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Personal profile

Research Interests

Research in my lab focuses on two topics: 1) activity-dependent development of circuits in the central nervous system and 2) healthful compensatory responses of cells and organisms to stressful conditions. We use genetically manipulated mice, primary neuron tissue culture and C.elegans in our studies; our approach is cell and molecular biology. Lab Website: http://kalbneuron.com

Training Experience

1983Internship, Montefiore Medical Center
1984Residency, Montefiore Medical Center
1987Residency, Yale-New Haven Hospital
1990Postdoctoral Fellowship, Yale University

Education/Academic qualification

MD, Cornell University Medical College

… → 1982

Fingerprint Dive into the research topics where Robert Gordon Kalb is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Grants 2017 2021

AMP-Activated Protein Kinases
Amyotrophic Lateral Sclerosis
Neurons
Glycolysis
Neurodegenerative Diseases
Motor Neurons
Spinal Cord
Spinal Muscular Atrophy
Proteins
Interneurons
Amyotrophic Lateral Sclerosis
Guanosine Triphosphate
Biological Phenomena
Toxic Actions
Motor Neurons

Research Output 1982 2019

1 Citation (Scopus)

L3MBTL1 regulates ALS/FTD-associated proteotoxicity and quality control

Lu, J., Periz, G., Lu, Y. N., Tang, Q., Liu, Y., Zhang, T., Shah, Y., Thombre, R., Aljumaah, R., Li, W., Mojsilovic-Petrovic, J., Ji, Y., Johnson, K., Kalb, R. G. & Wang, J., Jan 1 2019, In : Nature Neuroscience.

Research output: Contribution to journalArticle

Brain Neoplasms
Quality Control
Proteins
Amyotrophic Lateral Sclerosis
Neurodegenerative Diseases
1 Citation (Scopus)

Neuropeptide signaling regulates the susceptibility of developing C. elegans to anoxia

Doshi, S., Price, E., Landis, J., Barot, U., Sabatella, M., Lans, H. & Kalb, R. G., Feb 1 2019, In : Free Radical Biology and Medicine. 131, p. 197-208 12 p.

Research output: Contribution to journalArticle

Neuropeptides
Oxygen
Caenorhabditis elegans
Neurology
Cell death
4 Citations (Scopus)

PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression

Park, M. K., Yao, Y., Xia, W., Setijono, S. R., Kim, J. H., Vila, I. K., Chiu, H. H., Wu, Y., Billalabeitia, E. G., Lee, M. G., Kalb, R. G., Hung, M. C., Pandolfi, P. P., Song, S. J. & Song, M. S., Feb 7 2019, In : Nature communications. 10, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Phosphatidylinositol 3-Kinases
Tumors
tumors
retarding
Neoplasms

Publisher Correction: L3MBTL1 regulates ALS/FTD-associated proteotoxicity and quality control (Nature Neuroscience, (2019), 22, 6, (875-886), 10.1038/s41593-019-0384-5)

Lu, J., Periz, G., Lu, Y. N., Tang, Q., Liu, Y., Zhang, T., Shah, Y., Thombre, R., Aljumaah, R., Li, W., Mojsilovic-Petrovic, J., Ji, Y., Johnson, K., Kalb, R. G. & Wang, J., Jul 1 2019, In : Nature Neuroscience. 22, 7, 1 p.

Research output: Contribution to journalComment/debate

Open Access
Neurosciences
Quality Control
1 Citation (Scopus)

Enhancing GABAergic transmission improves locomotion in a caenorhabditis elegans model of spinal muscular atrophy

Wu, C. Y., Gagnon, D. A., Sardin, J. S., Barot, U., Telenson, A., Arratia, P. E. & Kalb, R. G., Nov 1 2018, In : eNeuro. 5, 6, e0289-18.2018.

Research output: Contribution to journalArticle

Spinal Muscular Atrophy
Caenorhabditis elegans
Locomotion
Motor Neurons
Motor Activity