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1975 …2021

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2020

Repurposing Papaverine as an Antiviral Agent against Influenza Viruses and Paramyxoviruses

Aggarwal, M., Leser, G. P. & Lamb, R. A., Feb 28 2020, In : Journal of virology. 94, 6

Research output: Contribution to journalArticle

Open Access

Structure of a paramyxovirus polymerase complex reveals a unique methyltransferase-CTD conformation

Abdella, R., Aggarwal, M., Okura, T., Lamb, R. A. & He, Y., Mar 3 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 9, p. 4931-4941 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
2019

ICTV Virus Taxonomy Profile: Paramyxoviridae

Rima, B., Balkema-Buschmann, A., Dundon, W. G., Duprex, P., Easton, A., Fouchier, R., Kurath, G., Lamb, R., Lee, B., Rota, P., Wang, L. & Ictv Report Consortium, R. C., Dec 1 2019, In : The Journal of general virology. 100, 12, p. 1593-1594 2 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Taxonomy of the order Mononegavirales: update 2019

Amarasinghe, G. K., Ayllón, M. A., Bào, Y., Basler, C. F., Bavari, S., Blasdell, K. R., Briese, T., Brown, P. A., Bukreyev, A., Balkema-Buschmann, A., Buchholz, U. J., Chabi-Jesus, C., Chandran, K., Chiapponi, C., Crozier, I., de Swart, R. L., Dietzgen, R. G., Dolnik, O., Drexler, J. F., Dürrwald, R. & 64 others, Dundon, W. G., Duprex, W. P., Dye, J. M., Easton, A. J., Fooks, A. R., Formenty, P. B. H., Fouchier, R. A. M., Freitas-Astúa, J., Griffiths, A., Hewson, R., Horie, M., Hyndman, T. H., Jiāng, D., Kitajima, E. W., Kobinger, G. P., Kondō, H., Kurath, G., Kuzmin, I. V., Lamb, R. A., Lavazza, A., Lee, B., Lelli, D., Leroy, E. M., Lǐ, J., Maes, P., Marzano, S. Y. L., Moreno, A., Mühlberger, E., Netesov, S. V., Nowotny, N., Nylund, A., Økland, A. L., Palacios, G., Pályi, B., Pawęska, J. T., Payne, S. L., Prosperi, A., Ramos-González, P. L., Rima, B. K., Rota, P., Rubbenstroth, D., Shī, M., Simmonds, P., Smither, S. J., Sozzi, E., Spann, K., Stenglein, M. D., Stone, D. M., Takada, A., Tesh, R. B., Tomonaga, K., Tordo, N., Towner, J. S., van den Hoogen, B., Vasilakis, N., Wahl, V., Walker, P. J., Wang, L. F., Whitfield, A. E., Williams, J. V., Zerbini, F. M., Zhāng, T., Zhang, Y. Z. & Kuhn, J. H., Jul 1 2019, In : Archives of Virology. 164, 7, p. 1967-1980 14 p.

Research output: Contribution to journalArticle

Open Access
34 Scopus citations

Taxonomy of the order Mononegavirales: second update 2018

Maes, P., Amarasinghe, G. K., Ayllón, M. A., Basler, C. F., Bavari, S., Blasdell, K. R., Briese, T., Brown, P. A., Bukreyev, A., Balkema-Buschmann, A., Buchholz, U. J., Chandran, K., Crozier, I., de Swart, R. L., Dietzgen, R. G., Dolnik, O., Domier, L. L., Drexler, J. F., Dürrwald, R., Dundon, W. G. & 57 others, Duprex, W. P., Dye, J. M., Easton, A. J., Fooks, A. R., Formenty, P. B. H., Fouchier, R. A. M., Freitas-Astúa, J., Ghedin, E., Griffiths, A., Hewson, R., Horie, M., Hurwitz, J. L., Hyndman, T. H., Jiāng, D., Kobinger, G. P., Kondō, H., Kurath, G., Kuzmin, I. V., Lamb, R. A., Lee, B., Leroy, E. M., Lǐ, J., Marzano, S. Y. L., Mühlberger, E., Netesov, S. V., Nowotny, N., Palacios, G., Pályi, B., Pawęska, J. T., Payne, S. L., Rima, B. K., Rota, P., Rubbenstroth, D., Simmonds, P., Smither, S. J., Song, Q., Song, T., Spann, K., Stenglein, M. D., Stone, D. M., Takada, A., Tesh, R. B., Tomonaga, K., Tordo, N., Towner, J. S., van den Hoogen, B., Vasilakis, N., Wahl, V., Walker, P. J., Wang, D., Wang, L. F., Whitfield, A. E., Williams, J. V., Yè, G., Zerbini, F. M., Zhang, Y. Z. & Kuhn, J. H., Apr 3 2019, In : Archives of Virology. 164, 4, p. 1233-1244 12 p.

