• 764 Citations
20032022
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Research Output 2003 2019

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2019

Identifying clinical and research priorities in sickle cell lung disease an official American Thoracic Society workshop report

American Thoracic Society Assembly on Pediatrics, Jan 1 2019, In : Annals of the American Thoracic Society. 16, 9, p. E17-E32

Research output: Contribution to journalArticle

Sickle Cell Anemia
Lung Diseases
Education
Research
Lung
Acute Chest Syndrome
Sickle Cell Anemia
Erythrocytes
Pain
Erythrocyte Count
2018

Balancing exercise risk and benefits: Lessons learned from sickle cell trait and sickle cell anemia

Liem, R. I., Nov 30 2018, In : Hematology. 2018, 1, p. 418-425 8 p.

Research output: Contribution to journalArticle

Sickle Cell Trait
Sickle Cell Anemia
Exercise
Athletes
Causality
7 Citations (Scopus)

Beliefs about hydroxyurea in youth with sickle cell disease

Badawy, S. M., Thompson, A. A. & Liem, R. I., Sep 1 2018, In : Hematology/ Oncology and Stem Cell Therapy. 11, 3, p. 142-148 7 p.

Research output: Contribution to journalArticle

Hydroxyurea
Sickle Cell Anemia
Quality of Life
Visual Analog Scale
Young Adult
1 Citation (Scopus)

Exercise capacity and clinical outcomes in adults followed in the Cooperative Study of Sickle Cell Disease (CSSCD)

Badawy, S. M., Payne, A. B., Rodeghier, M. J. & Liem, R. I., Oct 1 2018, In : European Journal of Haematology. 101, 4, p. 532-541 10 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Acute Chest Syndrome
Hospitalization
Sickle Hemoglobin
Pain
2 Citations (Scopus)

Healthcare utilization and hydroxyurea adherence in youth with sickle cell disease

Badawy, S. M., Thompson, A. A., Holl, J. L., Penedo, F. J. & Liem, R. I., Aug 18 2018, In : Pediatric Hematology and Oncology. 35, 5-6, p. 297-308 12 p.

Research output: Contribution to journalArticle

Hydroxyurea
Sickle Cell Anemia
Delivery of Health Care
Quality of Life
Hospital Emergency Service
1 Citation (Scopus)

Hydroxycarbamide in children with sickle cell anaemia after first-dose vs. chronic therapy: pharmacokinetics and predictive models for drug exposure

Estepp, J. H., Wiczling, P., Moen, J., Kang, G., Mack, J. M., Liem, R., Panepinto, J. A., Garg, U., Kearns, G. & Neville, K. A., Jul 1 2018, In : British Journal of Clinical Pharmacology. 84, 7, p. 1478-1485 8 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Pharmacokinetics
Pharmaceutical Preparations
Area Under Curve
Hydroxyurea
2 Citations (Scopus)
Neonatal Intensive Care
Venous Thromboembolism
Case-Control Studies
Thrombosis
Venous Thrombosis
2017
15 Citations (Scopus)
Hydroxyurea
Sickle Cell Anemia
Young Adult
Cross-Sectional Studies
Quality of Life
12 Citations (Scopus)

Association among sickle cell trait, fitness, and cardiovascular risk factors in CARDIA

Liem, R. I., Chan, C., Vu, T. H. T., Fornage, M., Thompson, A. A., Liu, K. & Carnethon, M. R., Feb 9 2017, In : Blood. 129, 6, p. 723-728 6 p.

Research output: Contribution to journalArticle

Sickle Cell Trait
Young Adult
Coronary Vessels
Medical problems
Hypertension
41 Citations (Scopus)

Association of sickle cell trait with hemoglobin A1c in African Americans

Lacy, M. E., Wellenius, G. A., Sumner, A. E., Correa, A., Carnethon, M. R., Liem, R. I., Wilson, J. G., Sacks, D. B., Jacobs, D. R., Carson, A. P., Luo, X., Gjelsvik, A., Reiner, A. P., Naik, R. P., Liu, S., Musani, S. K., Eaton, C. B. & Wu, W. C., Feb 7 2017, In : JAMA - Journal of the American Medical Association. 317, 5, p. 507-515 9 p.

