• 23981 Citations
1975 …2020

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3-azatetracyclo[5.2.1.15,8.01,5]undecane Derivatives: From wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant

Rey-Carrizo, M., Torres, E., Ma, C., Barniol-Xicota, M., Wang, J., Wu, Y., Naesens, L., Degrado, W. F., Lamb, R. A., Pinto, L. H. & Vázquez, S., Nov 27 2013, In : Journal of Medicinal Chemistry. 56, 22, p. 9265-9274 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

Ability of the hydrophobic fusion-related external domain of a paramyxovirus F protein to act as a membrane anchor

Paterson, R. G. & Lamb, R. A., Feb 13 1987, In : Cell. 48, 3, p. 441-452 12 p.

Research output: Contribution to journalArticle

60 Scopus citations

A Chimeric Pneumovirus Fusion Protein Carrying Neutralizing Epitopes of Both MPV and RSV

Wen, X., Pickens, J., Mousa, J. J., Leser, G. P., Lamb, R. A., Crowe, J. E. & Jardetzky, T. S., May 2016, In : PloS one. 11, 5, e0155917.

Research output: Contribution to journalArticle

9 Scopus citations

A core trimer of the paramyxovirus fusion protein: Parallels to influenza virus hemagglutinin and HIV-1 gp41

Joshi, S. B., Dutch, R. E. & Lamb, R. A., Aug 15 1998, In : Virology. 248, 1, p. 20-34 15 p.

Research output: Contribution to journalArticle

147 Scopus citations

Activation of a paramyxovirus fusion protein is modulated by inside-out signaling from the cytoplasmic tail

Waning, D. L., Russell, C. J., Jardetzky, T. S. & Lamb, R. A., Jun 22 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 25, p. 9217-9222 6 p.

Research output: Contribution to journalArticle

62 Scopus citations

Activation of the M2 ion channel of influenza virus: a role for the transmembrane domain histidine residue

Wang, C., Lamb, R. A. & Pinto, L. H., Jan 1 1995, In : Biophysical Journal. 69, 4, p. 1363-1371 9 p.

Research output: Contribution to journalArticle

201 Scopus citations

A dual-functional paramyxovirus F protein regulatory switch segment: Activation and membrane fusion

Russell, C. J., Kantor, K. L., Jardetzky, T. S. & Lamb, R. A., Oct 27 2003, In : Journal of Cell Biology. 163, 2, p. 363-374 12 p.

Research output: Contribution to journalArticle

87 Scopus citations

A fluorescence polarization assay using an engineered human respiratory syncytial virus F protein as a direct screening platform

Park, M., Matsuura, H., Lamb, R. A., Barron, A. E. & Jardetzky, T. S., Feb 15 2011, In : Analytical Biochemistry. 409, 2, p. 195-201 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

A functionally defined model for the M2 proton channel of influenza A virus suggests a mechanism for its ion selectivity

Pinto, L. H., Dieckmann, G. R., Gandhi, C. S., Papworth, C. G., Braman, J., Shaughnessy, M. A., Lear, J. D., Lamb, R. A. & Degrado, W. F., Oct 14 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 21, p. 11301-11306 6 p.

Research output: Contribution to journalArticle

301 Scopus citations

A glycine to alanine substitution in the paramyxovirus SV5 fusion peptide increases the initial rate of fusion

Bagai, S. & Lamb, R. A., Nov 24 1997, In : Virology. 238, 2, p. 283-290 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Alterations to influenza virus hemagglutinin cytoplasmic tail modulate virus infectivity

Simpson, D. A. & Lamb, R. A., Jan 1 1992, In : Journal of virology. 66, 2, p. 790-803 14 p.

Research output: Contribution to journalArticle

49 Scopus citations

Analysis and design of ion channel proteins

Degrado', W. F., Lear, J. I., Oieckmann, G. R., Schneider', J., Pinto, L. H., Gandhi, C. S. & Lamb, R. A., Dec 1 1997, In : FASEB Journal. 11, 9

Research output: Contribution to journalArticle

4 Scopus citations

Analysis and gene assignment of mRNAs of a paramyxovirus, simian virus 5

Paterson, R. G., Harris, T. J. R. & Lamb, R. A., Oct 30 1984, In : Virology. 138, 2, p. 310-323 14 p.

Research output: Contribution to journalArticle

56 Scopus citations

Analysis in vivo of GRP78-BiP/substrate interactions and their role in induction of the GRP78-BiP gene

Ng, D. T. W., Watowich, S. S. & Lamb, R. A., Jan 1 1992, In : Molecular biology of the cell. 3, 2, p. 143-155 13 p.

