Grants per year
Personal profile
Research Interests
Research in my lab focuses on two topics: 1) activity-dependent development of circuits in the central nervous system and 2) healthful compensatory responses of cells and organisms to stressful conditions. We use genetically manipulated mice, primary neuron tissue culture and C.elegans in our studies; our approach is cell and molecular biology. Lab Website: http://kalbneuron.com
Training Experience
1983 | Internship, Montefiore Medical Center |
1984 | Residency, Montefiore Medical Center |
1987 | Residency, Yale-New Haven Hospital |
1990 | Postdoctoral Fellowship, Yale University |
Education/Academic qualification
MD, Medicine, Cornell University Medical College
… → 1982
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Targeting SPOP and BRD4 to Blunt the Toxicity of C9ORF72-Derived Dipeptide Repeat Proteins
Kalb, R. G. (PD/PI) & Shilatifard, A. (Other)
U.S. Army Medical Research and Materiel Command
9/15/24 → 9/14/26
Project: Research project
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Defining oligonucleotide therapeutics that reverse TDP-43 proteinopathy.
Kalb, R. G. (PD/PI)
University of Pennsylvania, Kissick Family Foundation
7/1/24 → 6/30/25
Project: Research project
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Medical Scientist Training Program
Ardehali, H. (PD/PI), Hauser, A. R. (PD/PI), Hauser, A. R. (PD/PI), Brown, M. A. (Other), Brown, M. A. (Other), Kalb, R. G. (Other) & Kalb, R. G. (Other)
National Institute of General Medical Sciences
7/1/22 → 6/30/27
Project: Research project
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Predoctoral and Postdoctoral Training Program in Aging and Dementia
Vassar, R. J. (PD/PI), Vassar, R. J. (PD/PI), Weintraub, S. (PD/PI), Weintraub, S. (PD/PI), Allada, R. (Other), Allada, R. (Other), Bevan, M. D. (Other), Bevan, M. D. (Other), Caraveo Piso, G. (Other), Caraveo Piso, G. (Other), Carvill, G. L. (Other), Carvill, G. L. (Other), Chan, S. (Other), Chan, S. (Other), Contractor, A. (Other), Contractor, A. (Other), Disterhoft, J. F. (Other), Disterhoft, J. F. (Other), Dombeck, D. A. (Other), Dombeck, D. A. (Other), Dong, H. (Other), Dong, H. (Other), Ferreira, A. B. (Other), Ferreira, A. B. (Other), Flanagan, M. E. (Other), Flanagan, M. E. (Other), Gefen, T. D. (Other), Gefen, T. D. (Other), Geula, C. (Other), Geula, C. (Other), Gratton, C. (Other), Gratton, C. (Other), He, C. (Other), He, C. (Other), Kahnt, T. (Other), Kahnt, T. (Other), Kalb, R. G. (Other), Kalb, R. G. (Other), Kennedy, A. (Other), Kennedy, A. (Other), Kessler, J. (Other), Kessler, J. (Other), Kiskinis, E. (Other), Kiskinis, E. (Other), Klein, W. L. (Other), Klein, W. L. (Other), Kozorovitskiy, Y. (Other), Kozorovitskiy, Y. (Other), Krainc, D. (Other), Krainc, D. (Other), Li, L. (Other), Li, L. (Other), Mazzulli, J. (Other), Mazzulli, J. (Other), Mesulam, M.-M. (Other), Mesulam, M.-M. (Other), Miller, R. J. (Other), Miller, R. J. (Other), Morimoto, R. I. (Other), Morimoto, R. I. (Other), Opal, P. (Other), Opal, P. (Other), Ozdinler, H. (Other), Ozdinler, H. (Other), Paller, K. (Other), Paller, K. (Other), Parisiadou, L. (Other), Parisiadou, L. (Other), Penzes, P. (Other), Penzes, P. (Other), Pinto, L. (Other), Pinto, L. (Other), Prakriya, M. (Other), Prakriya, M. (Other), Reber, P. J. (Other), Reber, P. J. (Other), Roberts, A. L. (Other), Roberts, A. L. (Other), Rogalski, E. (Other), Rogalski, E. (Other), Savas, J. N. (Other), Savas, J. N. (Other), Surmeier Jr, D. J. (Other), Surmeier Jr, D. J. (Other), Swanson, G. T. (Other), Swanson, G. T. (Other), Voss, J. L. (Other), Voss, J. L. (Other), Zee, P. C. (Other), Zee, P. C. (Other), Zelano, C. (Other) & Zelano, C. (Other)
5/1/22 → 4/30/27
Project: Research project
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Defining mechanisms underlying C9orf72-associated frontotemporal dementia with C. elegans and mammalian models
Kalb, R. G. (PD/PI) & Kalb, R. G. (PD/PI)
National Institute of Neurological Disorders and Stroke
2/1/22 → 1/31/27
Project: Research project
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Analysis of proteome-wide degradation dynamics in ALS SOD1 iPSC-derived patient neurons reveals disrupted VCP homeostasis
Tsioras, K., Smith, K. C., Edassery, S. L., Garjani, M., Li, Y., Williams, C., McKenna, E. D., Guo, W., Wilen, A. P., Hark, T. J., Marklund, S. L., Ostrow, L. W., Gilthorpe, J. D., Ichida, J. K., Kalb, R. G., Savas, J. N. & Kiskinis, E., Oct 31 2023, In: Cell reports. 42, 10, 113160.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Erratum: A yeast functional screen predicts new candidate ALS disease genes (Proc. Natl. Acad. Sci. U.S.A. (2011) 108 (20881–20890) DOI: 10.1073/pnas.1109434108)
Couthouis, J., Hart, M. P., Shorter, J., DeJesus-Hernandez, M., Erion, R., Oristano, R., Liu, A. X., Ramos, D., Jethava, N., Hosangadi, D., Epstein, J., Chiang, A., Diaz, Z., Nakaya, T., Ibrahim, F., Kim, H. J., Solski, J. A., Williams, K. L., Mojsilovic-Petrovic, J. & Ingre, C. & 21 others, , Jan 3 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 1, e2220845120.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Enhanced Degradation of Mutant C9ORF72-Derived Toxic Dipeptide Repeat Proteins by 20S Proteasome Activation Results in Restoration of Proteostasis and Neuroprotection
Vanecek, A. S., Mojsilovic-Petrovic, J., Kalb, R. G. & Tepe, J. J., 2022, (Accepted/In press) In: ACS Chemical Neuroscience.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Neurons undergo pathogenic metabolic reprogramming in models of familial ALS
Riechers, S. P., Mojsilovic-Petrovic, J., Belton, T. B., Chakrabarty, R. P., Garjani, M., Medvedeva, V., Dalton, C., Wong, Y. C., Chandel, N. S., Dienel, G. & Kalb, R. G., Jun 2022, In: Molecular Metabolism. 60, 101468.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Preconditioning of Caenorhabditis elegans to anoxic insult by inactivation of cholinergic, GABAergic and muscle activity
Bennett, H. L., McClanahan, P. D., Fang-Yen, C. & Kalb, R. G., Apr 2021, In: Genes, Brain and Behavior. 20, 4, e12713.Research output: Contribution to journal › Article › peer-review