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Personal profile

Research Interests

Our research focuses on molecular and cellular mechanisms of Alzheimer's disease. In particular, we investigate the beta-secretase enzyme BACE1, which initiates the production of the beta-amyloid peptide that plays a central early role in the pathogenesis of Alzheimer's. We use a combination of biochemical, cell culture and animal model approaches to investigate the role of BACE1 in health and disease.

Training Experience

1996Postdoctoral Fellowship, Columbia University

Education/Academic qualification

Molecular Genetics, PhD, University of Chicago

… → 1992

Research interests

  • Aging
  • Alzheimer's Disease
  • Alzheimer's Drug
  • Biochemistry: Proteins
  • Cell Biology
  • Molecular Biology
  • Molecular Genetics
  • Neuroscience

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  • A promising new γ-secretase modulator for Alzheimer's disease

    Dobrowolska Zakaria, J. A. & Vassar, R. J., 2021, In: Journal of Experimental Medicine. 218, 4, e20210077.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • Early detection and personalized medicine: Future strategies against Alzheimer's disease

    Di Meco, A. & Vassar, R., Jan 2021, Progress in Molecular Biology and Translational Science. Teplow, D. B. (ed.). Elsevier B.V., p. 157-173 17 p. (Progress in Molecular Biology and Translational Science; vol. 177).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis

    Kunkle, B. W., Schmidt, M., Klein, H. U., Naj, A. C., Hamilton-Nelson, K. L., Larson, E. B., Evans, D. A., De Jager, P. L., Crane, P. K., Buxbaum, J. D., Ertekin-Taner, N., Barnes, L. L., Fallin, M. D., Manly, J. J., Go, R. C. P., Obisesan, T. O., Kamboh, M. I., Bennett, D. A., Hall, K. S., Goate, A. M. & 58 others, Foroud, T. M., Martin, E. R., Wang, L. S., Byrd, G. S., Farrer, L. A., Haines, J. L., Schellenberg, G. D., Mayeux, R., Pericak-Vance, M. A., Reitz, C., Graff-Radford, N. R., Martinez, I., Ayodele, T., Logue, M. W., Cantwell, L. B., Jean-Francois, M., Kuzma, A. B., Adams, L. D., Vance, J. M., Cuccaro, M. L., Chung, J., Mez, J., Lunetta, K. L., Jun, G. R., Lopez, O. L., Hendrie, H. C., Reiman, E. M., Kowall, N. W., Leverenz, J. B., Small, S. A., Levey, A. I., Golde, T. E., Saykin, A. J., Starks, T. D., Albert, M. S., Hyman, B. T., Petersen, R. C., Sano, M., Wisniewski, T., Vassar, R., Kaye, J. A., Henderson, V. W., Decarli, C., Laferla, F. M., Brewer, J. B., Miller, B. L., Swerdlow, R. H., Van Eldik, L. J., Paulson, H. L., Trojanowski, J. Q., Chui, H. C., Rosenberg, R. N., Craft, S., Grabowski, T. J., Asthana, S., Morris, J. C., Strittmatter, S. M. & Kukull, W. A., Jan 2021, In: JAMA Neurology. 78, 1, p. 102-113 12 p.

    Research output: Contribution to journalArticlepeer-review

    13 Scopus citations
  • The β-Secretase BACE1 in Alzheimer's Disease

    Hampel, H., Vassar, R., De Strooper, B., Hardy, J., Willem, M., Singh, N., Zhou, J., Yan, R., Vanmechelen, E., De Vos, A., Nisticò, R., Corbo, M., Imbimbo, B. P., Streffer, J., Voytyuk, I., Timmers, M., Tahami Monfared, A. A., Irizarry, M., Albala, B., Koyama, A. & 6 others, Watanabe, N., Kimura, T., Yarenis, L., Lista, S., Kramer, L. & Vergallo, A., Apr 15 2021, In: Biological psychiatry. 89, 8, p. 745-756 12 p.

    Research output: Contribution to journalReview articlepeer-review

    Open Access
    45 Scopus citations
  • Aβ-accelerated neurodegeneration caused by Alzheimer's-associated ACE variant R1279Q is rescued by angiotensin system inhibition in mice

    Cuddy, L. K., Prokopenko, D., Cunningham, E. P., Brimberry, R., Song, P., Kirchner, R., Chapman, B. A., Hofmann, O., Hide, W., Procissi, D., Hanania, T., Leiser, S. C., Tanzi, R. E. & Vassar, R., Sep 30 2020, In: Science translational medicine. 12, 563, eaaz2541.

    Research output: Contribution to journalArticlepeer-review

    3 Scopus citations