Research output: Contribution to journalArticle

52 Scopus citations

Analysis of parainfluenza virus-5 hemagglutinin-neuraminidase protein mutants that are blocked in internalization and degradation

Robach, J. G. & Lamb, R. A., Oct 1 2010, In : Virology. 406, 2, p. 189-201 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Analysis of the pH requirement for membrane fusion of different isolates of the paramyxovirus parainfluenza virus 5

Bissonnette, M. L. Z., Connolly, S. A., Young, D. F., Randall, R. E., Paterson, R. G. & Lamb, R. A., Mar 1 2006, In : Journal of virology. 80, 6, p. 3071-3077 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Analysis of the pore structure of the influenza A virus M2 ion channel by the substituted-cysteine accessibility method

Shuck, K., Lamb, R. A. & Pinto, L. H., Sep 2 2000, In : Journal of virology. 74, 17, p. 7755-7761 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

Analysis of the posttranslational modifications of the influenza virus M2 protein

Holsinger, L. J., Shaughnessy, M. A., Micko, A., Pinto, L. H. & Lamb, R. A., Feb 1 1995, In : Journal of Virology. 69, 2, p. 1219-1225 7 p.

Research output: Contribution to journalArticle

100 Scopus citations

Analysis of the relationship between cleavability of a paramyxovirus fusion protein and length of the connecting peptide

Paterson, R. G., Shaughnessy, M. A. & Lamb, R. A., Jan 1 1989, In : Journal of virology. 63, 3, p. 1293-1301 9 p.

Research output: Contribution to journalArticle

52 Scopus citations

An amantadine-sensitive chimeric BM2 ion channel of influenza B virus has implications for the mechanism of drug inhibition

Ohigashi, Y., Ma, C., Jing, X., Balannick, V., Pinto, L. H. & Lamb, R. A., Nov 3 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 44, p. 18775-18779 5 p.

Research output: Contribution to journalArticle

40 Scopus citations

A new influenza virus virulence determinant: The NS1 protein four C-terminal residues modulate pathogenicity

Jackson, D., Hossain, M. J., Hickman, D., Perez, D. R. & Lamb, R. A., Mar 18 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 11, p. 4381-4386 6 p.

Research output: Contribution to journalArticle

291 Scopus citations

A ninth unique influenza virus-coded polypeptide.

Lamb, R. A. & Choppin, P. W., Feb 25 1980, In : Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 288, 1029, p. 327-333 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

A pH-dependent conformational ensemble mediates proton transport through the influenza A/M2 protein

Polishchuk, A. L., Lear, J. D., Ma, C., Lamb, R. A., Pinto, L. H. & Degrado, W. F., Nov 30 2010, In : Biochemistry. 49, 47, p. 10061-10071 11 p.

Research output: Contribution to journalArticle

18 Scopus citations
75 Scopus citations

A role for caveolin 1 in assembly and budding of the paramyxovirus parainfluenza virus 5

Ravid, D., Leser, G. P. & Lamb, R. A., Oct 2010, In : Journal of virology. 84, 19, p. 9749-9759 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Asp44 stabilizes the Trp41 gate of the M2 proton channel of influenza a virus

Ma, C., Fiorin, G., Carnevale, V., Wang, J., Lamb, R. A., Klein, M. L., Wu, Y., Pinto, L. H. & Degrado, W. F., Nov 5 2013, In : Structure. 21, 11, p. 2033-2041 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

A specific sub-set of host-cell mRNAs prime influenza virus mRNA synthesis

Shaw, M. W. & Lamb, R. A., Jan 1 1984, In : Virus Research. 1, 6, p. 455-467 13 p.

Research output: Contribution to journalArticle

41 Scopus citations

Bimolecular complementation of paramyxovirus fusion and hemagglutinin-neuraminidase proteins enhances fusion: Implications for the mechanism of fusion triggering

Connolly, S. A., Leser, G. P., Jardetzky, T. S. & Lamb, R. A., Nov 1 2009, In : Journal of virology. 83, 21, p. 10857-10868 12 p.

Research output: Contribution to journalArticle

73 Scopus citations

Biological activity of paramyxovirus fusion proteins: Factors influencing formation of syncytia

Horvath, C. M., Paterson, R. G., Shaughnessy, M. A., Wood, R. & Lamb, R. A., Jan 1 1992, In : Journal of Virology. 66, 7, p. 4564-4569 6 p.

Research output: Contribution to journalArticle

149 Scopus citations

Capture and imaging of a prehairpin fusion intermediate of the paramyxovirus PIV5

Kim, Y. H., Donald, J. E., Grigoryan, G., Leser, G. P., Fadeev, A. Y., Lamb, R. A. & DeGrado, W. F., Dec 27 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 52, p. 20992-20997 6 p.

Research output: Contribution to journalArticle

43 Scopus citations

Cell surface expression and orientation in membranes of the 44-amino-acid SH protein of simian virus 5

Hiebert, S. W., Richardson, C. D. & Lamb, R. A., Jan 1 1988, In : Journal of Virology. 62, 7, p. 2347-2357 11 p.

Research output: Contribution to journalArticle

31 Scopus citations

Cell surface expression of biologically active influenza C virus HEF glycoprotein expressed from cDNA

Pekosz, A. & Lamb, R. A., Jan 1 1999, In : Journal of virology. 73, 10, p. 8808-8812 5 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Cell surface expression of glycosylated, nonglycosylated, and truncated forms of a cytoplasmic protein pyruvate kinase.

