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Personal profile

Research Interests

We study the structure, function and dynamic properties of intermediate filaments in essential mammalian cell biological phenomena. Our work focuses on the role of cytoskeletal intermediate filaments in regulating cell shape, mechanics, signal transduction, adhesion, cell motility and molecular cross talk with microtubules and microfilaments. We are also determining the roles of the nuclear lamins in regulating nuclear architecture and chromatin organization.

Education/Academic qualification

PhD, Princeton University

… → 1967

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  • 8 Similar Profiles
Intermediate Filaments Medicine & Life Sciences
Lamins Medicine & Life Sciences
Vimentin Medicine & Life Sciences
Intermediate Filament Proteins Medicine & Life Sciences
Lamin Type A Medicine & Life Sciences
Nuclear Lamina Medicine & Life Sciences
Microtubules Medicine & Life Sciences
Keratins Medicine & Life Sciences

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Grants 2001 2022

Giant Axonal Neuropathy
Intermediate Filaments
Ubiquitin-Protein Ligases
Intermediate Filaments
Actin Cytoskeleton
Intermediate Filament Proteins
Proteasome Endopeptidase Complex

Research Output 1969 2019

2 Citations (Scopus)

Kinesin-dependent transport of keratin filaments: A unified mechanism for intermediate filament transport

Robert, A., Tian, P., Adam, S. A., Kittisopikul, M., Jaqaman, K., Goldman, R. & Gelfand, V. I., Jan 1 2019, In : FASEB Journal. 33, 1, p. 388-399 12 p.

Research output: Contribution to journalArticle

Intermediate Filaments
Clustered Regularly Interspaced Short Palindromic Repeats
7 Citations (Scopus)

Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing

Butin-Israeli, V., Bui, T. M., Wiesolek, H. L., Mascarenhas, L., Lee, J. J., Mehl, L. C., Knutson, K. R., Adam, S. A., Goldman, R., Beyder, A., Wiesmuller, L., Hanauer, S. B. & Sumagin, R., Feb 1 2019, In : Journal of Clinical Investigation. 129, 2, p. 712-726 15 p.

Research output: Contribution to journalArticle

Genomic Instability
Wound Healing
Homologous Recombination

Physicochemical mechanotransduction alters nuclear shape and mechanics via heterochromatin formation

Stephens, A. D., Liu, P. Z., Kandula, V., Chen, H., Almassalha, L. M., Herman, C., Backman, V., O'Halloran, T. V., Adam, S. A., Goldman, R., Banigan, E. J. & Marko, J. F., Aug 1 2019, In : Molecular biology of the cell. 30, 17, p. 2320-2330 11 p.

Research output: Contribution to journalArticle

Open Access
Ion Channels

Probe Sensitivity to Cortical versus Intracellular Cytoskeletal Network Stiffness

Vahabikashi, A., Park, C. Y., Perkumas, K., Zhang, Z., Deurloo, E. K., Wu, H., Weitz, D. A., Stamer, W. D., Goldman, R., Fredberg, J. J. & Johnson, M., Feb 5 2019, In : Biophysical Journal. 116, 3, p. 518-529 12 p.

Research output: Contribution to journalArticle

Atomic Force Microscopy
21 Citations (Scopus)

Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins

Stephens, A. D., Liu, P. Z., Banigan, E. J., Almassalha, L. M., Backman, V., Adam, S. A., Goldman, R. D. & Marko, J. F., Jan 15 2018, In : Molecular biology of the cell. 29, 2, p. 220-233 14 p.

Research output: Contribution to journalArticle

Histone Code