• 16717 Citations
1981 …2024

Research output per year

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Personal profile

Research Interests

Our research focuses on molecular and cellular mechanisms of Alzheimer's disease. In particular, we investigate the beta-secretase enzyme BACE1, which initiates the production of the beta-amyloid peptide that plays a central early role in the pathogenesis of Alzheimer's. We use a combination of biochemical, cell culture and animal model approaches to investigate the role of BACE1 in health and disease.

Training Experience

1996Postdoctoral Fellowship, Columbia University

Education/Academic qualification

PhD, The University of Chicago

… → 1992

Research interests

  • Aging
  • Alzheimer's Disease
  • Alzheimer's Drug
  • Biochemistry: Proteins
  • Cell Biology
  • Molecular Biology
  • Molecular Genetics
  • Neuroscience

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Grants

  • Research Output

    3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice

    Lazic, D., Sagare, A. P., Nikolakopoulou, A. M., Griffin, J. H., Vassar, R. & Zlokovic, B. V., Feb 1 2019, In : Journal of Experimental Medicine. 216, 2, p. 279-293 15 p.

    Research output: Contribution to journalArticle

  • 9 Scopus citations

    Death by microglia

    Kemal, S. & Vassar, R., Nov 1 2019, In : Journal of Experimental Medicine. 216, 11, p. 2451-2452 2 p.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Scopus citations

    Modeling genetic diversity in Alzheimer’s disease

    Sadleir, K. R. & Vassar, R., Mar 1 2019, In : Lab animal. 48, 3, p. 87-88 2 p.

    Research output: Contribution to journalComment/debate