Grants per year
Personal profile
Research Interests
Our research focuses on molecular and cellular mechanisms of Alzheimer's disease. In particular, we investigate the beta-secretase enzyme BACE1, which initiates the production of the beta-amyloid peptide that plays a central early role in the pathogenesis of Alzheimer's. We use a combination of biochemical, cell culture and animal model approaches to investigate the role of BACE1 in health and disease.
Training Experience
| 1996 | Postdoctoral Fellowship, Columbia University |
Education/Academic qualification
Molecular Genetics, PhD, University of Chicago
… → 1992
Research interests keywords
- Aging
- Alzheimer's Disease
- Alzheimer's Drug
- Biochemistry: Proteins
- Cell Biology
- Molecular Biology
- Molecular Genetics
- Neuroscience
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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The Role of RNA Binding Protein Networks in Tauopathy and Related Dementia R01
Vassar, R. J. (PD/PI) & Kohtz, J. D. (Co-Investigator)
9/1/24 → 8/31/25
Project: Research project
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Exploring annexin A6 for the prevention of dystrophic neurites and tau seeding and spreading in Alzheimer's disease
Sadleir, K. R. (PD/PI), Vassar, R. J. (PD/PI), Contractor, A. (Co-Investigator), Demonbreun, A. R. (Co-Investigator) & McNally, E. M. (Co-Investigator)
1/1/24 → 12/31/28
Project: Research project
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Microbiome Consortium: Interaction of the microbiome with astrocytes and amyloid pathology
Vassar, R. J. (PD/PI)
Alzheimer's Disease Research Foundation
11/15/23 → 11/14/24
Project: Research project
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Vulnerability Profiles of Comorbid Alzheimer and TDP-43 Proteinopathies in Amnestic Dementia
Gefen, T. D. (PD/PI), Gefen, T. D. (PD/PI), Geula, C. (Co-Investigator), Geula, C. (Co-Investigator), Mesulam, M.-M. (Co-Investigator), Mesulam, M.-M. (Co-Investigator), Vassar, R. J. (Co-Investigator), Vassar, R. J. (Co-Investigator), Zhang, H. (Co-Investigator) & Zhang, H. (Co-Investigator)
9/1/23 → 8/31/25
Project: Research project
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Mechanisms of Angiotensin I Converting Enzyme in Alzheimer's disease
Vassar, R. J. (PD/PI), Cuddy, L. K. (Co-Investigator), Gate, D. (Co-Investigator) & Savas, J. N. (Co-Investigator)
12/15/22 → 11/30/25
Project: Research project
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Death Induced by Survival gene Elimination (DISE) correlates with neurotoxicity in Alzheimer’s disease and aging
Paudel, B., Jeong, S. Y., Martinez, C. P., Rickman, A., Haluck-Kangas, A., Bartom, E. T., Fredriksen, K., Affaneh, A., Kessler, J. A., Mazzulli, J. R., Murmann, A. E., Rogalski, E., Geula, C., Ferreira, A., Heckmann, B. L., Green, D. R., Sadleir, K. R., Vassar, R. & Peter, M. E., Dec 2024, In: Nature communications. 15, 1, 264.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer’s disease
Rajani, R. M., Ellingford, R., Hellmuth, M., Harris, S. S., Taso, O. S., Graykowski, D., Lam, F. K. W., Arber, C., Fertan, E., Danial, J. S. H., Swire, M., Lloyd, M., Giovannucci, T. A., Bourdenx, M., Klenerman, D., Vassar, R., Wray, S., Frigerio, C. S. & Busche, M. A., Jul 2024, In: PLoS biology. 22, 7 July, e3002727.Research output: Contribution to journal › Article › peer-review
Open Access -
The role of the gut microbiome in the regulation of astrocytes in Alzheimer's disease
Chandra, S. & Vassar, R., 2024, (Accepted/In press) In: Neurotherapeutics. e00425.Research output: Contribution to journal › Review article › peer-review
Open Access -
AD-BERT: Using pre-trained language model to predict the progression from mild cognitive impairment to Alzheimer's disease