Research output: Contribution to journalArticle

26 Scopus citations
2018

Problems of classification in the family Paramyxoviridae

Rima, B., Collins, P., Easton, A., Fouchier, R., Kurath, G., Lamb, R. A., Lee, B., Maisner, A., Rota, P. & Wang, L. F., May 1 2018, In : Archives of Virology. 163, 5, p. 1395-1404 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Structure of the paramyxovirus parainfluenza virus 5 nucleoprotein in complex with an amino-terminal peptide of the phosphoprotein

Aggarwal, M., Leser, G. P., Kors, C. A. & Lamb, R. A., Mar 1 2018, In : Journal of virology. 92, 5, e01304-17.

Research output: Contribution to journalArticle

12 Scopus citations

Taxonomy of the order Mononegavirales: update 2018

Amarasinghe, G. K., Aréchiga Ceballos, N. G., Banyard, A. C., Basler, C. F., Bavari, S., Bennett, A. J., Blasdell, K. R., Briese, T., Bukreyev, A., Caì, Y., Calisher, C. H., Campos Lawson, C., Chandran, K., Chapman, C. A., Chiu, C. Y., Choi, K. S., Collins, P. L., Dietzgen, R. G., Dolja, V. V., Dolnik, O. & 71 others, Domier, L. L., Dürrwald, R., Dye, J. M., Easton, A. J., Ebihara, H., Echevarría, J. E., Fooks, A. R., Formenty, P. B. H., Fouchier, R. A. M., Freuling, C. M., Ghedin, E., Goldberg, T. L., Hewson, R., Horie, M., Hyndman, T. H., Jiāng, D., Kityo, R., Kobinger, G. P., Kondō, H., Koonin, E. V., Krupovic, M., Kurath, G., Lamb, R. A., Lee, B., Leroy, E. M., Maes, P., Maisner, A., Marston, D. A., Mor, S. K., Müller, T., Mühlberger, E., Ramírez, V. M. N., Netesov, S. V., Ng, T. F. F., Nowotny, N., Palacios, G., Patterson, J. L., Pawęska, J. T., Payne, S. L., Prieto, K., Rima, B. K., Rota, P., Rubbenstroth, D., Schwemmle, M., Siddell, S., Smither, S. J., Song, Q., Song, T., Stenglein, M. D., Stone, D. M., Takada, A., Tesh, R. B., Thomazelli, L. M., Tomonaga, K., Tordo, N., Towner, J. S., Vasilakis, N., Vázquez-Morón, S., Verdugo, C., Volchkov, V. E., Wahl, V., Walker, P. J., Wang, D., Wang, L. F., Wellehan, J. F. X., Wiley, M. R., Whitfield, A. E., Wolf, Y. I., Yè, G., Zhāng, Y. Z. & Kuhn, J. H., Aug 1 2018, In : Archives of Virology. 163, 8, p. 2283-2294 12 p.

Research output: Contribution to journalArticle

72 Scopus citations
2017

ICTV virus taxonomy profile: Pneumoviridae

ICTV Report Consortium, Dec 2017, In : Journal of General Virology. 98, 12, p. 2912-2913 2 p., 000959.

