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Personal profile

Research Interests

Our research focuses on molecular and cellular mechanisms of Alzheimer's disease. In particular, we investigate the beta-secretase enzyme BACE1, which initiates the production of the beta-amyloid peptide that plays a central early role in the pathogenesis of Alzheimer's. We use a combination of biochemical, cell culture and animal model approaches to investigate the role of BACE1 in health and disease.

Training Experience

1996Postdoctoral Fellowship, Columbia University

Education/Academic qualification

PhD, University of Chicago

… → 1992

Research interests

  • Aging
  • Alzheimer's Disease
  • Alzheimer's Drug
  • Biochemistry: Proteins
  • Cell Biology
  • Molecular Biology
  • Molecular Genetics
  • Neuroscience

Fingerprint Dive into the research topics where Robert J Vassar is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 4 Similar Profiles
Alzheimer Disease Medicine & Life Sciences
Amyloid Precursor Protein Secretases Medicine & Life Sciences
Amyloid beta-Protein Precursor Medicine & Life Sciences
Amyloid Medicine & Life Sciences
Transgenic Mice Medicine & Life Sciences
Amyloid Plaques Medicine & Life Sciences
Enzymes Medicine & Life Sciences
Neurons Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2001 2024

Alzheimer Disease
Therapeutics
Pathology
Amyloid
Knockout Mice
Amyloid
Cerebrospinal Fluid
Alzheimer Disease
Biomarkers
Isotope Labeling
Microbiota
Amyloid
Astrocytes
Pathology
Microglia
Alzheimer Disease
Calcium
Doxycycline
Buffers
Neurites

Research Output 1981 2019

5 Citations (Scopus)

3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice

Lazic, D., Sagare, A. P., Nikolakopoulou, A. M., Griffin, J. H., Vassar, R. J. & Zlokovic, B. V., Feb 1 2019, In : Journal of Experimental Medicine. 216, 2, p. 279-293 15 p.

Research output: Contribution to journalArticle

Protein C
Cerebrovascular Circulation
Alzheimer Disease
Stroke
Protein Precursors
1 Citation (Scopus)
Knockout Mice
Hippocampus
Clinical Trials
Phenotype
Alzheimer Disease

Modeling genetic diversity in Alzheimer’s disease

Sadleir, K. R. & Vassar, R. J., Mar 1 2019, In : Lab animal. 48, 3, p. 87-88 2 p.

Research output: Contribution to journalComment/debate

Alzheimer disease
Alzheimer Disease
animal models
genetic variation
Post-Synaptic Density
Ubiquitin
Alzheimer Disease
6 Citations (Scopus)
Alzheimer Disease
Clinical Trials
Molecular Medicine
Asymptomatic Diseases
Amyloid Precursor Protein Secretases