Mao, C., Xu, J., Rasmussen, L., Li, Y., Adekkanattu, P., Pacheco, J., Bonakdarpour, B., Vassar, R., Shen, L., Jiang, G., Wang, F., Pathak, J. & Luo, Y., Aug 2023, In: Journal of Biomedical Informatics. 144, 104442.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity
Upadhyay, A., Chhangani, D., Rao, N. R., Kofler, J., Vassar, R., Rincon-Limas, D. E. & Savas, J. N., Dec 2023, In: Molecular neurodegeneration. 18, 1, 61.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations
Datasets
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Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model
Rice, H. C. (Creator), Marcassa, G. (Creator), Chrysidou, I. (Contributor), Horré, K. (Creator), Young-Pearse, T. L. (Creator), Müller, U. C. (Creator), Saito, T. (Creator), Saido, T. C. (Contributor), Vassar, R. (Creator), De Wit, J. (Contributor), De Strooper, B. (Contributor), Takaomi, S. (Contributor), Wit, J. D. (Creator) & Strooper, B. D. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.c.4810419, https://springernature.figshare.com/collections/Contribution_of_GABAergic_interneurons_to_amyloid-_plaque_pathology_in_an_APP_knock-in_mouse_model/4810419
Dataset
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Additional file 5 of Farnesyltransferase inhibitor LNK-754 attenuates axonal dystrophy and reduces amyloid pathology in mice
Cuddy, L. K. (Creator), Alia, A. O. (Creator), Salvo, M. A. (Creator), Chandra, S. (Creator), Grammatopoulos, T. N. (Creator), Justman, C. J. (Creator), Lansbury, P. T. (Creator), Mazzulli, J. R. (Creator), Vassar, R. (Creator) & Lansbury, P. T. (Creator), figshare, 2022
DOI: 10.6084/m9.figshare.20522624, https://springernature.figshare.com/articles/figure/Additional_file_5_of_Farnesyltransferase_inhibitor_LNK-754_attenuates_axonal_dystrophy_and_reduces_amyloid_pathology_in_mice/20522624
Dataset
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Additional file 4 of Farnesyltransferase inhibitor LNK-754 attenuates axonal dystrophy and reduces amyloid pathology in mice
Cuddy, L. K. (Creator), Alia, A. O. (Creator), Salvo, M. A. (Creator), Chandra, S. (Creator), Grammatopoulos, T. N. (Creator), Justman, C. J. (Creator), Lansbury, P. T. (Creator), Mazzulli, J. R. (Creator), Vassar, R. (Creator) & Lansbury, P. T. (Creator), figshare, 2022
DOI: 10.6084/m9.figshare.20522621, https://springernature.figshare.com/articles/figure/Additional_file_4_of_Farnesyltransferase_inhibitor_LNK-754_attenuates_axonal_dystrophy_and_reduces_amyloid_pathology_in_mice/20522621
Dataset
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Identification of natural products with neuronal and metabolic benefits through autophagy induction
Wang, N. (Creator), Zhang, W. (Contributor), He, C. (Contributor), Fan, Y. (Contributor), Rocchi, A. (Creator), Vassar, R. (Creator), Zhou, Y. (Contributor) & Weiran, Z. (Contributor), Taylor & Francis, 2016
DOI: 10.6084/m9.figshare.4123170.v1, https://tandf.figshare.com/articles/dataset/Identification_of_natural_products_with_neuronal_and_metabolic_benefits_through_autophagy_induction/4123170/1
Dataset
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Additional file 2 of Farnesyltransferase inhibitor LNK-754 attenuates axonal dystrophy and reduces amyloid pathology in mice
Cuddy, L. K. (Creator), Alia, A. O. (Creator), Salvo, M. A. (Creator), Chandra, S. (Creator), Grammatopoulos, T. N. (Creator), Justman, C. J. (Creator), Lansbury, P. T. (Creator), Mazzulli, J. R. (Creator), Vassar, R. (Creator) & Lansbury, P. T. (Creator), figshare, 2022
DOI: 10.6084/m9.figshare.20522615, https://springernature.figshare.com/articles/figure/Additional_file_2_of_Farnesyltransferase_inhibitor_LNK-754_attenuates_axonal_dystrophy_and_reduces_amyloid_pathology_in_mice/20522615
Dataset