Research output: Contribution to journalArticle

49 Scopus citations

Lateral organization of influenza virus proteins in the budozone region of the plasma membrane

Leser, G. P. & Lamb, R. A., May 1 2017, In : Journal of virology. 91, 9, e02104-16.

Research output: Contribution to journalArticle

19 Scopus citations

Monomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation

Wong, J. J. W., Young, T. A., Zhang, J., Liu, S., Leser, G. P., Komives, E. A., Lamb, R. A., Zhou, Z. H., Salafsky, J. & Jardetzky, T. S., Dec 1 2017, In : Nature communications. 8, 1, 781.

Research output: Contribution to journalArticle

11 Scopus citations

Possibility and challenges of conversion of current virus species names to Linnaean binomials

Postler, T. S., Clawson, A. N., Amarasinghe, G. K., Basler, C. F., Bavari, S., Benko, M., Blasdell, K. R., Briese, T., Buchmeier, M. J., Bukreyev, A., Calisher, C. H., Chandran, K., Charrel, R., Clegg, C. S., Collins, P. L., De La Torre, J. C., DeRisi, J. L., Dietzgen, R. G., Dolnik, O., Dürrwald, R. & 52 others, Dye, J. M., Easton, A. J., Emonet, S., Formenty, P., Fouchier, R. A. M., Ghedin, E., Gonzalez, J. P., Harrach, B., Hewson, R., Horie, M., Jiāng, D., Kobinger, G., Kondo, H., Kropinski, A. M., Krupovic, M., Kurath, G., Lamb, R. A., Leroy, E. M., Lukashevich, I. S., Maisner, A., Mushegian, A. R., Netesov, S. V., Nowotny, N., Patterson, J. L., Payne, S. L., Paweska, J. T., Peters, C. J., Radoshitzky, S. R., Rima, B. K., Romanowski, V., Rubbenstroth, D., Sabanadzovic, S., Sanfaçon, H., Salvato, M. S., Schwemmle, M., Smither, S. J., Stenglein, M. D., Stone, D. M., Takada, A., Tesh, R. B., Tomonaga, K., Tordo, N., Towner, J. S., Vasilakis, N., Volchkov, V. E., Wahl-Jensen, V., Walker, P. J., Wang, L. F., Varsani, A., Whitfield, A. E., Murilo Zerbini, F. & Kuhn, J. H., May 1 2017, In : Systematic Biology. 66, 3, p. 463-473 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Structural basis for antibody cross-neutralization of respiratory syncytial virus and human metapneumovirus

Wen, X., Mousa, J. J., Bates, J. T., Lamb, R. A., Crowe, J. E. & Jardetzky, T. S., Jan 30 2017, In : Nature Microbiology. 2, 16272.

Research output: Contribution to journalArticle

21 Scopus citations

Taxonomy of the order Mononegavirales: update 2017

Amarasinghe, G. K., Bào, Y., Basler, C. F., Bavari, S., Beer, M., Bejerman, N., Blasdell, K. R., Bochnowski, A., Briese, T., Bukreyev, A., Calisher, C. H., Chandran, K., Collins, P. L., Dietzgen, R. G., Dolnik, O., Dürrwald, R., Dye, J. M., Easton, A. J., Ebihara, H., Fang, Q. & 53 others, Formenty, P., Fouchier, R. A. M., Ghedin, E., Harding, R. M., Hewson, R., Higgins, C. M., Hong, J., Horie, M., James, A. P., Jiāng, D., Kobinger, G. P., Kondo, H., Kurath, G., Lamb, R. A., Lee, B., Leroy, E. M., Li, M., Maisner, A., Mühlberger, E., Netesov, S. V., Nowotny, N., Patterson, J. L., Payne, S. L., Paweska, J. T., Pearson, M. N., Randall, R. E., Revill, P. A., Rima, B. K., Rota, P., Rubbenstroth, D., Schwemmle, M., Smither, S. J., Song, Q., Stone, D. M., Takada, A., Terregino, C., Tesh, R. B., Tomonaga, K., Tordo, N., Towner, J. S., Vasilakis, N., Volchkov, V. E., Wahl-Jensen, V., Walker, P. J., Wang, B., Wang, D., Wang, F., Wang, L. F., Werren, J. H., Whitfield, A. E., Yan, Z., Ye, G. & Kuhn, J. H., Aug 1 2017, In : Archives of Virology. 162, 8, p. 2493-2504 12 p.

