• 15630 Citations
1981 …2023
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Personal profile

Research Interests

Our research focuses on molecular and cellular mechanisms of Alzheimer's disease. In particular, we investigate the beta-secretase enzyme BACE1, which initiates the production of the beta-amyloid peptide that plays a central early role in the pathogenesis of Alzheimer's. We use a combination of biochemical, cell culture and animal model approaches to investigate the role of BACE1 in health and disease.

Training Experience

1996Postdoctoral Fellowship, Columbia University

Education/Academic qualification

PhD, University of Chicago

… → 1992

Keywords

  • Aging
  • Alzheimer's Disease
  • Alzheimer's Drug
  • Biochemistry: Proteins
  • Cell Biology
  • Molecular Biology
  • Molecular Genetics
  • Neuroscience

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Grants 2001 2023

Microbiota
Amyloid
Astrocytes
Pathology
Microglia
Synapses
Alzheimer Disease
Genes
Dendritic Spines
Glutamate Receptors
Dependovirus
Genetic Therapy
Alzheimer Disease
Amyloid
Pathology
Alzheimer Disease
Calcium
Doxycycline
Buffers
Neurites

Research Output 1981 2019

2 Citations (Scopus)

3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice

Lazic, D., Sagare, A. P., Nikolakopoulou, A. M., Griffin, J. H., Vassar, R. J. & Zlokovic, B. V., Feb 1 2019, In : Journal of Experimental Medicine. 216, 2, p. 279-293 15 p.

Research output: Contribution to journalArticle

Protein C
Cerebrovascular Circulation
Alzheimer Disease
Stroke
Protein Precursors
Knockout Mice
Hippocampus
Clinical Trials
Phenotype
Alzheimer Disease

Modeling genetic diversity in Alzheimer’s disease

Sadleir, K. R. & Vassar, R. J., Mar 1 2019, In : Lab Animal. 48, 3, p. 87-88 2 p.

Research output: Contribution to journalComment/debate

Alzheimer disease
Alzheimer Disease
animal models
genetic variation
2 Citations (Scopus)
Alzheimer Disease
Clinical Trials
Molecular Medicine
Asymptomatic Diseases
Amyloid Precursor Protein Secretases
3 Citations (Scopus)

Axonal organization defects in the hippocampus of adult conditional BACE1 knockout mice

Ou-Yang, M. H., Kurz, J., Nomura, T., Popovic, J., Rajapaksha, T. W., Dong, H., Contractor, A., Chetkovich, D. M., Tourtellotte, W. G. & Vassar, R. J., Sep 19 2018, In : Science Translational Medicine. 10, 459, eaao5620.

Research output: Contribution to journalArticle

Knockout Mice
Hippocampus
Phenotype
Alzheimer Disease
Brain