamics. 196, 2, p. 91-102 12 p.

Research output: Contribution to journalArticle

Zinc Fingers
Oncogenes
Transcription Factors
Mesoderm
Genes
1992
2 Citations (Scopus)

Developmental potential

Holmgren, R. A. & Engel, J. D., Jan 1 1992, In : Genes and Development. 6, 2, p. 161-165 5 p.

Research output: Contribution to journalArticle

Drosophila
Transcription Factors
Cell Surface Receptors
Viral Proteins
Protein Kinases
1990
217 Citations (Scopus)

Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila

Orenic, T. V., Slusarski, D. C., Kroll, K. L. & Holmgren, R. A., Jan 1 1990, In : Genes and Development. 4, 6, p. 1053-1067 15 p.

Research output: Contribution to journalArticle

Drosophila
Organism Cloning
Zinc Fingers
Amino Acid Repetitive Sequences
Transcription Factor TFIIIA
1989
5 Citations (Scopus)

The isolation and in situ location of adligin: the microtubule cross-linking protein from Caenorhabditis elegans.

Aamodt, E., Holmgren, R. A. & Culotti, J., Jan 1 1989, In : The Journal of cell biology. 108, 3, p. 955-963 9 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans Proteins
Microtubule-Associated Proteins
Microtubules
Caenorhabditis elegans
Tubulin
176 Citations (Scopus)

The role of segment polarity genes during Drosophila neurogenesis.

Patel, N. H., Schafer, B., Goodman, C. S. & Holmgren, R., Jan 1 1989, In : Genes & development. 3, 6, p. 890-904 15 p.

Research output: Contribution to journalArticle

Neurogenesis
Drosophila
Ribes
Central Nervous System
Genes
1987
34 Citations (Scopus)

Cell and cubitus interruptus Dominant: Two segment polarity genes on the fourth chromosome in Drosophila

Orenic, T., Chidsey, J. & Holmgren, R. A., Jan 1 1987, In : Developmental Biology. 124, 1, p. 50-56 7 p.

Research output: Contribution to journalArticle

Drosophila
Chromosomes
Genes
Alleles
Mothers
1984
11 Citations (Scopus)

Cloning sequences from the hairy gene of Drosophila.

Holmgren, R., Mar 1 1984, In : EMBO Journal. 3, 3, p. 569-573 5 p.

Research output: Contribution to journalArticle

DNA Transposable Elements
Cloning
Drosophila
Organism Cloning
Mirrors
1981
112 Citations (Scopus)

Sequence homologies in the 5' regions of four Drosophila heat-shock genes

Holmgren, R., Corces, V., Morimoto, R., Blackman, R. & Meselson, M., Dec 1 1981, In : Proceedings of the National Academy of Sciences of the United States of America. 78, 6 I, p. 3775-3778 4 p.

Research output: Contribution to journalArticle

Sequence Homology
Drosophila
Shock
Hot Temperature
Genes
1980
110 Citations (Scopus)
Nucleic Acid Hybridization
Bacteriophage lambda
Genetic Vectors
Chromosome Mapping
DNA Restriction Enzymes
1979
132 Citations (Scopus)

Studies of cloned sequences from four drosophila heat shock loci

Holmgren, R., Livak, K., Morimoto, R., Freund, R. & Meselson, M., Jan 1 1979, In : Cell. 18, 4, p. 1359-1370 12 p.

Research output: Contribution to journalArticle

Heat-Shock Proteins
Drosophila
Shock
Hot Temperature
Messenger RNA
260 Citations (Scopus)

The chromatin structure of specific genes: I. Evidence for higher order domains of defined DNA sequence

Wu, C., M. Bingham, P., Livak, K. J., Holmgren, R. & Elgin, S. C. R., Jan 1 1979, In : Cell. 16, 4, p. 797-806 10 p.

Research output: Contribution to journalArticle

Deoxyribonuclease I
DNA sequences
Chromatin
Genes
Micrococcal Nuclease