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Personal profile

Research Interests

We study the structure, function and dynamic properties of intermediate filaments in essential mammalian cell biological phenomena. Our work focuses on the role of cytoskeletal intermediate filaments in regulating cell shape, mechanics, signal transduction, adhesion, cell motility and molecular cross talk with microtubules and microfilaments. We are also determining the roles of the nuclear lamins in regulating nuclear architecture and chromatin organization.

Education/Academic qualification

PhD, Princeton University

… → 1967

Fingerprint Dive into the research topics where Robert Goldman is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 8 Similar Profiles
Intermediate Filaments Medicine & Life Sciences
Lamins Medicine & Life Sciences
Vimentin Medicine & Life Sciences
Intermediate Filament Proteins Medicine & Life Sciences
Lamin Type A Medicine & Life Sciences
Microtubules Medicine & Life Sciences
Nuclear Lamina Medicine & Life Sciences
Actin Cytoskeleton Medicine & Life Sciences

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Grants 2001 2022

Giant Axonal Neuropathy
Intermediate Filaments
Pathology
Proteins
Ubiquitin-Protein Ligases
Vimentin
Intermediate Filaments
Mechanics
Actin Cytoskeleton
Microtubules
Intermediate Filament Proteins
Proteasome Endopeptidase Complex
Ubiquitin
Proteolysis
Intermediate Filaments
Acute Lung Injury
Lung Injury
Influenza A virus
Human Influenza

Research Output 1969 2019

2 Citations (Scopus)

High stretchability, strength, and toughness of living cells enabled by hyperelastic vimentin intermediate filaments

Hu, J., Li, Y., Hao, Y., Zheng, T., Gupta, S. K., Parada, G. A., Wu, H., Lin, S., Wang, S., Zhao, X., Goldman, R. D., Cai, S. & Guo, M., Aug 27 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 35, p. 17175-17180 6 p.

Research output: Contribution to journalArticle

Open Access
Intermediate Filaments
Vimentin
Actin Cytoskeleton
Microtubules
Actins
2 Citations (Scopus)

Kinesin-dependent transport of keratin filaments: A unified mechanism for intermediate filament transport

Robert, A., Tian, P., Adam, S. A., Kittisopikul, M., Jaqaman, K., Goldman, R. & Gelfand, V. I., Jan 1 2019, In : FASEB Journal. 33, 1, p. 388-399 12 p.

Research output: Contribution to journalArticle

Kinesin
Intermediate Filaments
Keratins
Clustered Regularly Interspaced Short Palindromic Repeats
Vimentin
10 Citations (Scopus)

Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing

Butin-Israeli, V., Bui, T. M., Wiesolek, H. L., Mascarenhas, L., Lee, J. J., Mehl, L. C., Knutson, K. R., Adam, S. A., Goldman, R., Beyder, A., Wiesmuller, L., Hanauer, S. B. & Sumagin, R., Feb 1 2019, In : Journal of Clinical Investigation. 129, 2, p. 712-726 15 p.

Research output: Contribution to journalArticle

Genomic Instability
Wound Healing
Neutrophils
Homologous Recombination
Inflammation

Physicochemical mechanotransduction alters nuclear shape and mechanics via heterochromatin formation

Stephens, A. D., Liu, P. Z., Kandula, V., Chen, H., Almassalha, L. M., Herman, C., Backman, V., O'Halloran, T. V., Adam, S. A., Goldman, R., Banigan, E. J. & Marko, J. F., Aug 1 2019, In : Molecular biology of the cell. 30, 17, p. 2320-2330 11 p.

Research output: Contribution to journalArticle

Open Access
Heterochromatin
Mechanics
Chromatin
Ion Channels
Cations

Probe Sensitivity to Cortical versus Intracellular Cytoskeletal Network Stiffness

Vahabikashi, A., Park, C. Y., Perkumas, K., Zhang, Z., Deurloo, E. K., Wu, H., Weitz, D. A., Stamer, W. D., Goldman, R., Fredberg, J. J. & Johnson, M., Feb 5 2019, In : Biophysical Journal. 116, 3, p. 518-529 12 p.

Research output: Contribution to journalArticle

Atomic Force Microscopy
Traction
Vimentin
Microscopy
Fibroblasts