• 752 Citations
20032022
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Research Output 2003 2019

5 1/2-month-old boy with right leg swelling and fever

Listernick, R., Tanz, R., Shulman, S. T., Katz, B., Bellet, J., Liem, R., Fuleihan, R. & Tse, W., May 1 2008, In : Pediatric Annals. 37, 5, p. 285-289 5 p.

Research output: Contribution to journalComment/debate

Wiskott-Aldrich Syndrome
Edema
Leg
Flow Cytometry
Fever

A 15-year-old obese girl with abdominal pain

Listernick, R., Benya, E. C., Trainor, J. L., Kabre-Swanson, R., Liem, R. I., Bhat, R., Rozenfeld, R. A. & Thompson, A. A., Apr 1 2015, In : Pediatric Annals. 44, 4, p. 126-129 4 p.

Research output: Contribution to journalComment/debate

Multimodal Imaging
Vena Cava Filters
Enoxaparin
Ovarian Cysts
X Ray Computed Tomography
4 Citations (Scopus)

Access to Patient-Centered medical homes in children with sickle cell disease

Liem, R. I., O'Suoji, C., Kingsberry, P. S., Pelligra, S. A., Kwon, S., Mason, M. & Thompson, A. A., Oct 1 2014, In : Maternal and child health journal. 18, 8, p. 1854-1862 9 p.

Research output: Contribution to journalArticle

Patient-Centered Care
Sickle Cell Anemia
Primary Health Care
Caregivers
Parents
16 Citations (Scopus)

Acute chest syndrome is associated with history of asthma in hemoglobin SC disease

Poulter, E. Y., Truszkowski, P., Thompson, A. A. & Liem, R. I., Aug 1 2011, In : Pediatric Blood and Cancer. 57, 2, p. 289-293 5 p.

Research output: Contribution to journalArticle

Hemoglobin SC Disease
Acute Chest Syndrome
Asthma
Sickle Hemoglobin
Respiratory Sounds
15 Citations (Scopus)
Hydroxyurea
Sickle Cell Anemia
Young Adult
Cross-Sectional Studies
Quality of Life
39 Citations (Scopus)

Alloimmunization in sickle cell anemia in the era of extended red cell typing

O'Suoji, C., Liem, R. I., Mack, A. K., Kingsberry, P., Ramsey, G. E. & Thompson, A. A., Sep 1 2013, In : Pediatric Blood and Cancer. 60, 9, p. 1487-1491 5 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Blood Grouping and Crossmatching
Erythrocytes
Antibodies
Erythrocyte Transfusion
36 Citations (Scopus)

A multicenter randomized controlled trial of intravenous magnesium for sickle cell pain crisis in children

for the Pediatric Emergency Care Applied Research Network (PECARN), Oct 1 2015, In : Blood. 126, 14, p. 1651-1657 7 p.

Research output: Contribution to journalArticle

Magnesium
Randomized Controlled Trials
Pain
Placebos
Quality of Life

An 11-year-old boy with seizures and fatigue.

Listernick, R., Nordli, D., Tanz, R., Stamos, J. K., Greene, M., Liem, R. & Kiesau, Y., Jan 1 2012, In : Pediatric Annals. 41, 11, p. 448-451 4 p.

Research output: Contribution to journalArticle

Adenomatous Polyposis Coli
Fatigue
Seizures
10 Citations (Scopus)
Iron Overload
Sickle Cell Anemia
Iron
Ferritins
Liver
12 Citations (Scopus)

Association among sickle cell trait, fitness, and cardiovascular risk factors in CARDIA

Liem, R. I., Chan, C., Vu, T. H. T., Fornage, M., Thompson, A. A., Liu, K. & Carnethon, M. R., Feb 9 2017, In : Blood. 129, 6, p. 723-728 6 p.

