• 23981 Citations
1975 …2020

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Article
2011

Comparison of differing cytopathic effects in human airway epithelium of parainfluenza virus 5 (W3A), parainfluenza virus type 3, and respiratory syncytial virus

Zhang, L., Collins, P. L., Lamb, R. A. & Pickles, R. J., Dec 5 2011, In : Virology. 421, 1, p. 67-77 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

Exploring organosilane amines as potent inhibitors and structural probes of influenza a virus M2 proton channel

Wang, J., Ma, C., Wu, Y., Lamb, R. A., Pinto, L. H. & Degrado, W. F., Sep 7 2011, In : Journal of the American Chemical Society. 133, 35, p. 13844-13847 4 p.

Research output: Contribution to journalArticle

51 Scopus citations

Exploring the requirements for the hydrophobic scaffold and polar amine in inhibitors of M2 from influenza A virus

Wang, J., Ma, C., Balannik, V., Pinto, L. H., Lamb, R. A. & Degrado, W. F., Apr 14 2011, In : ACS Medicinal Chemistry Letters. 2, 4, p. 307-312 6 p.

Research output: Contribution to journalArticle

44 Scopus citations

Exploring the size limit of templates for inhibitors of the M2 ion channel of influenza A virus

Duque, M. D., Ma, C., Torres, E., Wang, J., Naesens, L., Juárez-Jiménez, J., Camps, P., Luque, F. J., Degrado, W. F., Lamb, R. A., Pinto, L. H. & Vázquez, S., Apr 28 2011, In : Journal of Medicinal Chemistry. 54, 8, p. 2646-2657 12 p.

Research output: Contribution to journalArticle

55 Scopus citations

Influenza virus is not restricted by tetherin whereas influenza VLP production is restricted by tetherin

Watanabe, R., Leser, G. P. & Lamb, R. A., Aug 15 2011, In : Virology. 417, 1, p. 50-56 7 p.

Research output: Contribution to journalArticle

50 Scopus citations

Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2

Wang, J., Ma, C., Fiorin, G., Carnevale, V., Wang, T., Hu, F., Lamb, R. A., Pinto, L. H., Hong, M., Klein, M. L. & Degrado, W. F., Aug 17 2011, In : Journal of the American Chemical Society. 133, 32, p. 12834-12841 8 p.

Research output: Contribution to journalArticle

96 Scopus citations

Structure and mutagenesis of the parainfluenza virus 5 hemagglutinin-neuraminidase stalk domain reveals a four-helix bundle and the role of the stalk in fusion promotion

Bose, S., Welch, B. D., Kors, C. A., Yuan, P., Jardetzky, T. S. & Lamb, R. A., Dec 1 2011, In : Journal of virology. 85, 24, p. 12855-12866 12 p.

Research output: Contribution to journalArticle

63 Scopus citations

Structure of the Newcastle disease virus hemagglutinin-neuraminidase (HN) ectodomain reveals a four-helix bundle stalk

Yuan, P., Swanson, K. A., Leser, G. P., Paterson, R. G., Lamb, R. A. & Jardetzky, T. S., Sep 6 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 36, p. 14920-14925 6 p.

Research output: Contribution to journalArticle

107 Scopus citations
2010

Analysis of parainfluenza virus-5 hemagglutinin-neuraminidase protein mutants that are blocked in internalization and degradation

Robach, J. G. & Lamb, R. A., Oct 1 2010, In : Virology. 406, 2, p. 189-201 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

A pH-dependent conformational ensemble mediates proton transport through the influenza A/M2 protein

Polishchuk, A. L., Lear, J. D., Ma, C., Lamb, R. A., Pinto, L. H. & Degrado, W. F., Nov 30 2010, In : Biochemistry. 49, 47, p. 10061-10071 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

A role for caveolin 1 in assembly and budding of the paramyxovirus parainfluenza virus 5

Ravid, D., Leser, G. P. & Lamb, R. A., Oct 2010, In : Journal of virology. 84, 19, p. 9749-9759 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Functional studies and modeling of pore-lining residue mutants of the influenza A virus M2 ion channel

Balannik, V., Carnevale, V., Fiorin, G., Levine, B. G., Lamb, R. A., Klein, M. L., DeGrado, W. F. & Pinto, L. H., Feb 2 2010, In : Biochemistry. 49, 4, p. 696-708 13 p.

