Grants per year
Personal profile
Research Interests
Robert Lamb's laboratory studies the structure, replication and assembly of influenza virus and paramyxoviruses, a family of viruses that includes mumps virus, measles virus, parainfluenza virus 1-5, Newcastle disease virus, canine distemper virus and Hendra and Nipah virus. In particular the laboratory studies the structural mechanism by which paramyxoviruses causes virus-cell and cell-cell fusion and how influenza virus and paramyxoviruses assembly and bud from the plasma membrane of virus-infected cell.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
ScD, University of Cambridge
… → 1990
PhD, University of Cambridge
… → 1974
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Collaborations and top research areas from the last five years
Grants
- 22 Finished
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Acquisition of JEOL 1400 Electron Microscope
Howard Hughes Medical Institute
9/1/19 → 8/31/21
Project: Research project
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Pathogenesis of Jeilongvirus
University of Georgia, National Institute of Allergy and Infectious Diseases
7/1/17 → 6/30/21
Project: Research project
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Medical Scientist Training Program
Chetkovich, D. M., Ardehali, H., Ferster, D. L., Green, K. J., Hauser, A. R., Kessler, J., Lamb, R. A., McGee, R., Rice, S. E. & Schnaper, H. W.
National Institute of General Medical Sciences
7/1/16 → 6/30/17
Project: Research project
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The Structure and Function of the Influenza Virus Genome
National Institute of Allergy and Infectious Diseases
2/1/16 → 1/31/18
Project: Research project
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Elucidating the Kinetics of Paramyxovirus Virus membrane fusion
United Negro College Fund, Inc.
9/1/14 → 8/31/16
Project: Research project
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Resveratrol inhibits venezuelan equine encephalitis virus infection by interfering with the akt/gsk pathway
Lehman, C. W., Kehn-Hall, K., Aggarwal, M., Bracci, N. R., Pan, H. C., Panny, L., Lamb, R. A. & Lin, S. C., Feb 2021, In: Plants. 10, 2, p. 1-17 17 p., 346.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales
Kuhn, J. H., Adkins, S., Alioto, D., Alkhovsky, S. V., Amarasinghe, G. K., Anthony, S. J., Avšič-Županc, T., Ayllón, M. A., Bahl, J., Balkema-Buschmann, A., Ballinger, M. J., Bartonička, T., Basler, C., Bavari, S., Beer, M., Bente, D. A., Bergeron, É., Bird, B. H., Blair, C., Blasdell, K. R., & 209 others , Dec 1 2020, In: Archives of Virology. 165, 12, p. 3023-3072 50 p.Research output: Contribution to journal › Article › peer-review
Open Access134 Scopus citations -
Repurposing papaverine as an antiviral agent against influenza viruses and paramyxoviruses
Aggarwal, M., Leser, G. P. & Lamb, R. A., Feb 2020, In: Journal of virology. 94, 6, e01888-19.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
Structure of a paramyxovirus polymerase complex reveals a unique methyltransferase-CTD conformation
Abdella, R., Aggarwal, M., Okura, T., Lamb, R. A. & He, Y., Mar 3 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 9, p. 4931-4941 11 p.Research output: Contribution to journal › Article › peer-review
Open Access58 Scopus citations -
The structure, function, and pathobiology of the influenza A and B virus ion channels
Lamb, R. A., Nov 2020, In: Cold Spring Harbor Perspectives in Medicine. 10, 11, p. 1-6 6 p., a038505.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations
Datasets
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3T1E : The structure of the Newcastle disease virus hemagglutinin-neuraminidase (HN) ectodomain reveals a 4-helix bundle stalk
Jardetzky, T. S. (Contributor), Lamb, R. A. (Contributor), Yuan, P. (Contributor), Swanson, K. A. (Contributor), Leser, G. P. (Contributor) & Paterson, R. G. (Contributor), RCSB-PDB, 2011
DOI: 10.2210/pdb3t1e/pdb, https://www.rcsb.org/structure/3T1E
Dataset
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2B9B : Structure of the Parainfluenza Virus 5 F Protein in its Metastable, Pre-fusion Conformation
Jardetzky, T. S. (Contributor), Lamb, R. A. (Contributor), Paterson, R. G. (Contributor), Yin, H. (Contributor) & Wen, X. (Contributor), RCSB-PDB, 2006
DOI: 10.2210/pdb2b9b/pdb, https://www.rcsb.org/structure/2B9B
Dataset
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1Z50 : Parainfluenza Virus 5 (SV5) Hemagglutinin-Neuraminidase (HN) with ligand DANA (soaked with sialic acid, pH 8.0)
Yuan, P. (Contributor), Thompson, T. B. (Contributor), Wurzburg, B. A. (Contributor), Paterson, R. G. (Contributor), Lamb, R. A. (Contributor) & Jardetzky, T. S. (Contributor), RCSB-PDB, 2005
DOI: 10.2210/pdb1z50/pdb, https://www.rcsb.org/structure/1Z50
Dataset
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1ZTM : Structure of the Uncleaved Paramyxovirus (hPIV3) Fusion Protein
Paterson, R. G. (Contributor), Lamb, R. A. (Contributor), Jardetzky, T. S. (Contributor), Yin, H. (Contributor) & Wen, X. (Contributor), RCSB-PDB, 2005
DOI: 10.2210/pdb1ztm/pdb, https://www.rcsb.org/structure/1ZTM
Dataset
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4FZH : Structure of the Ulster Strain Newcastle Disease Virus Hemagglutinin-Neuraminidase Reveals Auto-Inhibitory Interactions Associated with Low Virulence
Yuan, P. (Contributor), Paterson, R. G. (Contributor), Leser, G. P. (Contributor), Lamb, R. A. (Contributor) & Jardetzky, T. S. (Contributor), RCSB-PDB, 2012
DOI: 10.2210/pdb4fzh/pdb, https://www.rcsb.org/structure/4FZH
Dataset