Research output: Contribution to journalArticle

117 Scopus citations
2016

A Chimeric Pneumovirus Fusion Protein Carrying Neutralizing Epitopes of Both MPV and RSV

Wen, X., Pickens, J., Mousa, J. J., Leser, G. P., Lamb, R. A., Crowe, J. E. & Jardetzky, T. S., May 2016, In : PloS one. 11, 5, e0155917.

Research output: Contribution to journalArticle

8 Scopus citations

Flexibility of the head-stalk linker domain of paramyxovirus HN glycoprotein is essential for triggering virus fusion

Adu-Gyamfi, E., Kim, L. S., Jardetzky, T. S. & Lamb, R. A., Jan 1 2016, In : Journal of virology. 90, 20, p. 9172-9181 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Immobilization of the N-terminal helix stabilizes prefusion paramyxovirus fusion proteins

Albert, S. S., Taylor, A. P., Luciano, A. A., Theodore, S. J., Matteo, D. P. & Lamb, R. A., Jul 5 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 27, p. E3844-E3851

Research output: Contribution to journalArticle

2 Scopus citations

Mutagenesis of paramyxovirus hemagglutinin-neuraminidase membrane-proximal stalk region influences stability, receptor binding, and neuraminidase activity

Adu-Gyamfi, E., Kim, L. S., Jardetzky, T. S. & Lamb, R. A., Jan 1 2016, In : Journal of virology. 90, 17, p. 7778-7788 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Structure and stabilization of the Hendra virus F glycoprotein in its prefusion form

Wong, J. J. W., Paterson, R. G., Lamb, R. A. & Jardetzky, T. S., Jan 26 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 4, p. 1056-1061 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

Taxonomy of the order Mononegavirales: update 2016

Afonso, C. L., Amarasinghe, G. K., Bányai, K., Bào, Y., Basler, C. F., Bavari, S., Bejerman, N., Blasdell, K. R., Briand, F. X., Briese, T., Bukreyev, A., Calisher, C. H., Chandran, K., Chéng, J., Clawson, A. N., Collins, P. L., Dietzgen, R. G., Dolnik, O., Domier, L. L., Dürrwald, R. & 63 others, Dye, J. M., Easton, A. J., Ebihara, H., Farkas, S. L., Freitas-Astúa, J., Formenty, P., Fouchier, R. A. M., Fù, Y., Ghedin, E., Goodin, M. M., Hewson, R., Horie, M., Hyndman, T. H., Jiāng, D., Kitajima, E. W., Kobinger, G. P., Kondo, H., Kurath, G., Lamb, R. A., Lenardon, S., Leroy, E. M., Li, C. X., Lin, X. D., Liú, L., Longdon, B., Marton, S., Maisner, A., Mühlberger, E., Netesov, S. V., Nowotny, N., Patterson, J. L., Payne, S. L., Paweska, J. T., Randall, R. E., Rima, B. K., Rota, P., Rubbenstroth, D., Schwemmle, M., Shi, M., Smither, S. J., Stenglein, M. D., Stone, D. M., Takada, A., Terregino, C., Tesh, R. B., Tian, J. H., Tomonaga, K., Tordo, N., Towner, J. S., Vasilakis, N., Verbeek, M., Volchkov, V. E., Wahl-Jensen, V., Walsh, J. A., Walker, P. J., Wang, D., Wang, L. F., Wetzel, T., Whitfield, A. E., Xiè, J., Yuen, K. Y., Zhang, Y. Z. & Kuhn, J. H., Aug 1 2016, In : Archives of Virology. 161, 8, p. 2351-2360 10 p.