Hiebert, S. W. & Lamb, R. A., Sep 1988, In : The Journal of cell biology. 107, 3, p. 865-876 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

Characterization of EBV gB indicates properties of both class I and class II viral fusion proteins

Backovic, M., Leser, G. P., Lamb, R. A., Longnecker, R. & Jardetzky, T. S., Nov 10 2007, In : Virology. 368, 1, p. 102-113 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Characterization of inhibition of M2 ion channel activity by BL-1743, an inhibitor of influenza A virus

Tu, Q., Pinto, L. H., Luo, G., Shaughnessy, M. A., Mullaney, D., Kurtz, S., Krystal, M. & Lamb, R. A., Jun 27 1996, In : Journal of virology. 70, 7, p. 4246-4252 7 p.

Research output: Contribution to journalArticle

43 Scopus citations

Characterization of the influenza virus M2 integral membrane protein and expression at the infected-cell surface from cloned cDNA

Zebedee, S. L., Richardson, C. D. & Lamb, R. A., Jan 1 1985, In : Journal of virology. 56, 2, p. 502-511 10 p.

Research output: Contribution to journalArticle

Open Access
92 Scopus citations

Characterization of the membrane association of the influenza virus matrix protein in living cells

Zhang, J. & Lamb, R. A., Nov 15 1996, In : Virology. 225, 2, p. 255-266 12 p.

Research output: Contribution to journalArticle

82 Scopus citations

Chemical rescue of histidine selectivity filter mutants of the M2 ion channel of influenza A virus

Venkataraman, P., Lamb, R. A. & Pinto, L. H., Jun 3 2005, In : Journal of Biological Chemistry. 280, 22, p. 21463-21472 10 p.

Research output: Contribution to journalArticle

80 Scopus citations

Comparison of differing cytopathic effects in human airway epithelium of parainfluenza virus 5 (W3A), parainfluenza virus type 3, and respiratory syncytial virus

Zhang, L., Collins, P. L., Lamb, R. A. & Pickles, R. J., Dec 5 2011, In : Virology. 421, 1, p. 67-77 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

Comparison of the relative roles of the F and HN surface glycoproteins of the paramyxovirus simian virus 5 in inducing protective immunity

Paterson, R. G., Lamb, R. A., Moss, B. & Murphy, B. R., Jan 1 1987, In : Journal of virology. 61, 6, p. 1972-1977 6 p.

Research output: Contribution to journalArticle

Open Access
31 Scopus citations

Complete nucleotide sequence of the neuraminidase gene of influenza B virus

Shaw, M. W., Lamb, R. A., Erickson, B. W., Briedis, D. J. & Choppin, P. W., Dec 1 1982, In : Proceedings of the National Academy of Sciences of the United States of America. 79, 22 I, p. 6817-6821 5 p.

Research output: Contribution to journalArticle

60 Scopus citations
66 Scopus citations

Conserved Cysteine-Rich Domain of Paramyxovirus Simian Virus 5 V Protein Plays an Important Role in Blocking Apoptosis

Sun, M., Rothermel, T. A., Shuman, L., Aligo, J. A., Xu, S., Lin, Y., Lamb, R. A. & He, B., May 1 2004, In : Journal of virology. 78, 10, p. 5068-5078 11 p.

Research output: Contribution to journalArticle

42 Scopus citations

Conserved glycine residues in the fusion peptide of the paramyxovirus fusion protein regulate activation of the native state

Russell, C. J., Jardetzky, T. S. & Lamb, R. A., Dec 1 2004, In : Journal of virology. 78, 24, p. 13727-13742 16 p.

Research output: Contribution to journalArticle

51 Scopus citations
21 Scopus citations

Creative Financing of the Infrastructure

LAMB, ROBERT. A., Jan 1 1984, In : Annals of the New York Academy of Sciences. 431, 1, p. 54-58 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Cu(II) inhibition of the proton translocation machinery of the influenza a virus M2 protein

Gandhi, C. S., Shuck, K., Lear, J. D., Dieckmann, G. R., DeGrado, W. F., Lamb, R. A. & Pinto, L. H., Feb 26 1999, In : Journal of Biological Chemistry. 274, 9, p. 5474-5482 9 p.

Research output: Contribution to journalArticle

102 Scopus citations
29 Scopus citations

Deletion of the cytoplasmic tail of the fusion protein of the paramyxovirus simian virus 5 affects fusion pore enlargement

Dutch, R. E. & Lamb, R. A., May 28 2001, In : Journal of virology. 75, 11, p. 5363-5369 7 p.

Research output: Contribution to journalArticle

45 Scopus citations

Design and pharmacological characterization of inhibitors of amantadine-resistant mutants of the M2 ion channel of influenza A virus

Balannik, V., Wang, J., Ohigashi, Y., Jing, X., Magavern, E., Lamb, R. A., DeGrado, W. F. & Pinto, L. H., Dec 22 2009, In : Biochemistry. 48, 50, p. 11872-11882 11 p.

Research output: Contribution to journalArticle

83 Scopus citations