Grants per year
Personal profile
Research Interests
We study the structure, function and dynamic properties of intermediate filaments in essential mammalian cell biological phenomena. Our work focuses on the role of cytoskeletal intermediate filaments in regulating cell shape, mechanics, signal transduction, adhesion, cell motility and molecular cross talk with microtubules and microfilaments. We are also determining the roles of the nuclear lamins in regulating nuclear architecture and chromatin organization.
Education/Academic qualification
PhD, Biology, Princeton University
… → 1967
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Mechanobiology of Vimentin Intermediate Filaments in 3D Collective Cell Migration
Goldman, R. (PD/PI) & Goldman, R. (PD/PI)
Massachusetts Institute of Technology, National Institute of General Medical Sciences
12/1/20 → 11/30/25
Project: Research project
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Center for 3D Structure and Physics of the Genome
Goldman, R. (PD/PI), Goldman, R. (PD/PI), Adam, S. A. (Co-Investigator) & Adam, S. A. (Co-Investigator)
University of Massachusetts Medical School, National Human Genome Research Institute
9/18/20 → 6/30/25
Project: Research project
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Center for 3D Structure and Physics of the Genome
Goldman, R. (PD/PI) & Adam, S. A. (Co-Investigator)
University of Massachusetts Medical School, National Human Genome Research Institute
8/5/22 → 6/30/23
Project: Research project
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The Role of Vimentin Cytoskeleton in the Mechanobiology of Schlemm's Canal Endothelium.
Goldman, R. (PD/PI)
6/1/21 → 7/31/23
Project: Research project
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Understanding pathophysiological mechanisms underlying neurodegeneration
Opal, P. (PD/PI), Goldman, R. (Co-Investigator) & Savas, J. N. (Co-Investigator)
National Institute of Neurological Disorders and Stroke
7/1/19 → 6/30/21
Project: Research project
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Cytoplasmic keratins couple with and maintain nuclear envelope integrity in colonic epithelial cells
Stenvall, C. G. A., Nyström, J. H., Butler-Hallissey, C., Jansson, T., Heikkilä, T. R. H., Adam, S. A., Foisner, R., Goldman, R. D., Ridge, K. M. & Toivola, D. M., Nov 1 2022, In: Molecular biology of the cell. 33, 13Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Expression of vimentin alters cell mechanics, cell-cell adhesion, and gene expression profiles suggesting the induction of a hybrid EMT in human mammary epithelial cells
Sivagurunathan, S., Vahabikashi, A., Yang, H., Zhang, J., Vazquez, K., Rajasundaram, D., Politanska, Y., Abdala-Valencia, H., Notbohm, J., Guo, M., Adam, S. A. & Goldman, R. D., Sep 19 2022, In: Frontiers in Cell and Developmental Biology. 10, 929495.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
High quality mapping of chromatin at or near the nuclear lamina from small numbers of cells reveals cell cycle and developmental changes of chromatin at the nuclear periphery
Tran, J. R., Zheng, X., Adam, S. A., Goldman, R. D. & Zheng, Y., Nov 11 2022, In: Nucleic acids research. 50, 20, p. E117Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Nuclear lamin isoforms differentially contribute to LINC complex-dependent nucleocytoskeletal coupling and whole-cell mechanics
Vahabikashi, A., Sivagurunathan, S., Nicdao, F. A. S., Han, Y. L., Park, C. Y., Kittisopikul, M., Wong, X., Tran, J. R., Gundersen, G. G., Reddy, K. L., Luxton, G. W. G., Guo, M., Fredberg, J. J., Zheng, Y., Adam, S. A. & Goldman, R. D., Apr 26 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 17, 2121816119.Research output: Contribution to journal › Article › peer-review
Open Access31 Scopus citations -
Nuclear lamins: Structure and function in mechanobiology
Vahabikashi, A., Adam, S. A., Medalia, O. & Goldman, R. D., Mar 1 2022, In: APL Bioengineering. 6, 1, 082656.Research output: Contribution to journal › Review article › peer-review
Open Access32 Scopus citations
Datasets
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Supplementary material from "Giant axonal neuropathy alters the structure of keratin intermediate filaments in human hair"
Soomro, A. (Contributor), Alsop, R. J. (Creator), Negishi, A. (Creator), Kreplak, L. (Creator), Fudge, D. (Creator), Kuczmarski, E. R. (Creator), Goldman, R. D. (Creator), Rheinstädter, M. C. (Creator) & Goldman, R. (Creator), figshare, 2017
DOI: 10.6084/m9.figshare.c.3734386, https://figshare.com/collections/Supplementary_material_from_Giant_axonal_neuropathy_alters_the_structure_of_keratin_intermediate_filaments_in_human_hair_/3734386
Dataset
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Crystal structure of human insulin-degrading enzyme in complex with ubiquitin
Ralat, L. A. (Contributor), Kalas, V. (Contributor), Zheng, Z. (Contributor), Goldman, R. D. (Contributor), Sosnick, T. R. (Contributor) & Tang, W.-J. (Contributor), Protein Data Bank (PDB), Sep 8 2010
DOI: 10.2210/pdb3OFI, https://www.wwpdb.org/pdb?id=pdb_00003ofi
Dataset
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Giant Axonal Neuropathy alters the structure of keratin intermediate filaments in human hair_JRSocInterface_TensileSummary
Soomro, A. (Contributor), Alsop, R. J. (Creator), Negishi, A. (Creator), Kreplak, L. (Creator), Fudge, D. (Creator), Kuczmarski, E. R. (Creator), Goldman, R. D. (Creator), Rheinstädter, M. C. (Creator) & Goldman, R. (Creator), The Royal Society, 2017
DOI: 10.6084/m9.figshare.4818070, https://rs.figshare.com/articles/dataset/Giant_Axonal_Neuropathy_alters_the_structure_of_keratin_intermediate_filaments_in_human_hair_JRSocInterface_TensileSummary/4818070
Dataset
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Structural heterogeneity of cellular K5/K14 filaments as revealed by cryo-electron microscopy
Weber, M. S. (Creator), Eibauer, M. (Creator), Sivagurunathan, S. (Creator), Magin, T. (Creator), Goldman, R. (Creator) & Medalia, O. (Creator), Dryad, 2021
DOI: 10.5061/dryad.gqnk98sn4, https://datadryad.org/stash/dataset/doi:10.5061/dryad.gqnk98sn4
Dataset
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Giant Axonal Neuropathy alters the structure of keratin intermediate filaments in human hair_JRSocInterface_TensileData
Soomro, A. (Contributor), Alsop, R. J. (Creator), Negishi, A. (Creator), Kreplak, L. (Creator), Fudge, D. (Creator), Kuczmarski, E. R. (Creator), Goldman, R. D. (Creator), Rheinstädter, M. C. (Creator) & Goldman, R. (Creator), The Royal Society, 2017
DOI: 10.6084/m9.figshare.4818118, https://rs.figshare.com/articles/dataset/Giant_Axonal_Neuropathy_alters_the_structure_of_keratin_intermediate_filaments_in_human_hair_JRSocInterface_TensileData/4818118
Dataset