Research output: Contribution to journalArticle

94 Scopus citations

Influenza virus budding does not require a functional AAA+ ATPase, VPS4

Watanabe, R. & Lamb, R. A., Oct 1 2010, In : Virus Research. 153, 1, p. 58-63 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

Influenza virus M2 ion channel protein is necessary for filamentous virion formation

Rossman, J. S., Jing, X., Leser, G. P., Balannik, V., Pinto, L. H. & Lamb, R. A., May 1 2010, In : Journal of virology. 84, 10, p. 5078-5088 11 p.

Research output: Contribution to journalArticle

122 Scopus citations

Influenza Virus M2 Protein Mediates ESCRT-Independent Membrane Scission

Rossman, J. S., Jing, X., Leser, G. P. & Lamb, R. A., Sep 1 2010, In : Cell. 142, 6, p. 902-913 12 p.

Research output: Contribution to journalArticle

306 Scopus citations

Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus

Acharya, R., Carnevale, V., Fiorin, G., Levine, B. G., Polishchuk, A. L., Balannik, V., Samish, I., Lamb, R. A., Pinto, L. H., DeGrado, W. F. & Klein, M. L., Aug 24 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 34, p. 15075-15080 6 p.

Research output: Contribution to journalArticle

184 Scopus citations

Structure of the Newcastle disease virus F protein in the post-fusion conformation

Swanson, K., Wen, X., Leser, G. P., Paterson, R. G., Lamb, R. A. & Jardetzky, T. S., Jul 1 2010, In : Virology. 402, 2, p. 372-379 8 p.

Research output: Contribution to journalArticle

64 Scopus citations
2009

An amantadine-sensitive chimeric BM2 ion channel of influenza B virus has implications for the mechanism of drug inhibition

Ohigashi, Y., Ma, C., Jing, X., Balannick, V., Pinto, L. H. & Lamb, R. A., Nov 3 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 44, p. 18775-18779 5 p.

Research output: Contribution to journalArticle

40 Scopus citations

Bimolecular complementation of paramyxovirus fusion and hemagglutinin-neuraminidase proteins enhances fusion: Implications for the mechanism of fusion triggering

Connolly, S. A., Leser, G. P., Jardetzky, T. S. & Lamb, R. A., Nov 1 2009, In : Journal of virology. 83, 21, p. 10857-10868 12 p.

Research output: Contribution to journalArticle

73 Scopus citations

Design and pharmacological characterization of inhibitors of amantadine-resistant mutants of the M2 ion channel of influenza A virus

Balannik, V., Wang, J., Ohigashi, Y., Jing, X., Magavern, E., Lamb, R. A., DeGrado, W. F. & Pinto, L. H., Dec 22 2009, In : Biochemistry. 48, 50, p. 11872-11882 11 p.

Research output: Contribution to journalArticle

83 Scopus citations

Functional Analysis of the Transmembrane Domain in Paramyxovirus F Protein-Mediated Membrane Fusion

Bissonnette, M. L. Z., Donald, J. E., DeGrado, W. F., Jardetzky, T. S. & Lamb, R. A., Feb 13 2009, In : Journal of Molecular Biology. 386, 1, p. 14-36 23 p.

Research output: Contribution to journalArticle

47 Scopus citations

Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel

Ma, C., Polishchuk, A. L., Ohigashi, Y., Stouffer, A. L., Schön, A., Magavern, E., Jing, X., Lear, J. D., Freire, E., Lamb, R. A., DeGrado, W. F. & Pinto, L. H., Jul 28 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 30, p. 12283-12288 6 p.

Research output: Contribution to journalArticle

119 Scopus citations
2008

A new influenza virus virulence determinant: The NS1 protein four C-terminal residues modulate pathogenicity

Jackson, D., Hossain, M. J., Hickman, D., Perez, D. R. & Lamb, R. A., Mar 18 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 11, p. 4381-4386 6 p.

Research output: Contribution to journalArticle

291 Scopus citations

Domain architecture and oligomerization properties of the paramyxovirus PIV 5 hemagglutinin-neuraminidase (HN) protein

Yuan, P., Leser, G. P., Demeler, B., Lamb, R. A. & Jardetzky, T. S., Sep 1 2008, In : Virology. 378, 2, p. 282-291 10 p.

Research output: Contribution to journalArticle

39 Scopus citations

Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel

Jing, X., Ma, C., Ohigashi, Y., Oliveira, F. A., Jardetzky, T. S., Pinto, L. H. & Lamb, R. A., Aug 5 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 31, p. 10967-10972 6 p.

Research output: Contribution to journalArticle

125 Scopus citations

Identification of the pore-lining residues of the BM2 ion channel protein of influenza B virus

Ma, C., Soto, C. S., Ohigashi, Y., Taylor, A., Bournas, V., Glawe, B., Udo, M. K., DeGrado, W. F., Lamb, R. A. & Pinto, L. H., Jun 6 2008, In : Journal of Biological Chemistry. 283, 23, p. 15921-15931 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

The influenza A virus spliced messenger RNA M mRNA3 is not required for viral replication in tissue culture

Jackson, D. & Lamb, R. A., Dec 1 2008, In : Journal of General Virology. 89, 12, p. 3097-3101 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

The influenza virus M2 protein cytoplasmic tail interacts with the M1 protein and influences virus assembly at the site of virus budding

Chen, B. J., Leser, G. P., Jackson, D. & Lamb, R. A., Oct 1 2008, In : Journal of virology. 82, 20, p. 10059-10070 12 p.

Research output: Contribution to journalArticle

165 Scopus citations

The Interplay of Functional Tuning, Drug Resistance, and Thermodynamic Stability in the Evolution of the M2 Proton Channel from the Influenza A Virus

Stouffer, A. L., Ma, C., Cristian, L., Ohigashi, Y., Lamb, R. A., Lear, J. D., Pinto, L. H. & DeGrado, W. F., Jul 9 2008, In : Structure. 16, 7, p. 1067-1076 10 p.

Research output: Contribution to journalArticle

46 Scopus citations

The oligomeric state of the active BM2 ion channel protein of influenza B virus

Balannik, V., Lamb, R. A. & Pinto, L. H., Feb 22 2008, In : Journal of Biological Chemistry. 283, 8, p. 4895-4904 10 p.

Research output: Contribution to journalArticle

30 Scopus citations
2007

Characterization of EBV gB indicates properties of both class I and class II viral fusion proteins

Backovic, M., Leser, G. P., Lamb, R. A., Longnecker, R. & Jardetzky, T. S., Nov 10 2007, In : Virology. 368, 1, p. 102-113 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Influenza virus hemagglutinin and neuraminidase, but not the matrix protein, are required for assembly and budding of plasmid-derived virus-like particles

Chen, B. J., Leser, G. P., Morita, E. & Lamb, R. A., Jul 1 2007, In : Journal of virology. 81, 13, p. 7111-7123 13 p.

Research output: Contribution to journalArticle

209 Scopus citations

Recombinant parainfluenza virus 5 (PIV5) expressing the influenza A virus hemagglutinin provides immunity in mice to influenza A virus challenge

Tompkins, S. M., Lin, Y., Leser, G. P., Kramer, K. A., Haas, D. L., Howerth, E. W., Xu, J., Kennett, M. J., Durbin, R. K., Durbin, J. E., Tripp, R., Lamb, R. A. & He, B., May 25 2007, In : Virology. 362, 1, p. 139-150 12 p.

Research output: Contribution to journalArticle

45 Scopus citations
2006

Analysis of the pH requirement for membrane fusion of different isolates of the paramyxovirus parainfluenza virus 5

Bissonnette, M. L. Z., Connolly, S. A., Young, D. F., Randall, R. E., Paterson, R. G. & Lamb, R. A., Mar 1 2006, In : Journal of virology. 80, 6, p. 3071-3077 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Functional antibody arrays through metal ion-affinity templates

Vega, R. A., Maspoch, D., Shen, C. K. F., Kakkassery, J. J., Chen, B. J., Lamb, R. A. & Mirkin, C. A., Nov 1 2006, In : ChemBioChem. 7, 11, p. 1653-1657 5 p.

Research output: Contribution to journalArticle

26 Scopus citations

Influenza A virus NS1 protein binds p85β and activates phosphatidylinositol-3-kinase signaling

Hale, B. G., Jackson, D., Chen, Y. H., Lamb, R. A. & Randall, R. E., Sep 19 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 38, p. 14194-14199 6 p.

