• 17194 Citations
1981 …2020

Research output per year

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Personal profile

Research Interests

Our research focuses on molecular and cellular mechanisms of Alzheimer's disease. In particular, we investigate the beta-secretase enzyme BACE1, which initiates the production of the beta-amyloid peptide that plays a central early role in the pathogenesis of Alzheimer's. We use a combination of biochemical, cell culture and animal model approaches to investigate the role of BACE1 in health and disease.

Training Experience

1996Postdoctoral Fellowship, Columbia University

Education/Academic qualification

PhD, The University of Chicago

… → 1992

Research interests

  • Aging
  • Alzheimer's Disease
  • Alzheimer's Drug
  • Biochemistry: Proteins
  • Cell Biology
  • Molecular Biology
  • Molecular Genetics
  • Neuroscience

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  • Research Output

    Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model

    Rice, H. C., Marcassa, G., Chrysidou, I., Horré, K., Young-Pearse, T. L., Müller, U. C., Saito, T., Saido, T. C., Vassar, R., De Wit, J. & De Strooper, B., Jan 8 2020, In : Molecular neurodegeneration. 15, 1, 3.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Scopus citations

    The β-Secretase BACE1 in Alzheimer's Disease

    Hampel, H., Vassar, R., De Strooper, B., Hardy, J., Willem, M., Singh, N., Zhou, J., Yan, R., Vanmechelen, E., De Vos, A., Nisticò, R., Corbo, M., Imbimbo, B. P., Streffer, J., Voytyuk, I., Timmers, M., Tahami Monfared, A. A., Irizarry, M., Albala, B., Koyama, A. & 6 others, Watanabe, N., Kimura, T., Yarenis, L., Lista, S., Kramer, L. & Vergallo, A., 2020, (Accepted/In press) In : Biological psychiatry.

    Research output: Contribution to journalReview article

    Open Access
  • 4 Scopus citations

    3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice

    Lazic, D., Sagare, A. P., Nikolakopoulou, A. M., Griffin, J. H., Vassar, R. & Zlokovic, B. V., Feb 1 2019, In : Journal of Experimental Medicine. 216, 2, p. 279-293 15 p.

    Research output: Contribution to journalArticle

  • 10 Scopus citations

    Death by microglia

    Kemal, S. & Vassar, R., Nov 1 2019, In : Journal of Experimental Medicine. 216, 11, p. 2451-2452 2 p.

    Research output: Contribution to journalArticle

    Open Access
  • 5 Scopus citations