Research output: Contribution to journalArticle

Sickle Cell Trait
African Americans
Hemoglobins
Glucose
Fasting
21 Citations (Scopus)
Hydroxyurea
Sickle Cell Anemia
Young Adult
Quality of Life
Visual Analog Scale
11 Citations (Scopus)

Determining the longitudinal validity and meaningful differences in HRQL of the PedsQL™ Sickle Cell Disease Module

and for the Pediatric Emergency Care Applied Research Network (PECARN), Jun 12 2017, In : Health and Quality of Life Outcomes. 15, 1, 124.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Quality of Life
Pain
Health Status
Fatigue
6 Citations (Scopus)

Feasibility and safety of home exercise training in children with sickle cell anemia

Liem, R. I., Akinosun, M., Muntz, D. S. & Thompson, A. A., Dec 1 2017, In : Pediatric Blood and Cancer. 64, 12, e26671.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Exercise
Safety
Heart Rate
Guidelines
19 Citations (Scopus)
Hydroxyurea
Sickle Cell Anemia
Young Adult
Quality of Life
Information Systems
4 Citations (Scopus)

Opioid prescription practices at discharge and 30-day returns in children with sickle cell disease and pain

Okorji, L. M., Muntz, D. S. & Liem, R. I., May 1 2017, In : Pediatric Blood and Cancer. 64, 5, e26319.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Opioid Analgesics
Prescriptions
Hospital Emergency Service
Pain
2 Citations (Scopus)

Red blood cell transfusions during sickle cell anemia vaso-occlusive crises: a report from the magnesium in crisis (MAGiC) study

Hulbert, M. L., Panepinto, J. A., Scott, J. P., Liem, R. I., Cook, L. J., Simmons, T. & Brousseau, D. C., Aug 1 2017, In : Transfusion. 57, 8, p. 1891-1897 7 p.

Research output: Contribution to journalArticle

Acute Chest Syndrome
Erythrocyte Transfusion
Sickle Cell Anemia
Magnesium
Hemoglobins
2 Citations (Scopus)

Self-reported physical activity and exercise patterns in children with sickle cell disease

Omwanghe, O. A., Muntz, D. S., Kwon, S., Montgomery, S., Kemiki, O., Hsu, L. L., Thompson, A. A. & Liem, R. I., Aug 1 2017, In : Pediatric Exercise Science. 29, 3, p. 388-395 8 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Exercise
Physical Education and Training
Sports
Nutrition Surveys
3 Citations (Scopus)

Successful medical management of a neonate with spontaneous splenic rupture and severe hemophilia A

Badawy, S. M., Rossoff, J., Yallapragada, S. G., Liem, R. I. & Sharathkumar, A. A., Mar 1 2017, In : Hematology/ Oncology and Stem Cell Therapy. 10, 1, p. 29-32 4 p.

Research output: Contribution to journalArticle

Splenic Rupture
Spontaneous Rupture
Hemophilia A
Fetal Erythroblastosis
Factor VIII
2016
10 Citations (Scopus)
Iron Overload
Sickle Cell Anemia
Iron
Ferritins
Liver
5 Citations (Scopus)

Pharmacokinetics and bioequivalence of a liquid formulation of hydroxyurea in children with sickle cell anemia

Estepp, J. H., Melloni, C., Thornburg, C. D., Wiczling, P., Rogers, Z., Rothman, J. A., Green, N. S., Liem, R. I., Brandow, A. M., Crary, S. E., Howard, T. H., Morris, M. H., Lewandowski, A., Garg, U., Jusko, W. J. & Neville, K. A., Mar 1 2016, In : Journal of Clinical Pharmacology. 56, 3, p. 298-306 9 p.

Research output: Contribution to journalArticle

Therapeutic Equivalency
Hydroxyurea
Sickle Cell Anemia
Pharmacokinetics
Capsules
35 Citations (Scopus)
Medication Adherence
Sickle Cell Anemia
Young Adult
Technology
Hydroxyurea
3 Citations (Scopus)

The Benefits and Challenges of Preconsent in a Multisite, Pediatric Sickle Cell Intervention Trial

Nimmer, M., Czachor, J., Turner, L., Thomas, B., Woodford, A. L., Carpenter, K., Gonzalez, V., Liem, R. I., Ellison, A., Casper, T. C., Brousseau, D. C. & for the sickle cell working group of the Pediatric Emergency Care Applied Research Network (PECARN), Sep 1 2016, In : Pediatric Blood and Cancer. 63, 9, p. 1649-1652 4 p.

