Grants per year
Personal profile
Research Interests
Our research focuses on molecular and cellular mechanisms of Alzheimer's disease. In particular, we investigate the beta-secretase enzyme BACE1, which initiates the production of the beta-amyloid peptide that plays a central early role in the pathogenesis of Alzheimer's. We use a combination of biochemical, cell culture and animal model approaches to investigate the role of BACE1 in health and disease.
Training Experience
| 1996 | Postdoctoral Fellowship, Columbia University |
Education/Academic qualification
Molecular Genetics, PhD, University of Chicago
… → 1992
Research interests keywords
- Aging
- Alzheimer's Disease
- Alzheimer's Drug
- Biochemistry: Proteins
- Cell Biology
- Molecular Biology
- Molecular Genetics
- Neuroscience
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Alzheimer’s Disease Tau Consortium: The role of Aβ-induced membrane damage in tau pathology
Vassar, R. J. (PD/PI) & Sadleir, K. R. (Co-PD/PI)
Alzheimer's Disease Research Foundation
2/2/25 → 2/1/27
Project: Research project
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Uncovering the Molecular Pathogenesis of Semantic dementia
Nassan, M. M. K. (PD/PI) & Vassar, R. J. (Co-PD/PI)
National Alzheimer's Association
10/1/24 → 9/30/26
Project: Research project
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Vasculo-neuronal pathophysiological interface in Alzheimer’s and Atherosclerosis
Arispe, L. (PD/PI), Vassar, R. J. (PD/PI), Cuddy, L. K. (Other) & Sadleir, K. R. (Other)
National Institute of Neurological Disorders and Stroke
9/18/24 → 8/31/27
Project: Research project
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The Role of RNA Binding Protein Networks in Tauopathy and Related Dementia R01
Vassar, R. J. (PD/PI) & Kohtz, J. D. (Co-Investigator)
9/1/24 → 8/31/25
Project: Research project
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Exploring annexin A6 for the prevention of dystrophic neurites and tau seeding and spreading in Alzheimer's disease
Sadleir, K. R. (PD/PI), Vassar, R. J. (PD/PI), Contractor, A. (Co-Investigator), Demonbreun, A. R. (Co-Investigator) & McNally, E. M. (Co-Investigator)
1/1/24 → 12/31/28
Project: Research project
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Oxidative stress induced protein aggregation via GGCT produced pyroglutamic acid in drug resistant glioblastoma
Tiek, D., Song, X., Yu, X., Wu, R., Iglesia, R., Catezone, A., McCortney, K., Walshon, J., Horbinski, C., Jamshidi, P., Castellani, R., Vassar, R., Miska, J., Hu, B. & Cheng, S. Y., Feb 21 2025, In: iScience. 28, 2, 111769.Research output: Contribution to journal › Article › peer-review
Open Access -
BACE Inhibitor Clinical Trials for Alzheimer's Disease
Watkins, E. A. & Vassar, R., 2024, In: Journal of Alzheimer's Disease. 101, s1, p. S41-S52Research output: Contribution to journal › Review article › peer-review
1 Scopus citations -
Death Induced by Survival gene Elimination (DISE) correlates with neurotoxicity in Alzheimer’s disease and aging
Paudel, B., Jeong, S. Y., Martinez, C. P., Rickman, A., Haluck-Kangas, A., Bartom, E. T., Fredriksen, K., Affaneh, A., Kessler, J. A., Mazzulli, J. R., Murmann, A. E., Rogalski, E., Geula, C., Ferreira, A., Heckmann, B. L., Green, D. R., Sadleir, K. R., Vassar, R. & Peter, M. E., Dec 2024, In: Nature communications. 15, 1, 264.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Gut microbiome-derived metabolites in Alzheimer's disease: Regulation of immunity and potential for therapeutics
Chandra, S. & Vassar, R. J., Oct 2024, In: Immunological Reviews. 327, 1, p. 33-42 10 p.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations -
Neuronal ACE1 knockout disrupts the hippocampal renin angiotensin system leading to memory impairment and vascular loss in normal aging
Jeon, S., Salvo, M. A., Alia, A. O., Popovic, J., Zagardo, M., Chandra, S., Nassan, M., Gate, D., Vassar, R. & Cuddy, L. K., Nov 2024, In: Neurobiology of Disease. 202, 106729.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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Additional file 5 of Farnesyltransferase inhibitor LNK-754 attenuates axonal dystrophy and reduces amyloid pathology in mice
Cuddy, L. K. (Creator), Alia, A. O. (Creator), Salvo, M. A. (Creator), Chandra, S. (Creator), Grammatopoulos, T. N. (Creator), Justman, C. J. (Creator), Lansbury, P. T. (Creator), Mazzulli, J. R. (Creator) & Vassar, R. (Creator), figshare, 2022
DOI: 10.6084/m9.figshare.20522624, https://springernature.figshare.com/articles/figure/Additional_file_5_of_Farnesyltransferase_inhibitor_LNK-754_attenuates_axonal_dystrophy_and_reduces_amyloid_pathology_in_mice/20522624
Dataset
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Additional file 4 of Farnesyltransferase inhibitor LNK-754 attenuates axonal dystrophy and reduces amyloid pathology in mice
Cuddy, L. K. (Creator), Alia, A. O. (Creator), Salvo, M. A. (Creator), Chandra, S. (Creator), Grammatopoulos, T. N. (Creator), Justman, C. J. (Creator), Lansbury, P. T. (Creator), Mazzulli, J. R. (Creator) & Vassar, R. (Creator), figshare, 2022
DOI: 10.6084/m9.figshare.20522621, https://springernature.figshare.com/articles/figure/Additional_file_4_of_Farnesyltransferase_inhibitor_LNK-754_attenuates_axonal_dystrophy_and_reduces_amyloid_pathology_in_mice/20522621
Dataset
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Additional file 3 of Farnesyltransferase inhibitor LNK-754 attenuates axonal dystrophy and reduces amyloid pathology in mice
Cuddy, L. K. (Creator), Alia, A. O. (Creator), Salvo, M. A. (Creator), Chandra, S. (Creator), Grammatopoulos, T. N. (Creator), Justman, C. J. (Creator), Lansbury, P. T. (Creator), Mazzulli, J. R. (Creator) & Vassar, R. (Creator), figshare, 2022
DOI: 10.6084/m9.figshare.20522618, https://springernature.figshare.com/articles/figure/Additional_file_3_of_Farnesyltransferase_inhibitor_LNK-754_attenuates_axonal_dystrophy_and_reduces_amyloid_pathology_in_mice/20522618
Dataset
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Additional file 12 of The gut microbiome regulates astrocyte reaction to Aβ amyloidosis through microglial dependent and independent mechanisms
Chandra, S. (Creator), Di Meco, A. (Creator), Dodiya, H. B. (Creator), Popovic, J. (Creator), Cuddy, L. K. (Creator), Weigle, I. Q. (Creator), Zhang, X. (Creator), Sadleir, K. (Creator), Sisodia, S. S. (Creator) & Vassar, R. (Creator), figshare, 2024
DOI: 10.6084/m9.figshare.26988553.v1, https://springernature.figshare.com/articles/dataset/Additional_file_12_of_The_gut_microbiome_regulates_astrocyte_reaction_to_A_amyloidosis_through_microglial_dependent_and_independent_mechanisms/26988553/1
Dataset
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Additional file 10 of The gut microbiome regulates astrocyte reaction to Aβ amyloidosis through microglial dependent and independent mechanisms
Chandra, S. (Creator), Di Meco, A. (Creator), Dodiya, H. B. (Creator), Popovic, J. (Creator), Cuddy, L. K. (Creator), Weigle, I. Q. (Creator), Zhang, X. (Creator), Sadleir, K. (Creator), Sisodia, S. S. (Creator) & Vassar, R. (Creator), figshare, 2024
DOI: 10.6084/m9.figshare.26988547.v1, https://springernature.figshare.com/articles/dataset/Additional_file_10_of_The_gut_microbiome_regulates_astrocyte_reaction_to_A_amyloidosis_through_microglial_dependent_and_independent_mechanisms/26988547/1
Dataset