Research output: Contribution to journalArticle

Sickle Cell Trait
Young Adult
Coronary Vessels
Medical problems
Hypertension
41 Citations (Scopus)

Association of sickle cell trait with hemoglobin A1c in African Americans

Lacy, M. E., Wellenius, G. A., Sumner, A. E., Correa, A., Carnethon, M. R., Liem, R. I., Wilson, J. G., Sacks, D. B., Jacobs, D. R., Carson, A. P., Luo, X., Gjelsvik, A., Reiner, A. P., Naik, R. P., Liu, S., Musani, S. K., Eaton, C. B. & Wu, W. C., Feb 7 2017, In : JAMA - Journal of the American Medical Association. 317, 5, p. 507-515 9 p.

Research output: Contribution to journalArticle

Sickle Cell Trait
African Americans
Hemoglobins
Glucose
Fasting

Balancing exercise risk and benefits: Lessons learned from sickle cell trait and sickle cell anemia

Liem, R. I., Nov 30 2018, In : Hematology. 2018, 1, p. 418-425 8 p.

Research output: Contribution to journalArticle

Sickle Cell Trait
Sickle Cell Anemia
Exercise
Athletes
Causality
20 Citations (Scopus)
Hydroxyurea
Sickle Cell Anemia
Young Adult
Quality of Life
Visual Analog Scale
6 Citations (Scopus)

Beliefs about hydroxyurea in youth with sickle cell disease

Badawy, S. M., Thompson, A. A. & Liem, R. I., Sep 1 2018, In : Hematology/ Oncology and Stem Cell Therapy. 11, 3, p. 142-148 7 p.

Research output: Contribution to journalArticle

Hydroxyurea
Sickle Cell Anemia
Quality of Life
Visual Analog Scale
Young Adult

Bone Marrow Aspiration and Biopsy

Liem, RI., 2007, Current Procedures: Pediatrics. Goodman, DM., Green, TP., Unti, SM. & Powell, EC. (eds.). New York City: The McGraw-Hill Companies

Research output: Chapter in Book/Report/Conference proceedingChapter

69 Citations (Scopus)

Challenges of alloimmunization in patients with haemoglobinopathies

Chou, S. T., Liem, R. I. & Thompson, A. A., Nov 1 2012, In : British Journal of Haematology. 159, 4, p. 394-404 11 p.

Research output: Contribution to journalReview article

Hemoglobinopathies
Erythrocyte Transfusion
Thalassemia
Sickle Cell Anemia
Blood Transfusion

Childhood Hematologic Diseases

Liem, RI. & Wayne, AS., 2004, Bethesda Handbook of Hematology. Young, NS. & Rodgers, GP. (eds.). Philadelphia: Lippincott Williams & Wilkins

Research output: Chapter in Book/Report/Conference proceedingChapter

11 Citations (Scopus)

Determining the longitudinal validity and meaningful differences in HRQL of the PedsQL™ Sickle Cell Disease Module

and for the Pediatric Emergency Care Applied Research Network (PECARN), Jun 12 2017, In : Health and Quality of Life Outcomes. 15, 1, 124.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Quality of Life
Pain
Health Status
Fatigue
29 Citations (Scopus)

Effect of Red Cell Exchange Transfusion on Plasma Levels of Inflammatory Mediators in Sickle Cell Patients with Acute Chest Syndrome

Liem, R. I., O'Gorman, M. R. & Brown, D. L., May 1 2004, In : American Journal of Hematology. 76, 1, p. 19-25 7 p.

Research output: Contribution to journalArticle

Acute Chest Syndrome
Interleukin-1
Vascular Cell Adhesion Molecule-1
Leukocyte Count
Neutrophils
9 Citations (Scopus)
Transferrin Receptors
Sickle Cell Anemia
Iron
Pediatrics
Hemolysis

Emergencies in Pediatric Hematology, Oncology, and Stem Cell Transplantation

Liem, R. I., Sep 1 2011, In : Clinical Pediatric Emergency Medicine. 12, 3, 1 p.

Research output: Contribution to journalEditorial

Stem Cell Transplantation
Hematology
Emergencies
Pediatrics

Exercise capacity and clinical outcomes in adults followed in the Cooperative Study of Sickle Cell Disease (CSSCD)

Badawy, S. M., Payne, A. B., Rodeghier, M. J. & Liem, R. I., Oct 1 2018, In : European Journal of Haematology. 101, 4, p. 532-541 10 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Acute Chest Syndrome
Hospitalization
Sickle Hemoglobin
Pain
6 Citations (Scopus)

Feasibility and safety of home exercise training in children with sickle cell anemia

Liem, R. I., Akinosun, M., Muntz, D. S. & Thompson, A. A., Dec 1 2017, In : Pediatric Blood and Cancer. 64, 12, e26671.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Exercise
Safety
Heart Rate
Guidelines
24 Citations (Scopus)
Sickle Cell Anemia
Young Adult
Exercise
Lung Diseases
Anemia
30 Citations (Scopus)

GATA-1 and Oct-1 are required for expression of the human α-hemoglobin-stabilizing protein gene

Gallagher, P. G., Liem, R. I., Wong, E., Weiss, M. J. & Bodine, D. M., Nov 25 2005, In : Journal of Biological Chemistry. 280, 47, p. 39016-39023 8 p.

Research output: Contribution to journalArticle

Hemoglobins
Genes
Proteins
Modifier Genes
Gene Expression
1 Citation (Scopus)

Healthcare utilization and hydroxyurea adherence in youth with sickle cell disease

Badawy, S. M., Thompson, A. A., Holl, J. L., Penedo, F. J. & Liem, R. I., Aug 18 2018, In : Pediatric Hematology and Oncology. 35, 5-6, p. 297-308 12 p.

Research output: Contribution to journalArticle

Hydroxyurea
Sickle Cell Anemia
Delivery of Health Care
Quality of Life
Hospital Emergency Service
18 Citations (Scopus)
Hydroxyurea
Sickle Cell Anemia
Young Adult
Quality of Life
Information Systems
27 Citations (Scopus)

Health-related quality of life in children with sickle cell anemia: Impact of blood transfusion therapy

Beverung, L. M., Strouse, J. J., Hulbert, M. L., Neville, K., Liem, R. I., Inusa, B., Fuh, B., King, A., Meier, E. R., Casella, J., Debaun, M. R. & Panepinto, J. A., Feb 1 2015, In : American Journal of Hematology. 90, 2, p. 139-143 5 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Blood Transfusion
Quality of Life
Observation
Therapeutics
6 Citations (Scopus)

Heart rate recovery is impaired after maximal exercise testing in children with sickle cell anemia

Alvarado, A. M., Ward, K. M., Muntz, D. S., Thompson, A. A., Rodeghier, M., Fernhall, B. & Liem, R. I., Jan 1 2015, In : Journal of Pediatrics. 166, 2, p. 389-393.e1

Research output: Contribution to journalArticle

Sickle Cell Anemia
Heart Rate
Exercise
Hydroxyurea
Autonomic Nervous System
1 Citation (Scopus)

Hydroxycarbamide in children with sickle cell anaemia after first-dose vs. chronic therapy: pharmacokinetics and predictive models for drug exposure

Estepp, J. H., Wiczling, P., Moen, J., Kang, G., Mack, J. M., Liem, R., Panepinto, J. A., Garg, U., Kearns, G. & Neville, K. A., Jul 1 2018, In : British Journal of Clinical Pharmacology. 84, 7, p. 1478-1485 8 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Pharmacokinetics
Pharmaceutical Preparations
Area Under Curve
Hydroxyurea

Identifying clinical and research priorities in sickle cell lung disease an official American Thoracic Society workshop report

American Thoracic Society Assembly on Pediatrics, Jan 1 2019, In : Annals of the American Thoracic Society. 16, 9, p. E17-E32

Research output: Contribution to journalArticle

Sickle Cell Anemia
Lung Diseases
Education
Research
Lung
20 Citations (Scopus)

Intravenous magnesium for pediatric sickle cell vaso-occlusive crisis: Methodological issues of a randomized controlled trial

Badaki-Makun, O., Scott, J. P., Panepinto, J. A., Casper, T. C., Hillery, C. A., Dean, J. M., Brousseau, D. C., Powell, E., Liem, R., Alpern, E., Smith-Whitley, K., Chamberlain, J., Hsu, L., Hogg, N., Chumpitazi, C., Airewele, G., Hickey, R., Krishnamurti, L., Leonard, J., Hulbert, M. & 2 others, Kannikeswaran, N. & Sarnaik, S., Jan 1 2014, In : Pediatric Blood and Cancer. 61, 6, p. 1049-1054 6 p.

Research output: Contribution to journalArticle

Magnesium
Emergency Medical Services
Randomized Controlled Trials
Pediatrics
Hospital Emergency Service
2 Citations (Scopus)

Longitudinal differences in aerobic capacity between children with sickle cell anemia and matched controls

Watson, A. M., Liem, R. I., Lu, Z., Saville, B., Acra, S., Shankar, S. & Buchowski, M., Jan 1 2015, In : Pediatric Blood and Cancer. 62, 4, p. 648-653 6 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Hemoglobins
Fats
Puberty
Linear Models
8 Citations (Scopus)

Misinterpretation of a calvert-derived formula leading to carboplatin overdose in two children

Liem, R. I., Higman, M. A., Chen, A. R. & Arceci, R. J., Oct 1 2003, In : Journal of Pediatric Hematology/Oncology. 25, 10, p. 818-821 4 p.

Research output: Contribution to journalArticle

Carboplatin
Pediatrics
Kidney
Peripheral Blood Stem Cell Transplantation
Glomerular Filtration Rate
3 Citations (Scopus)

Molecular mechanisms in the inherited red cell membrane disorders

Liem, R. I. & Gallagher, P. G., Dec 1 2005, In : Drug Discovery Today: Disease Mechanisms. 2, 4, p. 539-545 7 p.

Research output: Contribution to journalReview article

Cell Membrane
Erythrocyte Membrane
Mutation
Epigenomics
Proteins
25 Citations (Scopus)

Mutation of a barrier insulator in the human ankyrin-1 gene is associated with hereditary spherocytosis

Gallagher, P. G., Steiner, L. A., Liem, R. I., Owen, A. N., Cline, A. P., Seidel, N. E., Garrett, L. J. & Bodine, D. M., Dec 1 2010, In : Journal of Clinical Investigation. 120, 12, p. 4453-4465 13 p.

Research output: Contribution to journalArticle

Hereditary Spherocytosis
Ankyrins
Erythroid Cells
Mutation
Genes
2 Citations (Scopus)

Neonatal Compartment Syndrome Associated with Disseminated Intravascular Coagulation

Badawy, S. M., Gust, M. J., Liem, R. I., Ball, M. K., Gosain, A. K. & Sharathkumar, A. A., Feb 1 2016, In : Annals of Plastic Surgery. 76, 2, p. 256-258 3 p.

Research output: Contribution to journalReview article

Compartment Syndromes
Disseminated Intravascular Coagulation
Forearm
Extremities
Acute Chest Syndrome
Sickle Cell Anemia
Erythrocytes
Pain
Erythrocyte Count
4 Citations (Scopus)

Opioid prescription practices at discharge and 30-day returns in children with sickle cell disease and pain

Okorji, L. M., Muntz, D. S. & Liem, R. I., May 1 2017, In : Pediatric Blood and Cancer. 64, 5, e26319.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Opioid Analgesics
Prescriptions
Hospital Emergency Service
Pain
13 Citations (Scopus)

Parental attitudes toward research participation in pediatric sickle cell disease

Liem, R. I., Cole, A. H., Pelligra, S. A., Mason, M. & Thompson, A. A., Jul 15 2010, In : Pediatric Blood and Cancer. 55, 1, p. 129-133 5 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Pediatrics
Research
Biomedical Research
Legal Guardians

Pediatric Exercise Testing: Value and Implications of Peak Oxygen Uptake

Pianosi, P. T., Liem, R. I., McMurray, R. G., Cerny, F. J., Falk, B. & Kemper, H. C. G., Jan 24 2017, In : Children (Basel, Switzerland). 4, 1

Research output: Contribution to journalReview article

Exercise
Pediatrics
Oxygen
Biomarkers
Research Personnel
11 Citations (Scopus)
Thrombophilia
Portal Vein
Thrombosis
Portal Hypertension
Warfarin
5 Citations (Scopus)

Pharmacokinetics and bioequivalence of a liquid formulation of hydroxyurea in children with sickle cell anemia

Estepp, J. H., Melloni, C., Thornburg, C. D., Wiczling, P., Rogers, Z., Rothman, J. A., Green, N. S., Liem, R. I., Brandow, A. M., Crary, S. E., Howard, T. H., Morris, M. H., Lewandowski, A., Garg, U., Jusko, W. J. & Neville, K. A., Mar 1 2016, In : Journal of Clinical Pharmacology. 56, 3, p. 298-306 9 p.

Research output: Contribution to journalArticle

Therapeutic Equivalency
Hydroxyurea
Sickle Cell Anemia
Pharmacokinetics
Capsules
9 Citations (Scopus)

Population pharmacokinetics of hydroxyurea for children and adolescents with sickle cell disease

Wiczling, P., Liem, R. I., Panepinto, J. A., Garg, U., Abdel-Rahman, S. M., Kearns, G. L. & Neville, K. A., Jan 1 2014, In : Journal of Clinical Pharmacology. 54, 9, p. 1016-1022 7 p.

Research output: Contribution to journalArticle

Hydroxyurea
Sickle Cell Anemia
Pharmacokinetics
Population
Area Under Curve
18 Citations (Scopus)

Prolonged QTc interval in children and young adults with sickle cell disease at steady state

Liem, R. I., Young, L. T. & Thompson, A. A., Jul 1 2009, In : Pediatric Blood and Cancer. 52, 7, p. 842-846 5 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Young Adult
Left Ventricular Hypertrophy
Acute Chest Syndrome
Electrocardiography
4 Citations (Scopus)

Randomization is not associated with socio-economic and demographic factors in a multi-center clinical trial of children with sickle cell anemia

Roberts, D. O., Covert, B., Rodeghier, M. J., Parmar, N., Debaun, M. R., Thompson, A. A. & Liem, R. I., Jan 1 2014, In : Pediatric Blood and Cancer. 61, 9, p. 1529-1535 7 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Random Allocation
Economics
Demography
Clinical Trials
2 Citations (Scopus)

Red blood cell transfusions during sickle cell anemia vaso-occlusive crises: a report from the magnesium in crisis (MAGiC) study

Hulbert, M. L., Panepinto, J. A., Scott, J. P., Liem, R. I., Cook, L. J., Simmons, T. & Brousseau, D. C., Aug 1 2017, In : Transfusion. 57, 8, p. 1891-1897 7 p.

Research output: Contribution to journalArticle

Acute Chest Syndrome
Erythrocyte Transfusion
Sickle Cell Anemia
Magnesium
Hemoglobins
17 Citations (Scopus)

Reduced fitness and abnormal cardiopulmonary responses to maximal exercise testing in children and young adults with sickle cell anemia

Liem, R. I., Reddy, M., Pelligra, S. A., Savant, A. P., Fernhall, B., Rodeghier, M. & Thompson, A. A., Jan 1 2015, In : Physiological Reports. 3, 4, e12338.

Research output: Contribution to journalArticle

Open Access
Sickle Cell Anemia
Young Adult
Exercise
Oxygen
Sickle Hemoglobin
12 Citations (Scopus)

Reproducibility of detecting silent cerebral infarcts in pediatric sickle cell anemia

Liem, R. I., Liu, J., Gordon, M. O., Vendt, B. A., McKinstry, R. C., Kraut, M. A., Strouse, J. J., Ball, W. S. & DeBaun, M. R., Jan 1 2014, In : Journal of child neurology. 29, 12, p. 1685-1691 7 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Magnetic Resonance Spectroscopy
Pediatrics
Reading
Research
13 Citations (Scopus)
Sickle Cell Anemia
Pulmonary Hypertension
Young Adult
Tricuspid Valve Insufficiency
Doppler Echocardiography