Research output: Contribution to journalArticle

Research Ethics Committees
Legal Guardians
Pediatrics
Emergency Medicine
Hematology
2015
36 Citations (Scopus)

A multicenter randomized controlled trial of intravenous magnesium for sickle cell pain crisis in children

for the Pediatric Emergency Care Applied Research Network (PECARN), Oct 1 2015, In : Blood. 126, 14, p. 1651-1657 7 p.

Research output: Contribution to journalArticle

Magnesium
Randomized Controlled Trials
Pain
Placebos
Quality of Life
27 Citations (Scopus)

Health-related quality of life in children with sickle cell anemia: Impact of blood transfusion therapy

Beverung, L. M., Strouse, J. J., Hulbert, M. L., Neville, K., Liem, R. I., Inusa, B., Fuh, B., King, A., Meier, E. R., Casella, J., Debaun, M. R. & Panepinto, J. A., Feb 1 2015, In : American Journal of Hematology. 90, 2, p. 139-143 5 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Blood Transfusion
Quality of Life
Observation
Therapeutics
6 Citations (Scopus)

Heart rate recovery is impaired after maximal exercise testing in children with sickle cell anemia

Alvarado, A. M., Ward, K. M., Muntz, D. S., Thompson, A. A., Rodeghier, M., Fernhall, B. & Liem, R. I., Jan 1 2015, In : Journal of Pediatrics. 166, 2, p. 389-393.e1

Research output: Contribution to journalArticle

Sickle Cell Anemia
Heart Rate
Exercise
Hydroxyurea
Autonomic Nervous System
2 Citations (Scopus)

Longitudinal differences in aerobic capacity between children with sickle cell anemia and matched controls

Watson, A. M., Liem, R. I., Lu, Z., Saville, B., Acra, S., Shankar, S. & Buchowski, M., Jan 1 2015, In : Pediatric Blood and Cancer. 62, 4, p. 648-653 6 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Hemoglobins
Fats
Puberty
Linear Models
19 Citations (Scopus)

Reduced fitness and abnormal cardiopulmonary responses to maximal exercise testing in children and young adults with sickle cell anemia

Liem, R. I., Reddy, M., Pelligra, S. A., Savant, A. P., Fernhall, B., Rodeghier, M. & Thompson, A. A., Jan 1 2015, In : Physiological Reports. 3, 4, e12338.

Research output: Contribution to journalArticle

Open Access
Sickle Cell Anemia
Young Adult
Exercise
Oxygen
Sickle Hemoglobin
7 Citations (Scopus)

The acute phase inflammatory response to maximal exercise testing in children and young adults with sickle cell anaemia

Liem, R. I., Onyejekwe, K., Olszewski, M., Nchekwube, C., Zaldivar, F. P., Radom-Aizik, S., Rodeghier, M. J. & Thompson, A. A., Dec 1 2015, In : British Journal of Haematology. 171, 5, p. 854-861 8 p.

Research output: Contribution to journalArticle

Acute-Phase Reaction
Sickle Cell Anemia
Young Adult
Exercise
C-Reactive Protein
10 Citations (Scopus)

The Clinical Translation Gap in Child Health Exercise Research: A Call for Disruptive Innovation

Ashish, N., Bamman, M. M., Cerny, F. J., Cooper, D. M., D'Hemecourt, P., Eisenmann, J. C., Ericson, D., Fahey, J., Falk, B., Gabriel, D., Kahn, M. G., Kemper, H. C. G., Leu, S. Y., Liem, R. I., Mcmurray, R., Nixon, P. A., Olin, J. T., Pianosi, P. T., Purucker, M., Radom-Aizik, S. & 1 others, Taylor, A., Feb 1 2015, In : Clinical and Translational Science. 8, 1, p. 67-76 10 p.

