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Personal profile

Research Interests

We study the structure, function and dynamic properties of intermediate filaments in essential mammalian cell biological phenomena. Our work focuses on the role of cytoskeletal intermediate filaments in regulating cell shape, mechanics, signal transduction, adhesion, cell motility and molecular cross talk with microtubules and microfilaments. We are also determining the roles of the nuclear lamins in regulating nuclear architecture and chromatin organization.

Education/Academic qualification

PhD, Princeton University

… → 1967

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  • 8 Similar Profiles
Intermediate Filaments Medicine & Life Sciences
Lamins Medicine & Life Sciences
Vimentin Medicine & Life Sciences
Intermediate Filament Proteins Medicine & Life Sciences
Lamin Type A Medicine & Life Sciences
Nuclear Lamina Medicine & Life Sciences
Microtubules Medicine & Life Sciences
Keratins Medicine & Life Sciences

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Grants 2001 2022

Giant Axonal Neuropathy
Intermediate Filaments
Pathology
Proteins
Ubiquitin-Protein Ligases
Vimentin
Intermediate Filaments
Mechanics
Actin Cytoskeleton
Microtubules
Intermediate Filament Proteins
Proteasome Endopeptidase Complex
Ubiquitin
Proteolysis
Intermediate Filaments
Acute Lung Injury
Lung Injury
Influenza A virus
Human Influenza

Research Output 1969 2019

2 Citations (Scopus)

Kinesin-dependent transport of keratin filaments: A unified mechanism for intermediate filament transport

Robert, A., Tian, P., Adam, S. A., Kittisopikul, M., Jaqaman, K., Goldman, R. & Gelfand, V. I., Jan 1 2019, In : FASEB Journal. 33, 1, p. 388-399 12 p.

Research output: Contribution to journalArticle

Kinesin
Intermediate Filaments
Keratins
Clustered Regularly Interspaced Short Palindromic Repeats
Vimentin
6 Citations (Scopus)

Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing

Butin-Israeli, V., Bui, T. M., Wiesolek, H. L., Mascarenhas, L., Lee, J. J., Mehl, L. C., Knutson, K. R., Adam, S. A., Goldman, R., Beyder, A., Wiesmuller, L., Hanauer, S. B. & Sumagin, R., Feb 1 2019, In : Journal of Clinical Investigation. 129, 2, p. 712-726 15 p.

Research output: Contribution to journalArticle

Genomic Instability
Wound Healing
Neutrophils
Homologous Recombination
Inflammation

Probe Sensitivity to Cortical versus Intracellular Cytoskeletal Network Stiffness

Vahabikashi, A., Park, C. Y., Perkumas, K., Zhang, Z., Deurloo, E. K., Wu, H., Weitz, D. A., Stamer, W. D., Goldman, R., Fredberg, J. J. & Johnson, M., Feb 5 2019, In : Biophysical Journal. 116, 3, p. 518-529 12 p.

Research output: Contribution to journalArticle

Atomic Force Microscopy
Traction
Vimentin
Microscopy
Fibroblasts
19 Citations (Scopus)

Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins

Stephens, A. D., Liu, P. Z., Banigan, E. J., Almassalha, L. M., Backman, V., Adam, S. A., Goldman, R. D. & Marko, J. F., Jan 15 2018, In : Molecular biology of the cell. 29, 2, p. 220-233 14 p.

Research output: Contribution to journalArticle

Histone Code
Lamins
Blister
Chromatin
Heterochromatin
11 Citations (Scopus)

Mapping 3D genome organization relative to nuclear compartments using TSA-Seq as a cytological ruler

Chen, Y., Zhang, Y., Wang, Y., Zhang, L., Brinkman, E. K., Adam, S. A., Goldman, R., Van Steensel, B., Ma, J. & Belmont, A. S., Nov 1 2018, In : Journal of Cell Biology. 217, 11, p. 4025-4048 24 p.

Research output: Contribution to journalArticle

Chromosome Mapping
Genome
Chromosomes
Nuclear Lamina
Genes