Robert Dettman

  • 1593 Citations
1990 …2020
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Personal profile

Research Interests

My interest is in cell fate decisions that lead either to normal development or pathology. In many cases, epithelial cells are induced to undergo cell-shape and migratory changes that allow them to become mesenchymal fibroblasts. This is a process called epithelial-mesenchymal transition or EMT. Fibroblasts then differentiate into new cell types or, in the case of fibrotic disease, abnormal myofibroblasts. In the bladder, outlet obstruction leads to permanent changes to the bladder wall resulting in either a small, high resistance bladder or a very large, atonic bladder. In either case, this leads to difficulties in emptying the bladder and this causes retrograde pressure on the ureters and kidney injury. While clinically this problem is well understood, little is known about the cellular changes that affect the bladder wall. We are using Cre-loxP cell labeling techniques in combination with a bladder outlet obstruction model in mice. Current projects involve the use of the "Confetti" reporter to label small clones of cells in the adult bladder prior to injury. Inducible Cre expression in the urothelium, stroma and serosa will activate the color in these cells and bladders will be injured. We will then be able to determine which cells contribute myofibroblasts to the bladder wall and if this involves EMT. A second interest is in bladder regeneration. It is well reported that the bladder can re-grow after resection. It is also known that when acellular, extracellular matrix patches are used to replace resected bladders that endogenous cells migrate and repopulate the acellular patch (AKA augment). We have found that re-growth of the bladder after resection involves partial regeneration of the bladder in association with fibrotic changes to the bladder wall throughout the entire bladder. Future studies will be to study cell fates during regeneration (using Cre labeling) as well as drugs that could potentially improve the way in which the bladder regenerates.

Training Experience

1999Postdoctoral Fellowship, University of California, San Francisco

Education/Academic qualification

PhD, Indiana University

… → 1994

Research interests

  • Bladder and Urinary Tract
  • Cell Adhesion Mechanisms
  • Cell Biology
  • Connective Tissue Biology
  • Developmental Biology
  • Developmental Genetics
  • Fibrosis
  • Stem Cells

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Mesoderm Medicine & Life Sciences
Tubulin Medicine & Life Sciences
Integrins Medicine & Life Sciences
Pericardium Medicine & Life Sciences
Epithelial-Mesenchymal Transition Medicine & Life Sciences
Bone Morphogenetic Proteins Medicine & Life Sciences
Lung Medicine & Life Sciences
Hyperoxia Medicine & Life Sciences

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Grants 2001 2020

Research Output 1990 2018

  • 1593 Citations
  • 27 Article
  • 2 Editorial
  • 1 Short survey
Bone Morphogenetic Proteins
Brain Injuries
White Matter

Compensatory regrowth of the mouse bladder after partial cystectomy

Delos Santos, G. B., Devine, M. Y., Wetterlin, J., Firmiss, P. R., Kukulka, N. A., Bowen, D. K., Gong, E. M. & Dettman, R., Nov 1 2018, In : PloS one. 13, 11, e0206436.

Research output: Contribution to journalArticle

Urinary Bladder

Intrauterine growth restriction and hyperoxia as a cause of white matter injury

Chang, J. L., Bashir, M., Santiago, C., Farrow, K., Fung, C., Brown, A. S., Dettman, R. & Dizon, M. L. V., Dec 1 2018, In : Developmental Neuroscience. 40, 4, p. 344-357 14 p.

Research output: Contribution to journalArticle

Wounds and Injuries
Placental Insufficiency

Intrauterine Growth Restriction and Hyperoxia as a Cause of White Matter Injury

Chang, J. L., Bashir, M., Santiago, C., Farrow, K., Fung, C., Brown, A. S., Dettman, R. W. & Dizon, M. L. V., Nov 14 2018, In : Developmental Neuroscience. p. 1-14 14 p.

Research output: Contribution to journalArticle

Wounds and Injuries
Placental Insufficiency
Thromboxane A2
3 Citations (Scopus)
Bone Morphogenetic Proteins
Bone Morphogenetic Protein Receptors
Bone and Bones