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Robert P Schleimer

  • 20352 Citations
1976 …2024
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Personal profile

Research Interests

I am interested in the mechanisms of pathogenesis and treatment of a variety of allergic and inflammatory diseases associated with allergy. These include chronic rhinosinusitis, asthma, hay fever, rhinitis, food allergy and others. We also study the mechanisms of action of antiinflammatory glucocorticoids. Our studies focus on the molecular and cellular mechanisms underlying disease and steroid action as well as developing strategies to for new treatments.

Training Experience

1981Fellowship, Johns Hopkins University School of Medicine

Education/Academic qualification

PhD, University of California-Davis

… → 1979

Research interests

  • Allergies
  • Asthma
  • Immunology
  • Inflammation

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  • 20 Similar Profiles
Nasal Polyps Medicine & Life Sciences
Mast Cells Medicine & Life Sciences
Basophils Medicine & Life Sciences
Eosinophils Medicine & Life Sciences
Glucocorticoids Medicine & Life Sciences
Asthma Medicine & Life Sciences
Epithelial Cells Medicine & Life Sciences
Lung Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2004 2024

Chronic Rhinosinusitis Integrative Studies Program 2 (CRISP2)

Lindholm, P. F., Rademaker, A. W., Schleimer, R. P., Stevens, W. & Welch, K. C.

National Institute of Allergy and Infectious Diseases

8/15/19 → 7/31/24

Project: Research project

Natural History
Phenotype
Comorbidity
Longitudinal Studies
Bronchiectasis

Project 1: Mechanisms of barrier dysfunction and tissue hyperplasia in CRS

Berdnikovs, S., Hulse, K. E., Kern, R. C., Peters, A. T., Schleimer, R. P. & Tan, B. K.

National Institute of Allergy and Infectious Diseases

8/15/19 → 7/31/24

Project: Research project

Hyperplasia
Natural History
Phenotype
Comorbidity
Longitudinal Studies

5-laser 30-parameter FACSymphony-S6 SORP Cell Sorter from BD Biosciences

Abecassis, M. M., Bharat, A., Budinger, G. S., D'Aquila, R. T., Hope, T. J., Kato, A., Le Poole, I. C., Lesniak, M. S., Luo, X., Misharin, A., Perlman, H. R., Schleimer, R. P., Singer, B., Swaminathan, S., Sznajder, J. I., Tetreault, M., Thorp, E. B. & Wunderink, R. G.

Office of the Director, National Institutes of Health

8/8/19 → 8/7/20

Project: Research project

S 6
Lasers
Translational Medical Research
Health
Therapeutics

Type-2 inflammation mediates olfactory loss in Chronic Rhinosinusitis: mechanisms and therapeutic opportunities

Avram, M. J., Chmiel, J. S., Schleimer, R. P. & Tan, B. K.

National Institute on Deafness and Other Communication Disorders

7/23/18 → 6/30/23

Project: Research project

Smell
Inflammation
Proton-Translocating ATPases
Therapeutics
Ion Pumps

Autoantibody mediated pathogenesis in chronic rhinosinusitis with nasal polyps: mechanisms and consequences

Hulse, K. E., Schleimer, R. P. & Tan, B. K.

National Institute of Allergy and Infectious Diseases

5/25/18 → 4/30/23

Project: Research project

Nasal Polyps
Autoantibodies
B-Lymphocytes
Antibodies
Antigens

Research Output 1976 2020

Role of RANK-L as a potential inducer of ILC2-mediated type 2 inflammation in chronic rhinosinusitis with nasal polyps

Ogasawara, N., Poposki, J. A., Klingler, A. I., Tan, B. K., Hulse, K. E., Stevens, W. W., Peters, A. T., Grammer, L. C., Welch, K. C., Smith, S. S., Conley, D. B., Raviv, J. R., Soroosh, P., Takano, K. I., Himi, T., Kern, R. C., Schleimer, R. P. & Kato, A., Jan 1 2020, In : Mucosal Immunology. 13, 1, p. 86-95 10 p.

Research output: Contribution to journal › Article

Nasal Polyps
Inflammation
Cytokines
RANK Ligand
Coculture Techniques
1 Citation (Scopus)

TNF induces production of type 2 cytokines in human group 2 innate lymphoid cells

Ogasawara, N., Poposki, J. A., Klingler, A. I., Tan, B. K., Hulse, K. E., Stevens, W. W., Peters, A. T., Grammer, L. C., Welch, K. C., Smith, S. S., Conley, D. B., Takano, K. I., Himi, T., Kern, R. C., Schleimer, R. P. & Kato, A., Jan 2020, In : Journal of Allergy and Clinical Immunology. 145, 1, p. 437-440.e8

Research output: Contribution to journal › Article

Lymphocytes
Cytokines
5 Citations (Scopus)

Associations Between Inflammatory Endotypes and Clinical Presentations in Chronic Rhinosinusitis

Stevens, W. W., Peters, A. T., Tan, B. K., Klingler, A. I., Poposki, J. A., Hulse, K. E., Grammer, L. C., Welch, K. C., Smith, S. S., Conley, D. B., Kern, R. C., Schleimer, R. P. & Kato, A., Nov 1 2019, In : Journal of Allergy and Clinical Immunology: In Practice. 7, 8, p. 2812-2820.e3

Research output: Contribution to journal › Article

Inflammation
Suppuration
Smell
Galectin 2
Eosinophil Cationic Protein
3 Citations (Scopus)

Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations

CAAPA, Dec 1 2019, In : Nature communications. 10, 1, 880.

Research output: Contribution to journal › Article

asthma
loci
Asthma
Genes
Chromosomes
5 Citations (Scopus)

Clinical Characteristics of Patients with Chronic Rhinosinusitis without Nasal Polyps in an Academic Setting

Benjamin, M. R., Stevens, W., Li, N., Bose, S., Grammer III, L. C., Kern, R. C., Tan, B. K-H., Conley Jr, D. B., Smith, S. S., Welch, K. C., Schleimer, R. P. & Peters, A. T., Mar 1 2019, In : Journal of Allergy and Clinical Immunology: In Practice. 7, 3, p. 1010-1016 7 p.

Research output: Contribution to journal › Article

Nasal Polyps
Asthma
Population