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Robert Goldman

  • 21047 Citations
1969 …2022

Research output per year

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Personal profile

Research Interests

We study the structure, function and dynamic properties of intermediate filaments in essential mammalian cell biological phenomena. Our work focuses on the role of cytoskeletal intermediate filaments in regulating cell shape, mechanics, signal transduction, adhesion, cell motility and molecular cross talk with microtubules and microfilaments. We are also determining the roles of the nuclear lamins in regulating nuclear architecture and chromatin organization.

Education/Academic qualification

PhD, Princeton University

… → 1967

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Grants

Understanding pathophysiological mechanisms underlying neurodegeneration

Goldman, R., Opal, P. & Savas, J. N.

National Institute of Neurological Disorders and Stroke

7/1/19 → 6/30/20

Project: Research project

    • Goldman Admin Subproject for Institution # SP0044258

    Goldman, R.

    National Institute of General Medical Sciences

    9/1/18 → 7/31/22

    Project: Research project

    • Analysis of lamin-chromatin interactions and their regulation of chromosome organization and gene expression

    Goldman, R. & Adam, S. A.

    Carnegie Institution of Washington, National Institute of General Medical Sciences

    4/1/17 → 12/31/20

    Project: Research project

    • Project 2 - Role of Intermediate Filaments in Acute Lung Injury

    Goldman, R., Ridge, K. M., Shumaker, D. K. & Stehlik, C.

    National Heart, Lung, and Blood Institute

    9/1/15 → 6/30/20

    Project: Research project

    • Pathophysiology of Acute Lung Injury

    Budinger, G. S., Chandel, N., Dada, L., Goldman, R., Horvath, C. M., Lecuona, E., Perlman, H. R., Ridge, K. M., Stehlik, C., Sznajder, J. I. & Wunderink, R. G.

    National Heart, Lung, and Blood Institute

    9/1/15 → 6/30/20

    Project: Research project

    • Research Output

    High stretchability, strength, and toughness of living cells enabled by hyperelastic vimentin intermediate filaments

    Hu, J., Li, Y., Hao, Y., Zheng, T., Gupta, S. K., Parada, G. A., Wu, H., Lin, S., Wang, S., Zhao, X., Goldman, R. D., Cai, S. & Guo, M., Aug 27 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 35, p. 17175-17180 6 p.

    Research output: Contribution to journal › Article

    Open Access
    • 2 Scopus citations

    Kinesin-dependent transport of keratin filaments: A unified mechanism for intermediate filament transport

    Robert, A., Tian, P., Adam, S. A., Kittisopikul, M., Jaqaman, K., Goldman, R. D. & Gelfand, V. I., Jan 2019, In : FASEB Journal. 33, 1, p. 388-399 12 p.

    Research output: Contribution to journal › Article

    • 2 Scopus citations

    Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing

    Butin-Israeli, V., Bui, T. M., Wiesolek, H. L., Mascarenhas, L., Lee, J. J., Mehl, L. C., Knutson, K. R., Adam, S. A., Goldman, R. D., Beyder, A., Wiesmuller, L., Hanauer, S. B. & Sumagin, R., Feb 1 2019, In : Journal of Clinical Investigation. 129, 2, p. 712-726 15 p.

    Research output: Contribution to journal › Article

    • 13 Scopus citations

    Physicochemical mechanotransduction alters nuclear shape and mechanics via heterochromatin formation

    Stephens, A. D., Liu, P. Z., Kandula, V., Chen, H., Almassalha, L. M., Herman, C., Backman, V., O'Halloran, T., Adam, S. A., Goldman, R. D., Banigan, E. J. & Marko, J. F., Aug 1 2019, In : Molecular biology of the cell. 30, 17, p. 2320-2330 11 p.

    Research output: Contribution to journal › Article

    Open Access
    • 2 Scopus citations

    Probe Sensitivity to Cortical versus Intracellular Cytoskeletal Network Stiffness

    Vahabikashi, A., Park, C. Y., Perkumas, K., Zhang, Z., Deurloo, E. K., Wu, H., Weitz, D. A., Stamer, W. D., Goldman, R. D., Fredberg, J. J. & Johnson, M., Feb 5 2019, In : Biophysical Journal. 116, 3, p. 518-529 12 p.

    Research output: Contribution to journal › Article

    • 2 Scopus citations