Research output: Contribution to journalArticle

210 Scopus citations

Paramyxovirus fusion: Real-time measurement of parainfluenza virus 5 virus-cell fusion

Connolly, S. A. & Lamb, R. A., Nov 25 2006, In : Virology. 355, 2, p. 203-212 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Refolding of a paramyxovirus F protein from prefusion to postfusion conformations observed by liposome binding and electron microscopy

Connolly, S. A., Leser, G. P., Yin, H. S., Jardetzky, T. S. & Lamb, R. A., Nov 21 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 47, p. 17903-17908 6 p.

Research output: Contribution to journalArticle

73 Scopus citations

Structure of the parainfluenza virus 5 F protein in its metastable, prefusion conformation

Yin, H. S., Wen, X., Paterson, R. G., Lamb, R. A. & Jardetzky, T. S., Jan 5 2006, In : Nature. 439, 7072, p. 38-44 7 p.

Research output: Contribution to journalArticle

314 Scopus citations
2005

Chemical rescue of histidine selectivity filter mutants of the M2 ion channel of influenza A virus

Venkataraman, P., Lamb, R. A. & Pinto, L. H., Jun 3 2005, In : Journal of Biological Chemistry. 280, 22, p. 21463-21472 10 p.

Research output: Contribution to journalArticle

80 Scopus citations

Evidence for a new viral late-domain core sequence, FPIV, necessary for budding of a paramyxovirus

Schmitt, A. P., Leser, G. P., Morita, E., Sundquist, W. I. & Lamb, R. A., Mar 1 2005, In : Journal of virology. 79, 5, p. 2988-2997 10 p.

Research output: Contribution to journalArticle

124 Scopus citations

Influenza virus assembly and budding in raft-derived microdomains: A quantitative analysis of the surface distribution of HA, NA and M2 proteins

Leser, G. P. & Lamb, R. A., Nov 25 2005, In : Virology. 342, 2, p. 215-227 13 p.

Research output: Contribution to journalArticle

147 Scopus citations
98 Scopus citations

Structural studies of the parainfluenza virus 5 hemagglutinin-neuraminidase tetramer in complex with its receptor, sialyllactose

Yuan, P., Thompson, T. B., Wurzburg, B. A., Paterson, R. G., Lamb, R. A. & Jardetzky, T. S., May 1 2005, In : Structure. 13, 5, p. 803-815 13 p.

Research output: Contribution to journalArticle

150 Scopus citations

Structure of the uncleaved ectodomain of the paramyxovirus (hPIV3) fusion protein

Yin, H. S., Paterson, R. G., Wen, X., Lamb, R. A. & Jardetzky, T. S., Jun 28 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 26, p. 9288-9293 6 p.

Research output: Contribution to journalArticle

236 Scopus citations
2004

Activation of a paramyxovirus fusion protein is modulated by inside-out signaling from the cytoplasmic tail

Waning, D. L., Russell, C. J., Jardetzky, T. S. & Lamb, R. A., Jun 22 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 25, p. 9217-9222 6 p.

Research output: Contribution to journalArticle

62 Scopus citations

Conserved Cysteine-Rich Domain of Paramyxovirus Simian Virus 5 V Protein Plays an Important Role in Blocking Apoptosis

Sun, M., Rothermel, T. A., Shuman, L., Aligo, J. A., Xu, S., Lin, Y., Lamb, R. A. & He, B., May 1 2004, In : Journal of virology. 78, 10, p. 5068-5078 11 p.

Research output: Contribution to journalArticle

42 Scopus citations

Conserved glycine residues in the fusion peptide of the paramyxovirus fusion protein regulate activation of the native state

Russell, C. J., Jardetzky, T. S. & Lamb, R. A., Dec 1 2004, In : Journal of virology. 78, 24, p. 13727-13742 16 p.

Research output: Contribution to journalArticle

51 Scopus citations

Viral ion channels as models for ion transport and targets for antiviral drug action

Pinto, L. H. & Lamb, R. A., Feb 27 2004, In : FEBS Letters. 560, 1-3, p. 1-2 2 p.

Research output: Contribution to journalArticle

10 Scopus citations
2003

A dual-functional paramyxovirus F protein regulatory switch segment: Activation and membrane fusion

Russell, C. J., Kantor, K. L., Jardetzky, T. S. & Lamb, R. A., Oct 27 2003, In : Journal of Cell Biology. 163, 2, p. 363-374 12 p.

Research output: Contribution to journalArticle

87 Scopus citations