Research output: Contribution to journalArticle

238 Scopus citations
2015

Influenza a virus uses intercellular connections to spread to neighboring cells

Roberts, K. L., Manicassamy, B. & Lamb, R. A., Jan 1 2015, In : Journal of virology. 89, 3, p. 1537-1549 13 p.

Research output: Contribution to journalArticle

57 Scopus citations

In memoriam--Richard M. Elliott (1954-2015)

Brennan, B., Weber, F., Kormelink, R., Schnettler, E., Bouloy, M., Failloux, A. B., Weaver, S. C., Fazakerley, J. K., Fragkoudis, R., Harris, M., Barr, J. N., Palese, P., García-Sastre, A., Dalziel, R. G., Dutia, B. M., Lowen, A. C., Steel, J., Randall, R. E., Paul Duprex, W., Rice, C. M. & 30 others, Tesh, R. B., Murphy, F. A., Ebihara, H., Vasconcelos, P. F. C., Nunes, M. R., Fooks, A. R., Smith, G. L., Goodfellow, I., Pappu, H. R., Lamb, R. A., Paterson, R. G., Higgs, S., Vanlandingham, D. L., Dietzgen, R. G., Stephen Lodmell, J., Nichol, S. T., Daly, J., Ullman, D. E., Plyusnin, A., Plyusnina, A., Efstathiou, S., Hewson, R., Tordo, N., Cherry, S., Boutell, C., Hosie, M. J., Murcia, P. R., Neil, J. C., Palmarini, M. & Patel, A. H., Aug 1 2015, In : The Journal of general virology. 96, 8, p. 1975-1978 4 p.

Research output: Contribution to journalArticle

On the stability of parainfluenza virus 5 F proteins

Poor, T. A., Song, A. S., Welch, B. D., Kors, C. A., Jardetzky, T. S. & Lamb, R. A., Jan 1 2015, In : Journal of virology. 89, 6, p. 3438-3441 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Structure of the paramyxovirus parainfluenza virus 5 nucleoprotein-RNA complex

Alayyoubi, M., Leser, G. P., Kors, C. A. & Lamb, R. A., Apr 7 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 14, p. E1792-E1799

Research output: Contribution to journalArticle

49 Scopus citations

Type II integral membrane protein, TM of J paramyxovirus promotes cell-to-cell fusion

Li, Z., Hung, C., Paterson, R. G., Michel, F., Fuentes, S., Place, R., Lin, Y., Hogan, R. J., Lamb, R. A. & He, B., Oct 6 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 40, p. 12504-12509 6 p.

Research output: Contribution to journalArticle

5 Scopus citations
2014

Easily accessible polycyclic amines that inhibit the wild-type and amantadine-resistant mutants of the M2 channel of influenza A virus

Rey-Carrizo, M., Barniol-Xicota, M., Ma, C., Frigolé-Vivas, M., Torres, E., Naesens, L., Llabrés, S., Juárez-Jiménez, J., Luque, F. J., Degrado, W. F., Lamb, R. A., Pinto, L. H. & Vázquez, S., Jul 10 2014, In : Journal of Medicinal Chemistry. 57, 13, p. 5738-5747 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

Flipping in the pore: Discovery of dual inhibitors that bind in different orientations to the wild-type versus the amantadine-resistant s31n mutant of the influenza a virus m2 proton channel

Wu, Y., Canturk, B., Jo, H., Ma, C., Gianti, E., Klein, M. L., Pinto, L. H., Lamb, R. A., Fiorin, G., Wang, J. & Degrado, W. F., Dec 31 2014, In : Journal of the American Chemical Society. 136, 52, p. 17987-17995 9 p.

Research output: Contribution to journalArticle

48 Scopus citations

Fusion activation through attachment protein stalk domains indicates a conserved core mechanism of paramyxovirus entry into cells

Bose, S., Song, A. S., Jardetzky, T. S. & Lamb, R. A., Apr 2014, In : Journal of virology. 88, 8, p. 3925-3941 17 p.

