Grants per year
Personal profile
Research Interests
We study the structure, function and dynamic properties of intermediate filaments in essential mammalian cell biological phenomena. Our work focuses on the role of cytoskeletal intermediate filaments in regulating cell shape, mechanics, signal transduction, adhesion, cell motility and molecular cross talk with microtubules and microfilaments. We are also determining the roles of the nuclear lamins in regulating nuclear architecture and chromatin organization.
Education/Academic qualification
PhD, Princeton University
… → 1967
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The Role of Vimentin Cytoskeleton in the Mechanobiology of Schlemm's Canal Endothelium.
6/1/21 → 5/31/23
Project: Research project
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Mechanobiology of Vimentin Intermediate Filaments in 3D Collective Cell Migration
Massachusetts Institute of Technology, National Institute of General Medical Sciences
12/1/20 → 11/30/25
Project: Research project
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Center for 3D Structure and Physics of the Genome
University of Massachusetts Medical School, National Human Genome Research Institute
9/18/20 → 6/30/25
Project: Research project
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Regulation and Function of Intermediate Filaments in Cell Mechanics
Gelfand, V. I., Goldman, R., Kuczmarski, E. R., Ridge, K. M., Adam, S. A., Shumaker, D. K. & Johnson, M.
National Institute of General Medical Sciences
9/1/18 → 7/31/23
Project: Research project
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Understanding pathophysiological mechanisms underlying neurodegeneration
Opal, P., Goldman, R. & Savas, J. N.
National Institute of Neurological Disorders and Stroke
7/1/19 → 6/30/21
Project: Research project
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Nuclear lamin isoforms differentially contribute to LINC complex-dependent nucleocytoskeletal coupling and whole-cell mechanics
Vahabikashi, A., Sivagurunathan, S., Nicdao, F. A. S., Han, Y. L., Park, C. Y., Kittisopikul, M., Wong, X., Tran, J. R., Gundersen, G. G., Reddy, K. L., Luxton, G. W. G., Guo, M., Fredberg, J. J., Zheng, Y., Adam, S. A. & Goldman, R. D., Apr 26 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 17, 2121816119.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Nuclear lamins: Structure and function in mechanobiology
Vahabikashi, A., Adam, S. A., Medalia, O. & Goldman, R. D., Mar 1 2022, In: APL Bioengineering. 6, 1, 082656.Research output: Contribution to journal › Review article › peer-review
Open Access4 Scopus citations -
Roles of vimentin in health and disease
Ridge, K. M., Eriksson, J. E., Pekny, M. & Goldman, R. D., Apr 1 2022, In: Genes and Development. 36, 7, p. 391-407 17 p.Research output: Contribution to journal › Review article › peer-review
Open Access5 Scopus citations -
Transcriptional Evaluation of the Ductus Arteriosus at the Single-Cell Level Uncovers a Requirement for Vim (Vimentin) for Complete Closure
Salvador, J., Hernandez, G. E., Ma, F., Abrahamson, C. W., Pellegrini, M., Goldman, R., Ridge, K. M. & Iruela-Arispe, M. L., Jun 1 2022, In: Arteriosclerosis, thrombosis, and vascular biology. 42, 6, p. 732-742 11 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Vimentin intermediate filaments and filamentous actin form unexpected interpenetrating networks that redefine the cell cortex
Wu, H., Shen, Y., Sivagurunathan, S., Weber, M. S., Adam, S. A., Shin, J. H., Fredberg, J. J., Medalia, O., Goldman, R. & Weitz, D. A., Mar 8 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 10, e2115217119.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations