Grants per year
Personal profile
Research Interests
We study the structure, function and dynamic properties of intermediate filaments in essential mammalian cell biological phenomena. Our work focuses on the role of cytoskeletal intermediate filaments in regulating cell shape, mechanics, signal transduction, adhesion, cell motility and molecular cross talk with microtubules and microfilaments. We are also determining the roles of the nuclear lamins in regulating nuclear architecture and chromatin organization.
Education/Academic qualification
PhD, Princeton University
… → 1967
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Intermediate Filaments
Medicine & Life Sciences
Lamins
Medicine & Life Sciences
Vimentin
Medicine & Life Sciences
Intermediate Filament Proteins
Medicine & Life Sciences
Lamin Type A
Medicine & Life Sciences
Microtubules
Medicine & Life Sciences
Nuclear Lamina
Medicine & Life Sciences
Actin Cytoskeleton
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2001 2022
Understanding pathophysiological mechanisms underlying neurodegeneration
Goldman, R., Opal, P. & Savas, J. N.
National Institute of Neurological Disorders and Stroke
7/1/19 → 6/30/20
Project: Research project
Giant Axonal Neuropathy
Intermediate Filaments
Pathology
Proteins
Ubiquitin-Protein Ligases
Goldman Admin Subproject for Institution # SP0044258
National Institute of General Medical Sciences
9/1/18 → 7/31/22
Project: Research project
Vimentin
Intermediate Filaments
Mechanics
Actin Cytoskeleton
Microtubules
Hannah's Hope Fund for Dr. Goldman's Lab May 2017
Hannah's Hope for Giant Axonal Neuropathy, Inc.
6/1/17 → 12/31/19
Project: Research project
Intermediate Filament Proteins
Proteasome Endopeptidase Complex
Ubiquitin
Proteolysis
Analysis of lamin-chromatin interactions and their regulation of chromosome organization and gene expression
Carnegie Institution of Washington, National Institute of General Medical Sciences
4/1/17 → 12/31/20
Project: Research project
Lamins
Chromatin
Chromosomes
Gene Expression
Lamin Type B
Project 2 - Role of Intermediate Filaments in Acute Lung Injury
Goldman, R., Ridge, K. M., Shumaker, D. K. & Stehlik, C.
National Heart, Lung, and Blood Institute
9/1/15 → 6/30/20
Project: Research project
Intermediate Filaments
Acute Lung Injury
Lung Injury
Influenza A virus
Human Influenza
Research Output 1969 2019
2
Citations
(Scopus)
High stretchability, strength, and toughness of living cells enabled by hyperelastic vimentin intermediate filaments
Hu, J., Li, Y., Hao, Y., Zheng, T., Gupta, S. K., Parada, G. A., Wu, H., Lin, S., Wang, S., Zhao, X., Goldman, R. D., Cai, S. & Guo, M., Aug 27 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 35, p. 17175-17180 6 p.Research output: Contribution to journal › Article
Open Access
Intermediate Filaments
Vimentin
Actin Cytoskeleton
Microtubules
Actins
2
Citations
(Scopus)
Kinesin-dependent transport of keratin filaments: A unified mechanism for intermediate filament transport
Robert, A., Tian, P., Adam, S. A., Kittisopikul, M., Jaqaman, K., Goldman, R. & Gelfand, V. I., Jan 1 2019, In : FASEB Journal. 33, 1, p. 388-399 12 p.Research output: Contribution to journal › Article
Kinesin
Intermediate Filaments
Keratins
Clustered Regularly Interspaced Short Palindromic Repeats
Vimentin
10
Citations
(Scopus)
Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing
Butin-Israeli, V., Bui, T. M., Wiesolek, H. L., Mascarenhas, L., Lee, J. J., Mehl, L. C., Knutson, K. R., Adam, S. A., Goldman, R., Beyder, A., Wiesmuller, L., Hanauer, S. B. & Sumagin, R., Feb 1 2019, In : Journal of Clinical Investigation. 129, 2, p. 712-726 15 p.Research output: Contribution to journal › Article
Genomic Instability
Wound Healing
Neutrophils
Homologous Recombination
Inflammation
Physicochemical mechanotransduction alters nuclear shape and mechanics via heterochromatin formation
Stephens, A. D., Liu, P. Z., Kandula, V., Chen, H., Almassalha, L. M., Herman, C., Backman, V., O'Halloran, T. V., Adam, S. A., Goldman, R., Banigan, E. J. & Marko, J. F., Aug 1 2019, In : Molecular biology of the cell. 30, 17, p. 2320-2330 11 p.Research output: Contribution to journal › Article
Open Access
Heterochromatin
Mechanics
Chromatin
Ion Channels
Cations
Probe Sensitivity to Cortical versus Intracellular Cytoskeletal Network Stiffness
Vahabikashi, A., Park, C. Y., Perkumas, K., Zhang, Z., Deurloo, E. K., Wu, H., Weitz, D. A., Stamer, W. D., Goldman, R., Fredberg, J. J. & Johnson, M., Feb 5 2019, In : Biophysical Journal. 116, 3, p. 518-529 12 p.Research output: Contribution to journal › Article
Atomic Force Microscopy
Traction
Vimentin
Microscopy
Fibroblasts