Research output: Contribution to journalArticle

40 Scopus citations

Influenza A virus nucleoprotein selectively decreases neuraminidase gene-segment packaging while enhancing viral fitness and transmissibility

Brooke, C. B., Ince, W. L., Wei, J., Bennink, J. R., Yewdell, J. W. & Lamb, R. A., Nov 25 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 47, p. 16854-16859 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

In vitro evolution of high-titer, virus-like vesicles containing a single structural protein

Rose, N. F., Buonocore, L., Schell, J. B., Chattopadhyay, A., Bahl, K., Liu, X., Rose, J. K. & Lamb, R. A., Nov 25 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 47, p. 16866-16871 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Probing the functions of the paramyxovirus glycoproteins F and HN with a panel of synthetic antibodies

Welch, B. D., Paduch, M., Leser, G. P., Bergman, Z., Kors, C. A., Paterson, R. G., Jardetzky, T. S., Kossiakoff, A. A. & Lamb, R. A., Jan 1 2014, In : Journal of virology. 88, 20, p. 11713-11725 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Probing the paramyxovirus fusion (F) protein-refolding event from pre- to postfusion by oxidative footprinting

Poor, T. A., Jones, L. M., Sood, A., Leser, G. P., Plasencia, M. D., Rempel, D. L., Jardetzky, T. S., Woods, R. J., Gross, M. L. & Lamb, R. A., Jun 24 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 25, p. E2596-E2605

Research output: Contribution to journalArticle

29 Scopus citations

The Innate Immune Sensor LGP2 Activates Antiviral Signaling by Regulating MDA5-RNA Interaction and Filament Assembly

Bruns, A. M., Leser, G. P., Lamb, R. A. & Horvath, C. M., Jan 1 2014, In : Molecular cell. 55, 5, p. 771-781 11 p.

Research output: Contribution to journalArticle

109 Scopus citations
2013

3-azatetracyclo[5.2.1.15,8.01,5]undecane Derivatives: From wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant

Rey-Carrizo, M., Torres, E., Ma, C., Barniol-Xicota, M., Wang, J., Wu, Y., Naesens, L., Degrado, W. F., Lamb, R. A., Pinto, L. H. & Vázquez, S., Nov 27 2013, In : Journal of Medicinal Chemistry. 56, 22, p. 9265-9274 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

Asp44 stabilizes the Trp41 gate of the M2 proton channel of influenza a virus

Ma, C., Fiorin, G., Carnevale, V., Wang, J., Lamb, R. A., Klein, M. L., Wu, Y., Pinto, L. H. & Degrado, W. F., Nov 5 2013, In : Structure. 21, 11, p. 2033-2041 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Discovery of novel dual inhibitors of the wild-type and the most prevalent drug-resistant mutant, S31N, of the M2 proton channel from influenza A virus

Wang, J., Ma, C., Wang, J., Jo, H., Canturk, B., Fiorin, G., Pinto, L. H., Lamb, R. A., Klein, M. L. & DeGrado, W. F., Apr 11 2013, In : Journal of Medicinal Chemistry. 56, 7, p. 2804-2812 9 p.

Research output: Contribution to journalArticle

70 Scopus citations

Inhibitors of the Influenza A Virus M2 Proton Channel Discovered Using a High-Throughput Yeast Growth Restoration Assay

Balgi, A. D., Wang, J., Cheng, D. Y. H., Ma, C., Pfeifer, T. A., Shimizu, Y., Anderson, H. J., Pinto, L. H., Lamb, R. A., DeGrado, W. F. & Roberge, M., Feb 1 2013, In : PloS one. 8, 2, e55271.

Research output: Contribution to journalArticle

31 Scopus citations

Mutations in the parainfluenza virus 5 fusion protein reveal domains important for fusion triggering and metastability

Bose, S., Heath, C. M., Shah, P. A., Alayyoubi, M., Jardetzky, T. S. & Lamb, R. A., Dec 1 2013, In : Journal of virology. 87, 24, p. 13520-13531 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus

Wang, J., Wu, Y., Ma, C., Fiorin, G., Wang, J., Pinto, L. H., Lamb, R. A., Klein, M. L. & DeGrado, W. F., Jan 22 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 4, p. 1315-1320 6 p.

Research output: Contribution to journalArticle

138 Scopus citations

Structure of the Parainfluenza Virus 5 (PIV5) Hemagglutinin-Neuraminidase (HN) Ectodomain

Welch, B. D., Yuan, P., Bose, S., Kors, C. A., Lamb, R. A. & Jardetzky, T. S., Aug 1 2013, In : PLoS pathogens. 9, 8, e1003534.

Research output: Contribution to journalArticle

46 Scopus citations

The amphipathic helix of influenza a virus M2 protein is required for filamentous bud formation and scission of filamentous and spherical particles

Roberts, K. L., Leser, G. P., Ma, C. & Lamb, R. A., Sep 5 2013, In : Journal of virology. 87, 18, p. 9973-9982 10 p.

Research output: Contribution to journalArticle

37 Scopus citations
2012

Filamentous influenza virus enters cells via macropinocytosis

Rossman, J. S., Leser, G. P. & Lamb, R. A., Oct 1 2012, In : Journal of virology. 86, 20, p. 10950-10960 11 p.

Research output: Contribution to journalArticle

74 Scopus citations

Fusion activation by a headless parainfluenza virus 5 hemagglutinin- neuraminidase stalk suggests a modular mechanism for triggering

Bose, S., Zokarkar, A., Welch, B. D., Leser, G. P., Jardetzky, T. S. & Lamb, R. A., Sep 25 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 39, p. E2625-E2634

Research output: Contribution to journalArticle

55 Scopus citations

Reversible inhibition of fusion activity of a paramyxovirus fusion protein by an engineered disulfide bond in the membrane-proximal external region

Zokarkar, A., Connolly, S. A., Jardetzky, T. S. & Lamb, R. A., Nov 1 2012, In : Journal of virology. 86, 22, p. 12397-12401 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

Structure of the cleavage-activated prefusion form of the parainfluenza virus 5 fusion protein

Welch, B. D., Liu, Y., Kors, C. A., Leser, G. P., Jardetzky, T. S. & Lamb, R. A., Oct 9 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 41, p. 16672-16677 6 p.

Research output: Contribution to journalArticle

66 Scopus citations

Structure of the human metapneumovirus fusion protein with neutralizing antibody identifies a pneumovirus antigenic site

Wen, X., Krause, J. C., Leser, G. P., Cox, R. G., Lamb, R. A., Williams, J. V., Crowe, J. E. & Jardetzky, T. S., Apr 1 2012, In : Nature Structural and Molecular Biology. 19, 4, p. 461-463 3 p.

Research output: Contribution to journalArticle

34 Scopus citations

Structure of the Ulster Strain Newcastle Disease Virus Hemagglutinin-Neuraminidase Reveals Auto-Inhibitory Interactions Associated with Low Virulence

Yuan, P., Paterson, R. G., Leser, G. P., Lamb, R. A. & Jardetzky, T. S., Aug 1 2012, In : PLoS pathogens. 8, 8, e1002855.

Research output: Contribution to journalArticle

37 Scopus citations

The paramyxovirus fusion protein C-terminal region: Mutagenesis indicates an indivisible protein unit

Zokarkar, A. & Lamb, R. A., Mar 1 2012, In : Journal of virology. 86, 5, p. 2600-2609 10 p.

Research output: Contribution to journalArticle

16 Scopus citations
2011

A fluorescence polarization assay using an engineered human respiratory syncytial virus F protein as a direct screening platform

Park, M., Matsuura, H., Lamb, R. A., Barron, A. E. & Jardetzky, T. S., Feb 15 2011, In : Analytical Biochemistry. 409, 2, p. 195-201 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Capture and imaging of a prehairpin fusion intermediate of the paramyxovirus PIV5

Kim, Y. H., Donald, J. E., Grigoryan, G., Leser, G. P., Fadeev, A. Y., Lamb, R. A. & DeGrado, W. F., Dec 27 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 52, p. 20992-20997 6 p.

Research output: Contribution to journalArticle

42 Scopus citations