Research output: Contribution to journalArticle

Innovation
Health
Medicine
Exercise
Research
2014
4 Citations (Scopus)

Access to Patient-Centered medical homes in children with sickle cell disease

Liem, R. I., O'Suoji, C., Kingsberry, P. S., Pelligra, S. A., Kwon, S., Mason, M. & Thompson, A. A., Oct 1 2014, In : Maternal and child health journal. 18, 8, p. 1854-1862 9 p.

Research output: Contribution to journalArticle

Patient-Centered Care
Sickle Cell Anemia
Primary Health Care
Caregivers
Parents
20 Citations (Scopus)

Intravenous magnesium for pediatric sickle cell vaso-occlusive crisis: Methodological issues of a randomized controlled trial

Badaki-Makun, O., Scott, J. P., Panepinto, J. A., Casper, T. C., Hillery, C. A., Dean, J. M., Brousseau, D. C., Powell, E., Liem, R., Alpern, E., Smith-Whitley, K., Chamberlain, J., Hsu, L., Hogg, N., Chumpitazi, C., Airewele, G., Hickey, R., Krishnamurti, L., Leonard, J., Hulbert, M. & 2 others, Kannikeswaran, N. & Sarnaik, S., Jan 1 2014, In : Pediatric Blood and Cancer. 61, 6, p. 1049-1054 6 p.

Research output: Contribution to journalArticle

Magnesium
Emergency Medical Services
Randomized Controlled Trials
Pediatrics
Hospital Emergency Service
9 Citations (Scopus)

Population pharmacokinetics of hydroxyurea for children and adolescents with sickle cell disease

Wiczling, P., Liem, R. I., Panepinto, J. A., Garg, U., Abdel-Rahman, S. M., Kearns, G. L. & Neville, K. A., Jan 1 2014, In : Journal of Clinical Pharmacology. 54, 9, p. 1016-1022 7 p.

Research output: Contribution to journalArticle

Hydroxyurea
Sickle Cell Anemia
Pharmacokinetics
Population
Area Under Curve
4 Citations (Scopus)

Randomization is not associated with socio-economic and demographic factors in a multi-center clinical trial of children with sickle cell anemia

Roberts, D. O., Covert, B., Rodeghier, M. J., Parmar, N., Debaun, M. R., Thompson, A. A. & Liem, R. I., Jan 1 2014, In : Pediatric Blood and Cancer. 61, 9, p. 1529-1535 7 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Random Allocation
Economics
Demography
Clinical Trials
12 Citations (Scopus)

Reproducibility of detecting silent cerebral infarcts in pediatric sickle cell anemia

Liem, R. I., Liu, J., Gordon, M. O., Vendt, B. A., McKinstry, R. C., Kraut, M. A., Strouse, J. J., Ball, W. S. & DeBaun, M. R., Jan 1 2014, In : Journal of child neurology. 29, 12, p. 1685-1691 7 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Magnetic Resonance Spectroscopy
Pediatrics
Reading
Research
2013
40 Citations (Scopus)

Alloimmunization in sickle cell anemia in the era of extended red cell typing

O'Suoji, C., Liem, R. I., Mack, A. K., Kingsberry, P., Ramsey, G. E. & Thompson, A. A., Sep 1 2013, In : Pediatric Blood and Cancer. 60, 9, p. 1487-1491 5 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Blood Grouping and Crossmatching
Erythrocytes
Antibodies
Erythrocyte Transfusion
2012

An 11-year-old boy with seizures and fatigue.

Listernick, R., Nordli, D., Tanz, R., Stamos, J. K., Greene, M., Liem, R. & Kiesau, Y., Jan 1 2012, In : Pediatric Annals. 41, 11, p. 448-451 4 p.

Research output: Contribution to journalArticle

Adenomatous Polyposis Coli
Fatigue
Seizures
8 Citations (Scopus)

Risk factors for chronic anemia in pediatric orthotopic liver transplantation: Analysis of data from the SPLIT registry

Liem, R. I., Anand, R., Yin, W. & Alonso, E. M., Mar 1 2012, In : Pediatric transplantation. 16, 2, p. 137-143 7 p.

Research output: Contribution to journalArticle

Liver Transplantation
Registries
Anemia
Pediatrics
Transplants
2011
16 Citations (Scopus)

Acute chest syndrome is associated with history of asthma in hemoglobin SC disease

Poulter, E. Y., Truszkowski, P., Thompson, A. A. & Liem, R. I., Aug 1 2011, In : Pediatric Blood and Cancer. 57, 2, p. 289-293 5 p.

Research output: Contribution to journalArticle

Hemoglobin SC Disease
Acute Chest Syndrome
Asthma
Sickle Hemoglobin
Respiratory Sounds
6 Citations (Scopus)

Sickle Cell Disease in the Emergency Department: Atypical Complications and Management

Brandow, A. M. & Liem, R. I., Sep 1 2011, In : Clinical Pediatric Emergency Medicine. 12, 3, p. 202-212 11 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Hospital Emergency Service
Acute Chest Syndrome
Priapism
Hemolytic Anemia
3 Citations (Scopus)

The impact of thalassemia on Southeast Asian and Asian Indian families in the United States: A qualitative study

Liem, R. I., Gilgour, B., Pelligra, S. A., Mason, M. & Thompson, A. A., Jun 1 2011, In : Ethnicity and Disease. 21, 3, p. 361-369 9 p.

Research output: Contribution to journalArticle

Thalassemia
Parents
Interviews
Hope
Chelation Therapy
2010
9 Citations (Scopus)
Transferrin Receptors
Sickle Cell Anemia
Iron
Pediatrics
Hemolysis
25 Citations (Scopus)

Mutation of a barrier insulator in the human ankyrin-1 gene is associated with hereditary spherocytosis

Gallagher, P. G., Steiner, L. A., Liem, R. I., Owen, A. N., Cline, A. P., Seidel, N. E., Garrett, L. J. & Bodine, D. M., Dec 1 2010, In : Journal of Clinical Investigation. 120, 12, p. 4453-4465 13 p.

Research output: Contribution to journalArticle

Hereditary Spherocytosis
Ankyrins
Erythroid Cells
Mutation
Genes
13 Citations (Scopus)

Parental attitudes toward research participation in pediatric sickle cell disease

Liem, R. I., Cole, A. H., Pelligra, S. A., Mason, M. & Thompson, A. A., Jul 15 2010, In : Pediatric Blood and Cancer. 55, 1, p. 129-133 5 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Pediatrics
Research
Biomedical Research
Legal Guardians
13 Citations (Scopus)
Sickle Cell Anemia
Pulmonary Hypertension
Young Adult
Tricuspid Valve Insufficiency
Doppler Echocardiography
2009
24 Citations (Scopus)
Sickle Cell Anemia
Young Adult
Exercise
Lung Diseases
Anemia
18 Citations (Scopus)

Prolonged QTc interval in children and young adults with sickle cell disease at steady state

Liem, R. I., Young, L. T. & Thompson, A. A., Jul 1 2009, In : Pediatric Blood and Cancer. 52, 7, p. 842-846 5 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Young Adult
Left Ventricular Hypertrophy
Acute Chest Syndrome
Electrocardiography
20 Citations (Scopus)

Tricuspid regurgitant jet velocity elevation and its relationship to lung function in pediatric sickle cell disease

Liem, R. I., Nevin, M. A., Prestridge, A., Young, L. T. & Thompson, A. A., Mar 1 2009, In : Pediatric Pulmonology. 44, 3, p. 281-289 9 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Vital Capacity
Pediatrics
Lung
Oxygen
2008
18 Citations (Scopus)

Sudden onset blindness in sickle cell disease due to retinal artery occlusion

Liem, R. I., Calamaras, D. M., Chhabra, M. S., Files, B., Minniti, C. P. & Thompson, A. A., Mar 1 2008, In : Pediatric Blood and Cancer. 50, 3, p. 624-627 4 p.

Research output: Contribution to journalArticle

Retinal Artery Occlusion
Sickle Cell Anemia
Blindness
2007
40 Citations (Scopus)
Sickle Cell Anemia
Hemolysis
Pulmonary Hypertension
Reticulocyte Count
Young Adult